메뉴 건너뛰기




Volumn 29, Issue 5, 2011, Pages 551-565

Biology, risk stratification, and therapy of pediatric acute leukemias: An update

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; ANNAMYCIN; ANTHRACYCLINE; ASPARAGINASE; ASPARAGINASE MACROGOL; BLINATUMOMAB; BOSUTINIB; CLOFARABINE; CYTARABINE; DANUSERTIB; DASATINIB; DEXAMETHASONE; DOXORUBICIN; EPRATUZUMAB; ETOPOSIDE; FOLINIC ACID; FORODESINE; GEMTUZUMAB OZOGAMICIN; IMATINIB; INOTUZUMAB OZOGAMICIN; LESTAURTINIB; MERCAPTOPURINE; METHOTREXATE; NELARABINE; NILOTINIB; RITUXIMAB; SORAFENIB; TOZASERTIB; UNINDEXED DRUG; VINCRISTINE;

EID: 79952078495     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2010.30.7405     Document Type: Review
Times cited : (695)

References (152)
  • 1
    • 76749171200 scopus 로고    scopus 로고
    • Long-term results of the Italian Association of Pediatric Hematology and Oncology (AIEOP) Studies 82, 87, 88, 91 and 95 for childhood acute lymphoblastic leukemia
    • Conter V, Aricò M, Basso G, et al: Long-term results of the Italian Association of Pediatric Hematology and Oncology (AIEOP) Studies 82, 87, 88, 91 and 95 for childhood acute lymphoblastic leukemia. Leukemia 24:255-264, 2010
    • (2010) Leukemia , vol.24 , pp. 255-264
    • Conter, V.1    Aricò, M.2    Basso, G.3
  • 2
    • 76749102418 scopus 로고    scopus 로고
    • Long-term results of five consecutive trials in childhood acute lymphoblastic leukemia performed by the ALL-BFM study group from 1981 to 2000
    • Möricke A, Zimmermann M, Reiter A, et al: Long-term results of five consecutive trials in childhood acute lymphoblastic leukemia performed by the ALL-BFM study group from 1981 to 2000. Leukemia 24:265-284, 2010
    • (2010) Leukemia , vol.24 , pp. 265-284
    • Möricke, A.1    Zimmermann, M.2    Reiter, A.3
  • 3
    • 76749095066 scopus 로고    scopus 로고
    • Long-term results of the Children's Cancer Group studies for childhood acute lymphoblastic leukemia 1983-2002: A Children's Oncology Group Report
    • Gaynon PS, Angiolillo AL, Carroll WL, et al: Long-term results of the Children's Cancer Group studies for childhood acute lymphoblastic leukemia 1983-2002: A Children's Oncology Group Report. Leukemia 24:285-297, 2010
    • (2010) Leukemia , vol.24 , pp. 285-297
    • Gaynon, P.S.1    Angiolillo, A.L.2    Carroll, W.L.3
  • 4
    • 76749112909 scopus 로고    scopus 로고
    • Cooperative study group for childhood acute lymphoblastic leukaemia (COALL): Long-term results of trials 82,85,89,92 and 97
    • Escherich G, Horstmann MA, Zimmermann M, et al: Cooperative study group for childhood acute lymphoblastic leukaemia (COALL): Long-term results of trials 82,85,89,92 and 97. Leukemia 24: 298-308, 2010
    • (2010) Leukemia , vol.24 , pp. 298-308
    • Escherich, G.1    Horstmann, M.A.2    Zimmermann, M.3
  • 5
    • 76749136697 scopus 로고    scopus 로고
    • Long-term results of treatment of childhood acute lymphoblastic leukemia in the Czech Republic
    • Stary J, Jabali Y, Trka J, et al: Long-term results of treatment of childhood acute lymphoblastic leukemia in the Czech Republic. Leukemia 24: 425-428, 2010
    • (2010) Leukemia , vol.24 , pp. 425-428
    • Stary, J.1    Jabali, Y.2    Trka, J.3
  • 6
    • 76749108502 scopus 로고    scopus 로고
    • Long-term results of Dana-Farber Cancer Institute ALL Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1985-2000)
    • Silverman LB, Stevenson KE, O'Brien JE, et al: Long-term results of Dana-Farber Cancer Institute ALL Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1985-2000). Leukemia 24:320-334, 2010
    • (2010) Leukemia , vol.24 , pp. 320-334
    • Silverman, L.B.1    Stevenson, K.E.2    O'Brien, J.E.3
  • 7
    • 76749083364 scopus 로고    scopus 로고
    • Long-term results of the Israeli National Studies in childhood acute lymphoblastic leukemia: INS 84, 89 and 98
    • Stark B, Nirel R, Avrahami G, et al: Long-term results of the Israeli National Studies in childhood acute lymphoblastic leukemia: INS 84, 89 and 98. Leukemia 24:419-424, 2010
    • (2010) Leukemia , vol.24 , pp. 419-424
    • Stark, B.1    Nirel, R.2    Avrahami, G.3
  • 8
    • 76749115697 scopus 로고    scopus 로고
    • Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia
    • Schmiegelow K, Forestier E, Hellebostad M, et al: Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia. Leukemia 24:345-354, 2010
    • (2010) Leukemia , vol.24 , pp. 345-354
    • Schmiegelow, K.1    Forestier, E.2    Hellebostad, M.3
  • 9
    • 76749138468 scopus 로고    scopus 로고
    • Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia
    • Pui CH, Pei D, Sandlund JT, et al: Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia. Leukemia 24:371-382, 2010
    • (2010) Leukemia , vol.24 , pp. 371-382
    • Pui, C.H.1    Pei, D.2    Sandlund, J.T.3
  • 10
    • 67649410242 scopus 로고    scopus 로고
    • Treating childhood acute lymphoblastic leukemia without cranial irradiation
    • Pui CH, Campana D, Pei D, et al: Treating childhood acute lymphoblastic leukemia without cranial irradiation. N Engl J Med 360:2730-2741, 2009
    • (2009) N Engl J Med , vol.360 , pp. 2730-2741
    • Pui, C.H.1    Campana, D.2    Pei, D.3
  • 11
    • 76749093120 scopus 로고    scopus 로고
    • Long-term results of Tokyo Children's Cancer Study Group trials for childhood acute lymphoblastic leukemia, 1984-1999
    • Tsuchida M, Ohara A, Manabe A, et al: Long-term results of Tokyo Children's Cancer Study Group trials for childhood acute lymphoblastic leukemia, 1984-1999. Leukemia 24:383-396, 2010
    • (2010) Leukemia , vol.24 , pp. 383-396
    • Tsuchida, M.1    Ohara, A.2    Manabe, A.3
  • 12
    • 76749170269 scopus 로고    scopus 로고
    • Long-term results of Taiwan Pediatric Oncology Group studies 1997 and 2002 for childhood acute lymphoblastic leukemia
    • Liang DC, Yang CP, Lin DT, et al: Long-term results of Taiwan Pediatric Oncology Group studies 1997 and 2002 for childhood acute lymphoblastic leukemia. Leukemia 24:397-405, 2010
    • (2010) Leukemia , vol.24 , pp. 397-405
    • Liang, D.C.1    Yang, C.P.2    Lin, D.T.3
  • 13
    • 76749111534 scopus 로고    scopus 로고
    • Long-term follow-up of the United Kingdom medical research council protocols for childhood acute lymphoblastic leukaemia, 1980-2001
    • Mitchell C, Richards S, Harrison CJ, et al: Long-term follow-up of the United Kingdom medical research council protocols for childhood acute lymphoblastic leukaemia, 1980-2001. Leukemia 24:406-418, 2010
    • (2010) Leukemia , vol.24 , pp. 406-418
    • Mitchell, C.1    Richards, S.2    Harrison, C.J.3
  • 14
    • 76749171660 scopus 로고    scopus 로고
    • Long-term results of Dutch Childhood Oncology Group studies for children with acute lymphoblastic leukemia from 1984 to 2004
    • Kamps WA, van der Pal-de Bruin KM, Veerman AJ, et al: Long-term results of Dutch Childhood Oncology Group studies for children with acute lymphoblastic leukemia from 1984 to 2004. Leukemia 24:309-319, 2010
    • (2010) Leukemia , vol.24 , pp. 309-319
    • Kamps, W.A.1    Van Der Pal-de Bruin, K.M.2    Veerman, A.J.3
  • 16
    • 77449155696 scopus 로고    scopus 로고
    • Attempts to optimize induction and consolidation treatment in acute myeloid leukemia: Results of the MRC AML12 trial
    • Burnett AK, Hills RK, Milligan DW, et al: Attempts to optimize induction and consolidation treatment in acute myeloid leukemia: Results of the MRC AML12 trial. J Clin Oncol 28:586-595, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 586-595
    • Burnett, A.K.1    Hills, R.K.2    Milligan, D.W.3
  • 17
    • 34447282260 scopus 로고    scopus 로고
    • Repetitive cycles of high-dose cytarabine are effective for childhood acute myeloid leukemia: Long-term outcome of the children with AML treated on two consecutive trials of tokyo children's cancer study group
    • DOI 10.1002/pbc.20944
    • Tomizawa D, Tabuchi K, Kinoshita A, et al: Repetitive cycles of high-dose cytarabine are effective for childhood acute myeloid leukemia: Long-term outcome of the children with AML treated on two consecutive trials of Tokyo Children's Cancer Study Group. Pediatr Blood Cancer 49:127-132, 2007 (Pubitemid 47041100)
    • (2007) Pediatric Blood and Cancer , vol.49 , Issue.2 , pp. 127-132
    • Tomizawa, D.1    Tabuchi, K.2    Kinoshita, A.3    Hanada, R.4    Kigasawa, H.5    Tsukimoto, I.6    Tsuchida, M.7
  • 18
    • 28544438562 scopus 로고    scopus 로고
    • Treatment strategy and long-term results in pediatric patients treated in two consecutive AML-GATLA trials [1]
    • DOI 10.1038/sj.leu.2403854, PII 2403854
    • Armendariz H, Barbieri MA, Freigeiro D, et al: Treatment strategy and long-term results in pediatric patients treated in two consecutive AML-GATLA trials. Leukemia 19:2139-2142, 2005 (Pubitemid 41741606)
    • (2005) Leukemia , vol.19 , Issue.12 , pp. 2139-2142
    • Armendariz, H.1    Fernandez, B.M.A.2    Freigeiro, D.3    Lastiri, F.4    Felice, M.S.5    Dibar, E.6
  • 21
    • 28544445097 scopus 로고    scopus 로고
    • Long-term results of children with acute myeloid leukemia: A report of three consecutive Phase III trials by the Children's Cancer Group: CCG 251, CCG 213 and CCG 2891
    • DOI 10.1038/sj.leu.2403925, PII 2403925
    • Smith FO, Alonzo TA, Gerbing RB, et al: Long-term results of children with acute myeloid leukemia: A report of three consecutive phase III trials by the Children's Cancer Group: CCG 251, CCG 213 and CCG 2891. Leukemia 19:2054-2062, 2005 (Pubitemid 41741597)
    • (2005) Leukemia , vol.19 , Issue.12 , pp. 2054-2062
    • Smith, F.O.1    Alonzo, T.A.2    Gerbing, R.B.3    Woods, W.G.4    Arceci, R.J.5
  • 22
    • 16644375118 scopus 로고    scopus 로고
    • Treatment and prevention of tumor lysis syndrome in children
    • Pession A, Barbieri E: Treatment and prevention of tumor lysis syndrome in children. Contrib Nephrol 147:80-92, 2005
    • (2005) Contrib Nephrol , vol.147 , pp. 80-92
    • Pession, A.1    Barbieri, E.2
  • 25
    • 28544450726 scopus 로고    scopus 로고
    • Pediatric Oncology Group (POG) studies of acute myeloid leukemia (AML): A review of four consecutive childhood AML trials conducted between 1981 and 2000
    • Ravindranath Y, Chang M, Steuber CP, et al: Pediatric Oncology Group (POG) studies of acute myeloid leukemia (AML): A review of four consecutive childhood AML trials conducted between 1981 and 2000. Leukemia 19:2101-2116, 2005
    • (2005) Leukemia , vol.19 , pp. 2101-2116
    • Ravindranath, Y.1    Chang, M.2    Steuber, C.P.3
  • 26
    • 77953483479 scopus 로고    scopus 로고
    • Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: Results of the AML02 multicentre trial
    • Rubnitz JE, Inaba H, Dahl G, et al: Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: Results of the AML02 multicentre trial. Lancet Oncol 11:543-552, 2010
    • (2010) Lancet Oncol , vol.11 , pp. 543-552
    • Rubnitz, J.E.1    Inaba, H.2    Dahl, G.3
  • 28
    • 69849101233 scopus 로고    scopus 로고
    • Risk-stratified therapy and the intensive use of cytarabine improves the outcome in childhood acute myeloid leukemia: The AML99 trial from the Japanese Childhood AML Cooperative Study Group
    • Tsukimoto I, Tawa A, Horibe K, et al: Risk-stratified therapy and the intensive use of cytarabine improves the outcome in childhood acute myeloid leukemia: The AML99 trial from the Japanese Childhood AML Cooperative Study Group. J Clin Oncol 27:4007-4013, 2009
    • (2009) J Clin Oncol , vol.27 , pp. 4007-4013
    • Tsukimoto, I.1    Tawa, A.2    Horibe, K.3
  • 30
    • 67650158965 scopus 로고    scopus 로고
    • COG AAML03P1: Efficacy and safety in a pilot study of intensive chemotherapy including gemtuzumab in children newly diagnosed with acute myeloid leukemia (AML)
    • (abstr 13)
    • Franklin J, Alonzo T, Hurwitz CA, et al: COG AAML03P1: Efficacy and safety in a pilot study of intensive chemotherapy including gemtuzumab in children newly diagnosed with acute myeloid leukemia (AML). ASH Annual Meeting Abstracts 112:56, 2008 (abstr 13)
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 56
    • Franklin, J.1    Alonzo, T.2    Hurwitz, C.A.3
  • 31
    • 40749150603 scopus 로고    scopus 로고
    • Acute lymphoblastic leukaemia
    • DOI 10.1016/S0140-6736(08)60457-2, PII S0140673608604572
    • Pui CH, Robison LL, Look AT: Acute lymphoblastic leukaemia. Lancet 371:1030-1043, 2008 (Pubitemid 351389536)
    • (2008) The Lancet , vol.371 , Issue.9617 , pp. 1030-1043
    • Pui, C.-H.1    Robison, L.L.2    Look, A.T.3
  • 35
    • 76749108960 scopus 로고    scopus 로고
    • Long-term results of the pediatric oncology group studies for childhood acute lymphoblastic leukemia 1984-2001: A report from the Children's Oncology Group
    • Salzer WL, Devidas M, Carroll WL, et al: Long-term results of the pediatric oncology group studies for childhood acute lymphoblastic leukemia 1984-2001: A report from the Children's Oncology Group. Leukemia 24:355-370, 2010
    • (2010) Leukemia , vol.24 , pp. 355-370
    • Salzer, W.L.1    Devidas, M.2    Carroll, W.L.3
  • 36
    • 46449085873 scopus 로고    scopus 로고
    • Minimal residual disease values discriminate between low and high relapse risk in children with B-cell precursor acute lymphoblastic leukemia and an intrachromosomal amplification of chromosome 21: The Austrian and German acute lymphoblastic leukemia Berlin-Frankfurt-Munster (ALL-BFM) trials
    • Attarbaschi A, Mann G, Panzer-Grümayer R, et al: Minimal residual disease values discriminate between low and high relapse risk in children with B-cell precursor acute lymphoblastic leukemia and an intrachromosomal amplification of chromosome 21: The Austrian and German acute lymphoblastic leukemia Berlin-Frankfurt-Munster (ALL-BFM) trials. J Clin Oncol 26:3046-3050, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 3046-3050
    • Attarbaschi, A.1    Mann, G.2    Panzer-Grümayer, R.3
  • 37
    • 70449711127 scopus 로고    scopus 로고
    • Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: A Children's Oncology Group study
    • Schultz KR, Bowman WP, Aledo A, et al: Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: A Children's Oncology Group study. J Clin Oncol 27:5175-5181, 2009
    • (2009) J Clin Oncol , vol.27 , pp. 5175-5181
    • Schultz, K.R.1    Bowman, W.P.2    Aledo, A.3
  • 38
    • 30444437486 scopus 로고    scopus 로고
    • Treatment of acute lymphoblastic leukemia
    • Pui CH, Evans WE: Treatment of acute lymphoblastic leukemia. N Engl J Med 354:166-178, 2006
    • (2006) N Engl J Med , vol.354 , pp. 166-178
    • Pui, C.H.1    Evans, W.E.2
  • 40
    • 70350680415 scopus 로고    scopus 로고
    • Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia
    • Mullighan CG, Collins-Underwood JR, Phillips LA, et al: Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia. Nat Genet 41:1243-1246, 2009
    • (2009) Nat Genet , vol.41 , pp. 1243-1246
    • Mullighan, C.G.1    Collins-Underwood, J.R.2    Phillips, L.A.3
  • 41
    • 77954500629 scopus 로고    scopus 로고
    • Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol
    • Cario G, Zimmermann M, Romey R, et al: Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol. Blood 115:5393-5397, 2010
    • (2010) Blood , vol.115 , pp. 5393-5397
    • Cario, G.1    Zimmermann, M.2    Romey, R.3
  • 42
    • 77954516863 scopus 로고    scopus 로고
    • Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/ Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia
    • Harvey RC, Mullighan CG, Chen IM, et al: Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/ Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia. Blood 115:5312-5321, 2010
    • (2010) Blood , vol.115 , pp. 5312-5321
    • Harvey, R.C.1    Mullighan, C.G.2    Chen, I.M.3
  • 43
    • 57549087387 scopus 로고    scopus 로고
    • New genetic abnormalities and treatment response in acute lymphoblastic leukemia
    • Meijerink JP, den Boer ML, Pieters R: New genetic abnormalities and treatment response in acute lymphoblastic leukemia. Semin Hematol 46: 16-23, 2009
    • (2009) Semin Hematol , vol.46 , pp. 16-23
    • Meijerink, J.P.1    Den Boer, M.L.2    Pieters, R.3
  • 44
    • 58249140126 scopus 로고    scopus 로고
    • Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia
    • Graux C, Stevens-Kroef M, Lafage M, et al: Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia. Leukemia 23:125-133, 2009
    • (2009) Leukemia , vol.23 , pp. 125-133
    • Graux, C.1    Stevens-Kroef, M.2    Lafage, M.3
  • 45
    • 58749095816 scopus 로고    scopus 로고
    • Early T-cell precursor leukaemia: A subtype of very high-risk acute lymphoblastic leukaemia
    • Coustan-Smith E, Mullighan CG, Onciu M, et al: Early T-cell precursor leukaemia: A subtype of very high-risk acute lymphoblastic leukaemia. Lancet Oncol 10:147-156, 2009
    • (2009) Lancet Oncol , vol.10 , pp. 147-156
    • Coustan-Smith, E.1    Mullighan, C.G.2    Onciu, M.3
  • 46
    • 58749109707 scopus 로고    scopus 로고
    • Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia
    • Mullighan CG, Su X, Zhang J, et al: Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 360:470-480, 2009
    • (2009) N Engl J Med , vol.360 , pp. 470-480
    • Mullighan, C.G.1    Su, X.2    Zhang, J.3
  • 47
    • 58749097408 scopus 로고    scopus 로고
    • A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: A genome-wide classification study
    • Den Boer ML, van Slegtenhorst M, De Menezes RX, et al: A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: A genome-wide classification study. Lancet Oncol 10:125-134, 2009
    • (2009) Lancet Oncol , vol.10 , pp. 125-134
    • Den Boer, M.L.1    Van Slegtenhorst, M.2    De Menezes, R.X.3
  • 48
    • 67249146555 scopus 로고    scopus 로고
    • JAK mutations in high-risk childhood acute lymphoblastic leukemia
    • Mullighan CG, Zhang J, Harvey RC, et al: JAK mutations in high-risk childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A 106:9414-9418, 2009
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9414-9418
    • Mullighan, C.G.1    Zhang, J.2    Harvey, R.C.3
  • 49
    • 33747155025 scopus 로고    scopus 로고
    • Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia
    • DOI 10.1182/blood-2005-12-4956
    • Breit S, Stanulla M, Flohr T, et al: Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia. Blood 108: 1151-1157, 2006 (Pubitemid 44232009)
    • (2006) Blood , vol.108 , Issue.4 , pp. 1151-1157
    • Breit, S.1    Stanulla, M.2    Flohr, T.3    Schrappe, M.4    Ludwig, W.-D.5    Tolle, G.6    Happich, M.7    Muckenthaler, M.U.8    Kulozik, A.E.9
  • 50
    • 70149087158 scopus 로고    scopus 로고
    • High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia
    • Gutierrez A, Sanda T, Grebliunaite R, et al: High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood 114:647-650, 2009
    • (2009) Blood , vol.114 , pp. 647-650
    • Gutierrez, A.1    Sanda, T.2    Grebliunaite, R.3
  • 52
    • 77649214639 scopus 로고    scopus 로고
    • Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: A report from the International BFM Study Group
    • Hertzberg L, Vendramini E, Ganmore I, et al: Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: A report from the International BFM Study Group. Blood 115:1006-1017, 2010
    • (2010) Blood , vol.115 , pp. 1006-1017
    • Hertzberg, L.1    Vendramini, E.2    Ganmore, I.3
  • 53
    • 38349068493 scopus 로고    scopus 로고
    • Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences
    • van Grotel M, Meijerink JP, van Wering ER, et al: Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences. Leukemia 22:124-131, 2008
    • (2008) Leukemia , vol.22 , pp. 124-131
    • Van Grotel, M.1    Meijerink, J.P.2    Van Wering, E.R.3
  • 54
    • 61549114444 scopus 로고    scopus 로고
    • Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia
    • Yang JJ, Bhojwani D, Yang W, et al. Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia. Blood 112:4178-4183, 2008
    • (2008) Blood , vol.112 , pp. 4178-4183
    • Yang, J.J.1    Bhojwani, D.2    Yang, W.3
  • 57
    • 69349101565 scopus 로고    scopus 로고
    • Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia
    • Papaemmanuil E, Hosking FJ, Vijayakrishnan J, et al: Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. Nat Genet 41:1006-1010, 2009
    • (2009) Nat Genet , vol.41 , pp. 1006-1010
    • Papaemmanuil, E.1    Hosking, F.J.2    Vijayakrishnan, J.3
  • 58
    • 69349091330 scopus 로고    scopus 로고
    • Germline genomic variants associated with childhood acute lymphoblastic leukemia
    • Treviño LR, Yang W, French D, et al: Germline genomic variants associated with childhood acute lymphoblastic leukemia. Nat Genet 2009 41: 1001-1005, 2009
    • (2009) Nat Genet 2009 , vol.41 , pp. 1001-1005
    • Treviño, L.R.1    Yang, W.2    French, D.3
  • 59
    • 77950955951 scopus 로고    scopus 로고
    • ARID5B SNP rs10821936 is associated with risk of childhood acute lymphoblastic leukemia in blacks and contributes to racial differences in leukemia incidence
    • Yang W, Trevino LR, Yang JJ, et al: ARID5B SNP rs10821936 is associated with risk of childhood acute lymphoblastic leukemia in blacks and contributes to racial differences in leukemia incidence. Leukemia 24:894-896, 2010
    • (2010) Leukemia , vol.24 , pp. 894-896
    • Yang, W.1    Trevino, L.R.2    Yang, J.J.3
  • 60
    • 69849104865 scopus 로고    scopus 로고
    • The leukemic stem cell niche: Current concepts and therapeutic opportunities
    • Lane SW, Scadden DT, Gilliland DG: The leukemic stem cell niche: Current concepts and therapeutic opportunities. Blood 114:1150-1157, 2009
    • (2009) Blood , vol.114 , pp. 1150-1157
    • Lane, S.W.1    Scadden, D.T.2    Gilliland, D.G.3
  • 62
    • 65649098700 scopus 로고    scopus 로고
    • Backtracking of leukemic clones to birth
    • Wiemels J, Kang M, Greaves M: Backtracking of leukemic clones to birth. Methods Mol Biol 538:7-27, 2009
    • (2009) Methods Mol Biol , vol.538 , pp. 7-27
    • Wiemels, J.1    Kang, M.2    Greaves, M.3
  • 63
    • 34249674555 scopus 로고    scopus 로고
    • The quality of molecular response to chemotherapy is predictive for the outcome of AML1-ETO-positive AML and is independent of pretreatment risk factors
    • DOI 10.1038/sj.leu.2404659, PII 2404659
    • Weisser M, Haferlach C, Hiddemann W, et al: The quality of molecular response to chemotherapy is predictive for the outcome of AML1-ETO-positive AML and is independent of pretreatment risk factors. Leukemia 21:1177-1182, 2007 (Pubitemid 46831805)
    • (2007) Leukemia , vol.21 , Issue.6 , pp. 1177-1182
    • Weisser, M.1    Haferlach, C.2    Hiddemann, W.3    Schnittger, S.4
  • 65
    • 70350497118 scopus 로고    scopus 로고
    • Novel prognostic subgroups in childhood 11q23/ MLL-rearranged acute myeloid leukemia: Results of an international retrospective study
    • Balgobind BV, Raimondi SC, Harbott J, et al: Novel prognostic subgroups in childhood 11q23/ MLL-rearranged acute myeloid leukemia: Results of an international retrospective study. Blood 114: 2489-2496, 2009
    • (2009) Blood , vol.114 , pp. 2489-2496
    • Balgobind, B.V.1    Raimondi, S.C.2    Harbott, J.3
  • 66
    • 44449151696 scopus 로고    scopus 로고
    • Novel regions of acquired uniparental disomy discovered in acute myeloid leukemia
    • Gupta M, Raghavan M, Gale RE, et al: Novel regions of acquired uniparental disomy discovered in acute myeloid leukemia. Genes Chromosomes Cancer 47:729-739, 2008
    • (2008) Genes Chromosomes Cancer , vol.47 , pp. 729-739
    • Gupta, M.1    Raghavan, M.2    Gale, R.E.3
  • 67
    • 50949113696 scopus 로고    scopus 로고
    • Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia
    • Raghavan M, Smith LL, Lillington DM, et al: Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia. Blood 112:814-821, 2008
    • (2008) Blood , vol.112 , pp. 814-821
    • Raghavan, M.1    Smith, L.L.2    Lillington, D.M.3
  • 68
    • 69149083958 scopus 로고    scopus 로고
    • Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia
    • Radtke I, Mullighan CG, Ishii M, et al: Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia. Proc Natl Acad Sci U S A 106:12944-12949, 2009
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 12944-12949
    • Radtke, I.1    Mullighan, C.G.2    Ishii, M.3
  • 69
    • 69149100639 scopus 로고    scopus 로고
    • Acquired copy number alterations in adult acute myeloid leukemia genomes
    • Walter MJ, Payton JE, Ries RE, et al: Acquired copy number alterations in adult acute myeloid leukemia genomes. Proc Natl Acad Sci U S A 106:12950-12955, 2009
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 12950-12955
    • Walter, M.J.1    Payton, J.E.2    Ries, R.E.3
  • 70
    • 69249229646 scopus 로고    scopus 로고
    • Prevalence and prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia (AML): A report from the Children's Oncology Group
    • Ho PA, Alonzo TA, Gerbing RB, et al: Prevalence and prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia (AML): A report from the Children's Oncology Group. Blood 113:6558-6566, 2009
    • (2009) Blood , vol.113 , pp. 6558-6566
    • Ho, P.A.1    Alonzo, T.A.2    Gerbing, R.B.3
  • 72
    • 10044294000 scopus 로고    scopus 로고
    • GATA1 mutations in Down syndrome: Implications for biology and diagnosis of children with transient myeloproliferative disorder and acute megakaryoblastic leukemia
    • Crispino JD: GATA1 mutations in Down syndrome: Implications for biology and diagnosis of children with transient myeloproliferative disorder and acute megakaryoblastic leukemia. Pediatr Blood Cancer 44:40-44, 2005
    • (2005) Pediatr Blood Cancer , vol.44 , pp. 40-44
    • Crispino, J.D.1
  • 74
    • 33344465478 scopus 로고    scopus 로고
    • KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival
    • DOI 10.1182/blood-2005-04-1466
    • Schnittger S, Kohl TM, Haferlach T, et al: KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival. Blood 107:1791-1799, 2006 (Pubitemid 43289355)
    • (2006) Blood , vol.107 , Issue.5 , pp. 1791-1799
    • Schnittger, S.1    Kohl, T.M.2    Haferlach, T.3    Kern, W.4    Hiddemann, W.5    Spiekermann, K.6    Schoch, C.7
  • 75
    • 33646432204 scopus 로고    scopus 로고
    • Prognostic impact of c-KIT mutations in core binding factor leukemias: An Italian retrospective study
    • Cairoli R, Beghini A, Grillo G, et al: Prognostic impact of c-KIT mutations in core binding factor leukemias: An Italian retrospective study. Blood 107:3463-3468, 2006
    • (2006) Blood , vol.107 , pp. 3463-3468
    • Cairoli, R.1    Beghini, A.2    Grillo, G.3
  • 76
    • 23744498520 scopus 로고    scopus 로고
    • Mutations in the receptor tyrosine kinase pathway are associated with clinical outcome in patients with acute myeloblastic leukemia harboring t(8;21)(q22;q22)
    • DOI 10.1038/sj.leu.2403803
    • Nanri T, Matsuno N, Kawakita T, et al: Mutations in the receptor tyrosine kinase pathway are associated with clinical outcome in patients with acute myeloblastic leukemia harboring t(8;21)(q22; q22). Leukemia 19:1361-1366, 2005 (Pubitemid 41136329)
    • (2005) Leukemia , vol.19 , Issue.8 , pp. 1361-1366
    • Nanri, T.1    Matsuno, N.2    Kawakita, T.3    Suzushima, H.4    Kawano, F.5    Mitsuya, H.6    Asou, N.7
  • 78
    • 85015135541 scopus 로고    scopus 로고
    • Mutations in the Fms-related tyrosine kinase 3 (FLT3) gene independently predict poor outcome in acute myeloid leukemia (AML) with t(8;21): A study of the German-Austrian AML Study Group (AMLSG)
    • (abstr 825)
    • Paschka P, Du J, Schlenk RF, et al: Mutations in the Fms-related tyrosine kinase 3 (FLT3) gene independently predict poor outcome in acute myeloid leukemia (AML) with t(8;21): A study of the German-Austrian AML Study Group (AMLSG). Am Soc Hematol Annual Meeting Abstracts 114:340, 2009 (abstr 825)
    • (2009) Am Soc Hematol Annual Meeting Abstracts , vol.114 , pp. 340
    • Paschka, P.1    Du, J.2    Schlenk, R.F.3
  • 79
    • 39149092043 scopus 로고    scopus 로고
    • Cooperating mutations of receptor tyrosine kinases and Ras genes in childhood core-binding factor acute myeloid leukemia and a comparative analysis on paired diagnosis and relapse samples
    • Shih LY, Liang DC, Huang CF, et al: Cooperating mutations of receptor tyrosine kinases and Ras genes in childhood core-binding factor acute myeloid leukemia and a comparative analysis on paired diagnosis and relapse samples. Leukemia 22:303-307, 2008
    • (2008) Leukemia , vol.22 , pp. 303-307
    • Shih, L.Y.1    Liang, D.C.2    Huang, C.F.3
  • 80
    • 79952098374 scopus 로고    scopus 로고
    • Prevalence and clinical implications of N-RAS mutations in childhood AML: A report from the Children's Oncology Group
    • (abstr 3115)
    • Berman JN, Gerbing RB, Sung L, et al: Prevalence and clinical implications of N-RAS mutations in childhood AML: A report from the Children's Oncology Group. Am Soc Hematol Annual Meeting Abstracts 114:1211, 2009 (abstr 3115)
    • (2009) Am Soc Hematol Annual Meeting Abstracts , vol.114 , pp. 1211
    • Berman, J.N.1    Gerbing, R.B.2    Sung, L.3
  • 81
    • 61449204716 scopus 로고    scopus 로고
    • Clinical implications of molecular genetic aberrations in acute myeloid leukemia
    • Scholl S, Fricke HJ, Sayer HG, et al: Clinical implications of molecular genetic aberrations in acute myeloid leukemia. J Cancer Res Clin Oncol 135:491-505, 2009
    • (2009) J Cancer Res Clin Oncol , vol.135 , pp. 491-505
    • Scholl, S.1    Fricke, H.J.2    Sayer, H.G.3
  • 83
    • 60149088611 scopus 로고    scopus 로고
    • Favorable prognostic impact of NPM1 gene mutations in childhood acute myeloid leukemia, with emphasis on cytogenetically normal AML
    • Hollink IH, Zwaan CM, Zimmermann M, et al: Favorable prognostic impact of NPM1 gene mutations in childhood acute myeloid leukemia, with emphasis on cytogenetically normal AML. Leukemia 23:262-270, 2009
    • (2009) Leukemia , vol.23 , pp. 262-270
    • Hollink, I.H.1    Zwaan, C.M.2    Zimmermann, M.3
  • 84
    • 70349579540 scopus 로고    scopus 로고
    • Minimal residual disease levels assessed by NPM1 mutation-specific RQ-PCR provide important prognostic information in AML
    • Schnittger S, Kern W, Tschulik C, et al: Minimal residual disease levels assessed by NPM1 mutation-specific RQ-PCR provide important prognostic information in AML. Blood 114:2220-2231, 2009
    • (2009) Blood , vol.114 , pp. 2220-2231
    • Schnittger, S.1    Kern, W.2    Tschulik, C.3
  • 85
    • 70350637903 scopus 로고    scopus 로고
    • AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic features
    • Haferlach C, Mecucci C, Schnittger S, et al: AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic features. Blood 114:3024-3032, 2009
    • (2009) Blood , vol.114 , pp. 3024-3032
    • Haferlach, C.1    Mecucci, C.2    Schnittger, S.3
  • 86
    • 55549101623 scopus 로고    scopus 로고
    • DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
    • Ley TJ, Mardis ER, Ding L, et al: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature 456:66-72, 2008
    • (2008) Nature , vol.456 , pp. 66-72
    • Ley, T.J.1    Mardis, E.R.2    Ding, L.3
  • 87
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • Mardis ER, Ding L, Dooling DJ, et al: Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 361:1058-1066, 2009
    • (2009) N Engl J Med , vol.361 , pp. 1058-1066
    • Mardis, E.R.1    Ding, L.2    Dooling, D.J.3
  • 88
    • 77952424259 scopus 로고    scopus 로고
    • Molecular alterations of the IDH1 gene in AML: A Children's Oncology Group and Southwest Oncology Group study
    • Ho PA, Alonzo TA, Kopecky KJ, et al: Molecular alterations of the IDH1 gene in AML: A Children's Oncology Group and Southwest Oncology Group study. Leukemia 24:909-913, 2010
    • (2010) Leukemia , vol.24 , pp. 909-913
    • Ho, P.A.1    Alonzo, T.A.2    Kopecky, K.J.3
  • 89
    • 77956050251 scopus 로고    scopus 로고
    • Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia
    • Thol F, Damm F, Wagner K, et al: Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia. Blood 116:614-616, 2010
    • (2010) Blood , vol.116 , pp. 614-616
    • Thol, F.1    Damm, F.2    Wagner, K.3
  • 90
    • 77950968519 scopus 로고    scopus 로고
    • Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation
    • Chou WC, Hou HA, Chen CY, et al: Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation. Blood 115:2749-2754, 2010
    • (2010) Blood , vol.115 , pp. 2749-2754
    • Chou, W.C.1    Hou, H.A.2    Chen, C.Y.3
  • 91
    • 77952536841 scopus 로고    scopus 로고
    • IDH1 and IDH2 Gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
    • Marcucci G, Maharry K, Wu YZ, et al: IDH1 and IDH2 Gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study. J Clin Oncol 28:2348-2355, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 2348-2355
    • Marcucci, G.1    Maharry, K.2    Wu, Y.Z.3
  • 92
    • 77952481300 scopus 로고    scopus 로고
    • Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor
    • Wagner K, Damm F, Gohring G, et al: Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor. J Clin Oncol 28:2356-2364, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 2356-2364
    • Wagner, K.1    Damm, F.2    Gohring, G.3
  • 93
    • 58849167390 scopus 로고    scopus 로고
    • A decade of genome-wide gene expression profiling in acute myeloid leukemia: Flashback and prospects
    • Wouters BJ, Löwenberg B, Delwel R: A decade of genome-wide gene expression profiling in acute myeloid leukemia: Flashback and prospects. Blood 113:291-298, 2009
    • (2009) Blood , vol.113 , pp. 291-298
    • Wouters, B.J.1    Löwenberg, B.2    Delwel, R.3
  • 95
    • 63849197532 scopus 로고    scopus 로고
    • Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features
    • Figueroa ME, Wouters BJ, Skrabanek L, et al: Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features. Blood 113:2795-2804, 2009
    • (2009) Blood , vol.113 , pp. 2795-2804
    • Figueroa, M.E.1    Wouters, B.J.2    Skrabanek, L.3
  • 96
    • 72949114887 scopus 로고    scopus 로고
    • Leukaemogenesis: More than mutant genes
    • Chen J, Odenike O, Rowley JD: Leukaemogenesis: More than mutant genes. Nat Rev Cancer 10:23-36, 2010
    • (2010) Nat Rev Cancer , vol.10 , pp. 23-36
    • Chen, J.1    Odenike, O.2    Rowley, J.D.3
  • 97
    • 73649110641 scopus 로고    scopus 로고
    • DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia
    • Figueroa ME, Lugthart S, Li Y, et al: DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia. Cancer Cell 17:13-27, 2010
    • (2010) Cancer Cell , vol.17 , pp. 13-27
    • Figueroa, M.E.1    Lugthart, S.2    Li, Y.3
  • 98
    • 33748413822 scopus 로고    scopus 로고
    • Acute myelogenous leukemia
    • Pizzo P, Poplack G (eds): Philadelphia, PA, Lippincott Williams & Wilkins
    • Golub T, Arceci RJ: Acute myelogenous leukemia, in Pizzo P, Poplack G (eds): Principles and Practice of Pediatric Oncology. Philadelphia, PA, Lippincott Williams & Wilkins, 2006, pp 591-644
    • (2006) Principles and Practice of Pediatric Oncology , pp. 591-644
    • Golub, T.1    Arceci, R.J.2
  • 99
    • 79952092290 scopus 로고    scopus 로고
    • Myeloid leukemias and myelodysplastic syndromesCarroll W, Finlay J (eds)
    • Boston, MA, Jones and Bartlett Publishers
    • Arceci RJ, Brown P: Myeloid leukemias and myelodysplastic syndromes, in Carroll W, Finlay J (eds): Cancer in Children: The Clinical Biology of Childhood Cancer. Boston, MA, Jones and Bartlett Publishers, 2010, pp 185-215
    • (2010) Cancer in Children: The Clinical Biology of Childhood Cancer , pp. 185-215
    • Arceci, R.J.1    Brown, P.2
  • 100
    • 57549090224 scopus 로고    scopus 로고
    • Treatment of childhood acute lymphoblastic leukemia
    • Stanulla M, Schrappe M: Treatment of childhood acute lymphoblastic leukemia. Semin Hematol 46:52-63, 2009
    • (2009) Semin Hematol , vol.46 , pp. 52-63
    • Stanulla, M.1    Schrappe, M.2
  • 101
    • 33947588149 scopus 로고    scopus 로고
    • New therapeutic strategies for the treatment of acute lymphoblastic leukaemia
    • Pui CH, Jeha S: New therapeutic strategies for the treatment of acute lymphoblastic leukaemia. Nat Rev Drug Discov 6:149-165, 2007
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 149-165
    • Pui, C.H.1    Jeha, S.2
  • 103
    • 20644464975 scopus 로고    scopus 로고
    • Phase II study of nelarabine (compound 506U78) in children and young adults with refractory T-cell malignancies: A report from the Children's Oncology Group
    • Berg SL, Blaney SM, Devidas M, et al: Phase II study of nelarabine (compound 506U78) in children and young adults with refractory T-cell malignancies: A report from the Children's Oncology Group. J Clin Oncol 23:3376-3382, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 3376-3382
    • Berg, S.L.1    Blaney, S.M.2    Devidas, M.3
  • 104
    • 65749095348 scopus 로고    scopus 로고
    • Dexamethasone in induction can eliminate one third of all relapses in childhood acute lymphoblastic leukemia (ALL): Results of an international randomized trial in 3655 patients (Trial AEIOP-BFM ALL 2000)
    • (abstr 7)
    • Schrappe M, Zimmermann M, Möricke A, et al: Dexamethasone in induction can eliminate one third of all relapses in childhood acute lymphoblastic leukemia (ALL): Results of an international randomized trial in 3655 patients (Trial AEIOP-BFM ALL 2000). Am Soc Hematol Annual Meeting Abstracts 112:9, 2008 (abstr 7)
    • (2008) Am Soc Hematol Annual Meeting Abstracts , vol.112 , pp. 9
    • Schrappe, M.1    Zimmermann, M.2    Möricke, A.3
  • 106
    • 0036606506 scopus 로고    scopus 로고
    • Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region
    • Pui CH, Gaynon PS, Boyett JM, et al: Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region. Lancet 359:1909-1915, 2002
    • (2002) Lancet , vol.359 , pp. 1909-1915
    • Pui, C.H.1    Gaynon, P.S.2    Boyett, J.M.3
  • 107
    • 33746149660 scopus 로고    scopus 로고
    • Combinations of the FLT3 inhibitor CEP-701 and chemotherapy synergistically kill infant and childhood MLL-rearranged ALL cells in a sequence-dependent manner
    • DOI 10.1038/sj.leu.2404277, PII 2404277
    • Brown P, Levis M, McIntyre E, et al: Combinations of the FLT3 inhibitor CEP-701 and chemotherapy synergistically kill infant and childhood MLL-rearranged ALL cells in a sequence-dependent manner. Leukemia 20:1368-1376, 2006 (Pubitemid 44084049)
    • (2006) Leukemia , vol.20 , Issue.8 , pp. 1368-1376
    • Brown, P.1    Levis, M.2    McIntyre, E.3    Griesemer, M.4    Small, D.5
  • 108
    • 76249112147 scopus 로고    scopus 로고
    • Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options
    • Stumpel DJ, Schneider P, van Roon EH, et al: Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options. Blood 114:5490-5498, 2009
    • (2009) Blood , vol.114 , pp. 5490-5498
    • Stumpel, D.J.1    Schneider, P.2    Van Roon, E.H.3
  • 109
    • 77954721993 scopus 로고    scopus 로고
    • Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: Biology and therapeutic targeting
    • Schafer E, Irizarry R, Negi S, et al: Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: Biology and therapeutic targeting. Blood 115:4798-4809, 2010
    • (2010) Blood , vol.115 , pp. 4798-4809
    • Schafer, E.1    Irizarry, R.2    Negi, S.3
  • 110
    • 61849122810 scopus 로고    scopus 로고
    • Improvement in survival in younger patients with acute lymphoblastic leukemia from the 1980s to the early 21st century
    • Pulte D, Gondos A, Brenner H: Improvement in survival in younger patients with acute lymphoblastic leukemia from the 1980s to the early 21st century. Blood 113:1408-1411, 2009
    • (2009) Blood , vol.113 , pp. 1408-1411
    • Pulte, D.1    Gondos, A.2    Brenner, H.3
  • 111
    • 47849108085 scopus 로고    scopus 로고
    • What determines the outcomes for adolescents and young adults with acute lymphoblastic leukemia treated on cooperative group protocols? A comparison of Children's Cancer Group and Cancer and Leukemia Group B studies
    • Stock W, La M, Sanford B, et al: What determines the outcomes for adolescents and young adults with acute lymphoblastic leukemia treated on cooperative group protocols? A comparison of Children's Cancer Group and Cancer and Leukemia Group B studies. Blood 112:1646-1654, 2008
    • (2008) Blood , vol.112 , pp. 1646-1654
    • Stock, W.1    La, M.2    Sanford, B.3
  • 112
    • 70449700005 scopus 로고    scopus 로고
    • Young adults with acute lymphoblastic leukemia have an excellent outcome with chemotherapy alone and benefit from intensive postinduction treatment: A report from the children's oncology group
    • Nachman JB, La MK, Hunger SP, et al: Young adults with acute lymphoblastic leukemia have an excellent outcome with chemotherapy alone and benefit from intensive postinduction treatment: A report from the children's oncology group. J Clin Oncol 27:5189-5194, 2009
    • (2009) J Clin Oncol , vol.27 , pp. 5189-5194
    • Nachman, J.B.1    La, M.K.2    Hunger, S.P.3
  • 114
    • 11144266589 scopus 로고    scopus 로고
    • Significant difference in outcome for adolescents with acute lymphoblastic leukemia treated on pediatric vs adult protocols in the Netherlands [1]
    • DOI 10.1038/sj.leu.2403538
    • de Bont JM, Holt B, Dekker AW, et al: Significant difference in outcome for adolescents with acute lymphoblastic leukemia treated on pediatric vs adult protocols in the Netherlands. Leukemia 18:2032-2035, 2004 (Pubitemid 40028431)
    • (2004) Leukemia , vol.18 , Issue.12 , pp. 2032-2035
    • De, B.J.M.1    Van, D.H.B.2    Dekker, A.W.3    Van, D.D.-V.D.B.A.4    Sonneveld, R.5    Pieters, R.6
  • 115
    • 79952087452 scopus 로고    scopus 로고
    • Improved prognosis for older adolescents with acute lymphoblastic leukemia
    • (in press)
    • Pui CH, Pei D, Campana D, et al: Improved prognosis for older adolescents with acute lymphoblastic leukemia. J Clin Oncol (in press)
    • J Clin Oncol
    • Pui, C.H.1    Pei, D.2    Campana, D.3
  • 116
    • 41349100708 scopus 로고    scopus 로고
    • In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/ maintenance chemotherapy in all patients: Final results of the International ALL Trial (MRC UKALL XII/ECOG E2993)
    • Goldstone AH, Richards SM, Lazarus HM, et al: In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/ maintenance chemotherapy in all patients: Final results of the International ALL Trial (MRC UKALL XII/ECOG E2993). Blood 111:1827-1833, 2008
    • (2008) Blood , vol.111 , pp. 1827-1833
    • Goldstone, A.H.1    Richards, S.M.2    Lazarus, H.M.3
  • 117
    • 42949166852 scopus 로고    scopus 로고
    • Comparison of the results of the treatment of adolescents and young adults with standard-risk acute lymphoblastic leukemia with the Programa Espanol de Tratamiento en Hematologia pediatric-based protocol ALL-96
    • Ribera JM, Oriol A, Sanz MA, et al: Comparison of the results of the treatment of adolescents and young adults with standard-risk acute lymphoblastic leukemia with the Programa Espanol de Tratamiento en Hematologia pediatric-based protocol ALL-96. J Clin Oncol 26:1843-1849, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 1843-1849
    • Ribera, J.M.1    Oriol, A.2    Sanz, M.A.3
  • 118
    • 47849095770 scopus 로고    scopus 로고
    • A multicenter phase II study using a dose intensified pediatric regimen in adults with untreated acute lymphoblastic leukemia
    • (abstr 587)
    • DeAngelo DJ, Dahlberg S, Silverman LB, et al: A multicenter phase II study using a dose intensified pediatric regimen in adults with untreated acute lymphoblastic leukemia. Am Soc Hematol Annual Meeting Abstracts 110:181a, 2007 (abstr 587)
    • (2007) Am Soc Hematol Annual Meeting Abstracts , vol.110
    • DeAngelo, D.J.1    Dahlberg, S.2    Silverman, L.B.3
  • 119
    • 67049098987 scopus 로고    scopus 로고
    • Treatment of adults with BCR-ABL negative acute lymphoblastic leukaemia with a modified paediatric regimen
    • Storring JM, Minden MD, Kao S, et al: Treatment of adults with BCR-ABL negative acute lymphoblastic leukaemia with a modified paediatric regimen. Br J Haematol 146:76-85, 2009
    • (2009) Br J Haematol , vol.146 , pp. 76-85
    • Storring, J.M.1    Minden, M.D.2    Kao, S.3
  • 120
    • 22044456688 scopus 로고    scopus 로고
    • Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells
    • DOI 10.1182/blood-2004-12-4797
    • Imai C, Iwamoto S, Campana D: Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells. Blood 106:376-383, 2005 (Pubitemid 40967217)
    • (2005) Blood , vol.106 , Issue.1 , pp. 376-383
    • Imai, C.1    Iwamoto, S.2    Campana, D.3
  • 121
    • 31544467048 scopus 로고    scopus 로고
    • KIR-incompatible hematopoietic-cell transplantation for poor prognosis infant acute lymphoblastic leukemia [2]
    • DOI 10.1182/blood-2005-07-2809
    • Triplett B, Handgretinger R, Pui CH, et al: KIR-incompatible hematopoietic-cell transplantation for poor prognosis infant acute lymphoblastic leukemia. Blood 107:1238-1239, 2006 (Pubitemid 43156333)
    • (2006) Blood , vol.107 , Issue.3 , pp. 1238-1239
    • Triplett, B.1    Handgretinger, R.2    Pui, C.-H.3    Leung, W.4
  • 122
    • 49649120397 scopus 로고    scopus 로고
    • Tumor regression in cancer patients by very low doses of a T cell-engaging antibody
    • Bargou R, Leo E, Zugmaier G, et al: Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science 321:974-977, 2008
    • (2008) Science , vol.321 , pp. 974-977
    • Bargou, R.1    Leo, E.2    Zugmaier, G.3
  • 123
    • 70349390630 scopus 로고    scopus 로고
    • Dexamethasone-based therapy for childhood acute lymphoblastic leukaemia: Results of the prospective Dutch Childhood Oncology Group (DCOG) protocol ALL-9 (1997-2004)
    • Veerman AJ, Kamps WA, van den Berg H, et al: Dexamethasone-based therapy for childhood acute lymphoblastic leukaemia: Results of the prospective Dutch Childhood Oncology Group (DCOG) protocol ALL-9 (1997-2004). Lancet Oncol 10:957-966, 2009
    • (2009) Lancet Oncol , vol.10 , pp. 957-966
    • Veerman, A.J.1    Kamps, W.A.2    Van Den Berg, H.3
  • 125
    • 67651096058 scopus 로고    scopus 로고
    • Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia
    • Hollink IH, van den Heuvel-Eibrink MM, Zimmermann M, et al: Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia. Blood 113:5951-5960, 2009
    • (2009) Blood , vol.113 , pp. 5951-5960
    • Hollink, I.H.1    Van Den Heuvel-Eibrink, M.M.2    Zimmermann, M.3
  • 126
    • 77956275074 scopus 로고    scopus 로고
    • Prevalence and prognostic implications of WT1 mutations in pediatric acute myeloid leukemia (AML): A report from the Children's Oncology Group
    • Ho PA, Zeng R, Alonzo TA, et al: Prevalence and prognostic implications of WT1 mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group. Blood 116: 702-710, 2010
    • (2010) Blood , vol.116 , pp. 702-710
    • Ho, P.A.1    Zeng, R.2    Alonzo, T.A.3
  • 129
    • 71049144521 scopus 로고    scopus 로고
    • Treatment of children with acute promyelocytic leukemia: Results of the first North American Intergroup trial INT0129
    • Gregory J, Kim H, Alonzo T, et al: Treatment of children with acute promyelocytic leukemia: Results of the first North American Intergroup trial INT0129. Pediatr Blood Cancer 53:1005-1010, 2009
    • (2009) Pediatr Blood Cancer , vol.53 , pp. 1005-1010
    • Gregory, J.1    Kim, H.2    Alonzo, T.3
  • 130
    • 61949441174 scopus 로고    scopus 로고
    • Management of acute promyelocytic leukemia: Recommendations from an expert panel on behalf of the European LeukemiaNet
    • Sanz MA, Grimwade D, Tallman MS, et al: Management of acute promyelocytic leukemia: Recommendations from an expert panel on behalf of the European LeukemiaNet. Blood 113:1875-1891, 2009
    • (2009) Blood , vol.113 , pp. 1875-1891
    • Sanz, M.A.1    Grimwade, D.2    Tallman, M.S.3
  • 132
    • 70350621606 scopus 로고    scopus 로고
    • Comparison of clinical outcomes of patients with relapsed acute promyelocytic leukemia induced with arsenic trioxide and consolidated with either an autologous stem cell transplant or an arsenic trioxide-based regimen
    • Thirugnanam R, George B, Chendamarai E, et al: Comparison of clinical outcomes of patients with relapsed acute promyelocytic leukemia induced with arsenic trioxide and consolidated with either an autologous stem cell transplant or an arsenic trioxide-based regimen. Biol Blood Marrow Transplant 15:1479-1484, 2009
    • (2009) Biol Blood Marrow Transplant , vol.15 , pp. 1479-1484
    • Thirugnanam, R.1    George, B.2    Chendamarai, E.3
  • 135
    • 0037232260 scopus 로고    scopus 로고
    • Acute megakaryoblastic leukaemia: A national clinical and biological study of 53 adult and childhood cases by the Groupe Francais d'Hematologie Cellulaire (GFHC)
    • DOI 10.1080/1042819021000040279
    • Duchayne E, Fenneteau O, Pages MP, et al: Acute megakaryoblastic leukaemia: A national clinical and biological study of 53 adult and childhood cases by the Groupe Francais d'Hematologie Cellulaire (GFHC). Leuk Lymphoma 44:49-58, 2003 (Pubitemid 36113829)
    • (2003) Leukemia and Lymphoma , vol.44 , Issue.1 , pp. 49-58
    • Duchayne, E.1    Fenneteau, O.2    Pages, M.-P.3    Sainty, D.4    Arnoulet, C.5    Dastugue, N.6    Garand, R.7    Flandrin, G.8
  • 136
    • 77949887020 scopus 로고    scopus 로고
    • FLT3- Mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML
    • Pratz KW, Sato T, Murphy KM, et al: FLT3- mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML. Blood 115:1425-1432, 2010
    • (2010) Blood , vol.115 , pp. 1425-1432
    • Pratz, K.W.1    Sato, T.2    Murphy, K.M.3
  • 137
    • 33745626157 scopus 로고    scopus 로고
    • Role of allogeneic stem cell transplantation in FLT3/ ITD-positive AML
    • Meshinchi S, Arceci RJ, Sanders JE, et al: Role of allogeneic stem cell transplantation in FLT3/ ITD-positive AML. Blood 108:400-401, 2006
    • (2006) Blood , vol.108 , pp. 400-401
    • Meshinchi, S.1    Arceci, R.J.2    Sanders, J.E.3
  • 138
    • 77950612017 scopus 로고    scopus 로고
    • Prevalence and prognostic significance of KIT mutations in pediatric patients with core binding factor AML enrolled on serial pediatric cooperative trials for de novo AML
    • Pollard JA, Alonzo TA, Gerbing RB, et al: Prevalence and prognostic significance of KIT mutations in pediatric patients with core binding factor AML enrolled on serial pediatric cooperative trials for de novo AML. Blood 115:2372-2379, 2010
    • (2010) Blood , vol.115 , pp. 2372-2379
    • Pollard, J.A.1    Alonzo, T.A.2    Gerbing, R.B.3
  • 139
    • 0038579430 scopus 로고    scopus 로고
    • Immunophenotypic evidence of leukemia after induction therapy predicts relapse: Results from a prospective Children's Cancer Group study of 252 patients with acute myeloid leukemia
    • DOI 10.1182/blood-2002-10-3064
    • Sievers EL, Lange BJ, Alonzo TA, et al: Immunophenotypic evidence of leukemia after induction therapy predicts relapse: Results from a prospective Children's Cancer Group study of 252 acute myeloid leukemia patients. Blood 101:3398-3406, 2003 (Pubitemid 36857920)
    • (2003) Blood , vol.101 , Issue.9 , pp. 3398-3406
    • Sievers, E.L.1    Lange, B.J.2    Alonzo, T.A.3    Gerbing, R.B.4    Bernstein, I.D.5    Smith, F.O.6    Arceci, R.J.7    Woods, W.G.8    Loken, M.R.9
  • 140
    • 10044278287 scopus 로고    scopus 로고
    • Acute myeloid leukemia and Down syndrome evolution of modern therapy: State of the art review
    • Gamis AS: Acute myeloid leukemia and Down syndrome evolution of modern therapy: State of the art review. Pediatr Blood Cancer 44:13-20, 2005
    • (2005) Pediatr Blood Cancer , vol.44 , pp. 13-20
    • Gamis, A.S.1
  • 142
    • 50049084037 scopus 로고    scopus 로고
    • The expanding role of arsenic in acute promyelocytic leukemia
    • Tallman MS: The expanding role of arsenic in acute promyelocytic leukemia. Semin Hematol 45: S25-S29, 2008
    • (2008) Semin Hematol , vol.45
    • Tallman, M.S.1
  • 143
    • 35348849758 scopus 로고    scopus 로고
    • 3) on event-free survival (EFS) and overall survival (OS) among patients with newly diagnosed acute promyelocytic leukemia (APL): North American Intergroup Protocol C9710
    • (abstr 2)
    • 3) on event-free survival (EFS) and overall survival (OS) among patients with newly diagnosed acute promyelocytic leukemia (APL):
    • (2007) J Clin Oncol , vol.25
    • Powell, B.L.1
  • 144
    • 77649308061 scopus 로고    scopus 로고
    • Enhancing survival outcomes in the management of patients with higher-risk myelodysplastic syndromes
    • (suppl)
    • Gore SD, Hermes-DeSantis ER: Enhancing survival outcomes in the management of patients with higher-risk myelodysplastic syndromes. Cancer Control 16:2-10, 2009 (suppl)
    • (2009) Cancer Control , vol.16 , pp. 2-10
    • Gore, S.D.1    Hermes-DeSantis, E.R.2
  • 146
    • 0036625070 scopus 로고    scopus 로고
    • Experience with gemtuzumab ozogamycin ("mylotarg") and all-trans retinoic acid in untreated acute promyelocytic leukemia
    • DOI 10.1182/blood-2001-12-0174
    • Estey EH, Giles FJ, Beran M, et al: Experience with gemtuzumab ozogamycin ("mylotarg") and all-trans retinoic acid in untreated acute promyelocytic leukemia. Blood 99:4222-4224, 2002 (Pubitemid 35332070)
    • (2002) Blood , vol.99 , Issue.11 , pp. 4222-4224
    • Estey, E.H.1    Giles, F.J.2    Beran, M.3    O'Brien, S.4    Pierce, S.A.5    Faderl, S.H.6    Cortes, J.E.7    Kantarjian, H.M.8
  • 147
    • 31744441028 scopus 로고    scopus 로고
    • Treatment of acute promyelocytic leukemia with gemtuzumab ozogamicin
    • Lo Coco F, Ammatuna E, Noguera N: Treatment of acute promyelocytic leukemia with gemtuzumab ozogamicin. Clin Adv Hematol Oncol 4:57-62, 76-77, 2006
    • (2006) Clin Adv Hematol Oncol , vol.4
    • Lo Coco, F.1    Ammatuna, E.2    Noguera, N.3
  • 149
    • 67650357912 scopus 로고    scopus 로고
    • Therapeutic targeting of MLL
    • Liedtke M, Cleary ML: Therapeutic targeting of MLL. Blood 113:6061-6068, 2009
    • (2009) Blood , vol.113 , pp. 6061-6068
    • Liedtke, M.1    Cleary, M.L.2
  • 151
    • 59249100224 scopus 로고    scopus 로고
    • Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia
    • Yang JJ, Cheng C, Yang W, et al: Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. JAMA 301:393-403, 2009
    • (2009) JAMA , vol.301 , pp. 393-403
    • Yang, J.J.1    Cheng, C.2    Yang, W.3
  • 152
    • 73349098768 scopus 로고    scopus 로고
    • Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects
    • Treviño LR, Shimasaki N, Yang W, et al: Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. J Clin Oncol 27:5972-5978, 2009
    • (2009) J Clin Oncol , vol.27 , pp. 5972-5978
    • Treviño, L.R.1    Shimasaki, N.2    Yang, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.