메뉴 건너뛰기




Volumn 110, Issue 1, 2007, Pages 278-286

Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA SECRETASE INHIBITOR; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MYC PROTEIN; NOTCH RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

EID: 34347369749     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-08-039883     Document Type: Article
Times cited : (232)

References (44)
  • 1
    • 0033617522 scopus 로고    scopus 로고
    • Notch signaling: Cell fate control and signal integration in development
    • Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate control and signal integration in development. Science. 1999;284:770-776.
    • (1999) Science , vol.284 , pp. 770-776
    • Artavanis-Tsakonas, S.1    Rand, M.D.2    Lake, R.J.3
  • 2
    • 0842324623 scopus 로고    scopus 로고
    • Multiple niches for Notch in cancer: Context is everything
    • Weng AP, Aster JC. Multiple niches for Notch in cancer: context is everything. Curr Opin Genet Dev. 2004;14:48-54.
    • (2004) Curr Opin Genet Dev , vol.14 , pp. 48-54
    • Weng, A.P.1    Aster, J.C.2
  • 4
    • 0037218811 scopus 로고    scopus 로고
    • Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling
    • Weng AP, Nam Y, Wolfe MS, et al. Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol. 2003;23:655-664.
    • (2003) Mol Cell Biol , vol.23 , pp. 655-664
    • Weng, A.P.1    Nam, Y.2    Wolfe, M.S.3
  • 5
    • 33644782668 scopus 로고    scopus 로고
    • Recent insights into the role of Notch signaling in tumorigenesis
    • Leong KG, Karsan A. Recent insights into the role of Notch signaling in tumorigenesis. Blood. 2006;107:2223-2233.
    • (2006) Blood , vol.107 , pp. 2223-2233
    • Leong, K.G.1    Karsan, A.2
  • 6
    • 0029942842 scopus 로고    scopus 로고
    • Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
    • Pear WS, Aster JC, Scott ML, et al. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med. 1996;183:2283-2291.
    • (1996) J Exp Med , vol.183 , pp. 2283-2291
    • Pear, W.S.1    Aster, J.C.2    Scott, M.L.3
  • 7
    • 5044225888 scopus 로고    scopus 로고
    • Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
    • Weng AP, Ferrando AA, Lee W, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004;306:269-271.
    • (2004) Science , vol.306 , pp. 269-271
    • Weng, A.P.1    Ferrando, A.A.2    Lee, W.3
  • 8
    • 33645227683 scopus 로고    scopus 로고
    • Notch activation is an early and critical event during T-cell leukemogenesis in Ikaros-deficient mice
    • Dumortier A, Jeannet R, Kirstetter P, et al. Notch activation is an early and critical event during T-cell leukemogenesis in Ikaros-deficient mice. Mol Cell Biol. 2006;26:209-220.
    • (2006) Mol Cell Biol , vol.26 , pp. 209-220
    • Dumortier, A.1    Jeannet, R.2    Kirstetter, P.3
  • 9
    • 33644756556 scopus 로고    scopus 로고
    • Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma
    • Lin YW, Nichols RA, Letterio JJ, Aplan PD. Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma. Blood. 2006;107:2540-2543.
    • (2006) Blood , vol.107 , pp. 2540-2543
    • Lin, Y.W.1    Nichols, R.A.2    Letterio, J.J.3    Aplan, P.D.4
  • 10
    • 30444436343 scopus 로고    scopus 로고
    • Activating Notch1 mutations in mouse models of T-ALL
    • O'Neil J, Calvo J, McKenna K, et al. Activating Notch1 mutations in mouse models of T-ALL. Blood. 2006;107:781-785.
    • (2006) Blood , vol.107 , pp. 781-785
    • O'Neil, J.1    Calvo, J.2    McKenna, K.3
  • 11
    • 33646374372 scopus 로고    scopus 로고
    • Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms
    • Reschly EJ, Spaulding C, Vilimas T, et al. Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms. Blood. 2006;107:4115-4121.
    • (2006) Blood , vol.107 , pp. 4115-4121
    • Reschly, E.J.1    Spaulding, C.2    Vilimas, T.3
  • 12
    • 0037133497 scopus 로고    scopus 로고
    • Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis
    • Bellavia D, Campese AF, Checquolo S, et al. Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. Proc Natl Acad Sci U S A. 2002;99:3788-3793.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 3788-3793
    • Bellavia, D.1    Campese, A.F.2    Checquolo, S.3
  • 13
    • 13944266008 scopus 로고    scopus 로고
    • PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia
    • Felli MP, Vacca A, Calce A, et al. PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia. Oncogene. 2005;24:992-1000.
    • (2005) Oncogene , vol.24 , pp. 992-1000
    • Felli, M.P.1    Vacca, A.2    Calce, A.3
  • 14
    • 1642576036 scopus 로고    scopus 로고
    • The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells
    • Sade H, Krishna S, Sarin A. The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells. J Biol Chem. 2004;279:2937-2944.
    • (2004) J Biol Chem , vol.279 , pp. 2937-2944
    • Sade, H.1    Krishna, S.2    Sarin, A.3
  • 15
    • 24944444760 scopus 로고    scopus 로고
    • Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism
    • Ciofani M, Zuniga-Pflucker JC. Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. Nat Immunol. 2005;6:881-888.
    • (2005) Nat Immunol , vol.6 , pp. 881-888
    • Ciofani, M.1    Zuniga-Pflucker, J.C.2
  • 16
    • 0348133609 scopus 로고    scopus 로고
    • Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma
    • 4:1067-1072
    • Talora C, Campese AF, Bellavia D, et al. Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma. EMBO Rep. 2003;4:1067-1072.
    • EMBO Rep. 2003
    • Talora, C.1    Campese, A.F.2    Bellavia, D.3
  • 17
    • 0034600850 scopus 로고    scopus 로고
    • Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice
    • Bellavia D, Campese AF, Alesse E, et al. Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice. EMBO J. 2000;19:3337-3348.
    • (2000) EMBO J , vol.19 , pp. 3337-3348
    • Bellavia, D.1    Campese, A.F.2    Alesse, E.3
  • 18
    • 11144256544 scopus 로고    scopus 로고
    • Protein microarrays for multiplex analysis of signal transduction pathways
    • Chan SM, Ermann J, Su L, Fathman CG, Utz PJ. Protein microarrays for multiplex analysis of signal transduction pathways. Nat Med. 2004;10:1390-1396.
    • (2004) Nat Med , vol.10 , pp. 1390-1396
    • Chan, S.M.1    Ermann, J.2    Su, L.3    Fathman, C.G.4    Utz, P.J.5
  • 19
    • 20444505232 scopus 로고    scopus 로고
    • An array of possibilities for the study of autoimmunity
    • Fathman CG, Soares L, Chan SM, Utz PJ. An array of possibilities for the study of autoimmunity. Nature. 2005;435:605-611.
    • (2005) Nature , vol.435 , pp. 605-611
    • Fathman, C.G.1    Soares, L.2    Chan, S.M.3    Utz, P.J.4
  • 20
    • 33744530734 scopus 로고    scopus 로고
    • AbMiner: A bioinformatic resource on available monoclonal antibodies and corresponding gene identifiers for genomic, proteomic, and immunologic studies
    • Major SM, Nishizuka S, Morita D, et al. AbMiner: a bioinformatic resource on available monoclonal antibodies and corresponding gene identifiers for genomic, proteomic, and immunologic studies. BMC Bioinformatics. 2006;7:192.
    • (2006) BMC Bioinformatics , vol.7 , pp. 192
    • Major, S.M.1    Nishizuka, S.2    Morita, D.3
  • 21
    • 20244389684 scopus 로고    scopus 로고
    • Notch1 expression in early lymphopoiesis influences B versus T lineage determination
    • Pui JC, Allman D, Xu L, et al. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity. 1999;11:299-308.
    • (1999) Immunity , vol.11 , pp. 299-308
    • Pui, J.C.1    Allman, D.2    Xu, L.3
  • 22
    • 33746546368 scopus 로고    scopus 로고
    • c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
    • Weng AP, Millholland JM, Yashiro-Ohtani Y, et al. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev. 2006;20:2096-2109.
    • (2006) Genes Dev , vol.20 , pp. 2096-2109
    • Weng, A.P.1    Millholland, J.M.2    Yashiro-Ohtani, Y.3
  • 23
    • 33644749306 scopus 로고    scopus 로고
    • Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes
    • Nam Y, Sliz P, Song L, Aster JC, Blacklow SC. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell. 2006;124:973-983.
    • (2006) Cell , vol.124 , pp. 973-983
    • Nam, Y.1    Sliz, P.2    Song, L.3    Aster, J.C.4    Blacklow, S.C.5
  • 24
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A. 2001;98:5116-5121.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 25
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • Fingar DC, Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene. 2004;23:3151-3171.
    • (2004) Oncogene , vol.23 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 26
    • 33845306813 scopus 로고    scopus 로고
    • NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
    • Palomero T, Lim WK, Odom DT, et al. NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc Natl Acad Sci U S A. 2006;103:18261-18266.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 18261-18266
    • Palomero, T.1    Lim, W.K.2    Odom, D.T.3
  • 27
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 2004;18:1926-1945.
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 28
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell. 2006;124:471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 29
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
    • Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul. 1984;22:27-55.
    • (1984) Adv Enzyme Regul , vol.22 , pp. 27-55
    • Chou, T.C.1    Talalay, P.2
  • 30
    • 0032563202 scopus 로고    scopus 로고
    • Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis
    • Ling YH, Tornos C, Perez-Soler R. Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis. J Biol Chem. 1998;273:18984-18991.
    • (1998) J Biol Chem , vol.273 , pp. 18984-18991
    • Ling, Y.H.1    Tornos, C.2    Perez-Soler, R.3
  • 31
    • 33747819801 scopus 로고    scopus 로고
    • mTOR and cancer: Insights into a complex relationship
    • Sabatini DM. mTOR and cancer: insights into a complex relationship. Nat Rev Cancer. 2006;6:729-734.
    • (2006) Nat Rev Cancer , vol.6 , pp. 729-734
    • Sabatini, D.M.1
  • 32
    • 0345732640 scopus 로고    scopus 로고
    • mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
    • Fingar DC, Richardson CJ, Tee AR, Cheatham L, Tsou C, Blenis J. mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol. 2004;24:200-216.
    • (2004) Mol Cell Biol , vol.24 , pp. 200-216
    • Fingar, D.C.1    Richardson, C.J.2    Tee, A.R.3    Cheatham, L.4    Tsou, C.5    Blenis, J.6
  • 33
    • 0034141942 scopus 로고    scopus 로고
    • Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI
    • Raught B, Gingras AC, Gygi SP, et al. Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI. EMBO J. 2000;19:434-444.
    • (2000) EMBO J , vol.19 , pp. 434-444
    • Raught, B.1    Gingras, A.C.2    Gygi, S.P.3
  • 34
    • 0040737600 scopus 로고    scopus 로고
    • Phosphorylation and activation of phospholipase D1 by protein kinase C in vivo: Determination of multiple phosphorylation sites
    • Kim Y, Han JM, Park JB, et al. Phosphorylation and activation of phospholipase D1 by protein kinase C in vivo: determination of multiple phosphorylation sites. Biochemistry. 1999;38:10344-10351.
    • (1999) Biochemistry , vol.38 , pp. 10344-10351
    • Kim, Y.1    Han, J.M.2    Park, J.B.3
  • 35
    • 0035976615 scopus 로고    scopus 로고
    • Phosphatidic acid-mediated mitogenic activation of mTOR signaling
    • Fang Y, Vilella-Bach M, Bachmann R, Flanigan A, Chen J. Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science. 2001;294:1942-1945.
    • (2001) Science , vol.294 , pp. 1942-1945
    • Fang, Y.1    Vilella-Bach, M.2    Bachmann, R.3    Flanigan, A.4    Chen, J.5
  • 36
    • 33750317437 scopus 로고    scopus 로고
    • Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc
    • Sharma VM, Calvo JA, Draheim KM, et al. Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc. Mol Cell Biol. 2006;26:8022-8031.
    • (2006) Mol Cell Biol , vol.26 , pp. 8022-8031
    • Sharma, V.M.1    Calvo, J.A.2    Draheim, K.M.3
  • 38
    • 2442648845 scopus 로고    scopus 로고
    • The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
    • Ruggero D, Montanaro L, Ma L, et al. The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat Med. 2004;10:484-486.
    • (2004) Nat Med , vol.10 , pp. 484-486
    • Ruggero, D.1    Montanaro, L.2    Ma, L.3
  • 39
    • 32444434357 scopus 로고    scopus 로고
    • Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation
    • Cai D, Netzer WJ, Zhong M, et al. Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation. Proc Natl Acad Sci U S A. 2006;103:1941-1946.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 1941-1946
    • Cai, D.1    Netzer, W.J.2    Zhong, M.3
  • 40
    • 32444439640 scopus 로고    scopus 로고
    • Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons
    • Cai D, Zhong M, Wang R, et al. Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons. Proc Natl Acad Sci U S A. 2006;103:1936-1940.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 1936-1940
    • Cai, D.1    Zhong, M.2    Wang, R.3
  • 41
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science. 2005;307:1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 42
    • 0344063370 scopus 로고    scopus 로고
    • Will mTOR inhibitors make it as cancer drugs?
    • Sawyers CL. Will mTOR inhibitors make it as cancer drugs? Cancer Cell. 2003;4:343-348.
    • (2003) Cancer Cell , vol.4 , pp. 343-348
    • Sawyers, C.L.1
  • 43
    • 1542398693 scopus 로고    scopus 로고
    • Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
    • Atkins MB, Hidalgo M, Stadler WM, et al. Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol. 2004;22:909-918.
    • (2004) J Clin Oncol , vol.22 , pp. 909-918
    • Atkins, M.B.1    Hidalgo, M.2    Stadler, W.M.3
  • 44
    • 7244250027 scopus 로고    scopus 로고
    • Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis
    • Pece S, Serresi M, Santolini E, et al. Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol. 2004;167:215-221.
    • (2004) J Cell Biol , vol.167 , pp. 215-221
    • Pece, S.1    Serresi, M.2    Santolini, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.