-
1
-
-
0033617522
-
Notch signaling: Cell fate control and signal integration in development
-
Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate control and signal integration in development. Science. 1999;284:770-776.
-
(1999)
Science
, vol.284
, pp. 770-776
-
-
Artavanis-Tsakonas, S.1
Rand, M.D.2
Lake, R.J.3
-
2
-
-
0842324623
-
Multiple niches for Notch in cancer: Context is everything
-
Weng AP, Aster JC. Multiple niches for Notch in cancer: context is everything. Curr Opin Genet Dev. 2004;14:48-54.
-
(2004)
Curr Opin Genet Dev
, vol.14
, pp. 48-54
-
-
Weng, A.P.1
Aster, J.C.2
-
3
-
-
0029085935
-
Signalling downstream of activated mammalian
-
Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R, Israel A. Signalling downstream of activated mammalian Notch. Nature. 1995;377:355-358.
-
(1995)
Notch. Nature
, vol.377
, pp. 355-358
-
-
Jarriault, S.1
Brou, C.2
Logeat, F.3
Schroeter, E.H.4
Kopan, R.5
Israel, A.6
-
4
-
-
0037218811
-
Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling
-
Weng AP, Nam Y, Wolfe MS, et al. Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol. 2003;23:655-664.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 655-664
-
-
Weng, A.P.1
Nam, Y.2
Wolfe, M.S.3
-
5
-
-
33644782668
-
Recent insights into the role of Notch signaling in tumorigenesis
-
Leong KG, Karsan A. Recent insights into the role of Notch signaling in tumorigenesis. Blood. 2006;107:2223-2233.
-
(2006)
Blood
, vol.107
, pp. 2223-2233
-
-
Leong, K.G.1
Karsan, A.2
-
6
-
-
0029942842
-
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
-
Pear WS, Aster JC, Scott ML, et al. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med. 1996;183:2283-2291.
-
(1996)
J Exp Med
, vol.183
, pp. 2283-2291
-
-
Pear, W.S.1
Aster, J.C.2
Scott, M.L.3
-
7
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
Weng AP, Ferrando AA, Lee W, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004;306:269-271.
-
(2004)
Science
, vol.306
, pp. 269-271
-
-
Weng, A.P.1
Ferrando, A.A.2
Lee, W.3
-
8
-
-
33645227683
-
Notch activation is an early and critical event during T-cell leukemogenesis in Ikaros-deficient mice
-
Dumortier A, Jeannet R, Kirstetter P, et al. Notch activation is an early and critical event during T-cell leukemogenesis in Ikaros-deficient mice. Mol Cell Biol. 2006;26:209-220.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 209-220
-
-
Dumortier, A.1
Jeannet, R.2
Kirstetter, P.3
-
9
-
-
33644756556
-
Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma
-
Lin YW, Nichols RA, Letterio JJ, Aplan PD. Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma. Blood. 2006;107:2540-2543.
-
(2006)
Blood
, vol.107
, pp. 2540-2543
-
-
Lin, Y.W.1
Nichols, R.A.2
Letterio, J.J.3
Aplan, P.D.4
-
10
-
-
30444436343
-
Activating Notch1 mutations in mouse models of T-ALL
-
O'Neil J, Calvo J, McKenna K, et al. Activating Notch1 mutations in mouse models of T-ALL. Blood. 2006;107:781-785.
-
(2006)
Blood
, vol.107
, pp. 781-785
-
-
O'Neil, J.1
Calvo, J.2
McKenna, K.3
-
11
-
-
33646374372
-
Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms
-
Reschly EJ, Spaulding C, Vilimas T, et al. Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms. Blood. 2006;107:4115-4121.
-
(2006)
Blood
, vol.107
, pp. 4115-4121
-
-
Reschly, E.J.1
Spaulding, C.2
Vilimas, T.3
-
12
-
-
0037133497
-
Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis
-
Bellavia D, Campese AF, Checquolo S, et al. Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. Proc Natl Acad Sci U S A. 2002;99:3788-3793.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 3788-3793
-
-
Bellavia, D.1
Campese, A.F.2
Checquolo, S.3
-
13
-
-
13944266008
-
PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia
-
Felli MP, Vacca A, Calce A, et al. PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia. Oncogene. 2005;24:992-1000.
-
(2005)
Oncogene
, vol.24
, pp. 992-1000
-
-
Felli, M.P.1
Vacca, A.2
Calce, A.3
-
14
-
-
1642576036
-
The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells
-
Sade H, Krishna S, Sarin A. The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells. J Biol Chem. 2004;279:2937-2944.
-
(2004)
J Biol Chem
, vol.279
, pp. 2937-2944
-
-
Sade, H.1
Krishna, S.2
Sarin, A.3
-
15
-
-
24944444760
-
Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism
-
Ciofani M, Zuniga-Pflucker JC. Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. Nat Immunol. 2005;6:881-888.
-
(2005)
Nat Immunol
, vol.6
, pp. 881-888
-
-
Ciofani, M.1
Zuniga-Pflucker, J.C.2
-
16
-
-
0348133609
-
Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma
-
4:1067-1072
-
Talora C, Campese AF, Bellavia D, et al. Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma. EMBO Rep. 2003;4:1067-1072.
-
EMBO Rep. 2003
-
-
Talora, C.1
Campese, A.F.2
Bellavia, D.3
-
17
-
-
0034600850
-
Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice
-
Bellavia D, Campese AF, Alesse E, et al. Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice. EMBO J. 2000;19:3337-3348.
-
(2000)
EMBO J
, vol.19
, pp. 3337-3348
-
-
Bellavia, D.1
Campese, A.F.2
Alesse, E.3
-
18
-
-
11144256544
-
Protein microarrays for multiplex analysis of signal transduction pathways
-
Chan SM, Ermann J, Su L, Fathman CG, Utz PJ. Protein microarrays for multiplex analysis of signal transduction pathways. Nat Med. 2004;10:1390-1396.
-
(2004)
Nat Med
, vol.10
, pp. 1390-1396
-
-
Chan, S.M.1
Ermann, J.2
Su, L.3
Fathman, C.G.4
Utz, P.J.5
-
19
-
-
20444505232
-
An array of possibilities for the study of autoimmunity
-
Fathman CG, Soares L, Chan SM, Utz PJ. An array of possibilities for the study of autoimmunity. Nature. 2005;435:605-611.
-
(2005)
Nature
, vol.435
, pp. 605-611
-
-
Fathman, C.G.1
Soares, L.2
Chan, S.M.3
Utz, P.J.4
-
20
-
-
33744530734
-
AbMiner: A bioinformatic resource on available monoclonal antibodies and corresponding gene identifiers for genomic, proteomic, and immunologic studies
-
Major SM, Nishizuka S, Morita D, et al. AbMiner: a bioinformatic resource on available monoclonal antibodies and corresponding gene identifiers for genomic, proteomic, and immunologic studies. BMC Bioinformatics. 2006;7:192.
-
(2006)
BMC Bioinformatics
, vol.7
, pp. 192
-
-
Major, S.M.1
Nishizuka, S.2
Morita, D.3
-
21
-
-
20244389684
-
Notch1 expression in early lymphopoiesis influences B versus T lineage determination
-
Pui JC, Allman D, Xu L, et al. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity. 1999;11:299-308.
-
(1999)
Immunity
, vol.11
, pp. 299-308
-
-
Pui, J.C.1
Allman, D.2
Xu, L.3
-
22
-
-
33746546368
-
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
-
Weng AP, Millholland JM, Yashiro-Ohtani Y, et al. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev. 2006;20:2096-2109.
-
(2006)
Genes Dev
, vol.20
, pp. 2096-2109
-
-
Weng, A.P.1
Millholland, J.M.2
Yashiro-Ohtani, Y.3
-
23
-
-
33644749306
-
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes
-
Nam Y, Sliz P, Song L, Aster JC, Blacklow SC. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell. 2006;124:973-983.
-
(2006)
Cell
, vol.124
, pp. 973-983
-
-
Nam, Y.1
Sliz, P.2
Song, L.3
Aster, J.C.4
Blacklow, S.C.5
-
24
-
-
0035942271
-
Significance analysis of microarrays applied to the ionizing radiation response
-
Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A. 2001;98:5116-5121.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 5116-5121
-
-
Tusher, V.G.1
Tibshirani, R.2
Chu, G.3
-
25
-
-
2342545519
-
Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
-
Fingar DC, Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene. 2004;23:3151-3171.
-
(2004)
Oncogene
, vol.23
, pp. 3151-3171
-
-
Fingar, D.C.1
Blenis, J.2
-
26
-
-
33845306813
-
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
-
Palomero T, Lim WK, Odom DT, et al. NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc Natl Acad Sci U S A. 2006;103:18261-18266.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 18261-18266
-
-
Palomero, T.1
Lim, W.K.2
Odom, D.T.3
-
27
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 2004;18:1926-1945.
-
(2004)
Genes Dev
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
28
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell. 2006;124:471-484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
29
-
-
0021118703
-
Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
-
Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul. 1984;22:27-55.
-
(1984)
Adv Enzyme Regul
, vol.22
, pp. 27-55
-
-
Chou, T.C.1
Talalay, P.2
-
30
-
-
0032563202
-
Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis
-
Ling YH, Tornos C, Perez-Soler R. Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis. J Biol Chem. 1998;273:18984-18991.
-
(1998)
J Biol Chem
, vol.273
, pp. 18984-18991
-
-
Ling, Y.H.1
Tornos, C.2
Perez-Soler, R.3
-
31
-
-
33747819801
-
mTOR and cancer: Insights into a complex relationship
-
Sabatini DM. mTOR and cancer: insights into a complex relationship. Nat Rev Cancer. 2006;6:729-734.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 729-734
-
-
Sabatini, D.M.1
-
32
-
-
0345732640
-
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
-
Fingar DC, Richardson CJ, Tee AR, Cheatham L, Tsou C, Blenis J. mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol. 2004;24:200-216.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 200-216
-
-
Fingar, D.C.1
Richardson, C.J.2
Tee, A.R.3
Cheatham, L.4
Tsou, C.5
Blenis, J.6
-
33
-
-
0034141942
-
Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI
-
Raught B, Gingras AC, Gygi SP, et al. Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI. EMBO J. 2000;19:434-444.
-
(2000)
EMBO J
, vol.19
, pp. 434-444
-
-
Raught, B.1
Gingras, A.C.2
Gygi, S.P.3
-
34
-
-
0040737600
-
Phosphorylation and activation of phospholipase D1 by protein kinase C in vivo: Determination of multiple phosphorylation sites
-
Kim Y, Han JM, Park JB, et al. Phosphorylation and activation of phospholipase D1 by protein kinase C in vivo: determination of multiple phosphorylation sites. Biochemistry. 1999;38:10344-10351.
-
(1999)
Biochemistry
, vol.38
, pp. 10344-10351
-
-
Kim, Y.1
Han, J.M.2
Park, J.B.3
-
35
-
-
0035976615
-
Phosphatidic acid-mediated mitogenic activation of mTOR signaling
-
Fang Y, Vilella-Bach M, Bachmann R, Flanigan A, Chen J. Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science. 2001;294:1942-1945.
-
(2001)
Science
, vol.294
, pp. 1942-1945
-
-
Fang, Y.1
Vilella-Bach, M.2
Bachmann, R.3
Flanigan, A.4
Chen, J.5
-
36
-
-
33750317437
-
Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc
-
Sharma VM, Calvo JA, Draheim KM, et al. Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc. Mol Cell Biol. 2006;26:8022-8031.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 8022-8031
-
-
Sharma, V.M.1
Calvo, J.A.2
Draheim, K.M.3
-
37
-
-
33745131039
-
Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice
-
Klinakis A, Szabolcs M, Politi K, Kiaris H, Artavanis-Tsakonas S, Efstratiadis A. Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. Proc Natl Acad Sci U S A. 2006;103:9262-9267.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 9262-9267
-
-
Klinakis, A.1
Szabolcs, M.2
Politi, K.3
Kiaris, H.4
Artavanis-Tsakonas, S.5
Efstratiadis, A.6
-
38
-
-
2442648845
-
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
-
Ruggero D, Montanaro L, Ma L, et al. The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat Med. 2004;10:484-486.
-
(2004)
Nat Med
, vol.10
, pp. 484-486
-
-
Ruggero, D.1
Montanaro, L.2
Ma, L.3
-
39
-
-
32444434357
-
Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation
-
Cai D, Netzer WJ, Zhong M, et al. Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation. Proc Natl Acad Sci U S A. 2006;103:1941-1946.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 1941-1946
-
-
Cai, D.1
Netzer, W.J.2
Zhong, M.3
-
40
-
-
32444439640
-
Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons
-
Cai D, Zhong M, Wang R, et al. Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons. Proc Natl Acad Sci U S A. 2006;103:1936-1940.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 1936-1940
-
-
Cai, D.1
Zhong, M.2
Wang, R.3
-
41
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science. 2005;307:1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
42
-
-
0344063370
-
Will mTOR inhibitors make it as cancer drugs?
-
Sawyers CL. Will mTOR inhibitors make it as cancer drugs? Cancer Cell. 2003;4:343-348.
-
(2003)
Cancer Cell
, vol.4
, pp. 343-348
-
-
Sawyers, C.L.1
-
43
-
-
1542398693
-
Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
-
Atkins MB, Hidalgo M, Stadler WM, et al. Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol. 2004;22:909-918.
-
(2004)
J Clin Oncol
, vol.22
, pp. 909-918
-
-
Atkins, M.B.1
Hidalgo, M.2
Stadler, W.M.3
-
44
-
-
7244250027
-
Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis
-
Pece S, Serresi M, Santolini E, et al. Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol. 2004;167:215-221.
-
(2004)
J Cell Biol
, vol.167
, pp. 215-221
-
-
Pece, S.1
Serresi, M.2
Santolini, E.3
|