Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

Genes and Development

Volumn 12, Issue 15, 1998, Pages 2424-2433

  Zindy, Frederique ^a   Eischen, Christine M ^a   Randle, David H ^a,b   Kamijo, Takehiko ^a   Cleveland, John L ^a,b   Sherr, Charles J ^a,b   Roussel, Martine F ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

Apoptosis; ARF tumor suppressor; Immortalization; Myc signaling; p53

Indexed keywords

ONCOPROTEIN; PROTEIN P53;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL IMMORTALIZATION; CELL PROLIFERATION; EMBRYO; FIBROBLAST CULTURE; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

ANIMALIA;

EID: 0032145569     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.15.2424     Document Type: Article

References (53)

1. Askew, D.S., R.A Ashmun, B.C. Simmons, and J.L. Cleveland. 1991. Constitutive c-myc expression in an IL3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene 6: 1915-1922.
2. Barak, Y., T. Juven, R. Haffner, and M. Oren. 1993. Mdm2 expression is induced by wild type p53 activity. EMBO J. 12: 461-468.
3. Cheng, M., V. Sexl, C.J. Sherr, and M.F. Roussel. 1998. Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1). Proc. Natl. Acad. Sci. 95: 1091-1096.
4. Debbas, M. and E. White. 1993. Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes &. Dev. 7: 546-554.
5. DeGregori, J., G. Leone, A. Miron, L. Jakoi, and J. Nevins. 1997. Distinct roles for E2F proteins in cell growth control and apoptosis. Proc. Natl. Acad. Sci. 94: 7245-7250.
6. ARF tumor suppressor. Genes & Dev. (this issue).
7. Eilers, M., S. Schirm, and J.M. Bishop. 1991. The MYC protein activates transcription of the α-prothymosin gene. EMBO J. 10: 133-141.
8. El-Deiry, W.S., T. Tokino, V.E. Velculescu, D.B. Levy, R. Parsons, J.M. Trent, D. Lin, E. Mercer, K.W. Kinzler, and B. Vogelstein. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817-825.
9. Evan, G.I., A.H. Wyllie, C.S. Gilbert, T.D. Littlewood, H. Land, M. Brooks, C.M. Water, L.Z. Penn, and D.C. Hancock. 1992. Induction of apoptosis in fibroblasts by c-myc protein. Cell 69: 119-128.
10. Franza, B.R., K. Maruyama, J.I. Garrels, and H.E. Ruley. 1986. In vitro establishment is not sufficient prerequisite for transformation by activated ras oncogene. Cell 44: 409-418.
11. Gannon, J.V., R. Greaves, R. Iggo, and D.P. Lane. 1990. Activating mutations in p53 produce a common conformational effect: A monoclonal antibody specific for the mutant form. EMBO J. 9: 1595-1602.
12. Gorczya, W., J. Gong, and Z. Darzynkiewicz. 1993. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res. 53: 1945-1951.
13. Harper, J.W., G.R. Adami, N. Wei, K. Keyomarsi, and S.J. Elledge. 1993. The p21 cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75: 805-816.
14. Haupt, Y., R. Maya, A. Kazaz, and M. Oren. 1997. Mdm2 promotes the rapid degradation of p53. Nature 387: 296-299.
15. Hermeking, H. and D. Eick. 1994. Mediation of c-Myc-induced apoptosis by p53. Science 265: 2091-2093.
16. Hicks, G.C., S.E. Egan, A.H. Greenberg, and M. Mowat. 1991. Mutant p53 tumor suppressor alleles release ras-induced cell cycle growth arrest. Mol. Cell Biol. 11: 1344-1352.
17. Hirakawa, T. and H.E. Ruley. 1991. Rescue of cells from ras oncogene-induced growth arrest by a second, complementing oncogene. Proc. Natl. Acad. Sci. 85: 1519-1523.
18. Honda, R., H. Tanaka, and H. Yasuda. 1997. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Letts. 420: 25-27.
19. Kern, S.E., J.A. Pietenpol, S. Thiagalingam, A. Seymour, K. Kinzler, and B. Vogelstein. 1992. Oncogenic forms of p53 inhibit p53-regulated gene expression. Science 256: 827-830.
20. ARF. Cell 91: 641-659.
21. Kamijo, T., J.D. Weber, G. Zambetti, F. Zindy, M.F. Roussel, and C.J. Sherr. 1998. Interactions of the ARF tumor suppressor with p53 and Mdm2: Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. Proc. Natl. Acad. Sci. 95: 8292-8297.
22. Kowalik, T.F., J. DeGregori, T.K. Schwarz, and J.R. Nevins. 1995. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J. Virol. 69: 2491-2500.
23. Kubbutat, M.H., S.N. Jones, and K.H. Vousden. 1997. Regulation of p53 stability by Mdm2. Nature 387: 299-303.
24. Land, H., L.F. Parada, and R.A. Weinberg. 1983. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 304: 596-602.
25. Lin, H.-J., V. Eviner, G.C. Prendergast, and E. White. 1995. Activated H-ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest. Mol. Cell Biol. 15: 4536-4544.
26. Littlewood, T.D., D.C. Hancock, P.S. Danielian, M.G. Parker, and G.I. Evan. 1995. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res. 23: 1686-1690.
27. Lowe, S.W. and H.E. Ruley. 1993. Stabilization of the p53 tumor suppressor is induced by adenovirus-5 E1A and accompanies apoptosis. Genes & Dev. 7: 535-545.
28. Morgenbesser, S.D., B.O. Williams, T. Jacks, and R.A. DePinho. 1994. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature 371: 72-74.
29. Newbold, R.F. and R.O. Overell. 1983. Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene. Nature 304: 648-651.
30. ARF, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 92: 713-723.
31. Qin, X.Q., D.M. Livingston, W.G. Kaelin, Jr., and P.D. Adams. 1994. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. 91: 10918-19022.
32. INK4b genes. Oncogene 11: 635-645.
33. Quelle, D.E., F. Zindy, R.A. Ashmun, and C.J. Sherr. 1995b. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83: 993-1000.
34. Rao, L., M. Debbas, P. Sabbatini, D. Hockenbery, S. Korsmeyer, and E. White. 1992. The adenovirus E1A proteins induce apoptosis which is inhibited by the E1B 19K and Bc1-2 proteins. Proc. Natl. Acad. Sci. 89: 7742-7746.
35. Roussel, M.F. and C.J. Sherr. 1989. Mouse NIH/3T3 cells expressing human CSF-1 receptors overgrow in serum-free medium containing human CSF-1 as their only growth factor. Proc. Natl. Acad. Sci. 86: 7924-7927.
36. Roussel, M.F., A.M. Theodoras, M. Pagano, and C.J. Sherr. 1995. Rescue of defective mitogenic signaling by D-type cyclins. Proc. Natl. Acad. Sci. 92: 6837-6841.
37. Roy, B., J. Beamon, E. Balint, and D. Reisman. 1994. Transactivation of the human p53 tumor suppressor gene by c-Myc/ Max contributes to elevated mutant p53 expression in some tumors. Mol. Cell. Biol. 14: 7805-7815.
38. Ruley, H.E. 1983. Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. Nature 304: 602-606.
39. _. 1990. Transforming collaborations between ras and nuclear oncogenes. In Cancer cells 2 (ed. G.F. Vande Woude, A.J. Levine, W.C. Topp, and J.D. Watson), pp. 258-268. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
40. Serrano, M., G.J. Hannon, and D. Beach. 1993. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4. Nature 366: 704-707.
41. Serrano, M., H-W. Lee, L. Chin, C. Cordon-Cardo, D. Beach, and R.A. DePinho. 1996. Role of the INK4a locus in tumor suppression and cell mortality. Cell 85: 27-37.
42. INK4a. Cell 88: 593-602.
43. Shan, B. and W.H. Lee. 1994. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol. Cell Biol. 14: 8166-8173.
44. Sherr, C.J. 1996. Cancer cell cycles. Science 274: 1672-1677.
45. Wagner, A.J., J.M. Kokontis, and N. Hay. 1994. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21 waf1/ cip1. Genes & Dev. 8: 2817-2830.
46. Weinberg, R.A. 1997 The cat and mouse games that genes, viruses, and cells play. Cell 88: 573-575.
47. White, E., R. Cipriani, P. Sabbatini, and A. Denton. 1991. The adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins. J. Virol. 65: 2968-2978.
48. Wu, X. and A.J. Levine. 1994. p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. 91: 3602-3606.
49. Wu, X., J.H. Bayle, D. Olson, and A.J. Levine. 1993. The p53-mdm-2 autoregulatory feedback loop. Genes & Dev. 7: 1126-1132.
50. Xiong, Y., G.J. Hannon, H. Zhang, D. Casso, R. Kobayashi, and D. Beach. 1993. p21 is a universal inhibitor of cyclin kinases. Nature 366: 701-704.
51. Yewdell, J.W., J.V. Gannon, and D.P. Lane. 1986. Monoclonal antibody analysis of p53 expression in normal and transformed cells. J. Virol. 59: 444-452.
52. Zhang, Y., Y. Xiong, and W.G. Yarbrough. 1998. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppressor pathways. Cell 92: 725-734.
53. 1NK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene 15: 203-211.