Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

Nature

Volumn 435, Issue 7044, 2005, Pages 959-963

  Van Es, Johan H ^a   Van Gijn, Marielle E ^a   Riccio, Orbicia ^b   Van Den Born, Maaike ^a   Vooijs, Marc ^a   Begthel, Harry ^a   Cozijnsen, Miranda ^a   Robine, Sylvie ^c   Winton, Doug J ^d   Radtke, Freddy ^b   Clevers, Hans ^a  

^a HUBRECHT INSTITUTE   (Netherlands)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (Switzerland)

^c CNRS   (France)

^d ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; CELLS; CYTOLOGY; DISEASES; ENZYME INHIBITION; GENES;

ALZHEIMERS DISEASE; PROGENITOR CRYPT COMPARTMENTS; PROLIFERATIVE CELLS; SMALL INTESTINE;

ENZYMES;

GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; NOTCH RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CSL; UNCLASSIFIED DRUG; WNT PROTEIN; ASPARTIC PROTEINASE; BACE1 PROTEIN, MOUSE; DIBENZAZEPINE DERIVATIVE; DNA BINDING PROTEIN; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE BINDING PROTEIN; MEMBRANE PROTEIN; NUCLEAR PROTEIN; PROTEINASE; PROTEINASE INHIBITOR; RBPSUH PROTEIN, MOUSE; SECRETASE;

CELLS AND CELL COMPONENTS;

ADENOMA; ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION; COLORECTAL TUMOR; CRYPT CELL; ENZYME INHIBITION; GENE MUTATION; GOBLET CELL; INTESTINE CRYPT; INTESTINE EPITHELIUM; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE; ANIMAL; C57BL MOUSE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; FEMALE; GENETICS; MALE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; SMALL INTESTINE;

ANIMALIA; MUS MUSCULUS;

ADENOMA; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL DIFFERENTIATION; CELL PROLIFERATION; DIBENZAZEPINES; DNA-BINDING PROTEINS; ENDOPEPTIDASES; FEMALE; GENES, APC; GOBLET CELLS; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; INTESTINE, SMALL; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; NUCLEAR PROTEINS; PHENOTYPE; PROTEASE INHIBITORS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 20544460148     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03659     Document Type: Article

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