Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

Molecular and Cellular Biology

Volumn 26, Issue 12, 2006, Pages 4642-4651

  Malecki, Michael J ^a   Sanchez Irizarry, Cheryll ^a   Mitchell, Jennifer L ^a   Histen, Gavin ^a   Xu, Mina L ^a   Aster, Jon C ^a   Blacklow, Stephen C ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SECRETASE; FURIN; HETERODIMER; METALLOPROTEINASE; NOTCH1 RECEPTOR; TUMOR ANTIGEN; UREA;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CORRELATION ANALYSIS; COVALENT BOND; DIMERIZATION; ENZYME ACTIVITY; EXTRACELLULAR SPACE; GENE MUTATION; HUMAN; HUMAN CELL; LEUKEMOGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; BINDING SITES; CELL LINE; DIMERIZATION; HUMANS; LEUKEMIA, T-CELL, ACUTE; LIGANDS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, NOTCH1; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 33745045658     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01655-05     Document Type: Article

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