메뉴 건너뛰기




Volumn 14, Issue 7, 2012, Pages 585-599

Circumventing cellular control of PP2A by methylation promotes transformation in an Akt-dependent manner

Author keywords

[No Author keywords available]

Indexed keywords

LEUCINE CARBOXYL METHYLTRANSFERASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN CARBOXYL METHYLTRANSFERASE; PROTEIN KINASE B; PROTEIN P70; PROTEIN P85; S6 KINASE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; VIRUS LARGE T ANTIGEN; VIRUS MIDDLE T ANTIGEN; VIRUS SMALL T ANTIGEN;

EID: 84865662302     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.12768     Document Type: Article
Times cited : (50)

References (73)
  • 1
    • 0035252894 scopus 로고    scopus 로고
    • Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
    • Janssens V and Goris J (2001). Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J 353, 417-439.
    • (2001) Biochem J , vol.353 , pp. 417-439
    • Janssens, V.1    Goris, J.2
  • 2
  • 3
    • 41549090369 scopus 로고    scopus 로고
    • Multiple pathways regulated by the tumor suppressor PP2A in transformation
    • Westermarck J and Hahn WC (2008). Multiple pathways regulated by the tumor suppressor PP2A in transformation. Trends Mol Med 14, 152-160.
    • (2008) Trends Mol Med , vol.14 , pp. 152-160
    • Westermarck, J.1    Hahn, W.C.2
  • 4
    • 0033534615 scopus 로고    scopus 로고
    • Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A
    • Westphal RS, Coffee RL Jr, Marotta A, Pelech SL, and Wadzinski BE (1999). Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A. J Biol Chem 274, 687-692.
    • (1999) J Biol Chem , vol.274 , pp. 687-692
    • Westphal, R.S.1    Coffee Jr., R.L.2    Marotta, A.3    Pelech, S.L.4    Wadzinski, B.E.5
  • 5
    • 0034331359 scopus 로고    scopus 로고
    • Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits
    • Tolstykh T, Lee J, Vafai S, and Stock JB (2000). Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits. EMBO J 19, 5682-5691.
    • (2000) EMBO J , vol.19 , pp. 5682-5691
    • Tolstykh, T.1    Lee, J.2    Vafai, S.3    Stock, J.B.4
  • 6
    • 0034331296 scopus 로고    scopus 로고
    • Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo
    • Wu J, Tolstykh T, Lee J, Boyd K, Stock JB, and Broach JR (2000). Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo. EMBO J 19, 5672-5681.
    • (2000) EMBO J , vol.19 , pp. 5672-5681
    • Wu, J.1    Tolstykh, T.2    Lee, J.3    Boyd, K.4    Stock, J.B.5    Broach, J.R.6
  • 7
    • 0035846951 scopus 로고    scopus 로고
    • Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p
    • Wei H, Ashby DG, Moreno CS, Ogris E, Yeong FM, Corbett AH, and Pallas DC (2001). Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p. J Biol Chem 276, 1570-1577.
    • (2001) J Biol Chem , vol.276 , pp. 1570-1577
    • Wei, H.1    Ashby, D.G.2    Moreno, C.S.3    Ogris, E.4    Yeong, F.M.5    Corbett, A.H.6    Pallas, D.C.7
  • 8
    • 0035177048 scopus 로고    scopus 로고
    • Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Bα regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen
    • Yu XX, Du X, Moreno CS, Green RE, Ogris E, Feng Q, Chou L, McQuoid MJ, and Pallas DC (2001). Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Bα regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen. Mol Biol Cell 12, 185-199.
    • (2001) Mol Biol Cell , vol.12 , pp. 185-199
    • Yu, X.X.1    Du, X.2    Moreno, C.S.3    Green, R.E.4    Ogris, E.5    Feng, Q.6    Chou, L.7    McQuoid, M.J.8    Pallas, D.C.9
  • 9
    • 0033554835 scopus 로고    scopus 로고
    • Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue
    • De Baere I, Derua R, Janssens V, Van Hoof C, Waelkens E, Merlevede W, and Goris J (1999). Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue. Biochemistry 38, 16539-16547.
    • (1999) Biochemistry , vol.38 , pp. 16539-16547
    • de Baere, I.1    Derua, R.2    Janssens, V.3    van Hoof, C.4    Waelkens, E.5    Merlevede, W.6    Goris, J.7
  • 10
    • 0029952559 scopus 로고    scopus 로고
    • A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain
    • Lee J, Chen Y, Tolstykh T, and Stock J (1996). A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain. Proc Natl Acad Sci USA 93, 6043-6047.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6043-6047
    • Lee, J.1    Chen, Y.2    Tolstykh, T.3    Stock, J.4
  • 11
    • 0033553570 scopus 로고    scopus 로고
    • A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A
    • Ogris E, Du X, Nelson KC, Mak EK, Yu XX, Lane WS, and Pallas DC (1999). A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A. J Biol Chem 274, 14382-14391.
    • (1999) J Biol Chem , vol.274 , pp. 14382-14391
    • Ogris, E.1    Du, X.2    Nelson, K.C.3    Mak, E.K.4    Yu, X.X.5    Lane, W.S.6    Pallas, D.C.7
  • 12
    • 34848843828 scopus 로고    scopus 로고
    • Selection of protein phosphatase 2A regulatory subunits is mediated by the C terminus of the catalytic subunit
    • Longin S, Zwaenepoel K, Louis JV, Dilworth S, Goris J, and Janssens V (2007). Selection of protein phosphatase 2A regulatory subunits is mediated by the C terminus of the catalytic subunit. J Biol Chem 282, 26971-26980.
    • (2007) J Biol Chem , vol.282 , pp. 26971-26980
    • Longin, S.1    Zwaenepoel, K.2    Louis, J.V.3    Dilworth, S.4    Goris, J.5    Janssens, V.6
  • 13
    • 38349190654 scopus 로고    scopus 로고
    • Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55α regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt
    • Kuo YC, Huang KY, Yang CH, Yang YS, Lee WY, and Chiang CW (2008). Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55α regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt. J Biol Chem 283, 1882-1892.
    • (2008) J Biol Chem , vol.283 , pp. 1882-1892
    • Kuo, Y.C.1    Huang, K.Y.2    Yang, C.H.3    Yang, Y.S.4    Lee, W.Y.5    Chiang, C.W.6
  • 14
    • 78650407231 scopus 로고    scopus 로고
    • Identification of PP2A complexes and pathways involved in cell transformation
    • Sablina AA, Hector M, Colpaert N, and Hahn WC (2010). Identification of PP2A complexes and pathways involved in cell transformation. Cancer Res 70, 10474-10484.
    • (2010) Cancer Res , vol.70 , pp. 10474-10484
    • Sablina, A.A.1    Hector, M.2    Colpaert, N.3    Hahn, W.C.4
  • 15
    • 34247142858 scopus 로고    scopus 로고
    • Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity
    • Rocher G, Letourneux C, Lenormand P, and Porteu F (2007). Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity. J Biol Chem 282, 5468-5477.
    • (2007) J Biol Chem , vol.282 , pp. 5468-5477
    • Rocher, G.1    Letourneux, C.2    Lenormand, P.3    Porteu, F.4
  • 16
    • 0034671578 scopus 로고    scopus 로고
    • TGF-β inhibits p70 S6 kinase via protein phosphatase 2A to induce G1 arrest
    • Petritsch C, Beug H, Balmain A, and Oft M (2000). TGF-β inhibits p70 S6 kinase via protein phosphatase 2A to induce G1 arrest. Genes Dev 14, 3093-3101.
    • (2000) Genes Dev , vol.14 , pp. 3093-3101
    • Petritsch, C.1    Beug, H.2    Balmain, A.3    Oft, M.4
  • 17
    • 0025103372 scopus 로고    scopus 로고
    • Polyoma small and middleTantigens and SV40 small t antigen form stable complexes with protein phosphatase 2A
    • Pallas DC, Shahrik LK, Martin BL, Jaspers S, Miller TB, Brautigan DL, and RobertsTM(1990). Polyoma small and middleTantigens and SV40 small t antigen form stable complexes with protein phosphatase 2A. Cell 60, 167-176.
    • Cell , vol.60 , pp. 167-176
    • Pallas, D.C.1    Shahrik, L.K.2    Martin, B.L.3    Jaspers, S.4    Miller, T.B.5    Brautigan, D.L.6
  • 18
    • 0030821233 scopus 로고    scopus 로고
    • Protein phosphatase 2A subunit assembly: The catalytic subunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen
    • Ogris E, Gibson DM, and Pallas DC (1997). Protein phosphatase 2A subunit assembly: the catalytic subunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen. Oncogene 15, 911-917.
    • (1997) Oncogene , vol.15 , pp. 911-917
    • Ogris, E.1    Gibson, D.M.2    Pallas, D.C.3
  • 20
    • 0026016248 scopus 로고
    • Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: Inhibition by small-t antigen
    • Scheidtmann KH, Mumby MC, Rundell K, and Walter G (1991). Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen. Mol Cell Biol 11, 1996-2003.
    • (1991) Mol Cell Biol , vol.11 , pp. 1996-2003
    • Scheidtmann, K.H.1    Mumby, M.C.2    Rundell, K.3    Walter, G.4
  • 21
    • 0027772552 scopus 로고
    • The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates theMAP kinase pathway and induces cell proliferation
    • Sontag E, Fedorov S, Kamibayashi C, Robbins D, Cobb M, and Mumby M (1993). The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates theMAP kinase pathway and induces cell proliferation. Cell 75, 887-897.
    • (1993) Cell , vol.75 , pp. 887-897
    • Sontag, E.1    Fedorov, S.2    Kamibayashi, C.3    Robbins, D.4    Cobb, M.5    Mumby, M.6
  • 22
    • 0026537405 scopus 로고
    • Characterization of the interaction of polyomavirus middle T antigen with type 2A protein phosphatase
    • Ulug ET, Cartwright AJ, and Courtneidge SA (1992). Characterization of the interaction of polyomavirus middle T antigen with type 2A protein phosphatase. J Virol 66, 1458-1467.
    • (1992) J Virol , vol.66 , pp. 1458-1467
    • Ulug, E.T.1    Cartwright, A.J.2    Courtneidge, S.A.3
  • 24
    • 0026512195 scopus 로고
    • The third subunit of protein phosphatase 2A (PP2A), a 55-kilodalton protein which is apparently substituted for byTantigens in complexeswith the 36-and 63-kilodalton PP2A subunits, bears little resemblance to T antigens
    • Pallas DC, Weller W, Jaspers S, Miller TB, Lane WS, and Roberts TM (1992). The third subunit of protein phosphatase 2A (PP2A), a 55-kilodalton protein which is apparently substituted for byTantigens in complexeswith the 36-and 63-kilodalton PP2A subunits, bears little resemblance to T antigens. J Virol 66, 886-893.
    • (1992) J Virol , vol.66 , pp. 886-893
    • Pallas, D.C.1    Weller, W.2    Jaspers, S.3    Miller, T.B.4    Lane, W.S.5    Roberts, T.M.6
  • 25
    • 0034810773 scopus 로고    scopus 로고
    • Hepatic expression of SV40 small-T antigen blocks the in vivo CD95-mediated apoptosis
    • Gillet R, Cavard C, Grimber G, Briand P, and Joulin V (2001). Hepatic expression of SV40 small-T antigen blocks the in vivo CD95-mediated apoptosis. Biochem Biophys Res Comm 284, 369-376.
    • (2001) Biochem Biophys Res Comm , vol.284 , pp. 369-376
    • Gillet, R.1    Cavard, C.2    Grimber, G.3    Briand, P.4    Joulin, V.5
  • 27
    • 0036838980 scopus 로고    scopus 로고
    • Simian virus 40 small tumor antigen activates AKT and telomerase and induces anchorage-independent growth of human epithelial cells
    • Yuan H, Veldman T, Rundell K, and Schlegel R (2002). Simian virus 40 small tumor antigen activates AKT and telomerase and induces anchorage-independent growth of human epithelial cells. J Virol 76, 10685-10691.
    • (2002) J Virol , vol.76 , pp. 10685-10691
    • Yuan, H.1    Veldman, T.2    Rundell, K.3    Schlegel, R.4
  • 28
    • 0030769625 scopus 로고    scopus 로고
    • Protein phosphatase 2A is a critical regulator of protein kinase C ζ signaling targeted by SV40 small t to promote cell growth and NF-κB activation
    • Sontag E, Sontag JM, and Garcia A (1997). Protein phosphatase 2A is a critical regulator of protein kinase C ζ signaling targeted by SV40 small t to promote cell growth and NF-κB activation. EMBO J 16, 5662-5671.
    • (1997) EMBO J , vol.16 , pp. 5662-5671
    • Sontag, E.1    Sontag, J.M.2    Garcia, A.3
  • 29
    • 5044220058 scopus 로고    scopus 로고
    • Signaling and transcriptional changes critical for transformation of human cells by simian virus 40 small tumor antigen or protein phosphatase 2A B56γ knockdown
    • Moreno CS, Ramachandran S, Ashby DG, Laycock N, Plattner CA, Chen W, Hahn WC, and Pallas DC (2004). Signaling and transcriptional changes critical for transformation of human cells by simian virus 40 small tumor antigen or protein phosphatase 2A B56γ knockdown. Cancer Res 64, 6978-6988.
    • (2004) Cancer Res , vol.64 , pp. 6978-6988
    • Moreno, C.S.1    Ramachandran, S.2    Ashby, D.G.3    Laycock, N.4    Plattner, C.A.5    Chen, W.6    Hahn, W.C.7    Pallas, D.C.8
  • 30
    • 34247625153 scopus 로고    scopus 로고
    • Expression of protein phosphatase 2A mutants and silencing of the regulatory Bα subunit induce a selective loss of acetylated and detyrosinated microtubules
    • Nunbhakdi-Craig V, Schuechner S, Sontag JM, Montgomery L, Pallas DC, Juno C, Mudrak I, Ogris E, and Sontag E (2007). Expression of protein phosphatase 2A mutants and silencing of the regulatory Bα subunit induce a selective loss of acetylated and detyrosinated microtubules. J Neurochem 101, 959-971.
    • (2007) J Neurochem , vol.101 , pp. 959-971
    • Nunbhakdi-Craig, V.1    Schuechner, S.2    Sontag, J.M.3    Montgomery, L.4    Pallas, D.C.5    Juno, C.6    Mudrak, I.7    Ogris, E.8    Sontag, E.9
  • 31
    • 35648957688 scopus 로고    scopus 로고
    • Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells
    • Lee JA and Pallas DC (2007). Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells. J Biol Chem 282, 30974-30984.
    • (2007) J Biol Chem , vol.282 , pp. 30974-30984
    • Lee, J.A.1    Pallas, D.C.2
  • 32
    • 0031806103 scopus 로고    scopus 로고
    • Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport
    • Kitamura T, Ogawa W, Sakaue H, Hino Y, Kuroda S, Takata M, Matsumoto M, Maeda T, Konishi H, Kikkawa U, et al. (1998). Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport. Mol Cell Biol 18, 3708-3717.
    • (1998) Mol Cell Biol , vol.18 , pp. 3708-3717
    • Kitamura, T.1    Ogawa, W.2    Sakaue, H.3    Hino, Y.4    Kuroda, S.5    Takata, M.6    Matsumoto, M.7    Maeda, T.8    Konishi, H.9    Kikkawa, U.10
  • 33
    • 0022980997 scopus 로고
    • Polyomavirus small t antigen: Overproduction in bacteria, purification, and utilization for monoclonal and polyclonal antibody production
    • Pallas DC, Schley C, Mahoney M, Harlow E, Schaffhausen BS, and Roberts TM (1986). Polyomavirus small t antigen: overproduction in bacteria, purification, and utilization for monoclonal and polyclonal antibody production. J Virol 60, 1075-1084.
    • (1986) J Virol , vol.60 , pp. 1075-1084
    • Pallas, D.C.1    Schley, C.2    Mahoney, M.3    Harlow, E.4    Schaffhausen, B.S.5    Roberts, T.M.6
  • 34
    • 80053604188 scopus 로고    scopus 로고
    • Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste-Like kinase Mst3
    • Gordon J, Hwang J, Carrier KJ, Jones CA, Kern QL, Moreno CS, Karas RH, and Pallas DC (2011). Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste-Like kinase Mst3. BMC Biochem 12, e54.
    • (2011) BMC Biochem , vol.12 , pp. 54
    • Gordon, J.1    Hwang, J.2    Carrier, K.J.3    Jones, C.A.4    Kern, Q.L.5    Moreno, C.S.6    Karas, R.H.7    Pallas, D.C.8
  • 36
    • 2642595021 scopus 로고
    • Correlation of patterns of anchorage-independent growth with in vivo behavior of cells for a murine fibroblast
    • Cifone M and Fidler IJ (1980). Correlation of patterns of anchorage-independent growth with in vivo behavior of cells for a murine fibroblast. Proc Natl Acad Sci USA 77, 1039-1043.
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 1039-1043
    • Cifone, M.1    Fidler, I.J.2
  • 39
    • 0016318441 scopus 로고
    • Cellular tumorigenicity in nude mice: Correlation with cell growth in semi-solid medium
    • Freedman VH and Shin S (1974). Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium. Cell 3, 355-359.
    • (1974) Cell , vol.3 , pp. 355-359
    • Freedman, V.H.1    Shin, S.2
  • 40
    • 84857477485 scopus 로고    scopus 로고
    • Integrin signaling, cell survival, and anoikis: Distinctions, differences, and differentiation
    • Vachon PH (2011). Integrin signaling, cell survival, and anoikis: distinctions, differences, and differentiation. J Signal Transduct 2011, 738137.
    • (2011) J Signal Transduct , vol.2011 , pp. 738137
    • Vachon, P.H.1
  • 41
    • 17144395975 scopus 로고    scopus 로고
    • The activation of Akt/PKB signaling pathway and cell survival
    • Song G, Ouyang G, and Bao S (2005). The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 9, 59-71.
    • (2005) J Cell Mol Med , vol.9 , pp. 59-71
    • Song, G.1    Ouyang, G.2    Bao, S.3
  • 42
    • 0442276554 scopus 로고    scopus 로고
    • The glamour and gloom of glycogen synthase kinase-3
    • Jope RS and Johnson GV (2004). The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci 29, 95-102.
    • (2004) Trends Biochem Sci , vol.29 , pp. 95-102
    • Jope, R.S.1    Johnson, G.V.2
  • 43
    • 0032568269 scopus 로고    scopus 로고
    • Translation control: Connecting mitogens and the ribosome
    • Peterson RT and Schreiber SL (1998). Translation control: connecting mitogens and the ribosome. Curr Biol 8, R248-R250.
    • (1998) Curr Biol , vol.8 , pp. 248-250
    • Peterson, R.T.1    Schreiber, S.L.2
  • 44
    • 77956623574 scopus 로고    scopus 로고
    • Coordinated maintenance of muscle cell size control by AMP-activated protein kinase
    • Lantier L, Mounier R, Leclerc J, Pende M, Foretz M, and Viollet B (2010). Coordinated maintenance of muscle cell size control by AMP-activated protein kinase. FASEB J 24, 3555-3561.
    • (2010) FASEB J , vol.24 , pp. 3555-3561
    • Lantier, L.1    Mounier, R.2    Leclerc, J.3    Pende, M.4    Foretz, M.5    Viollet, B.6
  • 45
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR [review]
    • Hay N and Sonenberg N (2004). Upstream and downstream of mTOR [review]. Genes Dev 18, 1926-1945.
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 47
    • 69249229734 scopus 로고    scopus 로고
    • The adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit
    • Li SP, Brignole C, Marcellus R, Thirlwell S, Binda O, McQuoid MJ, Ashby D, Chan H, Zhang Z, Miron MJ, et al. (2009). The adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit. J Virol 83, 8340-8352.
    • (2009) J Virol , vol.83 , pp. 8340-8352
    • Li, S.P.1    Brignole, C.2    Marcellus, R.3    Thirlwell, S.4    Binda, O.5    McQuoid, M.J.6    Ashby, D.7    Chan, H.8    Zhang, Z.9    Miron, M.J.10
  • 48
    • 33846101533 scopus 로고    scopus 로고
    • Regulation of cell adhesion by PP2A and SV40 small tumor antigen: An important link to cell transformation
    • Sontag JM and Sontag E (2006). Regulation of cell adhesion by PP2A and SV40 small tumor antigen: an important link to cell transformation. Cell Mol Life Sci 63, 2979-2991.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 2979-2991
    • Sontag, J.M.1    Sontag, E.2
  • 49
    • 80052701113 scopus 로고    scopus 로고
    • Eukaryotic translation initiation factor 4E binding protein 1 (4EBP-1) function is suppressed by src and protein phosphatase 2A (PP2A) on extracellular matrix
    • Nho RS and Peterson M (2011). Eukaryotic translation initiation factor 4E binding protein 1 (4EBP-1) function is suppressed by src and protein phosphatase 2A (PP2A) on extracellular matrix. J Biol Chem 286, 31953-31965.
    • (2011) J Biol Chem , vol.286 , pp. 31953-31965
    • Nho, R.S.1    Peterson, M.2
  • 50
    • 77951985780 scopus 로고    scopus 로고
    • β1-Integrin-collagen interaction suppresses Fox-O3a by the coordination of Akt and PP2A
    • Nho RS and Kahm J (2010). β1-Integrin-collagen interaction suppresses Fox-O3a by the coordination of Akt and PP2A. J Biol Chem 285, 14195-14209.
    • (2010) J Biol Chem , vol.285 , pp. 14195
    • Nho, R.S.1    Kahm, J.2
  • 51
    • 53149133567 scopus 로고    scopus 로고
    • Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and B1 integrin and for tumor cell proliferation and migration
    • Kiely PA, Baillie GS, Lynch MJ, Houslay MD, and O'Conner R (2008). Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and B1 integrin and for tumor cell proliferation and migration. J Biol Chem 283, 22952-22961.
    • (2008) J Biol Chem , vol.283 , pp. 22952-22961
    • Kiely, P.A.1    Baillie, G.S.2    Lynch, M.J.3    Houslay M.D.O.Conner, R.4
  • 52
    • 50649107998 scopus 로고    scopus 로고
    • Polymerized collagen inhibits fibroblast proliferation via a mechanism involving the formation of a B1 integrin-protein phosphatase 2A-tuberous sclerosis complex 2 complex that suppresses S6K1 activity
    • Xia H, Nho R, Kleidon J, Kahm J, and Henke CA (2008). Polymerized collagen inhibits fibroblast proliferation via a mechanism involving the formation of a B1 integrin-protein phosphatase 2A-tuberous sclerosis complex 2 complex that suppresses S6K1 activity. J Biol Chem 283, 20350-20360.
    • (2008) J Biol Chem , vol.283 , pp. 20350-20360
    • Xia, H.1    Nho, R.2    Kleidon, J.3    Kahm, J.4    Henke, C.A.5
  • 54
    • 1542467646 scopus 로고    scopus 로고
    • Integrin α2β1 inhibits Fas-mediated apoptosis in T lymphocytes by protein phosphatase 2A-dependent activation of the MAPK/ERK pathway
    • Gendron S, Couture J, and Aoudjit F (2003). Integrin α2β1 inhibits Fas-mediated apoptosis in T lymphocytes by protein phosphatase 2A-dependent activation of the MAPK/ERK pathway. J Biol Chem 278, 48633-48643.
    • (2003) J Biol Chem , vol.278 , pp. 48633-48643
    • Gendron, S.1    Couture, J.2    Aoudjit, F.3
  • 55
    • 0026786471 scopus 로고
    • Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation
    • Chen J,Martin BL, and BrautiganDL (1992).Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation. Science 257, 1261-1264.
    • (1992) Science , vol.257 , pp. 1261-1264
    • Chen, J.1    Martin, B.L.2    Brautigan, D.L.3
  • 57
    • 34547141377 scopus 로고    scopus 로고
    • Functional analysis of the PP2A subfamily of protein phosphatases in regulating drosophila S6 kinase
    • Bielinski VA and Mumby MC (2007). Functional analysis of the PP2A subfamily of protein phosphatases in regulating drosophila S6 kinase. Exp Cell Res 313, 3117-3126.
    • (2007) Exp Cell Res , vol.313 , pp. 3117-3126
    • Bielinski, V.A.1    Mumby, M.C.2
  • 59
    • 49749098370 scopus 로고    scopus 로고
    • Targeted disruption of the pme-1 gene causes loss of demethylated PP2A and perinatal lethality in mice
    • Ortega-Gutierrez S, Leung D, Ficarro S, Peters EC, and Cravatt BF (2008). Targeted disruption of the pme-1 gene causes loss of demethylated PP2A and perinatal lethality in mice. PLoS One 3, e2486.
    • (2008) PLoS One , vol.3 , pp. 2486
    • Ortega-Gutierrez, S.1    Leung, D.2    Ficarro, S.3    Peters, E.C.4    Cravatt, B.F.5
  • 60
    • 66149089196 scopus 로고    scopus 로고
    • Pme-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma
    • Puustinen P, Junttila MR, Vanhatupa S, Sablina AA, Hector ME, Teittinen K, Raheem O, Ketola K, Lin S, Kast J, et al. (2009). Pme-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma. Cancer Res 69, 2870-2877.
    • (2009) Cancer Res , vol.69 , pp. 2870-2877
    • Puustinen, P.1    Junttila, M.R.2    Vanhatupa, S.3    Sablina, A.A.4    Hector, M.E.5    Teittinen, K.6    Raheem, O.7    Ketola, K.8    Lin, S.9    Kast, J.10
  • 61
    • 0019862690 scopus 로고
    • Increased phosphorylation of ribosomal protein S6 in hamster fibroblasts transformed by polyoma virus and simian virus 40
    • Kennedy IM and Leader DP (1981). Increased phosphorylation of ribosomal protein S6 in hamster fibroblasts transformed by polyoma virus and simian virus 40. Biochem J 198, 235-237.
    • (1981) Biochem J , vol.198 , pp. 235-237
    • Kennedy, I.M.1    Leader, D.P.2
  • 62
    • 0021276961 scopus 로고
    • Phosphorylation of the ribosomal protein S6 is elevated in cells transformed by a variety of tumor viruses
    • Blenis J and Erikson RL (1984). Phosphorylation of the ribosomal protein S6 is elevated in cells transformed by a variety of tumor viruses. J Virol 50, 966-969.
    • (1984) J Virol , vol.50 , pp. 966-969
    • Blenis, J.1    Erikson, R.L.2
  • 63
    • 0024023828 scopus 로고
    • Polyomavirus middle T antigen induces ribosomal protein S6 phosphorylation through pp60c-src-dependent and -independent pathways
    • Talmage DA, Blenis J, and Benjamin TL (1988). Polyomavirus middle T antigen induces ribosomal protein S6 phosphorylation through pp60c-src-dependent and -independent pathways. Mol Cell Biol 8, 2309-2315.
    • (1988) Mol Cell Biol , vol.8 , pp. 2309-2315
    • Talmage, D.A.1    Blenis, J.2    Benjamin, T.L.3
  • 64
    • 0032545943 scopus 로고    scopus 로고
    • Protein kinase B/Akt is activated by polyomavirus middle-T antigen via a phophatidylinositol 3-kinase-dependent mechanism
    • Meili R, Cron P, Hemmings BA, and Ballmer-Hofer K (1998). Protein kinase B/Akt is activated by polyomavirus middle-T antigen via a phophatidylinositol 3-kinase-dependent mechanism. Oncogene 16, 903-907.
    • (1998) Oncogene , vol.16 , pp. 903-907
    • Meili, R.1    Cron, P.2    Hemmings, B.A.3    Ballmer-Hofer, K.4
  • 65
    • 0031947340 scopus 로고    scopus 로고
    • Evidence of a role for phosphatidylinositol 3-kinase activation in the blocking of apoptosis by polyomavirus middle T antigen
    • Dahl J, Jurczak A, Cheng LA, Baker DC, and Benjamin TL (1998). Evidence of a role for phosphatidylinositol 3-kinase activation in the blocking of apoptosis by polyomavirus middle T antigen. J Virol 72, 3221-3226.
    • (1998) J Virol , vol.72 , pp. 3221-3226
    • Dahl, J.1    Jurczak, A.2    Cheng, L.A.3    Baker, D.C.4    Benjamin, T.L.5
  • 66
    • 37649024728 scopus 로고    scopus 로고
    • Protein phosphatase 2A regulates life and death decisions via Akt in a contextdependent manner
    • Andrabi S, Gjoerup OV, Kean JA, Roberts TM, and Schaffhausen B (2007). Protein phosphatase 2A regulates life and death decisions via Akt in a contextdependent manner. Proc Natl Acad Sci USA 104, 19011-19016.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19011-19016
    • Andrabi, S.1    Gjoerup, O.V.2    Kean, J.A.3    Roberts, T.M.4    Schaffhausen, B.5
  • 67
    • 77953391131 scopus 로고    scopus 로고
    • Multiple roles and therapeutic implications of Akt signaling and cancer
    • Calvo E, Bolos V, and Grande E (2009). Multiple roles and therapeutic implications of Akt signaling and cancer. Onco Targets Ther 2, 135-150.
    • (2009) Onco Targets Ther , vol.2 , pp. 135-150
    • Calvo, E.1    Bolos, V.2    Grande, E.3
  • 68
    • 37549028779 scopus 로고    scopus 로고
    • Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function
    • Jastrzebski K, Hannan KM, Tchhoubrieva EB, Hannan RD, and Pearson RB (2007). Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function. Growth Factors 25, 209-226.
    • (2007) Growth Factors , vol.25 , pp. 209-226
    • Jastrzebski, K.1    Hannan, K.M.2    Tchhoubrieva, E.B.3    Hannan, R.D.4    Pearson, R.B.5
  • 69
    • 34247127783 scopus 로고    scopus 로고
    • Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer
    • Nozawa H, Watanabe T, and Nagawa H (2007). Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer. Cancer Lett 251, 105-113.
    • (2007) Cancer Lett , vol.251 , pp. 105-113
    • Nozawa, H.1    Watanabe, T.2    Nagawa, H.3
  • 70
    • 34447340582 scopus 로고    scopus 로고
    • Increased phosphorylation of p70 S6 kinase is associated with HPV16 infection in cervical cancer and esophageal cancer
    • Zhou Y, Pan Y, Zhang S, Shi X, Ning T, and Ke Y (2007). Increased phosphorylation of p70 S6 kinase is associated with HPV16 infection in cervical cancer and esophageal cancer. Br J Cancer 97, 218-222.
    • (2007) Br J Cancer , vol.97 , pp. 218-222
    • Zhou, Y.1    Pan, Y.2    Zhang, S.3    Shi, X.4    Ning, T.5    Ke, Y.6
  • 71
    • 33750089285 scopus 로고    scopus 로고
    • Phosphorylated 4E binding protein 1: A hallmark of cell signaling that correlates with survival in ovarian cancer
    • Castellvi J, Garcia A, Rojo F, Ruiz-Marcellan C, Gil A, Baselga J, and Ramon y Cajal S (2006). Phosphorylated 4E binding protein 1: a hallmark of cell signaling that correlates with survival in ovarian cancer. Cancer 107, 1801-1811.
    • (2006) Cancer , vol.107 , pp. 1801-1811
    • Castellvi, J.1    Garcia, A.2    Rojo, F.3    Ruiz-Marcellan, C.4    Gil, A.5    Baselga, J.6    Cajal, S.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.