-
2
-
-
0036118368
-
Enumeration of the simian virus 40 early region elements necessary for human cell transformation
-
Hahn WC, Dessain SK, Brooks MW, et al. Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol 2002;22:2111-23.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 2111-2123
-
-
Hahn, W.C.1
Dessain, S.K.2
Brooks, M.W.3
-
3
-
-
0004165313
-
-
Sonenberg N, Hershey JWB, Mathews M, editors, 2nd ed. Cold Spring Harbor NY, Cold Spring Harbor Laboratory Press;
-
Sonenberg N, Hershey JWB, Mathews M, editors. Translational control of gene expression. 2nd ed. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2000.
-
(2000)
Translational control of gene expression
-
-
-
4
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004;18:1926-45.
-
(2004)
Genes Dev
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
5
-
-
0029772318
-
An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc
-
Jones RM, Branda J, Johnston KA, et al. An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc. Mol Cell Biol 1996;16:4754-64.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4754-4764
-
-
Jones, R.M.1
Branda, J.2
Johnston, K.A.3
-
7
-
-
1842790378
-
c-Myc as a therapeutic target in cancer
-
Prochownik EV. c-Myc as a therapeutic target in cancer. Expert Rev Anticancer Ther 2004;4:289-302.
-
(2004)
Expert Rev Anticancer Ther
, vol.4
, pp. 289-302
-
-
Prochownik, E.V.1
-
8
-
-
2342645571
-
The role of c-myc in regulation of translation initiation
-
Schmidt EV. The role of c-myc in regulation of translation initiation. Oncogene 2004;23:3217-21.
-
(2004)
Oncogene
, vol.23
, pp. 3217-3221
-
-
Schmidt, E.V.1
-
9
-
-
0030849451
-
Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination
-
Mateyak MK, Obaya AJ, Adachi S, Sedivy JM. Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination. Cell Growth Differ 1997;8:1039-48.
-
(1997)
Cell Growth Differ
, vol.8
, pp. 1039-1048
-
-
Mateyak, M.K.1
Obaya, A.J.2
Adachi, S.3
Sedivy, J.M.4
-
10
-
-
0032834055
-
eIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
-
Gingras AC, Raught B, Sonenberg N. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem 1999;68:913-63.
-
(1999)
Annu Rev Biochem
, vol.68
, pp. 913-963
-
-
Gingras, A.C.1
Raught, B.2
Sonenberg, N.3
-
11
-
-
33746637660
-
Current development of mTOR inhibitors as anticancer agents
-
Faivre S, Kroemer G, Raymond E. Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov 2006;5:671-88.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 671-688
-
-
Faivre, S.1
Kroemer, G.2
Raymond, E.3
-
12
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
Hara K, Maruki Y, Long X, et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 2002;110:177-89.
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
-
13
-
-
0141923009
-
Integration of growth factor and nutrient signaling: Implications for cancer biology
-
Shamji AF, Nghiem P, Schreiber SL. Integration of growth factor and nutrient signaling: implications for cancer biology. Mol Cell 2003;12:271-80.
-
(2003)
Mol Cell
, vol.12
, pp. 271-280
-
-
Shamji, A.F.1
Nghiem, P.2
Schreiber, S.L.3
-
14
-
-
1642586272
-
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
-
Wendel HG, De Stanchina E, Fridman JS, et al. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 2004;428:332-7.
-
(2004)
Nature
, vol.428
, pp. 332-337
-
-
Wendel, H.G.1
De Stanchina, E.2
Fridman, J.S.3
-
15
-
-
27744588780
-
Tuberous sclerosis: A GAP at the crossroads of multiple signaling pathways
-
Kwiatkowski DJ, Manning BD. Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways. Hum Mol Genet 2005;14 Spec No. 2:R251-8.
-
(2005)
Hum Mol Genet
, vol.14
, Issue.SPEC 2
-
-
Kwiatkowski, D.J.1
Manning, B.D.2
-
16
-
-
27844562649
-
Tuberous sclerosis complex: Linking growth and energy signaling pathways with human disease
-
Astrinidis A, Henske EP. Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease. Oncogene 2005;24:7475-81.
-
(2005)
Oncogene
, vol.24
, pp. 7475-7481
-
-
Astrinidis, A.1
Henske, E.P.2
-
17
-
-
0345732640
-
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
-
Fingar DC, Richardson CJ, Tee AR, Cheatham L, Tsou C, Blenis J. mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol 2004;24:200-16.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 200-216
-
-
Fingar, D.C.1
Richardson, C.J.2
Tee, A.R.3
Cheatham, L.4
Tsou, C.5
Blenis, J.6
-
18
-
-
0035805180
-
The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation
-
Tapon N, Ito N, Dickson BJ, Treisman JE, Hariharan IK. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 2001;105:345-55.
-
(2001)
Cell
, vol.105
, pp. 345-355
-
-
Tapon, N.1
Ito, N.2
Dickson, B.J.3
Treisman, J.E.4
Hariharan, I.K.5
-
19
-
-
0043068043
-
Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38
-
Rosner M, Hofer K, Kubista M, Hengstschlager M. Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38. Oncogene 2003;22:4786-98.
-
(2003)
Oncogene
, vol.22
, pp. 4786-4798
-
-
Rosner, M.1
Hofer, K.2
Kubista, M.3
Hengstschlager, M.4
-
20
-
-
0038492517
-
A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells
-
Li Z, Van Calcar S, Qu C, Cavenee WK, Zhang MQ, Ren B. A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells. Proc Natl Acad Sci U S A 2003;100:8164-9.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 8164-8169
-
-
Li, Z.1
Van Calcar, S.2
Qu, C.3
Cavenee, W.K.4
Zhang, M.Q.5
Ren, B.6
-
21
-
-
0030663735
-
Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase
-
Soucek T, Pusch O, Wienecke R, DeClue JE, Hengstschlager M. Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase. J Biol Chem 1997;272:29301-8.
-
(1997)
J Biol Chem
, vol.272
, pp. 29301-29308
-
-
Soucek, T.1
Pusch, O.2
Wienecke, R.3
DeClue, J.E.4
Hengstschlager, M.5
-
22
-
-
0942298123
-
Activated eIF4E-binding protein slows G1 progression and blocks transformation by c-myc without inhibiting cell growth
-
Lynch M, Fitzgerald C, Johnston KA, Wang S, Schmidt EV. Activated eIF4E-binding protein slows G1 progression and blocks transformation by c-myc without inhibiting cell growth. J Biol Chem 2004;279:3327-39.
-
(2004)
J Biol Chem
, vol.279
, pp. 3327-3339
-
-
Lynch, M.1
Fitzgerald, C.2
Johnston, K.A.3
Wang, S.4
Schmidt, E.V.5
-
23
-
-
0037184102
-
c-Myc sensitizes cells to tumor necrosis factor-mediated apoptosis by inhibiting nuclear factor κB transactivation
-
You Z, Madrid LV, Saims D, Sedivy J, Wang CY. c-Myc sensitizes cells to tumor necrosis factor-mediated apoptosis by inhibiting nuclear factor κB transactivation. J Biol Chem 2002;277:36671-7.
-
(2002)
J Biol Chem
, vol.277
, pp. 36671-36677
-
-
You, Z.1
Madrid, L.V.2
Saims, D.3
Sedivy, J.4
Wang, C.Y.5
-
24
-
-
22544464680
-
hnRNP K binds a core polypyrimidine element in the eukaryotic translation initiation factor 4E (eIF4E) promoter, and its regulation of eIF4E contributes to neoplastic transformation
-
Lynch M, Chen L, Ravitz MJ, et al. hnRNP K binds a core polypyrimidine element in the eukaryotic translation initiation factor 4E (eIF4E) promoter, and its regulation of eIF4E contributes to neoplastic transformation. Mol Cell Biol 2005;25:6436-53.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 6436-6453
-
-
Lynch, M.1
Chen, L.2
Ravitz, M.J.3
-
25
-
-
0002785977
-
Analysis of polysomal RNA
-
Krieg P, editor, New York NY, Wiley Liss;
-
Meyuhas O, Blierman Y, Pierandrei-Amaldi P, Amaldi F. Analysis of polysomal RNA. In: Krieg P, editor. A laboratory guide to RNA: isolation, analysis and synthesis. New York (NY): Wiley Liss; 1996. p. 65-81.
-
(1996)
A laboratory guide to RNA: Isolation, analysis and synthesis
, pp. 65-81
-
-
Meyuhas, O.1
Blierman, Y.2
Pierandrei-Amaldi, P.3
Amaldi, F.4
-
26
-
-
33644874185
-
DBTSS: DataBase of Human Transcription Start Sites, progress
-
Yamashita R, Suzuki Y, Wakaguri H, Tsuritani K, Nakai K, Sugano S. DBTSS: DataBase of Human Transcription Start Sites, progress report 2006. Nucleic Acids Res 2006;34:D86-9.
-
(2006)
Nucleic Acids Res
, vol.34
-
-
Yamashita, R.1
Suzuki, Y.2
Wakaguri, H.3
Tsuritani, K.4
Nakai, K.5
Sugano, S.6
-
27
-
-
3242888285
-
rVISTA 2.0: Evolutionary analysis of transcription factor binding sites
-
Loots GG, Ovcharenko I. rVISTA 2.0: evolutionary analysis of transcription factor binding sites. Nucleic Acids Res 2004;32:W217-21.
-
(2004)
Nucleic Acids Res
, vol.32
-
-
Loots, G.G.1
Ovcharenko, I.2
-
29
-
-
3142757865
-
Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent
-
Karbowniczek M, Cash T, Cheung M, Robertson GP, Astrinidis A, Henske EP. Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent. J Biol Chem 2004;279:29930-7.
-
(2004)
J Biol Chem
, vol.279
, pp. 29930-29937
-
-
Karbowniczek, M.1
Cash, T.2
Cheung, M.3
Robertson, G.P.4
Astrinidis, A.5
Henske, E.P.6
-
30
-
-
0035957406
-
Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells
-
Xu D, Popov N, Hou M, et al. Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. Proc Natl Acad Sci U S A 2001;98:3826-31.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 3826-3831
-
-
Xu, D.1
Popov, N.2
Hou, M.3
-
31
-
-
0033029809
-
Coordination of cell growth with cell division
-
Polymenis M, Schmidt EV. Coordination of cell growth with cell division. Curr Opin Genet Dev 1999;9:76-80.
-
(1999)
Curr Opin Genet Dev
, vol.9
, pp. 76-80
-
-
Polymenis, M.1
Schmidt, E.V.2
-
32
-
-
0025314596
-
Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5′ cap
-
Lazaris-Karatzas A, Montine KS, Sonenberg N. Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5′ cap. Nature 1990;345:544-7.
-
(1990)
Nature
, vol.345
, pp. 544-547
-
-
Lazaris-Karatzas, A.1
Montine, K.S.2
Sonenberg, N.3
-
33
-
-
2442648845
-
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
-
Ruggero D, Montanaro L, Ma L, et al. The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat Med 2004;10:484-6.
-
(2004)
Nat Med
, vol.10
, pp. 484-486
-
-
Ruggero, D.1
Montanaro, L.2
Ma, L.3
-
34
-
-
0032905924
-
c-Myc target genes involved in cell growth, apoptosis, and metabolism
-
Dang CV. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol 1999;19:1-11.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 1-11
-
-
Dang, C.V.1
-
35
-
-
1642535431
-
AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression
-
Gera JF, Mellinghoff IK, Shi Y, et al. AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression. J Biol Chem 2004;279:2737-46.
-
(2004)
J Biol Chem
, vol.279
, pp. 2737-2746
-
-
Gera, J.F.1
Mellinghoff, I.K.2
Shi, Y.3
-
36
-
-
0031755688
-
Studies on the mechanism of resistance to rapamycin in human cancer cells
-
Hosoi H, Dilling MB, Liu LN, et al. Studies on the mechanism of resistance to rapamycin in human cancer cells. Mol Pharmacol 1998;54:815-24.
-
(1998)
Mol Pharmacol
, vol.54
, pp. 815-824
-
-
Hosoi, H.1
Dilling, M.B.2
Liu, L.N.3
-
37
-
-
0028169192
-
c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box Ii
-
Li LH, Nerlov C, Prendergast G, MacGregor D, Ziff EB. c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box Ii. EMBO J 1994;13:4070-9.
-
(1994)
EMBO J
, vol.13
, pp. 4070-4079
-
-
Li, L.H.1
Nerlov, C.2
Prendergast, G.3
MacGregor, D.4
Ziff, E.B.5
-
38
-
-
0034947869
-
Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin
-
Takano A, Usui I, Haruta T, et al. Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin. Mol Cell Biol 2001;21:5050-62.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 5050-5062
-
-
Takano, A.1
Usui, I.2
Haruta, T.3
-
39
-
-
0347988005
-
Loss of Tsc1/ Tsc2 activates mTOR and disrupts PI3K-Akt signaling through down-regulation of PDGFR
-
Zhang H, Cicchetti G, Onda H, et al. Loss of Tsc1/ Tsc2 activates mTOR and disrupts PI3K-Akt signaling through down-regulation of PDGFR. J Clin Invest 2003;112:1223-33.
-
(2003)
J Clin Invest
, vol.112
, pp. 1223-1233
-
-
Zhang, H.1
Cicchetti, G.2
Onda, H.3
-
40
-
-
0344155279
-
Metastasis of benign tumor cells in tuberous sclerosis complex
-
Henske EP. Metastasis of benign tumor cells in tuberous sclerosis complex. Genes Chromosomes Cancer 2003;38:376-81.
-
(2003)
Genes Chromosomes Cancer
, vol.38
, pp. 376-381
-
-
Henske, E.P.1
-
41
-
-
25444508476
-
Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein
-
Zhang XY, DeSalle LM, Patel JH, et al. Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein. Proc Natl Acad Sci U S A 2005;102:13968-73.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 13968-13973
-
-
Zhang, X.Y.1
DeSalle, L.M.2
Patel, J.H.3
-
42
-
-
33745737494
-
Myc-binding-site recognition in the human genome is determined by chromatin context
-
Guccione E, Martinato F, Finocchiaro G, et al. Myc-binding-site recognition in the human genome is determined by chromatin context. Nat Cell Biol 2006;8:764-70.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 764-770
-
-
Guccione, E.1
Martinato, F.2
Finocchiaro, G.3
-
43
-
-
2942701935
-
Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays
-
Kim JW, Zeller KI, Wang Y, et al. Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays. Mol Cell Biol 2004;24:5923-36.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 5923-5936
-
-
Kim, J.W.1
Zeller, K.I.2
Wang, Y.3
|