메뉴 건너뛰기




Volumn 117, Issue 24, 2011, Pages 6650-6659

Posttranscriptional deregulation of MYC via PTEN constitutes a major alternative pathway of MYC activation in T-cell acute lymphoblastic leukemia

(25)  Bonnet, Mélanie a,b,c   Loosveld, Marie a,b,c,d   Montpellier, Bertrand a,b,c   Navarro, Jean Marc a,b,c   Quilichini, Benoit d   Picard, Christophe e,f   Cristofaro, Julie Di f   Bagnis, Claude f   Fossat, Chantal d   Hernandez, Lucie g   Mamessier, Emilie a,b,c   Roulland, Sandrine a,b,c   Morgado, Ester a,b,c   Formisano Tréziny, Christine e   Dik, Willem A h   Langerak, Anton W h   Prebet, Thomas i   Vey, Norbert i   Michel, Gérard g   Gabert, Jean e   more..

b INSERM   (France)
c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MYC PROTEIN; NOTCH1 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B;

EID: 79959248268     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-02-336842     Document Type: Article
Times cited : (68)

References (50)
  • 1
    • 30444437486 scopus 로고    scopus 로고
    • Treatment of acute lymphoblastic leukemia
    • DOI 10.1056/NEJMra052603
    • Pui CH, Evans WE. Treatment of acute lymphoblastic leukemia. N Engl J Med. 2006;354(2):166-178. (Pubitemid 43076714)
    • (2006) New England Journal of Medicine , vol.354 , Issue.2 , pp. 166-178
    • Pui, C.-H.1    Evans, W.E.2
  • 2
    • 52749085175 scopus 로고    scopus 로고
    • Molecular-genetic insights in paediatric T-cell acute lymphoblastic leukaemia
    • Van Vlierberghe P, Pieters R, Beverloo HB, Meijerink JP. Molecular-genetic insights in paediatric T-cell acute lymphoblastic leukaemia. Br J Haematol. 2008;143(2):153-168.
    • (2008) Br J Haematol , vol.143 , Issue.2 , pp. 153-168
    • Van Vlierberghe, P.1    Pieters, R.2    Beverloo, H.B.3    Meijerink, J.P.4
  • 12
    • 58149308526 scopus 로고    scopus 로고
    • Oncogenesis of T-ALL and non-malignant consequences of overexpressing intracellular NOTCH1
    • Li X, Gounari F, Protopopov A, Khazaie K, von Boehmer H. Oncogenesis of T-ALL and non-malignant consequences of overexpressing intracellular NOTCH1. J Exp Med. 2008;205(12): 2851-2861.
    • (2008) J Exp Med , vol.205 , Issue.12 , pp. 2851-2861
    • Li, X.1    Gounari, F.2    Protopopov, A.3    Khazaie, K.4    Von Boehmer, H.5
  • 14
    • 77951640687 scopus 로고    scopus 로고
    • MYC in oncogenesis and as a target for cancer therapies
    • Albihn A, Johnsen JI, Henriksson MA. MYC in oncogenesis and as a target for cancer therapies. Adv Cancer Res. 2010;107:163-224.
    • (2010) Adv Cancer Res , vol.107 , pp. 163-224
    • Albihn, A.1    Johnsen, J.I.2    Henriksson, M.A.3
  • 15
    • 41849140001 scopus 로고    scopus 로고
    • Mechanisms of MYC stabilization in human malignancies
    • Junttila MR, Westermarck J. Mechanisms of MYC stabilization in human malignancies. Cell Cycle. 2008;7(5):592-596. (Pubitemid 351498996)
    • (2008) Cell Cycle , vol.7 , Issue.5 , pp. 592-596
    • Junttila, M.R.1    Westermarck, J.2
  • 16
    • 56749184298 scopus 로고    scopus 로고
    • Reflecting on 25 years with MYC
    • Meyer N, Penn LZ. Reflecting on 25 years with MYC. Nat Rev Cancer. 2008;8(12):976-990.
    • (2008) Nat Rev Cancer , vol.8 , Issue.12 , pp. 976-990
    • Meyer, N.1    Penn, L.Z.2
  • 18
    • 23844495865 scopus 로고    scopus 로고
    • Cancer: Two in one
    • DOI 10.1038/436787a
    • Berns A. Cancer: two in one. Nature. 2005; 436(7052):787-789. (Pubitemid 41160626)
    • (2005) Nature , vol.436 , Issue.7052 , pp. 787-789
    • Berns, A.1
  • 19
    • 33748138585 scopus 로고    scopus 로고
    • Role of post-translational modifications in regulating c-Myc proteolysis, transcriptional activity and biological function
    • DOI 10.1016/j.semcancer.2006.08.004, PII S1044579X06000708, 25 Years of ther c-Myc Oncogene
    • Hann SR. Role of post-translational modifications in regulating c-Myc proteolysis, transcriptional activity and biological function. Semin Cancer Biol. 2006;16(4):288-302. (Pubitemid 44311043)
    • (2006) Seminars in Cancer Biology , vol.16 , Issue.4 , pp. 288-302
    • Hann, S.R.1
  • 20
    • 13944252067 scopus 로고    scopus 로고
    • The life cycle of c-Myc: From synthesis to degradation
    • Sears RC. The life cycle of C-myc: from synthesis to degradation. Cell Cycle. 2004;3(9):1133-1137. (Pubitemid 40268631)
    • (2004) Cell Cycle , vol.3 , Issue.9 , pp. 1133-1137
    • Sears, R.C.1
  • 21
    • 79959277682 scopus 로고    scopus 로고
    • t(8;14) (q24;q11)
    • Accessed April 2001
    • Boyer J. t(8;14) (q24;q11) Atlas Genet Cytogenet Oncol Haematol. http://AtlasGeneticsOncology.org/Anomalies/t0814ID1061.html. Accessed April 2001.
    • Atlas Genet Cytogenet Oncol Haematol
    • Boyer, J.1
  • 22
    • 0033569422 scopus 로고    scopus 로고
    • Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
    • DOI 10.1101/gad.13.20.2658
    • Eischen CM, Weber JD, Roussel MF, Sherr CJ, Cleveland JL. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev. 1999;13(20):2658-2669. (Pubitemid 29508553)
    • (1999) Genes and Development , vol.13 , Issue.20 , pp. 2658-2669
    • Eischen, C.M.1    Weber, J.D.2    Roussel, M.F.3    Sherr, C.J.4    Cleveland, J.L.5
  • 24
    • 19944369765 scopus 로고    scopus 로고
    • T-cell lymphomas mask slower developing B-lymphoid and myeloid tumours in transgenic mice with broad haemopoietic expression of MYC
    • DOI 10.1038/sj.onc.1208399
    • Smith DP, Bath ML, Harris AW, Cory S. T-cell lymphomas mask slower developing B-lymphoid and myeloid tumours in transgenic mice with broad haemopoietic expression of MYC. Oncogene. 2005;24(22):3544-3553. (Pubitemid 40756224)
    • (2005) Oncogene , vol.24 , Issue.22 , pp. 3544-3553
    • Smith, D.P.1    Bath, M.L.2    Harris, A.W.3    Cory, S.4
  • 27
    • 34250004905 scopus 로고    scopus 로고
    • Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation
    • DOI 10.1182/blood-2006-11-059071
    • Guo Z, Dose M, Kovalovsky D, et al. Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation. Blood. 2007; 109(12):5463-5472. (Pubitemid 46890570)
    • (2007) Blood , vol.109 , Issue.12 , pp. 5463-5472
    • Guo, Z.1    Dose, M.2    Kovalovsky, D.3    Chang, R.4    O'Neil, J.5    Look, A.T.6    Von Boehmer, H.7    Khazaie, K.8    Gounari, F.9
  • 28
    • 36248934318 scopus 로고    scopus 로고
    • The c-myc Promoter: Still MysterY and Challenge
    • DOI 10.1016/S0065-230X(07)99004-1, PII S0065230X07990041
    • Wierstra I, Alves J. The c-myc promoter: still MysterY and challenge. Adv Cancer Res. 2008;99: 113-333. (Pubitemid 350137254)
    • (2008) Advances in Cancer Research , vol.99 , pp. 113-333
    • Wierstra, I.1    Alves, J.2
  • 31
    • 65449135968 scopus 로고    scopus 로고
    • NOTCH1/ FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): A Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study
    • Asnafi V, Buzyn A, Le Noir S, et al. NOTCH1/ FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study. Blood. 2009;113(17):3918-3924.
    • (2009) Blood , vol.113 , Issue.17 , pp. 3918-3924
    • Asnafi, V.1    Buzyn, A.2    Le Noir, S.3
  • 32
    • 9144271651 scopus 로고    scopus 로고
    • Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQPCR) - A Europe against cancer program
    • Beillard E, Pallisgaard N, van der Velden V, et al. Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQPCR) - a Europe against cancer program. Leukemia. 2003;17(12):2474-2486.
    • (2003) Leukemia , vol.17 , Issue.12 , pp. 2474-2486
    • Beillard, E.1    Pallisgaard, N.2    Van Der Velden, V.3
  • 33
    • 0034985720 scopus 로고    scopus 로고
    • +-derived hematopoietic cells, including developing T cells and NOD/SCID mouse repopulating cells, following transduction with modified TRIP lentiviral vectors
    • DOI 10.1006/mthe.2001.0282
    • Sirven A, Ravet E, Charneau P, et al. Enhanced transgene expression in cord blood CD34(+)-derived hematopoietic cells, including developing T cells and NOD/SCID mouse repopulating cells, following transduction with modified trip lentiviral vectors. Mol Ther. 2001;3(4):438-448. (Pubitemid 32509837)
    • (2001) Molecular Therapy , vol.3 , Issue.4 , pp. 438-448
    • Sirven, A.1    Ravet, E.2    Charneau, P.3    Zennou, V.4    Coulombel, L.5    Guetard, D.6    Pflumio, F.7    Dubart-Kupperschmitt, A.8
  • 34
    • 68749109333 scopus 로고    scopus 로고
    • The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: A report from the Children's Oncology Group
    • Larson Gedman A, Chen Q, Kugel Desmoulin S, et al. The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group. Leukemia. 2009;23(8):1417-1425.
    • (2009) Leukemia , vol.23 , Issue.8 , pp. 1417-1425
    • Larson Gedman, A.1    Chen, Q.2    Kugel Desmoulin, S.3
  • 35
    • 77950668038 scopus 로고    scopus 로고
    • Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: Rationale for combined use of CK2- and gamma-secretase inhibitors
    • Silva A, Jotta PY, Silveira AB, et al. Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and gamma-secretase inhibitors. Haematologica. 2010;95(4):674-678.
    • (2010) Haematologica , vol.95 , Issue.4 , pp. 674-678
    • Silva, A.1    Jotta, P.Y.2    Silveira, A.B.3
  • 36
    • 78650307928 scopus 로고    scopus 로고
    • NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols
    • Zuurbier L, Homminga I, Calvert V, et al. NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols. Leukemia. 2010;24(12):2014-2022.
    • (2010) Leukemia , vol.24 , Issue.12 , pp. 2014-2022
    • Zuurbier, L.1    Homminga, I.2    Calvert, V.3
  • 37
    • 33747605773 scopus 로고    scopus 로고
    • Aberrant stabilization of c-Myc protein in some lymphoblastic leukemias
    • DOI 10.1038/sj.leu.2404317, PII 2404317
    • Malempati S, Tibbitts D, Cunningham M, et al. Aberrant stabilization of c-Myc protein in some lymphoblastic leukemias. Leukemia. 2006;20(9): 1572-1581. (Pubitemid 44264101)
    • (2006) Leukemia , vol.20 , Issue.9 , pp. 1572-1581
    • Malempati, S.1    Tibbitts, D.2    Cunningham, M.3    Akkari, Y.4    Olson, S.5    Fan, G.6    Sears, R.C.7
  • 38
    • 63149134997 scopus 로고    scopus 로고
    • FBXW7 and NOTCH1 mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma
    • Park MJ, Taki T, Oda M, et al. FBXW7 and NOTCH1 mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma. Br J Haematol. 2009;145(2):198-206.
    • (2009) Br J Haematol , vol.145 , Issue.2 , pp. 198-206
    • Park, M.J.1    Taki, T.2    Oda, M.3
  • 39
    • 0037370378 scopus 로고    scopus 로고
    • Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL
    • DOI 10.1038/ng1092
    • Marculescu R, Vanura K, Le T, Simon P, Jager U, Nadel B. Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL. Nat Genet. 2003;33(3):342-344. (Pubitemid 36278849)
    • (2003) Nature Genetics , vol.33 , Issue.3 , pp. 342-344
    • Marculescu, R.1    Vanura, K.2    Le, T.3    Simon, P.4    Jager, U.5    Nadel, B.6
  • 40
    • 33747892852 scopus 로고    scopus 로고
    • Recombinase, chromosomal translocations and lymphoid neoplasia: Targeting mistakes and repair failures
    • DOI 10.1016/j.dnarep.2006.05.015, PII S156878640600156X, Mechanisms of Chromosomal Translocations
    • Marculescu R, Vanura K, Montpellier B, et al. Recombinase, chromosomal translocations and lymphoid neoplasia: Targeting mistakes and repair failures. DNA Repair (Amst). 2006;5(9-10):1246-1258. (Pubitemid 44291609)
    • (2006) DNA Repair , vol.5 , Issue.9-10 , pp. 1246-1258
    • Marculescu, R.1    Vanura, K.2    Montpellier, B.3    Roulland, S.4    Le, T.5    Navarro, J.-M.6    Jager, U.7    McBlane, F.8    Nadel, B.9
  • 41
    • 77949527142 scopus 로고    scopus 로고
    • Acute Tcell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss
    • Medyouf H, Gao X, Armstrong F, et al. Acute Tcell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss. Blood. 2010;115(6):1175-1184.
    • (2010) Blood , vol.115 , Issue.6 , pp. 1175-1184
    • Medyouf, H.1    Gao, X.2    Armstrong, F.3
  • 42
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer. 2002;2(7):489-501. (Pubitemid 37328931)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 43
    • 70149087158 scopus 로고    scopus 로고
    • High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia
    • Gutierrez A, Sanda T, Grebliunaite R, et al. High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood. 2009;114(3):647-650.
    • (2009) Blood , vol.114 , Issue.3 , pp. 647-650
    • Gutierrez, A.1    Sanda, T.2    Grebliunaite, R.3
  • 44
    • 75849131117 scopus 로고    scopus 로고
    • The ups and downs of Myc biology
    • Soucek L, Evan GI. The ups and downs of Myc biology. Curr Opin Genet Dev. 2010;20(1):91-95.
    • (2010) Curr Opin Genet Dev , vol.20 , Issue.1 , pp. 91-95
    • Soucek, L.1    Evan, G.I.2
  • 45
    • 42249101428 scopus 로고    scopus 로고
    • Dynamic regulation of c-Myc proto-oncogene expression during lymphocyte development revealed by a GFP-c-Myc knock-in mouse
    • Huang CY, Bredemeyer AL, Walker LM, Bassing CH, Sleckman BP. Dynamic regulation of c-Myc proto-oncogene expression during lymphocyte development revealed by a GFP-c-Myc knock-in mouse. Eur J Immunol. 2008;38(2):342-349.
    • (2008) Eur J Immunol , vol.38 , Issue.2 , pp. 342-349
    • Huang, C.Y.1    Bredemeyer, A.L.2    Walker, L.M.3    Bassing, C.H.4    Sleckman, B.P.5
  • 46
    • 9644253003 scopus 로고    scopus 로고
    • The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells
    • DOI 10.1038/sj.onc.1207902
    • Asano T, Yao Y, Zhu J, Li D, Abbruzzese JL, Reddy SA. The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells. Oncogene. 2004; 23(53):8571-8580. (Pubitemid 39576463)
    • (2004) Oncogene , vol.23 , Issue.53 , pp. 8571-8580
    • Asano, T.1    Yao, Y.2    Zhu, J.3    Li, D.4    Abbruzzese, J.L.5    Reddy, S.A.G.6
  • 47
    • 77951765345 scopus 로고    scopus 로고
    • Subtle variations in Pten dose determine cancer susceptibility
    • Alimonti A, Carracedo A, Clohessy JG, et al. Subtle variations in Pten dose determine cancer susceptibility. Nat Genet. 2010;42(5):454-458.
    • (2010) Nat Genet , vol.42 , Issue.5 , pp. 454-458
    • Alimonti, A.1    Carracedo, A.2    Clohessy, J.G.3
  • 49
    • 55849138418 scopus 로고    scopus 로고
    • PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability
    • Silva A, Yunes JA, Cardoso BA, et al. PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability. J Clin Invest. 2008;118(11):3762-3774.
    • (2008) J Clin Invest , vol.118 , Issue.11 , pp. 3762-3774
    • Silva, A.1    Yunes, J.A.2    Cardoso, B.A.3
  • 50
    • 53049085101 scopus 로고    scopus 로고
    • Oncogenic NOTCH1 control of MYC and PI3K: Challenges and opportunities for anti-NOTCH1 therapy in T-cell acute lymphoblastic leukemias and lymphomas
    • Palomero T, Ferrando A. Oncogenic NOTCH1 control of MYC and PI3K: challenges and opportunities for anti-NOTCH1 therapy in T-cell acute lymphoblastic leukemias and lymphomas. Clin Cancer Res. 2008;14(17):5314-5317.
    • (2008) Clin Cancer Res , vol.14 , Issue.17 , pp. 5314-5317
    • Palomero, T.1    Ferrando, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.