PP2A regulatory subunit PP2A-B′ counteracts S6K phosphorylation

Cell Metabolism

Volumn 11, Issue 5, 2010, Pages 438-444

  Hahn, Katrin ^a   Miranda, Merce ^b,c   Francis, Víctor A ^a,b,d,e   Vendrell, Joan ^b,c   Zorzano, Antonio ^b,d,e   Teleman, Aurelio A ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

^d INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^e UNIVERSITY OF BARCELONA   (Spain)

Author keywords

HUMDISEASE; SIGNALING

Indexed keywords

CALCINEURIN; HOLOENZYME; INSULIN; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN SUBUNIT; S6 KINASE; TRIACYLGLYCEROL; DROSOPHILA PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2; PPP2R5C PROTEIN, HUMAN; RIBOSOMAL PROTEIN S6 KINASE, 70KD, POLYPEPTIDE 1; TWINS PROTEIN, DROSOPHILA;

ARTICLE; CONTROLLED STUDY; DROSOPHILA; FEMALE; HUMAN; HUMAN CELL; LONGEVITY; MALE; MAMMAL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; GENE INACTIVATION; GENETICS; METABOLISM; PHOSPHORYLATION;

ANIMALIA; MAMMALIA;

ANIMALS; DROSOPHILA; DROSOPHILA PROTEINS; GENE KNOCKOUT TECHNIQUES; HUMANS; INSULIN; LONGEVITY; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; TRIGLYCERIDES;

EID: 77955285637     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2010.03.015     Document Type: Article

References (29)

1. K.B. Adamo, and F. Tesson Gene-environment interaction and the metabolic syndrome Novartis Found. Symp. 293 2008 103 119, discussion 119-127
2. L.M. Ballou, P. Jeno, and G. Thomas Protein phosphatase 2A inactivates the mitogen-stimulated S6 kinase from Swiss mouse 3T3 cells J. Biol. Chem. 263 1988 1188 1194
3. V.A. Bielinski, and M.C. Mumby Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase Exp. Cell Res. 313 2007 3117 3126
4. R.C. Davis, E.E. Schadt, A.C. Cervino, M. Peterfy, and A.J. Lusis Ultrafine mapping of SNPs from mouse strains C57BL/6J, DBA/2J, and C57BLKS/J for loci contributing to diabetes and atherosclerosis susceptibility Diabetes 54 2005 1191 1199
5. M. Deichmann, M. Polychronidis, J. Wacker, M. Thome, and H. Naher The protein phosphatase 2A subunit Bgamma gene is identified to be differentially expressed in malignant melanomas by subtractive suppression hybridization Melanoma Res. 11 2001 577 585
6. D.C. Goberdhan, and C. Wilson The functions of insulin signaling: size isn't everything, even in Drosophila Differentiation 71 2003 375 397
7. W.J. Gong, and K.G. Golic Ends-out, or replacement, gene targeting in Drosophila Proc. Natl. Acad. Sci. USA 100 2003 2556 2561
8. J. Gotz, A. Probst, E. Ehler, B. Hemmings, and W. Kues Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha Proc. Natl. Acad. Sci. USA 95 1998 12370 12375
9. S.S. Grewal Insulin/TOR signaling in growth and homeostasis: a view from the fly world Int. J. Biochem. Cell Biol. 41 2009 1006 1010
10. E. Hafen Cancer, type 2 diabetes, and ageing: news from flies and worms Swiss Med. Wkly. 134 2004 711 719
11. N. Hay, and N. Sonenberg Upstream and downstream of mTOR Genes Dev. 18 2004 1926 1945
12. T. Ikeya, M. Galic, P. Belawat, K. Nairz, and E. Hafen Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila Curr. Biol. 12 2002 1293 1300
13. K. Jastrzebski, K.M. Hannan, E.B. Tchoubrieva, R.D. Hannan, and R.B. Pearson Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function Growth Factors 25 2007 209 226
14. P. Kapahi, B.M. Zid, T. Harper, D. Koslover, V. Sapin, and S. Benzer Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway Curr. Biol. 14 2004 885 890
15. S.C. Kozma, and G. Thomas Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K Bioessays 24 2002 65 71
16. Y. Mamane, E. Petroulakis, O. LeBacquer, and N. Sonenberg mTOR, translation initiation and cancer Oncogene 25 2006 6416 6422
17. T.A. Millward, S. Zolnierowicz, and B.A. Hemmings Regulation of protein kinase cascades by protein phosphatase 2A Trends Biochem. Sci. 24 1999 186 191
18. M. Mumby PP2A: unveiling a reluctant tumor suppressor Cell 130 2007 21 24
19. S. Oldham, H. Stocker, M. Laffargue, F. Wittwer, M. Wymann, and E. Hafen The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels Development 129 2002 4103 4109
20. S. Padmanabhan, A. Mukhopadhyay, S.D. Narasimhan, G. Tesz, M.P. Czech, and H.A. Tissenbaum A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation Cell 136 2009 939 951
21. O. Puig, M.T. Marr, M.L. Ruhf, and R. Tjian Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway Genes Dev. 17 2003 2006 2020
22. T. Radimerski, J. Montagne, F. Rintelen, H. Stocker, J. van der Kaay, C.P. Downes, E. Hafen, and G. Thomas dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1 Nat. Cell Biol. 4 2002 251 255
23. A. Taguchi, and M.F. White Insulin-like signaling, nutrient homeostasis, and life span Annu. Rev. Physiol. 70 2008 191 212
24. A.A. Teleman, Y.W. Chen, and S.M. Cohen 4E-BP functions as a metabolic brake used under stress conditions but not during normal growth Genes Dev. 19 2005 1844 1848
25. A.A. Teleman, V. Hietakangas, A.C. Sayadian, and S.M. Cohen Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila Cell Metab. 7 2008 21 32
26. S.H. Um, F. Frigerio, M. Watanabe, F. Picard, M. Joaquin, M. Sticker, S. Fumagalli, P.R. Allegrini, S.C. Kozma, J. Auwerx, and G. Thomas Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity Nature 431 2004 200 205
27. N. Vereshchagina, M.C. Ramel, E. Bitoun, and C. Wilson The protein phosphatase PP2A-B′ subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila J. Cell Sci. 121 2008 3383 3392
28. N.M. Viquez, C.R. Li, Y.P. Wairkar, and A. DiAntonio The B′ protein phosphatase 2A regulatory subunit well-rounded regulates synaptic growth and cytoskeletal stability at the Drosophila neuromuscular junction J. Neurosci. 26 2006 9293 9303
29. M.L. Wang, G. Panasyuk, J. Gwalter, I. Nemazanyy, T. Fenton, V. Filonenko, and I. Gout Regulation of ribosomal protein S6 kinases by ubiquitination Biochem. Biophys. Res. Commun. 369 2008 382 387