Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells

Retrovirology

Volumn 3, Issue , 2006, Pages

  Tomita, Mariko ^a   Kawakami, Hirochika ^a   Uchihara, Jun Nosuke ^a   Okudaira, Taeko ^a   Masuda, Masato ^a   Matsuda, Takehiro ^a   Tanaka, Yuetsu ^a   Ohshiro, Kazuiku ^b   Mori, Naoki ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

^b Naha Prefectural Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D2; CYCLIN DEPENDENT KINASE 4; CYTOKINE; INHIBITOR OF APOPTOSIS PROTEIN 2; JANUS KINASE; JANUS KINASE INHIBITOR; MYC PROTEIN; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; STAT PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; SURVIVIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PIM1; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS; LEUKEMIA CELL; LYMPHOCYTE PROLIFERATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; T CELL LEUKEMIA; T LYMPHOCYTE;

BASE SEQUENCE; CELL LINE; CELL LINE, TUMOR; DNA PRIMERS; ENZYME INHIBITORS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; LEUKEMIA-LYMPHOMA, ADULT T-CELL; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; T-LYMPHOCYTES; TYRPHOSTINS;

HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 33745621927     PISSN: 17424690     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-3-22     Document Type: Article

References (48)

1. Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC: Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci U S A 1980, 77(12):7415-7419.
2. Hinuma Y, Nagata K, Hanaoka M, Nakai M, Matsumoto T, Kinoshita KI, Shirakawa S, Miyoshi I: Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci U S A 1981, 78(10):6476-6480.
3. Yoshida M, Miyoshi I, Hinuma Y: Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci U S A 1982, 79(6):2031-2035.
4. Tajima K: The 4th nation-wide study of adult T-cell leukemia/ lymphoma (ATL) in Japan: estimates of risk of ATL and its geographical and clinical features. The T- and B-cell Malignancy Study Group. Int J Cancer 1990, 45(2):237-243.
5. Yamada Y, Tomonaga M, Fukuda H, Hanada S, Utsunomiya A, Tara M, Sano M, Ikeda S, Takatsuki K, Kozuru M, Araki K, Kawano F, Niimi M, Tobinai K, Hotta T, Shimoyama M: A new G-CSF-supported combination chemotherapy, LSG15, for adult T-cell leukaemia-lymphoma: Japan Clinical Oncology Group Study 9303. Br J Haematol 2001, 113(2):375-382.
6. Franchini G: Molecular mechanisms of human T-cell leukemia/ lymphotropic virus type I infection. Blood 1995, 86(10):3619-3639.
7. Schindler C, Darnell JEJ: Transcriptional responses to polypep-tide ligands: the JAK-STAT pathway. Annu Rev Biochem 1995, 64:621-651.
8. Darnell JEJ: STATs and gene regulation. Science 1997, 277(5332):1630-1635.
9. Bowman T, Garcia R, Turkson J, Jove R: STATs in oncogenesis. Oncogene 2000, 19(21):2474-2488.
10. Coffer PJ, Koenderman L, de Groot RP: The role of STATs in myeloid differentiation and leukemia. Oncogene 2000, 19(21):2511-2522.
11. Lin TS, Mahajan S, Frank DA: STAT signaling in the pathogenesis and treatment of leukemias. Oncogene 2000, 19(21):2496-2504.
12. Migone TS, Lin JX, Cereseto A, Mulloy JC, O'Shea JJ, Franchini G, Leonard WJ: Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-1. Science 1995, 269(5220):79-81.
13. Mulloy JC, Migone TS, Ross TM, Ton N, Green PL, Leonard WJ, Franchini G: Human and simian T-cell leukemia viruses type 2 (HTLV-2 and STLV-2pan-p) transform T cells independently of Jak/STAT activation. J Virol 1998, 72(5):4408-4412.
14. Takemoto S, Mulloy JC, Cereseto A, Migone TS, Patel BK, Matsuoka M, Yamaguchi K, Takatsuki K, Kamihira S, White JD, Leonard WJ, Waldmann T, Franchini G: Proliferation of adult T cell leukemia/ lymphoma cells is associated with the constitutive activation of JAK/STAT proteins. Proc Natl Acad Sci U S A 1997, 94(25):13897-13902.
15. Levitzki A: Tyrosine kinases as targets for cancer therapy. Eur J Cancer 2002, 38 Suppl 5:S11-8.
16. Meydan N, Grunberger T, Dadi H, Shahar M, Arpaia E, Lapidot Z, Leeder JS, Freedman M, Cohen A, Gazit A, Levitzki A, Roifman CM: Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature 1996, 379(6566):645-648.
17. Wang LH, Kirken RA, Erwin RA, Yu CR, Farrar WL: JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response. J Immunol 1999, 162(7):3897-3904.
18. Kirken RA, Erwin RA, Wang L, Wang Y, Rui H, Farrar WL: Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukemia virus type I-transformed human T cells. J Immunol 2000, 165(9):5097-5104.
19. Koiwa T, Hamano-Usami A, Ishida T, Okayama A, Yamaguchi K, Kamihira S, Watanabe T. 5′-long terminal repeat-selective CpG methylation of latent human T-cell leukemia virus type I provirus in vitro and in vivo. J Virol 2002, 76(18):9389-9397.
20. Ishiyama M, Tominaga H, Shiga M, Sasamoto K, Ohkura Y, Ueno K: A combined assay of cell viability and in vitro cytotoxicity with a highly water-soluble tetrazolium salt, neutral red and crystal violet. Biol Pharm Bull 1996, 19(11):1518-1520.
21. Rainio EM, Sandholm J, Koskinen PJ: Cutting edge: Transcriptional activity of NFAT cl is enhanced by the Pim-I kinase. J Immunol 2002, 168(4):1524-1527.
22. Galaktionov K, Chen X, Beach D: Cdc25 cell-cycle phosphatase as a target of c-myc. Nature 1996, 382(6591):511-517.
23. Borg KE, Zhang M, Hegge D, Stephen RL, Buckley DJ, Magnuson NS, Buckley AR: Prolactin regulation of pim-1 expression: positive and negative promoter elements. Endocrinology 1999, 140(12):5659-5668.
24. Kiuchi N, Nakajima K, Ichiba M, Fukada T, Narimatsu M, Mizuno K, Hibi M, Hirano T: STAT3 is required for the gp 130-mediated full activation of the c-myc gene. J Exp Med 1999,189(1):63-73.
25. Mohapatra S, Chu B, Wei S, Djeu J, Epling-Burnette PK, Loughran T, Jove R, Pledger WJ: Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type I-transformed cell line MT-2. Cancer Res 2003, 63(23):8523-8530.
26. Aoki Y, Feldman GM, Tosato G: Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood 2003, 101(4):1535-1542.
27. Huang Y, Ohtani K, Iwanaga R, Matsumura Y, Nakamura M: Direct trans-activation of the human cyclin D2 gene by the oncogene product Tax of human T-cell leukemia virus type I. Oncogene 2001, 20(9):1094-1102.
28. Mori N, Fujii M, Hinz M, Nakayama K, Yamada Y, Ikeda S, Yamasaki Y, Kashanchi F, Tanaka Y, Tomonaga M, Yamamoto N: Activation of cyclin D1 and D2 promoters by human T-cell leukemia virus type I tax protein is associated with IL-2-independent growth of T cells. Int J Cancer 2002, 99(3):378-385.
29. Iwanaga R, Ohtani K, Hayashi T, Nakamura M: Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I. Oncogene 2001, 20(17):2055-2067.
30. Kawakami A, Nakashima T, Sakai H, Urayama S, Yamasaki S, Hida A, Tsuboi M, Nakamura H, Ida H, Migita K, Kawabe Y, Eguchi K: Inhibition of caspase cascade by HTLV-I tax through induction of NF-κB nuclear translocation. Blood 1999, 94(11):3847-3854.
31. Kawakami H, Tomita. M, Matsuda T, Ohta T, Tanaka Y, Fujii M, Hatano M, Tokuhisa T, Mori N: Transcriptional activation of survivin through the NF-κB pathway by human T-cell leukemia virus type I tax. Int J Cancer 2005, 115:967-974.
32. Nakamura N, Fujii M, Tsukahara T, Arai M, Ohashi T, Wakao H, Kannagi M, Yamamoto N: Human T-cell leukemia virus type I Tax protein induces the expression of STAT1 and STAT5 genes in T-cells. Oncogene 1999, 18(17):2667-2675.
33. Matsuoka M: Human T-cell leukemia virus type I (HTLV-1) infection and the onset of adult T-cell leukemia (ATL). Retrovirology 2005, 2(1):27.
34. Nicot C, Mulloy JC, Ferrari MG, Johnson JM, Fu K, Fukumoto R, Trovato R, Fullen J, Leonard WJ, Franchini G: HTLV-I p 121 protein enhances STAT5 activation and decreases the interleulkin-2 requirement for proliferation of primary human peripheral blood mononuclear cells. Blood 2001, 98(3):823-829.
35. De Vos J, Jourdan M, Tarte K, Jasmin C, Klein B: JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells. Br J Haematol 2000, 109(4):823-828.
36. Constantin G, Laudanna C, Brocke S, Butcher EC: Inhibition of experimental autoimmune encephalomyelitis by a tyrosine kinase inhibitor. J Immunol 1999, 162(2):1144-1149.
37. Mori N, Fujii M, Ikeda S, Yamada Y, Tomonaga M, Ballard DW, Yamamoto N: Constitutive activation of NF-κB in primary adult T-cell leukemia cells. Blood 1999, 93(7):2360-2368.
38. Mori N, Yamada Y, Ikeda S, Yamasaki Y, Tsukasaki K, Tanaka Y, Tomonaga M, Yamamoto N, Fujii M: Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. Blood 2002, 100(5):1828-1834.
39. Tomita M, Kawakami H, Uchihara JN, Okudaira T, Masuda M, Takasu N, Matsuda T, Ohta T, Tanaka Y, Ohshiro K, Mori N: Curcumin (diferuloylmethane) inhibits constitutive active NF-κB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells. Int J Cancer 2006, 118(3):765-772.
40. Miyoshi I, Kubonishi I, Yoshimoto S, Akagi T, Ohtsuki Y, Shiraishi Y, Nagata K, Hinuma Y: Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells. Nature 1981, 294(5843):770-771.
41. Maeda M, Shimizu A, Ikuta K, Okamoto H, Kashihara M, Uchiyama T, Honjo T, Yodoi J: Origin of human T-lymphotrophic virus I-positive T cell lines in adult T cell leukemia. Analysis of T cell receptor gene rearrangement. J Exp Med 1985, 162(6):2169-2174.
42. Nagata. K, Ohtani K, Nakamura M, Sugamura K: Activation of endogenous c-fos proto-oncogene expression by human T-cell leukemia virus type I-encoded p40tax protein in the human T-cell line, Jurkat. J Virol 1989, 63(8):3220-3226.
43. Tanaka Y, Yoshida A, Takayama Y, Tsujimoto H, Tsujimoto A, Hayami M, Tozawa H: Heterogeneity of antigen molecules recognized by anti-taxI monoclonal antibody Lt-4 in cell lines bearing human T cell leukemia virus type I and related retroviruses. Jpn J Cancer Res 1990, 81(3):225-231.
44. Tanaka Y, Yasumoto M, Nyunoya H, Ogura T, Kikuchi M, Shimotohno K, Shiraki H, Kuroda N, Shida H, Tozawa H: Generation and characterization of monoclonal antibodies against multiple epitopes on the C-terminal half of envelope gp46 of human T-cell leukemia virus type-I (HTLV-1). Int J Cancer 1990, 46(4):675-681.
45. Tanaka Y, Lee B, Inoi T, Tozawa H, Yamamoto N, Hinuma Y: Antigens related to three core proteins of HTLV-I (p24, p19 and p15) and their intracellular localizations, as defined by monoclonal antibodies. Int J Cancer 1986, 37(1):35-42.
46. Tomita M, Choe J, Tsukazaki T, Mori N: The Kaposi's sarcoma-associated herpesvirus K-bZIP protein represses transforming growth factor b signaling through interaction with CREB-binding protein. Oncogene 2004, 23(50):8272-8281.
47. Mori N, Fujii M, Iwai K, Ikeda S, Yamasaki Y, Hata T, Yamada Y, Tanaka Y, Tomonaga. M, Yamamoto N: Constitutive activation of transcription factor AP-I in primary adult T-cell leukemia cells. Blood 2000, 95(12):3915-3921.
48. Mori N, Prager D: Transactivation of the interleukin- Iα promoter by human T-cell leukemia virus type I and type II Tax proteins. Blood 1996, 87(8):3410-3417.