-
1
-
-
33747623018
-
Notch signalling: A simple pathway becomes complex
-
Bray, S.J. Notch signalling: a simple pathway becomes complex. Nat. Rev. Mol. Cell Biol. 7, 678-689 (2006).
-
(2006)
Nat. Rev. Mol. Cell Biol
, vol.7
, pp. 678-689
-
-
Bray, S.J.1
-
2
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
Weng, A.P. et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306, 269-271 (2004).
-
(2004)
Science
, vol.306
, pp. 269-271
-
-
Weng, A.P.1
-
3
-
-
0030877659
-
Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
-
Blaumueller, C.M., Qi, H., Zagouras, P. & Artavanis-Tsakonas, S. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell 90, 281-291 (1997).
-
(1997)
Cell
, vol.90
, pp. 281-291
-
-
Blaumueller, C.M.1
Qi, H.2
Zagouras, P.3
Artavanis-Tsakonas, S.4
-
4
-
-
0032493302
-
The Notch1 receptor is cleaved constitutively by a furin-like convertase
-
Logeat, F. et al. The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc. Natl. Acad. Sci. USA 95, 8108-8112 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 8108-8112
-
-
Logeat, F.1
-
5
-
-
6344251643
-
Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats
-
Sanchez-Irizarry, C. et al. Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Mol. Cell. Biol. 24, 9265-9273 (2004).
-
(2004)
Mol. Cell. Biol
, vol.24
, pp. 9265-9273
-
-
Sanchez-Irizarry, C.1
-
6
-
-
0025277746
-
Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila
-
Fehon, R.G. et al. Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell 61, 523-534 (1990).
-
(1990)
Cell
, vol.61
, pp. 523-534
-
-
Fehon, R.G.1
-
7
-
-
0030748716
-
The ins and outs of notch signaling
-
Weinmaster, G. The ins and outs of notch signaling. Mol. Cell. Neurosci. 9, 91-102 (1997).
-
(1997)
Mol. Cell. Neurosci
, vol.9
, pp. 91-102
-
-
Weinmaster, G.1
-
8
-
-
0033868818
-
A novel proteolytic cleavage involved in Notch signaling: The role of the disintegrin-metalloprotease TACE
-
Brou, C. et al. A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol. Cell 5, 207-216 (2000).
-
(2000)
Mol. Cell
, vol.5
, pp. 207-216
-
-
Brou, C.1
-
9
-
-
0033867521
-
A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1
-
Mumm, J.S. et al. A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Mol. Cell 5, 197-206 (2000).
-
(2000)
Mol. Cell
, vol.5
, pp. 197-206
-
-
Mumm, J.S.1
-
10
-
-
0034669031
-
A common enzyme connects notch signaling and Alzheimer's disease
-
Kopan, R. & Goate, A. A common enzyme connects notch signaling and Alzheimer's disease. Genes Dev. 14, 2799-2806 (2000).
-
(2000)
Genes Dev
, vol.14
, pp. 2799-2806
-
-
Kopan, R.1
Goate, A.2
-
11
-
-
0032574993
-
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
-
Schroeter, E.H., Kisslinger, J.A. & Kopan, R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 393, 382-386 (1998).
-
(1998)
Nature
, vol.393
, pp. 382-386
-
-
Schroeter, E.H.1
Kisslinger, J.A.2
Kopan, R.3
-
12
-
-
0032524325
-
Nuclear access and action of notch in vivo
-
Struhl, G. & Adachi, A. Nuclear access and action of notch in vivo. Cell 93, 649-660 (1998).
-
(1998)
Cell
, vol.93
, pp. 649-660
-
-
Struhl, G.1
Adachi, A.2
-
13
-
-
0027219557
-
Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo
-
Struhl, G., Fitzgerald, K. & Greenwald, I. Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo. Cell 74, 331-345 (1993).
-
(1993)
Cell
, vol.74
, pp. 331-345
-
-
Struhl, G.1
Fitzgerald, K.2
Greenwald, I.3
-
14
-
-
0030003538
-
Signal transduction by activated mNotch: Importance of proteolytic processing and its regulation by the extracellular domain
-
Kopan, R., Schroeter, E.H., Weintraub, H. & Nye, J.S. Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proc. Natl. Acad. Sci. USA 93, 1683-1688 (1996).
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 1683-1688
-
-
Kopan, R.1
Schroeter, E.H.2
Weintraub, H.3
Nye, J.S.4
-
15
-
-
0027386233
-
Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei
-
Lieber, T., Kidd, S., Alcamo, E., Corbin, V. & Young, M.W. Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei. Genes Dev. 7, 1949-1965 (1993).
-
(1993)
Genes Dev
, vol.7
, pp. 1949-1965
-
-
Lieber, T.1
Kidd, S.2
Alcamo, E.3
Corbin, V.4
Young, M.W.5
-
16
-
-
0027306001
-
Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor
-
Rebay, I., Fehon, R.G. & Artavanis-Tsakonas, S. Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell 74, 319-329 (1993).
-
(1993)
Cell
, vol.74
, pp. 319-329
-
-
Rebay, I.1
Fehon, R.G.2
Artavanis-Tsakonas, S.3
-
17
-
-
0031030361
-
Germ-line tumor formation caused by activation of glp-1, a Caenorhabditis elegans member of the Notch family of receptors
-
Berry, L.W., Westlund, B. & Schedl, T. Germ-line tumor formation caused by activation of glp-1, a Caenorhabditis elegans member of the Notch family of receptors. Development 124, 925-936 (1997).
-
(1997)
Development
, vol.124
, pp. 925-936
-
-
Berry, L.W.1
Westlund, B.2
Schedl, T.3
-
18
-
-
0025316499
-
Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans
-
Greenwald, I. & Seydoux, G. Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans. Nature 346, 197-199 (1990).
-
(1990)
Nature
, vol.346
, pp. 197-199
-
-
Greenwald, I.1
Seydoux, G.2
-
19
-
-
0038808602
-
Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1
-
Vardar, D., North, C.L., Sanchez-Irizarry, C., Aster, J.C. & Blacklow, S.C. Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1. Biochemistry 42, 7061-7067 (2003).
-
(2003)
Biochemistry
, vol.42
, pp. 7061-7067
-
-
Vardar, D.1
North, C.L.2
Sanchez-Irizarry, C.3
Aster, J.C.4
Blacklow, S.C.5
-
20
-
-
0029785147
-
Mapping the protein universe
-
Holm, L. & Sander, C. Mapping the protein universe. Science 273, 595-603 (1996).
-
(1996)
Science
, vol.273
, pp. 595-603
-
-
Holm, L.1
Sander, C.2
-
21
-
-
11144357605
-
Solution structure of the SEA Domain from the murine homologue of ovarian cancer antigen CA125 (MUC16)
-
Maeda, T. et al. Solution structure of the SEA Domain from the murine homologue of ovarian cancer antigen CA125 (MUC16). J. Biol. Chem. 279, 13174-13182 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 13174-13182
-
-
Maeda, T.1
-
22
-
-
30044448792
-
Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin
-
Macao, B., Johansson, D.G.A., Hansson, G.C. & Hard, T. Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin. Nat. Struct. Mol. Biol. 13, 71-76 (2006).
-
(2006)
Nat. Struct. Mol. Biol
, vol.13
, pp. 71-76
-
-
Macao, B.1
Johansson, D.G.A.2
Hansson, G.C.3
Hard, T.4
-
23
-
-
0034671686
-
Notch signaling: From the outside in
-
Mumm, J.S. & Kopan, R. Notch signaling: from the outside in. Dev. Biol. 228, 151-165 (2000).
-
(2000)
Dev. Biol
, vol.228
, pp. 151-165
-
-
Mumm, J.S.1
Kopan, R.2
-
24
-
-
0037238008
-
Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta
-
Itoh, M. et al. Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev. Cell 4, 67-82 (2003).
-
(2003)
Dev. Cell
, vol.4
, pp. 67-82
-
-
Itoh, M.1
-
25
-
-
18844414504
-
The roles of receptor and ligand endocytosis in regulating Notch signaling
-
Le Borgne, R., Bardin, A. & Schweisguth, F. The roles of receptor and ligand endocytosis in regulating Notch signaling. Development 132, 1751-1762 (2005).
-
(2005)
Development
, vol.132
, pp. 1751-1762
-
-
Le Borgne, R.1
Bardin, A.2
Schweisguth, F.3
-
26
-
-
9444297354
-
Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch
-
Wang, W. & Struhl, G. Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch. Development 131, 5367-5380 (2004).
-
(2004)
Development
, vol.131
, pp. 5367-5380
-
-
Wang, W.1
Struhl, G.2
-
27
-
-
21644462494
-
Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila
-
Wang, W. & Struhl, G. Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila. Development 132, 2883-2894 (2005).
-
(2005)
Development
, vol.132
, pp. 2883-2894
-
-
Wang, W.1
Struhl, G.2
-
28
-
-
0242558207
-
Neurogenic phenotype of mind bomb mutants leads to severe patterning defects in the zebrafish hindbrain
-
Bingham, S. et al. Neurogenic phenotype of mind bomb mutants leads to severe patterning defects in the zebrafish hindbrain. Dev. Dyn. 228, 451-463 (2003).
-
(2003)
Dev. Dyn
, vol.228
, pp. 451-463
-
-
Bingham, S.1
-
29
-
-
18844429102
-
The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta
-
Lai, E.C., Roegiers, F., Qin, X., Jan, Y.N. & Rubin, G.M. The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta. Development 132, 2319-2332 (2005).
-
(2005)
Development
, vol.132
, pp. 2319-2332
-
-
Lai, E.C.1
Roegiers, F.2
Qin, X.3
Jan, Y.N.4
Rubin, G.M.5
-
30
-
-
18844452750
-
Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila
-
Le Borgne, R., Remaud, S., Hamel, S. & Schweisguth, F. Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila. PLoS Biol. 3, 688-696 (2005).
-
(2005)
PLoS Biol
, vol.3
, pp. 688-696
-
-
Le Borgne, R.1
Remaud, S.2
Hamel, S.3
Schweisguth, F.4
-
31
-
-
0038686503
-
Unequal segregation of Neuralized biases Notch activation during asymmetric cell division
-
Le Borgne, R. & Schweisguth, F. Unequal segregation of Neuralized biases Notch activation during asymmetric cell division. Dev. Cell 5, 139-148 (2003).
-
(2003)
Dev. Cell
, vol.5
, pp. 139-148
-
-
Le Borgne, R.1
Schweisguth, F.2
-
32
-
-
0035653308
-
neuralized encodes a peripheral membrane protein involved in delta signaling and endocytosis
-
Pavlopoulos, E. et al. neuralized encodes a peripheral membrane protein involved in delta signaling and endocytosis. Dev. Cell 1, 807-816 (2001).
-
(2001)
Dev. Cell
, vol.1
, pp. 807-816
-
-
Pavlopoulos, E.1
-
33
-
-
0031573944
-
Requirement for dynamin during Notch signaling in Drosophila neurogenesis
-
Seugnet, L., Simpson, P. & Haenlin, M. Requirement for dynamin during Notch signaling in Drosophila neurogenesis. Dev. Biol. 192, 585-598 (1997).
-
(1997)
Dev. Biol
, vol.192
, pp. 585-598
-
-
Seugnet, L.1
Simpson, P.2
Haenlin, M.3
-
34
-
-
0034051852
-
Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
-
Parks, A.L., Klueg, K.M., Stout, J.R. & Muskavitch, M.A. Ligand endocytosis drives receptor dissociation and activation in the Notch pathway. Development 127, 1373-1385 (2000).
-
(2000)
Development
, vol.127
, pp. 1373-1385
-
-
Parks, A.L.1
Klueg, K.M.2
Stout, J.R.3
Muskavitch, M.A.4
-
35
-
-
11244321993
-
The adhesion force of Notch with Delta and the rate of Notch signaling
-
Ahimou, F., Mok, L.P., Bardot, B. & Wesley, C. The adhesion force of Notch with Delta and the rate of Notch signaling. J. Cell Biol. 167, 1217-1229 (2004).
-
(2004)
J. Cell Biol
, vol.167
, pp. 1217-1229
-
-
Ahimou, F.1
Mok, L.P.2
Bardot, B.3
Wesley, C.4
-
36
-
-
0344019404
-
Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme
-
Maskos, K. et al. Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme. Proc. Natl. Acad. Sci. USA 95, 3408-3412 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 3408-3412
-
-
Maskos, K.1
-
37
-
-
33745045658
-
Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes
-
Malecki, M.J. et al. Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes. Mol. Cell. Biol. 26, 4642-4651 (2006).
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 4642-4651
-
-
Malecki, M.J.1
-
38
-
-
0031059866
-
Processing of X-ray diffraction data collected in oscillation mode
-
Otwinowsk, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307-326 (1997).
-
(1997)
Methods Enzymol
, vol.276
, pp. 307-326
-
-
Otwinowsk, Z.1
Minor, W.2
-
39
-
-
0032964481
-
Automated protein model building combined with iterative structure refinement
-
Perrakis, A., Morris, R. & Lazmin, V. Automated protein model building combined with iterative structure refinement. Nat. Struct. Biol. 6, 458-463 (1999).
-
(1999)
Nat. Struct. Biol
, vol.6
, pp. 458-463
-
-
Perrakis, A.1
Morris, R.2
Lazmin, V.3
-
41
-
-
3543012707
-
Crystallography and NMR system: A new software suite for macromolecular structure determination
-
Brunger, A.T., Adams, P. & Clore, G. Crystallography and NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr D Biol. Crystallogr. 54, 905-921 (1998).
-
(1998)
Acta Crystallogr D Biol. Crystallogr
, vol.54
, pp. 905-921
-
-
Brunger, A.T.1
Adams, P.2
Clore, G.3
-
42
-
-
0030924992
-
Refinement of macromolecular structures by the maximum-likelihood method
-
Murshudov, G., Vagin, A. & Dodson, E. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr. D Biol. Crystallogr. 53, 240-245 (1997).
-
(1997)
Acta Crystallogr. D Biol. Crystallogr
, vol.53
, pp. 240-245
-
-
Murshudov, G.1
Vagin, A.2
Dodson, E.3
|