-
1
-
-
24944489213
-
Genetic insights in the pathogenesis of T-cell acute lymphoblastic leukemia
-
De Keersmaecker K, Marynen P, Cools J. Genetic insights in the pathogenesis of T-cell acute lymphoblastic leukemia. Haematologica 2005;90:1116-27.
-
(2005)
Haematologica
, vol.90
, pp. 1116-1127
-
-
De Keersmaecker, K.1
Marynen, P.2
Cools, J.3
-
2
-
-
33646366173
-
Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia
-
Grabher C, von Boehmer H, Look AT. Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nat Rev Cancer 2006;6:347-59.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 347-359
-
-
Grabher, C.1
von Boehmer, H.2
Look, A.T.3
-
3
-
-
33747608619
-
Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: From thymocyte to lymphoblast
-
Graux C, Cools J, Michaux L, Vandenberghe P, Hagemeijer A. Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast. Leukemia 2006;20:1496-510.
-
(2006)
Leukemia
, vol.20
, pp. 1496-1510
-
-
Graux, C.1
Cools, J.2
Michaux, L.3
Vandenberghe, P.4
Hagemeijer, A.5
-
4
-
-
33745197598
-
Notch and Wnt signaling in T-lymphocyte development and acute lymphoblastic leukemia
-
Weerkamp F, van Dongen JJ, Staal FJ. Notch and Wnt signaling in T-lymphocyte development and acute lymphoblastic leukemia. Leukemia 2006;20:1197-205.
-
(2006)
Leukemia
, vol.20
, pp. 1197-1205
-
-
Weerkamp, F.1
van Dongen, J.J.2
Staal, F.J.3
-
5
-
-
33745207170
-
Molecular cytogenetic study of 126 unselected T-ALL cases reveals high incidence of TCRbeta locus rearrangements and putative new T-cell oncogenes
-
Cauwelier B, Dastugue N, Cools J, Poppe B, Herens C, De Paepe A, et al. Molecular cytogenetic study of 126 unselected T-ALL cases reveals high incidence of TCRbeta locus rearrangements and putative new T-cell oncogenes. Leukemia 2006;20:1238-44.
-
(2006)
Leukemia
, vol.20
, pp. 1238-1244
-
-
Cauwelier, B.1
Dastugue, N.2
Cools, J.3
Poppe, B.4
Herens, C.5
De Paepe, A.6
-
6
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
Weng AP, Ferrando AA, Lee W, Morris JPt, Silverman LB, Sanchez-Irizarry C, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004;306:269-71.
-
(2004)
Science
, vol.306
, pp. 269-271
-
-
Weng, A.P.1
Ferrando, A.A.2
Lee, W.3
Morris, J.P.4
Silverman, L.B.5
Sanchez-Irizarry, C.6
-
7
-
-
42149181188
-
Bone marrow stromal cells and the upregulation of interleukin-8 production in human T-cell acute lymphoblastic leukemia through the CXCL12/CXCR4 axis and the NF-kB and JNK/AP-1 pathways
-
Scupoli MT, Donadelli M, Cioffi F, Rossi M, Perbellini O, Malpeli G, et al. Bone marrow stromal cells and the upregulation of interleukin-8 production in human T-cell acute lymphoblastic leukemia through the CXCL12/CXCR4 axis and the NF-kB and JNK/AP-1 pathways. Haematologica 2008; 93:524-32.
-
(2008)
Haematologica
, vol.93
, pp. 524-532
-
-
Scupoli, M.T.1
Donadelli, M.2
Cioffi, F.3
Rossi, M.4
Perbellini, O.5
Malpeli, G.6
-
8
-
-
42149109062
-
In vitro validation of γ-secretase inhibitors alone or in combination with other anti-cancer drugs for treatment of T-cell acute lymphoblastic leukemia
-
De Keersmaecker K, Lahortiga I, Mentens N, Folens C, Van Neste L, Bekaert S, et al. In vitro validation of γ-secretase inhibitors alone or in combination with other anti-cancer drugs for treatment of T-cell acute lymphoblastic leukemia. Haematologica 2008; 93:533-542.
-
(2008)
Haematologica
, vol.93
, pp. 533-542
-
-
De Keersmaecker, K.1
Lahortiga, I.2
Mentens, N.3
Folens, C.4
Van Neste, L.5
Bekaert, S.6
-
9
-
-
33646203680
-
Development of human lymphoid cells
-
Blom B, Spits H. Development of human lymphoid cells. Annu Rev Immunol 2006;24:287-320.
-
(2006)
Annu Rev Immunol
, vol.24
, pp. 287-320
-
-
Blom, B.1
Spits, H.2
-
11
-
-
22344445528
-
New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling
-
Dik WA, Pike-Overzet K, Weerkamp F, de Ridder D, de Haas EF, Baert MR, et al. New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling. J Exp Med 2005;201:1715-23.
-
(2005)
J Exp Med
, vol.201
, pp. 1715-1723
-
-
Dik, W.A.1
Pike-Overzet, K.2
Weerkamp, F.3
de Ridder, D.4
de Haas, E.F.5
Baert, M.R.6
-
12
-
-
16244386483
-
Age-related changes in the cellular composition of the thymus in children
-
Weerkamp F, de Haas EF, Naber BA, Comans-Bitter WM, Bogers AJ, van Dongen JJ, et al. Age-related changes in the cellular composition of the thymus in children. J Allergy Clin Immunol 2005;115:834-40.
-
(2005)
J Allergy Clin Immunol
, vol.115
, pp. 834-840
-
-
Weerkamp, F.1
de Haas, E.F.2
Naber, B.A.3
Comans-Bitter, W.M.4
Bogers, A.J.5
van Dongen, J.J.6
-
13
-
-
0036127858
-
The immunophenotype of 325 adult acute leukemias: Relationship to morphologic and molecular classification and proposal for a minimal screening program highly predictive for lineage discrimination
-
Thalhammer-Scherrer R, Mitterbauer G, Simonitsch I, Jaeger U, Lechner K, Schneider B, et al. The immunophenotype of 325 adult acute leukemias: relationship to morphologic and molecular classification and proposal for a minimal screening program highly predictive for lineage discrimination. Am J Clin Pathol 2002;117:380-9.
-
(2002)
Am J Clin Pathol
, vol.117
, pp. 380-389
-
-
Thalhammer-Scherrer, R.1
Mitterbauer, G.2
Simonitsch, I.3
Jaeger, U.4
Lechner, K.5
Schneider, B.6
-
15
-
-
0037769822
-
Analysis of TCR, pT alpha, and RAG-1 in T-acute lymphoblastic leukemias improves understanding of early human T-lymphoid lineage commitment
-
Asnafi V, Beldjord K, Boulanger E, Comba B, Le Tutour P, Estienne MH, et al. Analysis of TCR, pT alpha, and RAG-1 in T-acute lymphoblastic leukemias improves understanding of early human T-lymphoid lineage commitment. Blood 2003;101:2693-703.
-
(2003)
Blood
, vol.101
, pp. 2693-2703
-
-
Asnafi, V.1
Beldjord, K.2
Boulanger, E.3
Comba, B.4
Le Tutour, P.5
Estienne, M.H.6
-
16
-
-
33645731202
-
Human thymus contains multipotent progenitors with T/B lymphoid, myeloid, and erythroid lineage potential
-
Weerkamp F, Baert MR, Brugman MH, Dik WA, de Haas EF, Visser TP, et al. Human thymus contains multipotent progenitors with T/B lymphoid, myeloid, and erythroid lineage potential. Blood 2006;107:3131-7.
-
(2006)
Blood
, vol.107
, pp. 3131-3137
-
-
Weerkamp, F.1
Baert, M.R.2
Brugman, M.H.3
Dik, W.A.4
de Haas, E.F.5
Visser, T.P.6
-
17
-
-
22044457152
-
HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL)
-
Soulier J, Clappier E, Cayuela JM, Regnault A, Garcia-Peydro M, Dombret H, et al. HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL). Blood 2005;106:274-86.
-
(2005)
Blood
, vol.106
, pp. 274-286
-
-
Soulier, J.1
Clappier, E.2
Cayuela, J.M.3
Regnault, A.4
Garcia-Peydro, M.5
Dombret, H.6
-
18
-
-
0038240453
-
Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: Dominance of HOX dysregulation
-
Ferrando AA, Armstrong SA, Neuberg DS, Sallan SE, Silverman LB, Korsmeyer SJ, et al. Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. Blood 2003;102:262-8.
-
(2003)
Blood
, vol.102
, pp. 262-268
-
-
Ferrando, A.A.1
Armstrong, S.A.2
Neuberg, D.S.3
Sallan, S.E.4
Silverman, L.B.5
Korsmeyer, S.J.6
-
19
-
-
6944252248
-
Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia
-
Graux C, Cools J, Melotte C, Quentmeier H, Ferrando A, Levine R, et al. Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia. Nat Genet 2004;36:1084-9.
-
(2004)
Nat Genet
, vol.36
, pp. 1084-1089
-
-
Graux, C.1
Cools, J.2
Melotte, C.3
Quentmeier, H.4
Ferrando, A.5
Levine, R.6
-
21
-
-
10744233606
-
Chance or necessity? Insertional mutagenesis in gene therapy and its consequences
-
Baum C, von Kalle C, Staal FJ, Li Z, Fehse B, Schmidt M, et al. Chance or necessity? Insertional mutagenesis in gene therapy and its consequences. Mol Ther 2004;9:5-13.
-
(2004)
Mol Ther
, vol.9
, pp. 5-13
-
-
Baum, C.1
von Kalle, C.2
Staal, F.J.3
Li, Z.4
Fehse, B.5
Schmidt, M.6
-
22
-
-
35549013276
-
New insights and unresolved issues regarding insertional mutagenesis in X-linked SCID gene therapy
-
Pike-Overzet K, van der Burg M, Wagemaker G, van Dongen JJ, Staal FJ. New insights and unresolved issues regarding insertional mutagenesis in X-linked SCID gene therapy. Mol Ther 2007;15:1910-6.
-
(2007)
Mol Ther
, vol.15
, pp. 1910-1916
-
-
Pike-Overzet, K.1
van der Burg, M.2
Wagemaker, G.3
van Dongen, J.J.4
Staal, F.J.5
-
23
-
-
0033136717
-
Deficient T cell fate specification in mice with an induced inactivation of Notch1
-
Radtke F, Wilson A, Stark G, Bauer M, van Meerwijk J, MacDonald HR, et al. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 1999;10:547-58.
-
(1999)
Immunity
, vol.10
, pp. 547-558
-
-
Radtke, F.1
Wilson, A.2
Stark, G.3
Bauer, M.4
van Meerwijk, J.5
MacDonald, H.R.6
-
25
-
-
0025856717
-
TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
-
Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD, et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 1991;66:649-61.
-
(1991)
Cell
, vol.66
, pp. 649-661
-
-
Ellisen, L.W.1
Bird, J.2
West, D.C.3
Soreng, A.L.4
Reynolds, T.C.5
Smith, S.D.6
-
26
-
-
0034284471
-
A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice
-
Feldman BJ, Hampton T, Cleary ML. A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice. Blood 2000;96:1906-13.
-
(2000)
Blood
, vol.96
, pp. 1906-1913
-
-
Feldman, B.J.1
Hampton, T.2
Cleary, M.L.3
-
27
-
-
35748972639
-
NOTCH and PI3K-AKT pathways intertwined
-
Gutierrez A, Look AT. NOTCH and PI3K-AKT pathways intertwined. Cancer Cell 2007;12:411-3.
-
(2007)
Cancer Cell
, vol.12
, pp. 411-413
-
-
Gutierrez, A.1
Look, A.T.2
-
28
-
-
34547780475
-
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
-
O'Neil J, Grim J, Strack P, Rao S, Tibbitts D, Winter C, et al. FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med 2007;204:1813-24.
-
(2007)
J Exp Med
, vol.204
, pp. 1813-1824
-
-
O'Neil, J.1
Grim, J.2
Strack, P.3
Rao, S.4
Tibbitts, D.5
Winter, C.6
-
29
-
-
35348887715
-
Mechanisms of transcription factor deregulation in lymphoid cell transformation
-
O'Neil J, Look AT. Mechanisms of transcription factor deregulation in lymphoid cell transformation. Oncogene 2007;26:6838-49.
-
(2007)
Oncogene
, vol.26
, pp. 6838-6849
-
-
O'Neil, J.1
Look, A.T.2
-
30
-
-
34547820257
-
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
-
Thompson BJ, Buonamici S, Sulis ML, Palomero T, Vilimas T, Basso G, et al. The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. J Exp Med 2007;204:1825-35.
-
(2007)
J Exp Med
, vol.204
, pp. 1825-1835
-
-
Thompson, B.J.1
Buonamici, S.2
Sulis, M.L.3
Palomero, T.4
Vilimas, T.5
Basso, G.6
-
31
-
-
33746546368
-
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
-
Weng AP, Millholland JM, Yashiro-Ohtani Y, Arcangeli ML, Lau A, Wai C, et al. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev 2006;20:2096-109.
-
(2006)
Genes Dev
, vol.20
, pp. 2096-2109
-
-
Weng, A.P.1
Millholland, J.M.2
Yashiro-Ohtani, Y.3
Arcangeli, M.L.4
Lau, A.5
Wai, C.6
-
32
-
-
0037133497
-
Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis
-
Bellavia D, Campese AF, Checquolo S, Balestri A, Biondi A, Cazzaniga G, et al. Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. Proc Natl Acad Sci USA 2002;99:3788-93.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 3788-3793
-
-
Bellavia, D.1
Campese, A.F.2
Checquolo, S.3
Balestri, A.4
Biondi, A.5
Cazzaniga, G.6
-
33
-
-
33750306240
-
Activating mutations in NOTCH1 in acute myeloid leukemia and lineage switch leukemias
-
Palomero T, McKenna K, J ON, Galinsky I, Stone R, Suzukawa K, et al. Activating mutations in NOTCH1 in acute myeloid leukemia and lineage switch leukemias. Leukemia 2006;20:1963-6.
-
(2006)
Leukemia
, vol.20
, pp. 1963-1966
-
-
Palomero, T.1
McKenna, K.2
ON, J.3
Galinsky, I.4
Stone, R.5
Suzukawa, K.6
-
34
-
-
33846048039
-
Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia
-
Vilimas T, Mascarenhas J, Palomero T, Mandal M, Buonamici S, Meng F, et al. Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. Nat Med 2007;13:70-7.
-
(2007)
Nat Med
, vol.13
, pp. 70-77
-
-
Vilimas, T.1
Mascarenhas, J.2
Palomero, T.3
Mandal, M.4
Buonamici, S.5
Meng, F.6
-
35
-
-
34247623669
-
The diagnostic value of C-reactive protein, interleukin-8, and monocyte chemotactic protein in risk stratification of febrile neutropenic children with hematologic malignancies
-
El-Maghraby SM, Moneer MM, Ismail MM, Shalaby LM, El-Mahallawy HA. The diagnostic value of C-reactive protein, interleukin-8, and monocyte chemotactic protein in risk stratification of febrile neutropenic children with hematologic malignancies. J Pediatr Hematol Oncol 2007;29:131-6.
-
(2007)
J Pediatr Hematol Oncol
, vol.29
, pp. 131-136
-
-
El-Maghraby, S.M.1
Moneer, M.M.2
Ismail, M.M.3
Shalaby, L.M.4
El-Mahallawy, H.A.5
-
36
-
-
34247850857
-
Expression of soluble CD27 and interleukins-8 and -10 in B-cell chronic lymphocytic leukemia: Correlation with disease stage and prognosis
-
Kara IO, Sahin B, Gunesacar R. Expression of soluble CD27 and interleukins-8 and -10 in B-cell chronic lymphocytic leukemia: correlation with disease stage and prognosis. Adv Ther 2007;24:29-40.
-
(2007)
Adv Ther
, vol.24
, pp. 29-40
-
-
Kara, I.O.1
Sahin, B.2
Gunesacar, R.3
-
37
-
-
0037323946
-
Plasma interleukin 8 level predicts for survival in chronic lymphocytic leukaemia
-
Wierda WG, Johnson MM, Do KA, Manshouri T, Dey A, O'Brien S, et al. Plasma interleukin 8 level predicts for survival in chronic lymphocytic leukaemia. Br J Haematol 2003;120:452-6.
-
(2003)
Br J Haematol
, vol.120
, pp. 452-456
-
-
Wierda, W.G.1
Johnson, M.M.2
Do, K.A.3
Manshouri, T.4
Dey, A.5
O'Brien, S.6
-
38
-
-
0025677250
-
Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus
-
Staal FJ, Roederer M, Herzenberg LA, Herzenberg LA. Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus. Proc Natl Acad Sci USA 1990;87:9943-7.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 9943-9947
-
-
Staal, F.J.1
Roederer, M.2
Herzenberg, L.A.3
Herzenberg, L.A.4
-
39
-
-
11244305618
-
WNT signalling and haematopoiesis: A WNT-WNT situation
-
Staal FJ, Clevers HC. WNT signalling and haematopoiesis: a WNT-WNT situation. Nat Rev Immunol 2005;5:21-30.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 21-30
-
-
Staal, F.J.1
Clevers, H.C.2
-
40
-
-
33644772155
-
Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules
-
Weerkamp F, Baert MR, Naber BA, Koster EE, de Haas EF, Atkuri KR, et al. Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules. Proc Natl Acad Sci USA 2006;103:3322-6.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 3322-3326
-
-
Weerkamp, F.1
Baert, M.R.2
Naber, B.A.3
Koster, E.E.4
de Haas, E.F.5
Atkuri, K.R.6
-
41
-
-
85117739330
-
-
Guo Z, Dose M, Kovalovsky D, Chang R, O'Neil J, Look AT, et al. {beta}-Catenin stabilization stalls the transition from Double-Positive to Single Positive stage and predisposes thymocytes to malignant transformation. Blood 2007;109:5463-72.
-
Guo Z, Dose M, Kovalovsky D, Chang R, O'Neil J, Look AT, et al. {beta}-Catenin stabilization stalls the transition from Double-Positive to Single Positive stage and predisposes thymocytes to malignant transformation. Blood 2007;109:5463-72.
-
-
-
-
42
-
-
34548018349
-
Gamma-secretase inhibitors suppress the growth of leukemia and lymphoma cells
-
Kogoshi H, Sato T, Koyama T, Nara N, Tohda S. Gamma-secretase inhibitors suppress the growth of leukemia and lymphoma cells. Oncol Rep 2007;18:77-80.
-
(2007)
Oncol Rep
, vol.18
, pp. 77-80
-
-
Kogoshi, H.1
Sato, T.2
Koyama, T.3
Nara, N.4
Tohda, S.5
|