Characterization of notch1 antibodies that inhibit signaling of both normal and mutated notch1 receptors

PLoS ONE

Volumn 5, Issue 2, 2010, Pages

  Aste Amézaga, Miguel ^a   Zhang, Ningyan ^a   Lineberger, Janet E ^a   Arnold, Beth A ^a   Toner, Timothy J ^a   Gu, Mingcheng ^a   Huang, Lingyi ^a   Vitelli, Salvatore ^a   Vo, Kim T ^a   Haytko, Peter ^a   Zhao, Jing Zhang ^a   Baleydier, Frederic ^b   L'Heureux, Sarah ^b   Wang, Hongfang ^b   Gordon, Wendy R ^b   Thoryk, Elizabeth ^a   Andrawes, Marie Blanke ^b   Tiyanont, Kittichoat ^b   Stegmaier, Kimberly ^c,d   Roti, Giovanni ^c   Ross, Kenneth N ^d   Franlin, Laura L ^a   Wang, Hui ^a   Wang, Fubao ^a   Chastain, Michael ^a   Bett, Andrew J ^a   Audoly, Laurent P ^a   Aster, Jon C ^b   Blacklow, Stephen C ^b   Huber, Hans E ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; GAMMA SECRETASE INHIBITOR; METALLOPROTEINASE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY NOTCH1; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; NOTCH3 RECEPTOR; NOTCH4 RECEPTOR; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR HES 5; UNCLASSIFIED DRUG; JAG2 PROTEIN, HUMAN; LIGAND; MEMBRANE PROTEIN; SIGNAL PEPTIDE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANGIOGENESIS; ARTICLE; CONTROLLED STUDY; DELTEX1 GENE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; LIGAND BINDING; PHAGE DISPLAY; POINT MUTATION; PROTEIN DOMAIN; REPORTER GENE; T LYMPHOCYTE; TUMOR CELL LINE; ANIMAL; ANTIBODY SPECIFICITY; BINDING COMPETITION; BINDING SITE; CELL LINE; CELL PROLIFERATION; CELL STRAIN 3T3; DRUG EFFECT; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE; MUTATION; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

METAZOA;

3T3 CELLS; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BINDING SITES; BINDING, COMPETITIVE; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MEMBRANE PROTEINS; MICE; MUTATION; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RECEPTOR, NOTCH1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 77949395629     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009094     Document Type: Article

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