Regulation of pyruvate dehydrogenase kinase expression by the farnesoid X receptor

Biochemical and Biophysical Research Communications

Volumn 329, Issue 1, 2005, Pages 391-396

  Savkur, Rajesh S ^a   Bramlett, Kelli S ^a,b   Michael, Laura F ^a   Burris, Thomas P ^a,b  

^a ELI LILLY AND COMPANY   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

Bile acids; Diabetes; FOXO; Glucocorticoids; Glucose; Lipid; PDK4; PPAR; TRB 3

Indexed keywords

FARNESOID X RECEPTOR; GLUCOCORTICOID RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PYRUVATE DEHYDROGENASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME METABOLISM; GENE CONTROL; GENE EXPRESSION; GLYCOLYSIS; HEPATOMA CELL; LIVER CELL; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 13844280404     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.01.141     Document Type: Article

References (29)

1. P.J. Randle Fuel selection in animals Biochem. Soc. Trans. 14 1986 799 806
2. M.C. Sugden, and M.J. Holness Interactive regulation of the pyruvate dehydrogenase complex and the carnitine palmitoyltransferase system Faseb J. 8 1994 54 61
3. M.M. Bowker-Kinley, W.I. Davis, P. Wu, R.A. Harris, and K.M. Popov Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex Biochem. J. 329 1998 191 196
4. M.C. Sugden, L.G. Fryer, K.A. Orfali, D.A. Priestman, E. Donald, and M.J. Holness Studies of the long-term regulation of hepatic pyruvate dehydrogenase kinase Biochem. J. 329 1998 89 94
5. P. Wu, P.V. Blair, J. Sato, J. Jaskiewicz, K.M. Popov, and R.A. Harris Starvation increases the amount of pyruvate dehydrogenase kinase in several mammalian tissues Arch. Biochem. Biophys. 381 2000 1 7
6. M.C. Sugden, K. Bulmer, G.F. Gibbons, B.L. Knight, and M.J. Holness Peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin Biochem. J. 364 2002 361 368
7. M.C. Sugden, K. Bulmer, G.F. Gibbons, and M.J. Holness Role of peroxisome proliferator-activated receptor-alpha in the mechanism underlying changes in renal pyruvate dehydrogenase kinase isoform 4 protein expression in starvation and after refeeding Arch. Biochem. Biophys. 395 2001 246 252
8. P. Wu, J.M. Peters, and R.A. Harris Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha Biochem. Biophys. Res. Commun. 287 2001 391 396
9. M.J. Holness, N.D. Smith, K. Bulmer, T. Hopkins, G.F. Gibbons, and M.C. Sugden Evaluation of the role of peroxisome-proliferator-activated receptor alpha in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism Biochem. J. 364 2002 687 694
10. M.J. Holness, K. Bulmer, N.D. Smith, and M.C. Sugden Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone Biochem. J. 369 2003 687 695
11. B. Huang, P. Wu, M.M. Bowker-Kinley, and R.A. Harris Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulin Diabetes 51 2002 276 283
12. K. Motojima, and K. Seto Fibrates and statins rapidly and synergistically induce pyruvate dehydrogenase kinase 4 mRNA in the liver and muscles of mice Biol. Pharm. Bull 26 2003 954 958
13. T. Lemberger, B. Staels, R. Saladin, B. Desvergne, J. Auwerx, and W. Wahli Regulation of the peroxisome proliferator-activated receptor-alpha gene by glucocorticoids J. Biol. Chem. 269 1994 24527 24530
14. B.M. Forman, E. Goode, J. Chen, A.E. Oro, D.J. Bradley, T. Perlmann, D.J. Noonan, L.T. Burka, T. McMorris, and W.W. Lamph Identification of a nuclear receptor that is activated by farnesol metabolites Cell 81 1995 687 693
15. M. Makishima, A.Y. Okamoto, J.J. Repa, H. Tu, R.M. Learned, A. Luk, M.V. Hull, K.D. Lustig, D.J. Mangelsdorf, and B. Shan Identification of a nuclear receptor for bile acids Science 284 1999 1362 1365
16. D.J. Parks, S.G. Blanchard, R.K. Bledsoe, G. Chandra, T.G. Consler, S.A. Kliewer, J.B. Stimmel, T.M. Willson, A.M. Zavacki, D.D. Moore, and J.M. Lehmann Bile acids: natural ligands for an orphan nuclear receptor Science 284 1999 1365 1368
17. K.S. Bramlett, S.F. Yao, and T.P. Burris Correlation of farnesoid X receptor coactivator recruitment and cholesterol 7 alpha-hydroxylase gene repression by bile acids Mol. Genet. Metab. 71 2000 609 615
18. T.T. Lu, M. Makishima, J.J. Repa, K. Schoonjans, T.A. Kerr, J. Auwerx, and D.J. Mangelsdorf Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors Mol. Cell 6 2000 507 515
19. B. Goodwin, S.A. Jones, R.R. Price, M.A. Watson, D.D. McKee, L.B. Moore, C. Galardi, J.G. Wilson, M.C. Lewis, M.E. Roth, P.R. Maloney, T.M. Willson, and S.A. Kliewer A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis Mol. Cell 6 2000 517 526
20. C.J. Sinal, M. Tohkin, M. Miyata, J.M. Ward, G. Lambert, and F.J. Gonzalez Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis Cell 102 2000 731 744
21. H.R. Kast, B. Goodwin, P.T. Tarr, S.A. Jones, A.M. Anisfeld, C.M. Stoltz, P. Tontonoz, S. Kliewer, T.M. Willson, and P.A. Edwards Regulation of multidrug resistance-associated protein 2 (ABCC2) by nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor J. Biol. Chem. 277 2002 2908 2915
22. K.R. Stayrook, K.S. Bramlett, R.S. Savkur, J. Ficorilli, T. Cook, M.E. Christe, L.F. Michael, T.P. Burris, Regulation of carbohydrate metabolism by the farnesoid X receptor, Endocrinology. 10.1210/en.2004-0965
23. H.S. Kwon, B. Huang, T.G. Unterman, and R.A. Harris Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors Diabetes 53 2004 899 910
24. G.Q. Cao, Y. Liang, C.L. Broderick, B.A. Oldham, T.P. Beyer, R.J. Schmidt, Y.Y. Zhang, K.R. Stayrook, C. Suen, K.A. Otto, A.R. Miller, J.N. Dai, P. Foxworthy, H. Gao, T.P. Ryan, X.C. Jiang, T.P. Burris, P.I. Eacho, and G.J. Etgen Antidiabetic action of a liver X receptor agonist mediated by inhibition of hepatic gluconeogenesis J. Biol. Chem. 278 2003 1131 1136
25. P.R. Maloney, D.J. Parks, C.D. Haffner, A.M. Fivush, G. Chandra, K.D. Plunket, K.L. Creech, L.B. Moore, J.G. Wilson, M.C. Lewis, S.A. Jones, and T.M. Willson Identification of a chemical tool for the orphan nuclear receptor FXR J. Med. Chem. 43 2000 2971 2974
26. I.P. Torra, T. Claudel, C. Duval, V. Kosykh, J.C. Fruchart, and B. Staels Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor Mol. Endocrinol. 17 2003 259 272
27. K.Y. Du, S. Herzig, R.N. Kulkarni, and M. Montminy TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver Science 300 2003 1574 1577
28. S.H. Koo, H. Satoh, S. Herzig, C.H. Lee, S. Hedrick, R. Kulkarni, R.M. Evans, J. Olefsky, and M. Montminy PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3 Nat. Med. 10 2004 530 534
29. M. Watanabe, S.M. Houten, L. Wang, A. Moschetta, D.J. Mangelsdorf, R.A. Heyman, D.D. Moore, and J. Auwerx Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c J. Clin. Invest. 113 2004 1408 1418