Oxidation of hepatic carnitine palmitoyl transferase-I (CPT-I) impairs fatty acid beta-oxidation in rats fed a methionine-choline deficient diet

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Serviddio, Gaetano ^a   Giudetti, Anna M ^b   Bellanti, Francesco ^a   Priore, Paola ^b   Rollo, Tiziana ^a   Tamborra, Rosanna ^a   Siculella, Luisa ^b   Vendemiale, Gianluigi ^a,c   Altomare, Emanuele ^a   Gnoni, Gabriele V ^b  

^a UNIVERSITY OF FOGGIA   (Italy)

^b UNIVERSITY OF SALENTO   (Italy)

^c CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; CARNITINE PALMITOYLTRANSFERASE I; CHOLINE; DIGITONIN; KETONE BODY; METHIONINE; 3 HYDROXYACYL COENZYME A DEHYDROGENASE; ACETYL COENZYME A CARBOXYLASE; CARNITINE PALMITOYLTRANSFERASE; FATTY ACID; MALONYL COENZYME A; MESSENGER RNA; PALMITIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; DIET RESTRICTION; DIETARY INTAKE; ENZYME ACTIVITY; ENZYME METABOLISM; ENZYME MODIFICATION; FATTY ACID OXIDATION; LIPID DIET; LIVER CELL; LIVER MITOCHONDRION; MALE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; RAT; ANIMAL; BLOOD; CELL MEMBRANE PERMEABILITY; DIET; DRUG EFFECT; ENZYME ASSAY; ENZYMOLOGY; FEEDING BEHAVIOR; GENE EXPRESSION REGULATION; GENETICS; GLUCOSE BLOOD LEVEL; LIVER; METABOLISM; MITOCHONDRIAL MEMBRANE; OXIDATION REDUCTION REACTION; PATHOLOGY; WISTAR RAT;

RATTUS;

3-HYDROXYACYL COA DEHYDROGENASES; ACETYL-COA CARBOXYLASE; ANIMALS; BLOOD GLUCOSE; CARNITINE O-PALMITOYLTRANSFERASE; CELL MEMBRANE PERMEABILITY; CHOLINE; DIET; ENZYME ASSAYS; FATTY ACIDS; FEEDING BEHAVIOR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; LIVER; MALE; MALONYL COENZYME A; METHIONINE; MITOCHONDRIA, LIVER; MITOCHONDRIAL MEMBRANES; OXIDATION-REDUCTION; PALMITIC ACID; RATS; RATS, WISTAR; RNA, MESSENGER;

EID: 80052356803     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024084     Document Type: Article

References (36)

1. Ludwig J, Viggiano TR, McGill DB, Oh BJ, (1980) Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 55: 434-438.
2. Angulo P, (2002) Nonalcoholic fatty liver disease. N Engl J Med 346: 1221-1231.
3. Caldwell SH, Swerdlow RH, Khan EM, Iezzoni JC, Hespenheide EE, et al. (1999) Mitochondrial abnormalities in non-alcoholic steatohepatitis. J Hepatol 31: 430-434.
4. Serviddio G, Bellanti F, Tamborra R, Rollo T, Romano AD, et al. (2008) Alterations of hepatic ATP homeostasis and respiratory chain during development of non-alcoholic steatohepatitis in a rodent model. Eur J Clin Invest 38: 245-252.
5. Cortez-Pinto H, Chatham J, Chacko VP, Arnold C, Rashid A, et al. (1999) Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study. JAMA 282: 1659-1664.
6. Perez-Carreras M, Del Hoyo P, Martin MA, Rubio JC, Martin A, et al. (2003) Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis. Hepatology 38: 999-1007.
7. Serviddio G, Bellanti F, Tamborra R, Rollo T, Capitanio N, et al. (2008) Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury. Gut 57: 957-965.
8. Grattagliano I, Caraceni P, Calamita G, Ferri D, Gargano I, et al. (2008) Severe liver steatosis correlates with nitrosative and oxidative stress in rats. Eur J Clin Invest 38: 523-530.
9. Leclercq IA, Lebrun VA, Stärkel P, Horsmans YJ, (2007) Intrahepatic insulin resistance in a murine model of steatohepatitis: effect of PPARγ agonist pioglitazone. Lab Invest 87: 56-65.
10. Begriche K, Igoudjil A, Pessayre D, Fromenty B, (2006) Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. Mitochondrion 6: 1-28.
11. Fromenty B, Robin MA, Igoudjil A, Mansouri A, Pessayre D, (2004) The ins and outs of mitochondrial dysfunction in NASH. Diabetes Metab 30: 121-138.
12. Slater TF, (1984) Free-radical mechanisms in tissue injury. Biochem J 222: 1-15.
13. Uchida K, Stadtman ER, (1992) Modification of histidine residues in proteins by reaction with 4-hydroxynonenal. Proc Natl Acad Sci U S A 89: 4544-4548.
14. Serviddio G, Sastre J, Bellanti F, Vina J, Vendemiale G, et al. (2008) Mitochondrial involvement in non-alcoholic steatohepatitis. Mol Aspects Med 29: 22-35.
15. Eaton S, (2002) Control of mitochondrial beta-oxidation flux. Prog Lipid Res 41: 197-239.
16. Bartlett K, Eaton S, (2004) Mitochondrial beta-oxidation. Eur J Biochem 271: 462-469.
17. Cong WN, Tao RY, Tian JY, Liu GT, Ye F, (2008) The establishment of a novel non-alcoholic steatohepatitis model accompanied with obesity and insulin resistance in mice. Life Sci 82: 983-990.
18. Serviddio G, Siculella L, Giudetti AM, Bellanti F, Romano AD, et al. (2006) CPT-I is a key target of mitochondria nitrosylation during NASH development. J Hepatol 44: S263.
19. Nakamuta M, Kohjima M, Morizono S, Kotoh K, Yoshimoto T, et al. (2005) Evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. Int J Mol Med 16: 631-635.
20. Kohjima M, Enjoji M, Higuchi N, Kato M, Kotoh K, et al. (2007) Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. Int J Mol Med 20: 351-358.
21. Teramoto K, Bowers JL, Khettry U, Palombo JD, Clouse ME, (1993) A rat fatty liver transplant model. Transplantation 55: 737-741.
22. Giudetti AM, Beynen AC, Lemmens AG, Gnoni GV, Geelen MJH, (2005) Hepatic lipid and carbohydrate metabolism in rats fed a commercial mixture of conjugated linoleic acids (Clarinol G-80™). Eur J Nutr 44: 33-39.
23. Priore P, Giudetti AM, Natali F, Gnoni GV, Geelen MJH, (2007) Metabolism and short-term metabolic effects of conjugated linoleic acids in rat hepatocytes. Biochim Biophys Acta 1771: 1299-1307.
24. Geelen MJH, (2005) The use of digitonin-permeabilized mammalian cells for measuring enzyme activities in the course of studies on lipid metabolism. Anal Biochem 347: 1-9.
25. Giudetti AM, Leo M, Siculella L, Gnoni GV, (2006) Hypothyroidism down-regulates mitochondrial citrate carrier activity and expression in rat liver. Biochim Biophys Acta 1761: 484-491.
26. Kashfi K, Mynatt RL, Park EA, Cook GA, (2011) Membrane microenvironment regulation of carnitine palmitoyltranferases I and II. Biochem Soc Trans 39: 833-837.
27. Giudetti AM, Sabetta S, di Summa R, Leo M, Damiano F, et al. (2003) Differential effects of coconut oil- and fish oil-enriched diets on tricarboxylate carrier in rat liver mitochondria. J Lipid Res 44: 2135-2141.
28. Otogawa K, Kinoshita K, Fujii H, Sakabe M, Shiga R, et al. (2007) Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis. Am J Pathol 170: 967-980.
29. Dey A, Cederbaum AI, (2007) Induction of cytochrome P450 2E1 [corrected] promotes liver injury in ob/ob mice. Hepatology 45: 1355-1365.
30. Rizki G, Arnaboldi L, Gabrielli B, Yan J, Lee GS, et al. (2006) Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1. J Lipid Res 47: 2280-2290.
31. Rinella ME, Green RM, (2004) The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance. J Hepatol 40: 47-51.
32. Ghoshal AK, Farber E, (1993) Choline deficiency, lipotrope deficiency and the development of liver disease including liver cancer: a new perspective. Lab Invest 68: 255-260.
33. Merrill GF, Kurth EJ, Rasmussen BB, Winder WW, (1998) Influence of malonyl-CoA and palmitate concentration on rate of palmitate oxidation in rat muscle. J Appl Physiol 85: 1909-14.
34. Day CP, (2002) Pathogenesis of steatohepatitis. Best PractRes Clin Gastroenterol 16: 663-78.
35. Poli G, Biasi F, Leonarduzzi G, (2008) 4-Hydroxynonenal-protein adducts: A reliable biomarker of lipid oxidation in liver diseases. Mol Aspects Med 29: 67-71.
36. Namikawa C, Shu-Ping Z, Vyselaar JR, Nozaki Y, Nemoto Y, et al. (2004) Polymorphisms of microsomaltriglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis. J Hepatol 40: 781-786.