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Volumn 9, Issue 1, 2007, Pages 72-77

PPARδ agonists and metabolic diseases

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYACYL COENZYME A DEHYDROGENASE; 4 [4 [3 (4 ACETYL 3 HYDROXY 2 PROPYLPHENOXY)PROPOXY]PHENOXY]ACETIC ACID; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; APOLIPOPROTEIN A1; APOLIPOPROTEIN A2; APOLIPOPROTEIN B; APOLIPOPROTEIN C3; CITRATE SYNTHASE; FATTY ACID; FATTY ACID BINDING PROTEIN; GLUCOSE; GW 0742; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2;

EID: 33846164791     PISSN: 15233804     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02693931     Document Type: Review
Times cited : (23)

References (34)
  • 1
    • 0037116641 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome among US adults: Findings from the third National Health and Nutrition Examination Survey
    • Ford ES, Giles WH, Dietz WH: Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 2002, 287:356-359.
    • (2002) JAMA , vol.287 , pp. 356-359
    • Ford, E.S.1    Giles, W.H.2    Dietz, W.H.3
  • 2
    • 33644750396 scopus 로고    scopus 로고
    • Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes
    • Hotamisligil GS: Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes 2005, 54(Suppl 2):S73-78.
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 2
    • Hotamisligil, G.S.1
  • 3
    • 0012473279 scopus 로고
    • The nuclear receptor superfamily: The second decade
    • Mangelsdorf DJ, Thummel C, Beato M, et al.: The nuclear receptor superfamily: the second decade. Cell 1995, 83:835-839.
    • (1995) Cell , vol.83 , pp. 835-839
    • Mangelsdorf, D.J.1    Thummel, C.2    Beato, M.3
  • 4
    • 0035976638 scopus 로고    scopus 로고
    • Nuclear receptors and lipid physiology: Opening the X-files
    • Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ: Nuclear receptors and lipid physiology: opening the X-files. Science 2001, 294:1866-1870.
    • (2001) Science , vol.294 , pp. 1866-1870
    • Chawla, A.1    Repa, J.J.2    Evans, R.M.3    Mangelsdorf, D.J.4
  • 5
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism
    • Desvergne B, Wahli W: Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 1999, 20:649-688.
    • (1999) Endocr Rev , vol.20 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 6
    • 0037900979 scopus 로고    scopus 로고
    • Minireview: Lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors
    • Lee CH, Olson P, Evans RM: Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology 2003, 144:2201-2207.
    • (2003) Endocrinology , vol.144 , pp. 2201-2207
    • Lee, C.H.1    Olson, P.2    Evans, R.M.3
  • 7
    • 0032699670 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
    • Kersten S, Seydoux J, Peters JM, et al.: Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest 1999, 103:1489-1498.
    • (1999) J Clin Invest , vol.103 , pp. 1489-1498
    • Kersten, S.1    Seydoux, J.2    Peters, J.M.3
  • 8
    • 0033594980 scopus 로고    scopus 로고
    • A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: The PPARalpha-null mouse as a model of fatty acid oxidation disorders
    • Leone TC, Weinheimer CJ, Kelly DP: A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci U S A 1999, 96:7473-7478.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 7473-7478
    • Leone, T.C.1    Weinheimer, C.J.2    Kelly, D.P.3
  • 9
    • 0033213637 scopus 로고    scopus 로고
    • PPAR gamma is required for placental, cardiac, and adipose tissue development
    • Barak Y, Nelson MC, Ong ES, et al.: PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell 1999, 4:585-595.
    • (1999) Mol Cell , vol.4 , pp. 585-595
    • Barak, Y.1    Nelson, M.C.2    Ong, E.S.3
  • 10
    • 0033212964 scopus 로고    scopus 로고
    • PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
    • Kubota N, Terauchi Y, Miki H, et al.: PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell 1999, 4:597-609.
    • (1999) Mol Cell , vol.4 , pp. 597-609
    • Kubota, N.1    Terauchi, Y.2    Miki, H.3
  • 11
    • 0033213631 scopus 로고    scopus 로고
    • PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro
    • Rosen ED, Sarraf P, Troy AE, et al.: PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell 1999, 4:611-617.
    • (1999) Mol Cell , vol.4 , pp. 611-617
    • Rosen, E.D.1    Sarraf, P.2    Troy, A.E.3
  • 12
    • 0006132932 scopus 로고    scopus 로고
    • Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma
    • Kliewer SA, Sundseth SS, Jones SA, et al.: Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc Natl Acad Sci U S A 1997, 94:4318-4323.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 4318-4323
    • Kliewer, S.A.1    Sundseth, S.S.2    Jones, S.A.3
  • 13
    • 0030985318 scopus 로고    scopus 로고
    • Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator- dependent receptor ligand assay
    • Krey G, Braissant O, L'Horset F, et al.: Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator- dependent receptor ligand assay. Mol Endocrinol 1997, 11:779-791.
    • (1997) Mol Endocrinol , vol.11 , pp. 779-791
    • Krey, G.1    Braissant, O.2    L'Horset, F.3
  • 14
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
    • Lehmann JM, Moore LB, Smith-Oliver TA, et al.: An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem 1995, 270:12953-12956.
    • (1995) J Biol Chem , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3
  • 15
    • 0037039374 scopus 로고    scopus 로고
    • Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer
    • Barak Y, Liao D, He W, et al.: Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci U S A 2002, 99:303-308.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 303-308
    • Barak, Y.1    Liao, D.2    He, W.3
  • 16
    • 0033625677 scopus 로고    scopus 로고
    • Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta (delta)
    • Peters JM, Lee SS, Li W, et al.: Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta (delta). Mol Cell Biol 2000, 20:5119-5128.
    • (2000) Mol Cell Biol , vol.20 , pp. 5119-5128
    • Peters, J.M.1    Lee, S.S.2    Li, W.3
  • 17
    • 2442692690 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor beta/delta regulates very low density lipoprotein production and catabolism in mice on a western diet
    • Akiyama TE, Lambert G, Nicol CJ, et al.: Peroxisome proliferator-activated receptor beta/delta regulates very low density lipoprotein production and catabolism in mice on a western diet. J Bio Chem 2004, 279:20874-20881.
    • (2004) J Bio Chem , vol.279 , pp. 20874-20881
    • Akiyama, T.E.1    Lambert, G.2    Nicol, C.J.3
  • 18
    • 33644766913 scopus 로고    scopus 로고
    • PPAR delta regulates glucose metabolism and insulin sensitivity
    • Lee CH, Olson P, Hevener A, et al.: PPAR delta regulates glucose metabolism and insulin sensitivity. Proc Natl Acad Sci U S A 2006, 103:3444-3449.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 3444-3449
    • Lee, C.H.1    Olson, P.2    Hevener, A.3
  • 19
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity
    • Wang YX, Lee CH, Tiep S, et al.: Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell 2003, 113:159-170.
    • (2003) Cell , vol.113 , pp. 159-170
    • Wang, Y.X.1    Lee, C.H.2    Tiep, S.3
  • 20
    • 0642303113 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta controls muscle development and oxidative capability
    • Luquet S, Lopez-Soriano J, Holst D, et al.: Peroxisome proliferator-activated receptor delta controls muscle development and oxidative capability. FASEB J 2003, 17:2299-2301.
    • (2003) FASEB J , vol.17 , pp. 2299-2301
    • Luquet, S.1    Lopez-Soriano, J.2    Holst, D.3
  • 21
    • 8844276054 scopus 로고    scopus 로고
    • Regulation of muscle fiber type and running endurance by PPARdelta
    • Wang YX, Zhang CL, Yu RT, et al.: Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol 2004, 2:e294.
    • (2004) PLoS Biol , vol.2
    • Wang, Y.X.1    Zhang, C.L.2    Yu, R.T.3
  • 22
    • 9144262378 scopus 로고    scopus 로고
    • Cardiomyocyte-restricted peroxisome proliferator-activated receptor-defta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy
    • Cheng L, Ding G, Qin Q, et al.: Cardiomyocyte-restricted peroxisome proliferator-activated receptor-defta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat Med 2004, 10:1245-1250.
    • (2004) Nat Med , vol.10 , pp. 1245-1250
    • Cheng, L.1    Ding, G.2    Qin, Q.3
  • 23
    • 13844256366 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor beta/delta activation inhibits hypertrophy in neonatal rat cardiomyocytes
    • Planavila A, Rodriguez-Calvo R, Jove M, et al.: Peroxisome proliferator-activated receptor beta/delta activation inhibits hypertrophy in neonatal rat cardiomyocytes. Cardiovasc Res 2005, 65:832-841.
    • (2005) Cardiovasc Res , vol.65 , pp. 832-841
    • Planavila, A.1    Rodriguez-Calvo, R.2    Jove, M.3
  • 24
    • 12444289447 scopus 로고    scopus 로고
    • Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta) - Synthesis and biological activity
    • Sznaidman ML, Haffner CD, Maloney PR, et al.: Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta) - synthesis and biological activity. Bioorg Med Chem Lett 2003, 13:1517-1521.
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 1517-1521
    • Sznaidman, M.L.1    Haffner, C.D.2    Maloney, P.R.3
  • 25
    • 33645753739 scopus 로고    scopus 로고
    • GW-501516 GlaxoSmithKline/Ligand
    • Pelton P: GW-501516 GlaxoSmithKline/Ligand. Curr Opin Investig Drugs 2006, 7:360-370.
    • (2006) Curr Opin Investig Drugs , vol.7 , pp. 360-370
    • Pelton, P.1
  • 26
    • 0035942162 scopus 로고    scopus 로고
    • A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport
    • Oliver WR Jr, Shenk JL, Snaith MR, et al.: A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc Natl Acad Sci U S A 2001, 98:5306-5311.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 5306-5311
    • Oliver Jr., W.R.1    Shenk, J.L.2    Snaith, M.R.3
  • 27
    • 22144492005 scopus 로고    scopus 로고
    • Effects of peroxisome proliferator-activated receptor alpha/delta agonists on HDL-cholesterol in vervet monkeys
    • Wallace JM, Schwarz M, Coward P, et al.: Effects of peroxisome proliferator-activated receptor alpha/delta agonists on HDL-cholesterol in vervet monkeys. J Lipid Res 2005, 46:1009-1016.
    • (2005) J Lipid Res , vol.46 , pp. 1009-1016
    • Wallace, J.M.1    Schwarz, M.2    Coward, P.3
  • 28
    • 0142116239 scopus 로고    scopus 로고
    • Transcriptional repression of atherogenic inflammation: Modulation by PPARdelta
    • Lee CH, Chawla A, Urbiztondo N, et al.: Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. Science 2003, 302:453-457.
    • (2003) Science , vol.302 , pp. 453-457
    • Lee, C.H.1    Chawla, A.2    Urbiztondo, N.3
  • 29
    • 20444378931 scopus 로고    scopus 로고
    • The PPARdelta agonist GW0742X reduces atherosclerosis in LDLR(-/-) mice
    • Graham TL, Mookherjee C, Suckling KE, et al.: The PPARdelta agonist GW0742X reduces atherosclerosis in LDLR(-/-) mice. Atherosclerosis 2005, 18:29-37.
    • (2005) Atherosclerosis , vol.18 , pp. 29-37
    • Graham, T.L.1    Mookherjee, C.2    Suckling, K.E.3
  • 30
    • 85047693466 scopus 로고    scopus 로고
    • Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma
    • Li AC, Binder CJ, Gutierrez A, et al.: Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. J Clin Invest 2004, 114:1564-1576.
    • (2004) J Clin Invest , vol.114 , pp. 1564-1576
    • Li, A.C.1    Binder, C.J.2    Gutierrez, A.3
  • 31
    • 9144271149 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome
    • Tanaka T, Yamamoto J, Iwasaki S, et al.: Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc Natl Acad Sci U S A 2003, 100:15924-15929.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15924-15929
    • Tanaka, T.1    Yamamoto, J.2    Iwasaki, S.3
  • 32
    • 0034685589 scopus 로고    scopus 로고
    • Activation of PPARdelta alters lipid metabolism in db/db mice
    • Leibowitz MD, Fievet C, Hennuyer N, et al.: Activation of PPARdelta alters lipid metabolism in db/db mice. FEBS Lett 2000, 473:333-336.
    • (2000) FEBS Lett , vol.473 , pp. 333-336
    • Leibowitz, M.D.1    Fievet, C.2    Hennuyer, N.3
  • 33
    • 1442301053 scopus 로고    scopus 로고
    • Genetic polymorphisms in peroxisome proliferator-activated receptor delta associated with obesity
    • Shin HD, Park BL, Kim LH, et al.: Genetic polymorphisms in peroxisome proliferator-activated receptor delta associated with obesity. Diabetes 2004, 53:847-851.
    • (2004) Diabetes , vol.53 , pp. 847-851
    • Shin, H.D.1    Park, B.L.2    Kim, L.H.3
  • 34
    • 0348134971 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor delta genotype in relation to cardiovascular risk factors and risk of coronary heart disease in hypercholesterolaemic men
    • Skogsberg J, McMahon AD, Karpe F, et al.: Peroxisome proliferator activated receptor delta genotype in relation to cardiovascular risk factors and risk of coronary heart disease in hypercholesterolaemic men. J Intern Med 2003, 254:597-604.
    • (2003) J Intern Med , vol.254 , pp. 597-604
    • Skogsberg, J.1    McMahon, A.D.2    Karpe, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.