Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model

Journal of Hepatology

Volumn 52, Issue 5, 2010, Pages 727-736

  Rector, R Scott ^a   Thyfault, John P ^a,b,c   Uptergrove, Grace M ^a   Morris, E Matthew ^a,c   Naples, Scott P ^c   Borengasser, Sarah J ^c   Mikus, Catherine R ^c   Laye, Matthew J ^c   Laughlin, M Harold ^a,c,d   Booth, Frank W ^a,c,d   Ibdah, Jamal A ^a,b,c  

^a UNIVERSITY OF MISSOURI   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c University of Missouri   (United States)

^d UNIVERSITY OF MISSOURI   (United States)

Author keywords

Fatty acid oxidation; Mitochondrial dysfunction; Non alcoholic fatty liver disease; OLETF rat

Indexed keywords

3 HYDROXYACYL COENZYME A DEHYDROGENASE; ALANINE AMINOTRANSFERASE; CARNITINE PALMITOYLTRANSFERASE I; CITRATE SYNTHASE; CYTOCHROME C; FATTY ACID; GLUCOSE; GLUTATHIONE; GLUTATHIONE DISULFIDE; INSULIN; TRIACYLGLYCEROL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; FATTY ACID OXIDATION; FATTY LIVER; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIVER FIBROSIS; LIVER HOMOGENATE; MALE; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; OTSUKA LONG EVANS TOKUSHIMA FATTY RAT; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TRANSMISSION ELECTRON MICROSCOPY; TRIACYLGLYCEROL BLOOD LEVEL; WESTERN BLOTTING;

ADIPOSE TISSUE; ANIMALS; AZO COMPOUNDS; BODY COMPOSITION; DISEASE MODELS, ANIMAL; ENERGY INTAKE; FATTY LIVER; GLUTATHIONE; GLUTATHIONE DISULFIDE; INSULIN RESISTANCE; MALE; MITOCHONDRIA, LIVER; OBESITY; OXIDATION-REDUCTION; PALMITIC ACID; RATS; RATS, LONG-EVANS; REFERENCE VALUES; SUPEROXIDE DISMUTASE;

EID: 77951632831     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2009.11.030     Document Type: Article

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