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Iizuka K, Miller B, Uyeda K. Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice. Am J Physiol Endocrinol Metab 2006; 291:E358-E364.
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31
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3543150636
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Merla G, Howald C, Antonarakis SE, Reymond A. The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3. Hum Mol Genet 2004; 13:1505-1514.
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Kawaguchi T, Osatomi K, Yamashita H, et al. Mechanism for fatty acid 'sparing' effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase. J Biol Chem 2002; 277:3829-3835.
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Tsatsos NG, Towle HC. Glucose activation of ChREBP in hepatocytes occurs via a two-step mechanism. Biochem Biophys Res Commun 2006; 340:449-456.
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42449123308
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Identification and function of phosphorylation in the glucose-regulated transcription factor ChREBP
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This study identified multiple sites of phosphorylation within the ChREBP protein
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Tsatsos NG, Davies MN, O'Callaghan BL, Towle HC. Identification and function of phosphorylation in the glucose-regulated transcription factor ChREBP. Biochem J 2008; 11:261-270. This study identified multiple sites of phosphorylation within the ChREBP protein.
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Tsatsos, N.G.1
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35
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Identification of cis-regulatory elements and trans-acting proteins of the rat carbohydrate response element binding protein gene
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37
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33847006599
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The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR
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This was the first study to identify ChREBP as a direct target of LXRs in liver
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Cha JY, Repa JJ. The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem 2007; 282:743-751. This was the first study to identify ChREBP as a direct target of LXRs in liver.
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Cha, J.Y.1
Repa, J.J.2
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The nuclear receptor LXR is a glucose sensor
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This study identified LXRs as glucose sensors in the hepatoma cell line HepG2
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Mitro N, Mak PA, Vargas L, et al. The nuclear receptor LXR is a glucose sensor. Nature 2007; 445:219-223. This study identified LXRs as glucose sensors in the hepatoma cell line HepG2.
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Mitro, N.1
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The authors present arguments against the hypothesis that LXRs may be considered as glucose sensors in liver
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Lazar MA, Willson TM. Sweet dreams for LXR. Cell Metab 2007; 5:159-161. The authors present arguments against the hypothesis that LXRs may be considered as glucose sensors in liver.
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Lazar, M.A.1
Willson, T.M.2
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