Antioxidant defence mechanisms: New players in the pathogenesis of non-alcoholic steatohepatitis?

Clinical Science

Volumn 106, Issue 3, 2004, Pages 235-237

  Leclercq, Isabelle A ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Antioxidant pathway; Glutathione; Non alcoholic fatty liver disease; Oxidative stress

Indexed keywords

CYTOCHROME P450; SUPEROXIDE DISMUTASE;

ANTIOXIDANT ACTIVITY; DEFENSE MECHANISM; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE MARKER; ENZYME ACTIVITY; FATTY LIVER; HUMAN; LIVER BIOPSY; LIVER FATTY DEGENERATION; OBESITY; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; REVIEW;

ANTIOXIDANTS; CYTOCHROME P-450 ENZYME SYSTEM; DISEASE PROGRESSION; FATTY LIVER; HUMANS; LIVER; OXIDATIVE STRESS;

EID: 1642292288     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20030368     Document Type: Review

References (18)

1. Angulo, P. (2002) Nonalcoholic fatty liver disease. N. Eng. J. Med. 346, 1221-1231
2. Marchesini, G., Brizi, M., Morselli-Labate, A. M. et al. (1999) Association of non alcoholic fatty liver disease with insulin resistance. Am. J. Med. 107, 450-455
3. Day, C. P. and James, O. (1998) Steatohepatitis: a tale of two "hits"? Gastroenterology 114, 842-845
4. Robertson, G. R., Leclercq, I. and Farrell, G. C. (2001) Nonalcoholic steatosis and steatohepatitis: cytochrome P-450 enzymes and oxidative stress. Am. J. Physiol. Gastrointest. Liver Physiol. 281, G1135-G1139
5. Seki, S., Kitada, T., Yamada, T., Sakagushi, H., Nakatani, K. and Wakasa, K. (2002) In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases. J. Hepatol. 37, 56-62
6. Macdonald, G. A., Bridle, K. R., Ward, P. J. et al. (2001) Lipid peroxidation in hepatic steatosis is associated with hepatic fibrosis and occurs predominantly in acinar zone 3. J. Gastroenterol. Hepatol. 16, 599-606
7. Sanyal, A. J., Campbell-Sargent, C., Mishahi, F. et al. (2001) Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 120, 1183-1192
8. Videla, L. A., Rodrigo, R., Orellana, M. et al. (2004) Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients. Clin. Sci. 106, 261-268
9. Pessayre, D., Mansouri, A. and Fromenty, B. (2002) Nonalcoholic steatosis and steatohepatitis: mitochondrial dysfunction in steatohepatitis. Am. J. Physiol. Gastrointest. Liver Physiol. 282, G193-G199
10. Cortez-Pinto, H., Chatham, J., Chacko, V. P., Arnold, C., Rashid, A. and Diehl, A. M. (1999) Alteration of liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study. JAMA, J. Am. Med. Assoc. 282, 1659-1664
11. Perez-Carreras, M., Del Hoyo, P., Martin, M. A. et al. (2003) Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis. Hepatology 38, 999-1007
12. Reddy, J. K. (2001) Nonalcoholic steatosis and steatohepatitis: peroxisomal β-oxidation, PPAR-α and steatohepatitis. Am. J. Physiol. Gastrointest. Liver Physiol. 281, G1333-G1339
13. Weltman, M. D., Farrell, G. C., Hall, P., Ingelman-Sundberg, M. and Liddle, C. (1998) Hepatic cytochrome P450 2E1 is increased in patients with non alcoholic steatohepatitis. Hepatology 28, 128-133
14. Emery, M. G., Fisher, J. M., Chien, J. Y. et al. (2003) CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease. Hepatology 38, 428-435
15. Allen, R. G. and Tresini, M. (2000) Oxidative stress and gene regulation. Free Radical Biol. Med. 28, 463-499
16. Liu, H., Jones, B. E., Bradham, C. and Czaja, M. J. (2002) Increased cytochrome P-450 2E1 expression sensitises hepatocytes to c-Jun mediated cell death from TNF-α. Am. J. Physiol. Gastrointest. Liver Physiol. 282, G257-G226
17. Takamura, T., Honda, M., Sakurai, M., Ota, T. and Kaneko, S. (2003) Differential gene expression in the liver of type 2 diabetic patients: features of atherosclerosis and NASH. Hepatology 38, 507A
18. Sreekumar, R., Rosado, B., Rasmussen, D. and Charlton, M. (2003) Hepatic gene expression in histologically progressive nonalcoholic steatohepatitis. Hepatology 38, 244-251