메뉴 건너뛰기




Volumn 114, Issue 2, 2004, Pages 147-152

Molecular mediators of hepatic steatosis and liver injury

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE CITRATE LYASE; BINDING PROTEIN; CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN; CARNITINE PALMITOYLTRANSFERASE; FATTY ACID; FATTY ACID SYNTHASE; HORMONE SENSITIVE LIPASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIVER TYPE PYRUVATE KINASE; LONG CHAIN FATTY ACID; LONG CHAIN FATTY ACID ELONGASE; MALONYL COENZYME A; PYRUVATE KINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

EID: 4043077961     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200422422     Document Type: Review
Times cited : (1847)

References (84)
  • 1
    • 0038644536 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Summary of an AASLD single topic conference
    • Neuschwander-Tetri, B., and Caldwell, S. 2003. Nonalcoholic steatohepatitis: summary of an AASLD single topic conference. Hepatology. 37:1202-1219.
    • (2003) Hepatology , vol.37 , pp. 1202-1219
    • Neuschwander-Tetri, B.1    Caldwell, S.2
  • 2
    • 0038805259 scopus 로고    scopus 로고
    • The prevalence and etiology of elevated aminotransferase levels in the United States
    • Clark, J.M., Brancati, F.L., and Diehl, A.M. 2003. The prevalence and etiology of elevated aminotransferase levels in the United States. Am. J. Gastroenterol. 98:960-967.
    • (2003) Am. J. Gastroenterol. , vol.98 , pp. 960-967
    • Clark, J.M.1    Brancati, F.L.2    Diehl, A.M.3
  • 3
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo, P. 2002. Nonalcoholic fatty liver disease. N. Engl. J. Med. 346:1221-1231.
    • (2002) N. Engl. J. Med. , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 4
    • 0035431018 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease a feature of the metabolic syndrome
    • Marchesini, G., et al. 2001. Nonalcoholic fatty liver disease a feature of the metabolic syndrome. Diabetes. 50:1844-1850.
    • (2001) Diabetes , vol.50 , pp. 1844-1850
    • Marchesini, G.1
  • 5
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two "hits"?
    • Day, C.P., and James, O.F.W. 1998. Steatohepatitis: a tale of two "hits"? Gastroenterology. 114:842-845.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.W.2
  • 6
    • 0023714299 scopus 로고
    • Prevalence of fatty liver in a general population in Okinawa, Japan
    • Nomura, H., et al. 1988. Prevalence of fatty liver in a general population in Okinawa, Japan. Jpn. J. Med. 27:142-149.
    • (1988) Jpn. J. Med. , vol.27 , pp. 142-149
    • Nomura, H.1
  • 7
    • 0017739740 scopus 로고
    • Liver histology in a "normal" population - Examination of 503 consecutive fatal traffic casualties
    • Hilden, M., Christoffersen, P., Juhl, E., and Dalgaard, J.B. 1977. Liver histology in a "normal" population - examination of 503 consecutive fatal traffic casualties. Scand. J. Gastroenterol. 12:593-597.
    • (1977) Scand. J. Gastroenterol. , vol.12 , pp. 593-597
    • Hilden, M.1    Christoffersen, P.2    Juhl, E.3    Dalgaard, J.B.4
  • 8
    • 0033982172 scopus 로고    scopus 로고
    • Prevalence of and risk factors for hepatic steatosis in northern Italy
    • Bellentani, S., et al. 2000. Prevalence of and risk factors for hepatic steatosis in northern Italy. Ann. Intern. Med. 132:112-117.
    • (2000) Ann. Intern. Med. , vol.132 , pp. 112-117
    • Bellentani, S.1
  • 9
    • 0034982170 scopus 로고    scopus 로고
    • Prevalence of overweight in US children: Comparison of US growth charts from the Centers for Disease Control and Prevention with other reference values for body mass index
    • Flegal, K.M., Ogden, C.L., Wei, R., Kuczmarski, R.L., and Johnson, C.L. 2001. Prevalence of overweight in US children: comparison of US growth charts from the Centers for Disease Control and Prevention with other reference values for body mass index. Am. J. Clin. Nutr. 73:1086-1093.
    • (2001) Am. J. Clin. Nutr. , vol.73 , pp. 1086-1093
    • Flegal, K.M.1    Ogden, C.L.2    Wei, R.3    Kuczmarski, R.L.4    Johnson, C.L.5
  • 13
    • 0036217052 scopus 로고    scopus 로고
    • Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
    • Lewis, G.F., Carpentier, A., Adeli, K., and Giacca, A. 2002. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr. Rev. 23:201-229.
    • (2002) Endocr. Rev. , vol.23 , pp. 201-229
    • Lewis, G.F.1    Carpentier, A.2    Adeli, K.3    Giacca, A.4
  • 14
    • 0021436667 scopus 로고
    • Turnover and splanchnic metabolism of free fatty acids and ketones in insulin-dependent diabetics at rest and in response to exercise
    • Wahren, J., Sato, Y., Ostman, J., Hagenfeldt, L., and Felig, P. 1984. Turnover and splanchnic metabolism of free fatty acids and ketones in insulin-dependent diabetics at rest and in response to exercise. J. Clin. Invest. 73:1367-1376.
    • (1984) J. Clin. Invest. , vol.73 , pp. 1367-1376
    • Wahren, J.1    Sato, Y.2    Ostman, J.3    Hagenfeldt, L.4    Felig, P.5
  • 15
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • doi:10.1172/JCI200215593
    • Horton, J.D., Goldstein, J.L., and Brown, M.S. 2002. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109:1125-1131. doi:10.1172/JCI200215593.
    • (2002) J. Clin. Invest. , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 16
    • 2942706241 scopus 로고    scopus 로고
    • Increase in long-chain poly-unsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
    • Araya, J., et al. 2004. Increase in long-chain poly-unsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin. Sci. (Lond). 106:635-643.
    • (2004) Clin. Sci. (Lond) , vol.106 , pp. 635-643
    • Araya, J.1
  • 17
    • 0032567445 scopus 로고    scopus 로고
    • Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver
    • Shimomura, I., Shimano, H., Korn, B.S., Bashmakov, Y., and Horton, J.D. 1998. Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver. J. Biol. Chem. 273:35299-35306.
    • (1998) J. Biol. Chem. , vol.273 , pp. 35299-35306
    • Shimomura, I.1    Shimano, H.2    Korn, B.S.3    Bashmakov, Y.4    Horton, J.D.5
  • 18
    • 0035937750 scopus 로고    scopus 로고
    • Glucose and insulin function through two distinct transcription factors to stimulate expression of lipogenic enzyme genes in liver
    • Koo, S.-H., Dutcher, A.K., and Towle, H.C. 2001. Glucose and insulin function through two distinct transcription factors to stimulate expression of lipogenic enzyme genes in liver. J. Biol. Chem. 276:9437-9445.
    • (2001) J. Biol. Chem. , vol.276 , pp. 9437-9445
    • Koo, S.-H.1    Dutcher, A.K.2    Towle, H.C.3
  • 19
    • 0037178818 scopus 로고    scopus 로고
    • The role of SREBP-1c in nutritional regulation of lipogenic enzyme gene expression
    • Stoeckman, A.K., and Towle, H.C. 2002. The role of SREBP-1c in nutritional regulation of lipogenic enzyme gene expression. J. Biol. Chem. 277:27029-27035.
    • (2002) J. Biol. Chem. , vol.277 , pp. 27029-27035
    • Stoeckman, A.K.1    Towle, H.C.2
  • 20
    • 0033598749 scopus 로고    scopus 로고
    • Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes
    • Shimomura, I., et al. 1999. Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. Proc. Natl. Acad. Sci. U. S. A. 96:13656-13661.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 13656-13661
    • Shimomura, I.1
  • 21
    • 0033607176 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
    • Foretz, M., Guichard, C., Ferre, P., and Foufelle, F. 1999. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Proc. Natl. Acad. Sci. U. S. A. 96:12737-12742.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 12737-12742
    • Foretz, M.1    Guichard, C.2    Ferre, P.3    Foufelle, F.4
  • 22
    • 0030941803 scopus 로고    scopus 로고
    • The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
    • Brown, M.S., and Goldstein, J.L. 1997. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 89:331-340.
    • (1997) Cell , vol.89 , pp. 331-340
    • Brown, M.S.1    Goldstein, J.L.2
  • 23
    • 0142027805 scopus 로고    scopus 로고
    • Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
    • Horton, J.D., et al. 2003. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc. Natl. Acad. Sci. U. S. A. 100:12027-12032.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 12027-12032
    • Horton, J.D.1
  • 24
    • 0030907175 scopus 로고    scopus 로고
    • Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
    • Shimano, H., et al. 1997. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J. Clin. Invest. 99:846-854.
    • (1997) J. Clin. Invest. , vol.99 , pp. 846-854
    • Shimano, H.1
  • 25
    • 0033570119 scopus 로고    scopus 로고
    • Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus
    • Shimomura, I., Bashmakov, Y., and Horton, J.D. 1999. Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J. Biol. Chem. 274:30028-30032.
    • (1999) J. Biol. Chem. , vol.274 , pp. 30028-30032
    • Shimomura, I.1    Bashmakov, Y.2    Horton, J.D.3
  • 26
    • 0016394819 scopus 로고
    • In vivo lipogenesis, and enzyme levels in adipose tissue and liver tissues from pair-fed genetically obese and lean rats
    • Martin, R.J. 1974. In vivo lipogenesis, and enzyme levels in adipose tissue and liver tissues from pair-fed genetically obese and lean rats. Life Sci. 14:1447-1453.
    • (1974) Life Sci. , vol.14 , pp. 1447-1453
    • Martin, R.J.1
  • 27
  • 28
    • 0344406146 scopus 로고    scopus 로고
    • Mechanisms of the free fatty acid-induced increase in hepatic glucose production
    • Lam, T.K.T., et al. 2003. Mechanisms of the free fatty acid-induced increase in hepatic glucose production. Am. J. Physiol. Endociinol. Metab. 284:E863-E873.
    • (2003) Am. J. Physiol. Endociinol. Metab. , vol.284
    • Lam, T.K.T.1
  • 29
    • 0029073613 scopus 로고
    • Weight-reducing effects of the plasma protein encoded by the obese gene
    • Halaas, J.L., et al. 1995. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 269:543-546.
    • (1995) Science , vol.269 , pp. 543-546
    • Halaas, J.L.1
  • 30
    • 0037205433 scopus 로고    scopus 로고
    • Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lepob/Lepob mice
    • Yahagi, N., et al. 2002. Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lepob/Lepob mice. J. Biol. Chem. 277:19353-19357.
    • (2002) J. Biol. Chem. , vol.277 , pp. 19353-19357
    • Yahagi, N.1
  • 31
    • 0034652297 scopus 로고    scopus 로고
    • The subcellular localization of acetyl-CoA carboxylase 2
    • Abu-Elheiga, L., et al. 2000. The subcellular localization of acetyl-CoA carboxylase 2. Proc. Natl. Acad. Sci. U. S. A. 97:1444-1449.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 1444-1449
    • Abu-Elheiga, L.1
  • 32
    • 0017738601 scopus 로고
    • A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis
    • McGarry, J.D., Mannaerts, G.P., and Foster, D.W. 1977. A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis. J. Clin. Invest. 60:265-270.
    • (1977) J. Clin. Invest. , vol.60 , pp. 265-270
    • McGarry, J.D.1    Mannaerts, G.P.2    Foster, D.W.3
  • 33
    • 0035970805 scopus 로고    scopus 로고
    • Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2
    • Abu-Elheiga, L., Matzuk, M.M., Abo-Hashema, K.A.H., and Wakil, S.J. 2001. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science. 291:2613-2616.
    • (2001) Science , vol.291 , pp. 2613-2616
    • Abu-Elheiga, L.1    Matzuk, M.M.2    Abo-Hashema, K.A.H.3    Wakil, S.J.4
  • 34
    • 0042337449 scopus 로고    scopus 로고
    • Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets
    • Abu-Elheiga, L., Oh, W., Kordari, P., and Wakil, S.J. 2003. Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets. Proc. Natl. Acad. Sci. U. S. A. 100:10207-10212.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 10207-10212
    • Abu-Elheiga, L.1    Oh, W.2    Kordari, P.3    Wakil, S.J.4
  • 35
    • 2342509057 scopus 로고    scopus 로고
    • Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance
    • An, J., et al. 2004. Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nat. Med. 10:268-274.
    • (2004) Nat. Med. , vol.10 , pp. 268-274
    • An, J.1
  • 36
    • 0035979214 scopus 로고    scopus 로고
    • A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver
    • Yamashita, H., et al. 2001. A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver. Proc. Natl. Acad. Sci. U. S. A. 98:9116-9121.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 9116-9121
    • Yamashita, H.1
  • 37
    • 0037040185 scopus 로고    scopus 로고
    • Mechanism for fatty acid "sparing" effect on glucose-induced transcription. Regulation of carbohydrace-responsive element-binding protein by Amp-activated protein kinase
    • Kawaguchi, T., Osatomi, K., Yamashita, H., Kabashima, T., and Uyeda, K. 2002. Mechanism for fatty acid "sparing" effect on glucose-induced transcription. Regulation of carbohydrace-responsive element-binding protein by Amp-activated protein kinase. J. Biol. Chem. 277:3829-3835.
    • (2002) J. Biol. Chem. , vol.277 , pp. 3829-3835
    • Kawaguchi, T.1    Osatomi, K.2    Yamashita, H.3    Kabashima, T.4    Uyeda, K.5
  • 38
    • 2442435802 scopus 로고    scopus 로고
    • Deficiency of carbohydrate response element binding protein (ChREBP) reduces lipogenesis as well as glycolysis
    • In press
    • Iizuka, K., Bruick, R.K., Liang, G., Horton, J.D., and Uyeda, K. 2004. Deficiency of carbohydrate response element binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc. Nat. Acad. Sci. U. S. A. In press.
    • (2004) Proc. Nat. Acad. Sci. U. S. A.
    • Iizuka, K.1    Bruick, R.K.2    Liang, G.3    Horton, J.D.4    Uyeda, K.5
  • 39
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
    • Tontonoz, P., Hu, E., and Spiegelman, B.M. 1994. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell. 79:1147-1156.
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 40
    • 0032587268 scopus 로고    scopus 로고
    • Rosiglitazone (BRL49653), a PPARgamma-selective agonist, causes peroxisome proliferator-like liver effects in obese mice
    • Edvardsson, U., et al. 1999. Rosiglitazone (BRL49653), a PPARgamma-selective agonist, causes peroxisome proliferator-like liver effects in obese mice. J. Lipid. Res. 40:1177-1184.
    • (1999) J. Lipid. Res. , vol.40 , pp. 1177-1184
    • Edvardsson, U.1
  • 41
    • 0033708410 scopus 로고    scopus 로고
    • Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones
    • Chao, L., et al. 2000. Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones. J. Clin. Invest. 106:1221-1228.
    • (2000) J. Clin. Invest. , vol.106 , pp. 1221-1228
    • Chao, L.1
  • 42
  • 43
    • 0032793068 scopus 로고    scopus 로고
    • Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: Implications for adipocyte differentiation and metabolism
    • Fajas, L., et al. 1999. Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism. Mol. Cell. Biol. 19:5495-5503.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 5495-5503
    • Fajas, L.1
  • 44
    • 0037373008 scopus 로고    scopus 로고
    • Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes
    • doi:10.1172/JCI200317223
    • Matsusue, K., et al. 2003. Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J. Clin. Invest. 111:737-747. doi:10.1172/JCI200317223.
    • (2003) J. Clin. Invest. , vol.111 , pp. 737-747
    • Matsusue, K.1
  • 45
    • 0141446024 scopus 로고    scopus 로고
    • Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steacosis, triglyceride clearance, and regulation of body fat mass
    • Gavrilova, O., et al. 2003. Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steacosis, triglyceride clearance, and regulation of body fat mass. J. Biol. Chem. 278:34268-34276.
    • (2003) J. Biol. Chem. , vol.278 , pp. 34268-34276
    • Gavrilova, O.1
  • 46
    • 0344081177 scopus 로고    scopus 로고
    • Minireview: The AMP-activated protein kinase cascade: The key sensor of cellular energy status
    • Hardie, D.G. 2003. Minireview: The AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology. 144:5179-5183.
    • (2003) Endocrinology , vol.144 , pp. 5179-5183
    • Hardie, D.G.1
  • 47
    • 0037067570 scopus 로고    scopus 로고
    • Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss
    • Cohen, P., et al. 2002. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science. 297:240-243.
    • (2002) Science , vol.297 , pp. 240-243
    • Cohen, P.1
  • 48
    • 0037143752 scopus 로고    scopus 로고
    • Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
    • Ntambi, J.M., et al. 2002. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc. Natl. Acad. Sci. U. S. A. 99:11482-11486.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 11482-11486
    • Ntambi, J.M.1
  • 49
    • 2342652187 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver
    • Dobrzyn, P., et al. 2004. Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proc. Natl. Acad. Sci. U. S. A. 101:6409-6414.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 6409-6414
    • Dobrzyn, P.1
  • 50
    • 0038199737 scopus 로고    scopus 로고
    • Management of cellular energy by the AMP-activated protein kinase system
    • Hardie, D.G., Scott, J.W., Pan, D.A., and Hudson, E.R. 2003. Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett. 546:113-120.
    • (2003) FEBS Lett. , vol.546 , pp. 113-120
    • Hardie, D.G.1    Scott, J.W.2    Pan, D.A.3    Hudson, E.R.4
  • 51
    • 0035923516 scopus 로고    scopus 로고
    • Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein
    • Kawaguchi, T., Takenoshica, M., Kabashima, T., and Uyeda, K. 2001. Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein. Proc. Natl. Acad. Sci. U. S. A. 98:13710-13715.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 13710-13715
    • Kawaguchi, T.1    Takenoshica, M.2    Kabashima, T.3    Uyeda, K.4
  • 52
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • doi:10.1172/JCI200113505
    • Zhou, G., et al. 2001. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 108:1167-1174. doi:10.1172/JCI200113505.
    • (2001) J. Clin. Invest. , vol.108 , pp. 1167-1174
    • Zhou, G.1
  • 53
    • 0012785395 scopus 로고    scopus 로고
    • Metformin reverses fatty liver disease in obese, leptin-deficient mice
    • Lin, H.Z., et al. 2000. Metformin reverses fatty liver disease in obese, leptin-deficient mice. Nat. Med. 6:998-1003.
    • (2000) Nat. Med. , vol.6 , pp. 998-1003
    • Lin, H.Z.1
  • 54
    • 0035883890 scopus 로고    scopus 로고
    • Metformin in non-alcoholic steatohepatitis
    • Marchesini, G., et al. 2001. Metformin in non-alcoholic steatohepatitis. Lancet. 358:893-894.
    • (2001) Lancet , vol.358 , pp. 893-894
    • Marchesini, G.1
  • 55
    • 0037067666 scopus 로고    scopus 로고
    • The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
    • Fryer, L.G., Parbu-Patel, A., and Carling, D. 2002. The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J. Biol. Chem. 277:25226-25232.
    • (2002) J. Biol. Chem. , vol.277 , pp. 25226-25232
    • Fryer, L.G.1    Parbu-Patel, A.2    Carling, D.3
  • 56
    • 0346374720 scopus 로고    scopus 로고
    • Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo
    • Saha, A.K., et al. 2004. Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo. Biochem. Biophys. Res. Commun. 314:580-585.
    • (2004) Biochem. Biophys. Res. Commun. , vol.314 , pp. 580-585
    • Saha, A.K.1
  • 57
    • 0037567697 scopus 로고    scopus 로고
    • Pioglitazone reduces hepatic fat content and augments splanchnic glucose uptake in patients with type 2 diabetes
    • Bajaj, M., et al. 2003. Pioglitazone reduces hepatic fat content and augments splanchnic glucose uptake in patients with type 2 diabetes. Diabetes. 52:1364-1370.
    • (2003) Diabetes , vol.52 , pp. 1364-1370
    • Bajaj, M.1
  • 58
    • 1442355447 scopus 로고    scopus 로고
    • A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis
    • Promrat, K., et al. 2004. A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis. Hepatology. 39:188-196.
    • (2004) Hepatology , vol.39 , pp. 188-196
    • Promrat, K.1
  • 59
    • 0141532275 scopus 로고    scopus 로고
    • Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone
    • Neuschwander-Tetri, B.A., et al. 2003. Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone. Hepatology. 38:1008-1017.
    • (2003) Hepatology , vol.38 , pp. 1008-1017
    • Neuschwander-Tetri, B.A.1
  • 60
    • 0029846701 scopus 로고    scopus 로고
    • Regulation of hepatic de novo lipogenesis in humans
    • Hellerstein, M.K., Schwarz, J.M., and Neese, R.A. 1996. Regulation of hepatic de novo lipogenesis in humans. Annu. Rev. Nutr. 16:523-557.
    • (1996) Annu. Rev. Nutr. , vol.16 , pp. 523-557
    • Hellerstein, M.K.1    Schwarz, J.M.2    Neese, R.A.3
  • 61
    • 0036079637 scopus 로고    scopus 로고
    • Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity
    • Diraison, F., Dusserre, E., Vidal, H., Sothier, M., and Beylot, M. 2002. Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity. Am. J. Physiol. Endocrinol. Metab. 282:E46-E51.
    • (2002) Am. J. Physiol. Endocrinol. Metab. , vol.282
    • Diraison, F.1    Dusserre, E.2    Vidal, H.3    Sothier, M.4    Beylot, M.5
  • 62
    • 0035196704 scopus 로고    scopus 로고
    • Nonalcoholic steatosis and steatohepatitis: II. Cytochrome P-450 enzymes and oxidative stress
    • Robertson, G., Leclercq, I., and Farrell, G.C. 2001. Nonalcoholic steatosis and steatohepatitis: II. Cytochrome P-450 enzymes and oxidative stress. Am. J. Physiol. Gastrointest. Liver Physiol. 281:G1135-G1139.
    • (2001) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.281
    • Robertson, G.1    Leclercq, I.2    Farrell, G.C.3
  • 63
    • 0742306111 scopus 로고    scopus 로고
    • CYP2E1: From ASH to NASH
    • Lieber, C.S. 2004. CYP2E1: from ASH to NASH. Hepatol. Res. 28:1-11.
    • (2004) Hepatol. Res. , vol.28 , pp. 1-11
    • Lieber, C.S.1
  • 64
    • 0034573050 scopus 로고    scopus 로고
    • Peroxisomal lipid degradation via beta- and alpha-oxidation in mammals
    • Mannaerts, G.P., Van Veldhoven, P.P., and Casteels, M. 2000. Peroxisomal lipid degradation via beta- and alpha-oxidation in mammals. Cell Biochem. Biophys. 32:73-87.
    • (2000) Cell Biochem. Biophys. , vol.32 , pp. 73-87
    • Mannaerts, G.P.1    Van Veldhoven, P.P.2    Casteels, M.3
  • 65
    • 0028788763 scopus 로고
    • Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: Studies with isolated mitochondria and rat hepatocytes
    • Garcia-Ruiz, C., Colell, A., Morales, A., Kaplowitz, N., and Fernandez-Checa, J.C. 1995. Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes. Mol. Pharmacol. 48:825-834.
    • (1995) Mol. Pharmacol. , vol.48 , pp. 825-834
    • Garcia-Ruiz, C.1    Colell, A.2    Morales, A.3    Kaplowitz, N.4    Fernandez-Checa, J.C.5
  • 66
    • 0034019329 scopus 로고    scopus 로고
    • Dietary choline restriction causes complex I dysfunction and increased H(2)O(2) generation in liver mitochondria
    • Hensley, K., et al. 2000. Dietary choline restriction causes complex I dysfunction and increased H(2)O(2) generation in liver mitochondria. Carcinogenesis. 21:983-989.
    • (2000) Carcinogenesis , vol.21 , pp. 983-989
    • Hensley, K.1
  • 68
    • 0034659814 scopus 로고    scopus 로고
    • Mitochondrial adaptations to obesity-related oxidant stress
    • Yang, S., et al. 2000. Mitochondrial adaptations to obesity-related oxidant stress. Arch. Biochem. Biophys. 378:259-268.
    • (2000) Arch. Biochem. Biophys. , vol.378 , pp. 259-268
    • Yang, S.1
  • 69
    • 0035991444 scopus 로고    scopus 로고
    • In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases
    • Seki, S., et al. 2002. In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases. J. Hepatol. 37:56-62.
    • (2002) J. Hepatol. , vol.37 , pp. 56-62
    • Seki, S.1
  • 70
  • 71
    • 0033198978 scopus 로고    scopus 로고
    • Mitochondrial abnormalities in non-alcoholic steatohepatitis
    • Caldwell, S.H., et al. 1999. Mitochondrial abnormalities in non-alcoholic steatohepatitis. J. Hepatol. 31:430-434.
    • (1999) J. Hepatol. , vol.31 , pp. 430-434
    • Caldwell, S.H.1
  • 72
    • 0031921972 scopus 로고    scopus 로고
    • Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes
    • Berson, A., et al. 1998. Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes. Gastroenterology. 114:764-774.
    • (1998) Gastroenterology , vol.114 , pp. 764-774
    • Berson, A.1
  • 73
    • 18144444592 scopus 로고    scopus 로고
    • Defective hepatic mitochondrial respiratory chain in patients with non-alcoholic steatohepatitis
    • Perez-Carreras, M., et al. 2003. Defective hepatic mitochondrial respiratory chain in patients with non-alcoholic steatohepatitis. Hepatology. 38:999-1007.
    • (2003) Hepatology , vol.38 , pp. 999-1007
    • Perez-Carreras, M.1
  • 75
    • 0029796038 scopus 로고    scopus 로고
    • Role of the peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation
    • Johnson, E.F., Palmer, C.N., Griffin, K.J., and Hsu, M.H. 1996. Role of the peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation. FASEB J. 10:1241-1248.
    • (1996) FASEB J. , vol.10 , pp. 1241-1248
    • Johnson, E.F.1    Palmer, C.N.2    Griffin, K.J.3    Hsu, M.H.4
  • 76
    • 0032699670 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
    • Kersten, S., et al. 1999. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J. Clin. Invest. 103:1489-1498.
    • (1999) J. Clin. Invest. , vol.103 , pp. 1489-1498
    • Kersten, S.1
  • 77
    • 0021809180 scopus 로고
    • Effect of Reye's syndrome serum on isolated chinchilla liver mitochondria
    • Tonsgard, J.H., and Getz, G.S. 1985. Effect of Reye's syndrome serum on isolated chinchilla liver mitochondria. J. Clin. Invest. 76:816-825.
    • (1985) J. Clin. Invest. , vol.76 , pp. 816-825
    • Tonsgard, J.H.1    Getz, G.S.2
  • 78
    • 0032512651 scopus 로고    scopus 로고
    • Mitochondria uncoupling by a long chain fatty acyl analogue
    • Hermesh, O., Kalderon, B., and Bar-Tana, J. 1998. Mitochondria uncoupling by a long chain fatty acyl analogue. J. Biol. Chem. 273:3937-3942.
    • (1998) J. Biol. Chem. , vol.273 , pp. 3937-3942
    • Hermesh, O.1    Kalderon, B.2    Bar-Tana, J.3
  • 79
    • 0025814980 scopus 로고
    • Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
    • Esterbauer, H., Schaur, R.J., and Zollner, H. 1991. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic. Biol. Med. 11:81-128.
    • (1991) Free Radic. Biol. Med. , vol.11 , pp. 81-128
    • Esterbauer, H.1    Schaur, R.J.2    Zollner, H.3
  • 80
    • 0024354775 scopus 로고
    • Oxygen radical chemistry of polyunsaturated fatty acids
    • Gardner, H.W. 1989. Oxygen radical chemistry of polyunsaturated fatty acids. Free Radic. Biol. Med. 7:65-86.
    • (1989) Free Radic. Biol. Med. , vol.7 , pp. 65-86
    • Gardner, H.W.1
  • 81
    • 0028207325 scopus 로고
    • Free radical-mediated lipid peroxidation in cells: Oxidizability is a function of cell lipid bis-allylic hydrogen content
    • Wagner, B.A., Buettner, G.R., and Bums, C.P. 1994. Free radical-mediated lipid peroxidation in cells: oxidizability is a function of cell lipid bis-allylic hydrogen content. Biochemistry. 33:4449-4453.
    • (1994) Biochemistry , vol.33 , pp. 4449-4453
    • Wagner, B.A.1    Buettner, G.R.2    Bums, C.P.3
  • 82
    • 0033955887 scopus 로고    scopus 로고
    • Secondary carnitine deficiency and impaired docosahexaenoic (22:6n-3) acid synthesis: A common denominator in the pathophysiology of diseases of oxidative phosphorylation and beta-oxidation
    • Infante, J.P., and Huszagh, V.A. 2000. Secondary carnitine deficiency and impaired docosahexaenoic (22:6n-3) acid synthesis: a common denominator in the pathophysiology of diseases of oxidative phosphorylation and beta-oxidation. FEBS Lett. 468:1-5.
    • (2000) FEBS Lett. , vol.468 , pp. 1-5
    • Infante, J.P.1    Huszagh, V.A.2
  • 83
    • 85047692761 scopus 로고    scopus 로고
    • Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production
    • doi:10.1172/JC1200419197
    • Pan, M., et al. 2004. Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production. J. Clin. Invest. 113:1277-1287. doi:10.1172/JC1200419197.
    • (2004) J. Clin. Invest. , vol.113 , pp. 1277-1287
    • Pan, M.1
  • 84
    • 0037462684 scopus 로고    scopus 로고
    • Globular adiponectin protected ob/ob mice from diabetes and apoE-deficient mice from atherosclerosis
    • Yamauchi, T., et al. 2003. Globular adiponectin protected ob/ob mice from diabetes and apoE-deficient mice from atherosclerosis. J. Biol. Chem. 278:2461-2468.
    • (2003) J. Biol. Chem. , vol.278 , pp. 2461-2468
    • Yamauchi, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.