메뉴 건너뛰기




Volumn 432, Issue 7020, 2004, Pages 1027-1032

Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; FATTY ACIDS; GENES; GLUCOSE; INSULIN; LIPIDS; OXIDATION;

EID: 11144244418     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03047     Document Type: Article
Times cited : (352)

References (30)
  • 1
    • 0141705364 scopus 로고    scopus 로고
    • Insulin regulates the activity of forkhead transcription factor Hnf-3β/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization
    • Wolfrum, C., Besser, D., Luca, E. & Stoffel, M. Insulin regulates the activity of forkhead transcription factor Hnf-3β/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization. Proc. Natl Acad. Sci. USA 100, 11624-11629 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 11624-11629
    • Wolfrum, C.1    Besser, D.2    Luca, E.3    Stoffel, M.4
  • 2
    • 0141839103 scopus 로고    scopus 로고
    • Novel concepts in insulin regulation of hepatic gluconeogenesis
    • Barthel, A. & Schmoll, D. Novel concepts in insulin regulation of hepatic gluconeogenesis. Am. J. Physiol. Endocrinol. Metab. 285, E685-E692 (2003).
    • (2003) Am. J. Physiol. Endocrinol. Metab. , vol.285
    • Barthel, A.1    Schmoll, D.2
  • 3
    • 0033400713 scopus 로고    scopus 로고
    • Ketone bodies: A review of physiology, pathophysiology and application of monitoring to diabetes
    • Laffel, L. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab. Res. Rev. 15, 412-426 (1999).
    • (1999) Diabetes Metab. Res. Rev. , vol.15 , pp. 412-426
    • Laffel, L.1
  • 5
    • 0036217052 scopus 로고    scopus 로고
    • Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
    • Lewis, G. E, Carpentier, A., Adeli, K. & Giacca, A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr. Rev. 23, 201-229 (2002).
    • (2002) Endocr. Rev. , vol.23 , pp. 201-229
    • Lewis, G.E.1    Carpentier, A.2    Adeli, K.3    Giacca, A.4
  • 6
    • 0036092239 scopus 로고    scopus 로고
    • Banting lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
    • McGarry, J. D. Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51, 7-18 (2002).
    • (2002) Diabetes , vol.51 , pp. 7-18
    • McGarry, J.D.1
  • 7
    • 0035185021 scopus 로고    scopus 로고
    • The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
    • Nakae, J., Kitamura, T., Silver, D. L. & Accili, D. The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J. Clin. Invest. 108, 1359-1367 (2001).
    • (2001) J. Clin. Invest. , vol.108 , pp. 1359-1367
    • Nakae, J.1    Kitamura, T.2    Silver, D.L.3    Accili, D.4
  • 8
    • 0031039024 scopus 로고    scopus 로고
    • Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
    • Franke, T. E, Kaplan, D. R., Cantley, L. C. & Toker, A. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4- bisphosphate. Science 275, 665-668 (1997).
    • (1997) Science , vol.275 , pp. 665-668
    • Franke, T.E.1    Kaplan, D.R.2    Cantley, L.C.3    Toker, A.4
  • 9
    • 0141727772 scopus 로고    scopus 로고
    • Inhibition of Foxo 1 function is associated with improved fasting glycemia in diabetic mice
    • Altomonte, J. at al. Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice. Am. J. Physiol. Endocrinol. Metab. 285, E718-E728 (2003).
    • (2003) Am. J. Physiol. Endocrinol. Metab. , vol.285
    • Altomonte, J.1
  • 10
    • 0038187621 scopus 로고    scopus 로고
    • Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1a interaction
    • Puigserver, P. et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1a interaction. Nature 423, 550-555 (2003).
    • (2003) Nature , vol.423 , pp. 550-555
    • Puigserver, P.1
  • 11
    • 0032532152 scopus 로고    scopus 로고
    • Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: Model for congenital generalized hpodystrophy
    • Shimomura, I. et al. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized hpodystrophy. Genes Dev. 12, 3182-3194 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 3182-3194
    • Shimomura, I.1
  • 12
    • 0033636780 scopus 로고    scopus 로고
    • Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
    • Shimomura, I. et al. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol. Cell 6, 77-86 (2000).
    • (2000) Mol. Cell , vol.6 , pp. 77-86
    • Shimomura, I.1
  • 13
    • 0023706706 scopus 로고
    • Inhibition of the mitochondrial oxidation of fatty acids by tetracycline in mice and in man: Possible role in microvesicular steatosis induced by this antibiotic
    • Freneaux, E. et al. Inhibition of the mitochondrial oxidation of fatty acids by tetracycline in mice and in man: possible role in microvesicular steatosis induced by this antibiotic. Hepatology 8, 1056-1062 (1988).
    • (1988) Hepatology , vol.8 , pp. 1056-1062
    • Freneaux, E.1
  • 14
    • 0028025566 scopus 로고
    • The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo
    • Weinstein, D. C. et al. The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo. Cell 78, 575-588 (1994).
    • (1994) Cell , vol.78 , pp. 575-588
    • Weinstein, D.C.1
  • 15
    • 0035855858 scopus 로고    scopus 로고
    • Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
    • Yoon, J. C. et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413, 131-138 (2001).
    • (2001) Nature , vol.413 , pp. 131-138
    • Yoon, J.C.1
  • 16
    • 0035855905 scopus 로고    scopus 로고
    • CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
    • Herzig, S. et al. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 413, 179-183 (2001).
    • (2001) Nature , vol.413 , pp. 179-183
    • Herzig, S.1
  • 17
    • 0025223778 scopus 로고
    • Regulation of the gene expression of glucokinase and L-type pyruvate kinase in primary cultures of rat hepatocytes by hormones and carbohydrates
    • Matsuda, T., Noguchi, T., Yamada, K., Takenaka,M. & Tanaka, T. Regulation of the gene expression of glucokinase and L-type pyruvate kinase in primary cultures of rat hepatocytes by hormones and carbohydrates. J. Biochem. (Tokyo) 108, 778-784 (1990).
    • (1990) J. Biochem. (Tokyo) , vol.108 , pp. 778-784
    • Matsuda, T.1    Noguchi, T.2    Yamada, K.3    Takenaka, M.4    Tanaka, T.5
  • 18
    • 0028158283 scopus 로고
    • Transcriptional control of metabolic regulation genes by carbohydrates
    • Vaulont, S. & Kahn, A. Transcriptional control of metabolic regulation genes by carbohydrates. FASEB J. 8, 28-35 (1994).
    • (1994) FASEB J. , vol.8 , pp. 28-35
    • Vaulont, S.1    Kahn, A.2
  • 19
    • 0033605261 scopus 로고    scopus 로고
    • Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion
    • Chavin, K. D. et al. Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion. J. Biol. Chem. 274, 5692-5700 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 5692-5700
    • Chavin, K.D.1
  • 20
    • 2342509057 scopus 로고    scopus 로고
    • Hepatic expression of malonyl-Coa expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance
    • An, J. et al. Hepatic expression of malonyl-Coa expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nature Med. 10, 268-274 (2004).
    • (2004) Nature Med. , vol.10 , pp. 268-274
    • An, J.1
  • 21
    • 0041314066 scopus 로고    scopus 로고
    • Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice
    • Voshol, P. J. et al. Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice. Endocrinology 144, 3456-3462 (2003).
    • (2003) Endocrinology , vol.144 , pp. 3456-3462
    • Voshol, P.J.1
  • 22
    • 0030695445 scopus 로고    scopus 로고
    • The maturity-onset diabetes of the young (MODY 1) transcription factor HNF4α regulates expression of genes required for glucose transport and metabolism
    • Stoffel, M. & Duncan, S. A. The maturity-onset diabetes of the young (MODY 1) transcription factor HNF4α regulates expression of genes required for glucose transport and metabolism. Proc. Natl. Acad. Sci. USA 94, 13209-13214 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 13209-13214
    • Stoffel, M.1    Duncan, S.A.2
  • 23
    • 0037064057 scopus 로고    scopus 로고
    • The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression bit cAMP in combination with HNF4α and cAMP-response element-binding protein (CREB)
    • Louet, J. F., Hayhurst, G., Gonzalez, F. J., Girard, J. & Decaux, J. F. The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression bit cAMP in combination with HNF4α and cAMP-response element-binding protein (CREB). J. Biol. Chem. 277, 37991-38000 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 37991-38000
    • Louet, J.F.1    Hayhurst, G.2    Gonzalez, F.J.3    Girard, J.4    Decaux, J.F.5
  • 24
    • 0842263985 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor-γ in the glucose-sensing apparatus of liver and β-cells
    • Kim, H. I. & Ahn, Y. H. Role of peroxisome proliferator-activated receptor-γ in the glucose-sensing apparatus of liver and β-cells. Diabetes 53 (Suppl. 1), S60-S65 (2004).
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 1
    • Kim, H.I.1    Ahn, Y.H.2
  • 25
    • 0029938951 scopus 로고    scopus 로고
    • Preparation of transcriptionally active nuclear extracts from mammalian tissues
    • Stuempfle, K. J., Koptides, M., Karinch, A. M. & Floros, J. Preparation of transcriptionally active nuclear extracts from mammalian tissues. BioTechniques 21, 48-50, 52 (1996).
    • (1996) BioTechniques , vol.21 , pp. 48-50
    • Stuempfle, K.J.1    Koptides, M.2    Karinch, A.M.3    Floros, J.4
  • 26
    • 0027967521 scopus 로고
    • Hepatocyte nuclear factor-3 (HNF-3) binds to the insulin response sequence in the IGF binding protein-1 (IGFBP-1) promoter and enhances promoter function
    • Unterman, T. G. et al. Hepatocyte nuclear factor-3 (HNF-3) binds to the insulin response sequence in the IGF binding protein-1 (IGFBP-1) promoter and enhances promoter function. Biochem. Biophys. Res. Commun. 203, 1835-1841 (1994).
    • (1994) Biochem. Biophys. Res. Commun. , vol.203 , pp. 1835-1841
    • Unterman, T.G.1
  • 27
    • 0035072875 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-1α is an essential regulator of bile acid and plasma cholesterol metabolism
    • Shih, D. Q. et al. Hepatocyte nuclear factor-1α is an essential regulator of bile acid and plasma cholesterol metabolism. Nature Genet. 27, 375-382 (2001).
    • (2001) Nature Genet. , vol.27 , pp. 375-382
    • Shih, D.Q.1
  • 28
    • 0020065759 scopus 로고
    • Mechanism of insulin resistance in fructosefed rats
    • Tobey, T. A., Mondon, C. E., Zavaroni, I. & Reaven, G. M. Mechanism of insulin resistance in fructosefed rats. Metabolism 31, 608-612 (1982).
    • (1982) Metabolism , vol.31 , pp. 608-612
    • Tobey, T.A.1    Mondon, C.E.2    Zavaroni, I.3    Reaven, G.M.4
  • 29
    • 0018399518 scopus 로고
    • Riboflavin and rat hepatic cell structure and function. Mitochondrial oxidative metabolism in deficiency states
    • Hoppel, C., DiMarco, J. P. & Tandler, B. Riboflavin and rat hepatic cell structure and function. Mitochondrial oxidative metabolism in deficiency states. J. Biol. Chem. 254, 4164-4170 (1979).
    • (1979) J. Biol. Chem. , vol.254 , pp. 4164-4170
    • Hoppel, C.1    DiMarco, J.P.2    Tandler, B.3
  • 30
    • 0035130711 scopus 로고    scopus 로고
    • Impaired hepatic fatty acid oxidation in rats with short-term cholestasis: Characterization and mechanism
    • Lang, C. et al. Impaired hepatic fatty acid oxidation in rats with short-term cholestasis: characterization and mechanism. J. Lipid Res. 42, 22-30 (2001).
    • (2001) J. Lipid Res. , vol.42 , pp. 22-30
    • Lang, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.