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Volumn 30, Issue 3, 2009, Pages 171-179

Oxysterols and neurodegenerative diseases

Author keywords

Amyloid; 24S Hydroxycholesterol; 27 Hydroxycholesterol; Activity regulated cytoskeleton associated protein; Blood brain barrier; CYP27; CYP46

Indexed keywords

26 HYDROXYCHOLESTEROL; BIOLOGICAL MARKER; CHOLESTEROL; OXYSTEROL;

EID: 67349094556     PISSN: 00982997     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mam.2009.02.001     Document Type: Review
Times cited : (239)

References (57)
  • 4
    • 2442557294 scopus 로고    scopus 로고
    • Brain cholesterol: long secret life behind a barrier
    • Björkhem I., and Meaney S. Brain cholesterol: long secret life behind a barrier. Arterioscl. Thromb. Vasc. Biol. 24 (2004) 806-815
    • (2004) Arterioscl. Thromb. Vasc. Biol. , vol.24 , pp. 806-815
    • Björkhem, I.1    Meaney, S.2
  • 5
    • 0030729021 scopus 로고    scopus 로고
    • Importance of a novel oxidative mechanism for elimination of brain cholesterol
    • Björkhem I., Lütjohann D., Breuer O., Sakinis A., and och Wennmalm A. Importance of a novel oxidative mechanism for elimination of brain cholesterol. J. Biol. Chem. 272 (1997) 30178-30184
    • (1997) J. Biol. Chem. , vol.272 , pp. 30178-30184
    • Björkhem, I.1    Lütjohann, D.2    Breuer, O.3    Sakinis, A.4    och Wennmalm, A.5
  • 6
    • 0031848338 scopus 로고    scopus 로고
    • Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of this oxysterol in the circulation
    • Björkhem I., Lütjohann D., Diczfalusy U., Ståhle L., Ahlborg G., and Wahren J. Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of this oxysterol in the circulation. Lipid Res. 39 (1998) 1594-1600
    • (1998) Lipid Res. , vol.39 , pp. 1594-1600
    • Björkhem, I.1    Lütjohann, D.2    Diczfalusy, U.3    Ståhle, L.4    Ahlborg, G.5    Wahren, J.6
  • 11
    • 0343729334 scopus 로고    scopus 로고
    • Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface
    • Brétillon L., Lütjohann D., Ståhle L., Widhe T., Bindl L., Eggertsen G., Diczfalusy U., and Björkhem I. Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface. J. Lipid Res. 41 (2000) 840-845
    • (2000) J. Lipid Res. , vol.41 , pp. 840-845
    • Brétillon, L.1    Lütjohann, D.2    Ståhle, L.3    Widhe, T.4    Bindl, L.5    Eggertsen, G.6    Diczfalusy, U.7    Björkhem, I.8
  • 15
    • 3543104951 scopus 로고    scopus 로고
    • Cholesterol metabolism in the central nervous system during early development and in the mature animal
    • Dietschy J.M., and Turley S.D. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J. Lipid Res. 45 (2004) 1375-1397
    • (2004) J. Lipid Res. , vol.45 , pp. 1375-1397
    • Dietschy, J.M.1    Turley, S.D.2
  • 16
    • 34249828178 scopus 로고    scopus 로고
    • Regulation of α-and β-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the -secretase pathway
    • Famer D., Meaney S., Mousavi M., Björkhem I., and Crisby M. Regulation of α-and β-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the -secretase pathway. Biochem. Biophys. Res. Commun. 359 (2007) 46-50
    • (2007) Biochem. Biophys. Res. Commun. , vol.359 , pp. 46-50
    • Famer, D.1    Meaney, S.2    Mousavi, M.3    Björkhem, I.4    Crisby, M.5
  • 17
    • 0033933738 scopus 로고    scopus 로고
    • Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons
    • Ginsberg S.D., Hemby S.E., Lee V.M., Eberwine J.H., and Trojanowski J.Q. Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons. Ann. Neurol. 48 (2000) 77-87
    • (2000) Ann. Neurol. , vol.48 , pp. 77-87
    • Ginsberg, S.D.1    Hemby, S.E.2    Lee, V.M.3    Eberwine, J.H.4    Trojanowski, J.Q.5
  • 18
    • 0034213297 scopus 로고    scopus 로고
    • Inhibition of activity-dependent arc protein expression in rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory
    • Guzowski J.F., Lyford G.L., Stevenson G.D., Houston F.P., McGaugh J.L., Worley P.F., and Barnes C.A. Inhibition of activity-dependent arc protein expression in rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. J. Neurosci. 20 (2000) 3993-4001
    • (2000) J. Neurosci. , vol.20 , pp. 3993-4001
    • Guzowski, J.F.1    Lyford, G.L.2    Stevenson, G.D.3    Houston, F.P.4    McGaugh, J.L.5    Worley, P.F.6    Barnes, C.A.7
  • 20
    • 23744498856 scopus 로고    scopus 로고
    • Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain and possible consequences for cerebral cholesterol homeostasis
    • Heverin M., Meaney S., Lütjohann D., Diczfalusy U., Wahren J., and Björkhem I. Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain and possible consequences for cerebral cholesterol homeostasis. J. Lipid Res. 46 (2005) 1047-1052
    • (2005) J. Lipid Res. , vol.46 , pp. 1047-1052
    • Heverin, M.1    Meaney, S.2    Lütjohann, D.3    Diczfalusy, U.4    Wahren, J.5    Björkhem, I.6
  • 26
    • 0037131563 scopus 로고    scopus 로고
    • Changes in plasma levels of the brain specific oxysterol 24S-hydroxycholesterol reflect progression of multiple sclerosis
    • Leoni V., Mastermann T., Diczfalusy U., DeLuca F., Hillert J., and Björkhem I. Changes in plasma levels of the brain specific oxysterol 24S-hydroxycholesterol reflect progression of multiple sclerosis. Neurosci. Lett. 331 (2002) 163-166
    • (2002) Neurosci. Lett. , vol.331 , pp. 163-166
    • Leoni, V.1    Mastermann, T.2    Diczfalusy, U.3    DeLuca, F.4    Hillert, J.5    Björkhem, I.6
  • 27
    • 0141700567 scopus 로고    scopus 로고
    • Side-chain oxidized oxysterols in cerebrospinal fluid and integrity of the blood-brain and blood-cerebrospinal fluid barriers
    • Leoni V., Masterman T., Patel P., Meaney S., Diczfalusy U., and Björkhem I. Side-chain oxidized oxysterols in cerebrospinal fluid and integrity of the blood-brain and blood-cerebrospinal fluid barriers. J. Lipid Res. 44 (2003) 793-799
    • (2003) J. Lipid Res. , vol.44 , pp. 793-799
    • Leoni, V.1    Masterman, T.2    Patel, P.3    Meaney, S.4    Diczfalusy, U.5    Björkhem, I.6
  • 29
    • 33644752889 scopus 로고    scopus 로고
    • Are the CSF levels of 24S-hydroxycholesterol a suitable biomarker for mild cognitive impairment?
    • Leoni V., Shaafati M., Salomon A., Kivipelto M., Björkhem I., and Wahlund L.-O. Are the CSF levels of 24S-hydroxycholesterol a suitable biomarker for mild cognitive impairment?. Neurosci. Lett. 397 (2006) 83-87
    • (2006) Neurosci. Lett. , vol.397 , pp. 83-87
    • Leoni, V.1    Shaafati, M.2    Salomon, A.3    Kivipelto, M.4    Björkhem, I.5    Wahlund, L.-O.6
  • 31
    • 0036128358 scopus 로고    scopus 로고
    • Reduction of plasma 24S-hydroxycholesterol levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain
    • Locatelli S., Lutjohann D., Schmidt H.H., Otto C., Beisiegel U., and vonBergmann U. Reduction of plasma 24S-hydroxycholesterol levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain. Arch. Neurol. 59 (2002) 213-216
    • (2002) Arch. Neurol. , vol.59 , pp. 213-216
    • Locatelli, S.1    Lutjohann, D.2    Schmidt, H.H.3    Otto, C.4    Beisiegel, U.5    vonBergmann, U.6
  • 32
    • 0033594903 scopus 로고    scopus 로고
    • CDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain
    • Lund E.G., Guileyardo J.M., and Russell D.W. CDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc. Natl. Acad. Sci. USA 96 (1999) 7238-7243
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 7238-7243
    • Lund, E.G.1    Guileyardo, J.M.2    Russell, D.W.3
  • 33
    • 0038265008 scopus 로고    scopus 로고
    • Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover
    • Lund E.G., Xie C., Kotti T., Turley S.D., Dietschy J., and Russell D.W. Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. J. Biol. Chem. 278 (2003) 22980-22988
    • (2003) J. Biol. Chem. , vol.278 , pp. 22980-22988
    • Lund, E.G.1    Xie, C.2    Kotti, T.3    Turley, S.D.4    Dietschy, J.5    Russell, D.W.6
  • 34
    • 0029835410 scopus 로고    scopus 로고
    • Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
    • Lütjohann D., Breuer O., Ahlborg G., Nennesmo I., Sidén A., Diczfalusy U., and Björkhem I. Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc. Natl. Acad. Sci. USA 93 (1996) 9799-9804
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9799-9804
    • Lütjohann, D.1    Breuer, O.2    Ahlborg, G.3    Nennesmo, I.4    Sidén, A.5    Diczfalusy, U.6    Björkhem, I.7
  • 35
    • 0345492012 scopus 로고    scopus 로고
    • Broad substrate specificity of human cytochrome P-450 which initiates cholesterol degradation in the brain
    • Mast N., Norcross R., Andersson U., Shov M., Nakayama K., Björkhem I., and Pikuleva I. Broad substrate specificity of human cytochrome P-450 which initiates cholesterol degradation in the brain. Biochemistry 42 (2003) 14284-14292
    • (2003) Biochemistry , vol.42 , pp. 14284-14292
    • Mast, N.1    Norcross, R.2    Andersson, U.3    Shov, M.4    Nakayama, K.5    Björkhem, I.6    Pikuleva, I.7
  • 36
    • 47749117627 scopus 로고    scopus 로고
    • Crystal structure of substrate-bound and substrate-free cytochrome P-450 46A1 the principal cholesterol-hydroxylase in the brain
    • Mast N., White M.A., Björkhem I., Johnson E.F., Stout C., and Pikuleva I. Crystal structure of substrate-bound and substrate-free cytochrome P-450 46A1 the principal cholesterol-hydroxylase in the brain. Proc. Natl. Acad. Sci. USA 105 (2008) 9546-9551
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 9546-9551
    • Mast, N.1    White, M.A.2    Björkhem, I.3    Johnson, E.F.4    Stout, C.5    Pikuleva, I.6
  • 39
  • 42
    • 0037710127 scopus 로고    scopus 로고
    • Outsourcing in the brain: do neurons depend on cholesterol delivery by astrocytes?
    • Pfrieger F.W. Outsourcing in the brain: do neurons depend on cholesterol delivery by astrocytes?. Bioessays 60 (2003) 1158-1171
    • (2003) Bioessays , vol.60 , pp. 1158-1171
    • Pfrieger, F.W.1
  • 43
    • 0345669752 scopus 로고    scopus 로고
    • Alzheimer's disease: the cholesterol connection
    • Puglielli L., Tanzi R.E., and Kovacs D.M. Alzheimer's disease: the cholesterol connection. Nat. Neurosci. 6 (2003) 345-351
    • (2003) Nat. Neurosci. , vol.6 , pp. 345-351
    • Puglielli, L.1    Tanzi, R.E.2    Kovacs, D.M.3
  • 46
    • 34548634369 scopus 로고    scopus 로고
    • Levels of ApoE in cerebrospinal fluid are correlated with Tau and 24S-hydroxycholesterol in patients with cognitive disorders
    • Shafaati M., Solomon A., Kivipelto M., Björkhem I., and Leoni V. Levels of ApoE in cerebrospinal fluid are correlated with Tau and 24S-hydroxycholesterol in patients with cognitive disorders. Neurosci. Lett. 425 (2007) 78-82
    • (2007) Neurosci. Lett. , vol.425 , pp. 78-82
    • Shafaati, M.1    Solomon, A.2    Kivipelto, M.3    Björkhem, I.4    Leoni, V.5
  • 47
    • 57849108909 scopus 로고    scopus 로고
    • Transcriptional regulation of cholesterol 24S-hydroxylase by histone deacetylase inhibitors
    • Shafaati M., ÓDriscoll R., Björkhem I., and Meaney S. Transcriptional regulation of cholesterol 24S-hydroxylase by histone deacetylase inhibitors. Biochem. Biophys. Res. Commun. 378 (2009) 689-694
    • (2009) Biochem. Biophys. Res. Commun. , vol.378 , pp. 689-694
    • Shafaati, M.1    ÓDriscoll, R.2    Björkhem, I.3    Meaney, S.4
  • 49
    • 0041589132 scopus 로고    scopus 로고
    • Decreased levels of brain specific 24S-hydroxycholesterol and cholesterol precursors in serum of multiple sclerosis patients
    • Teunissen C.E., Dijkstra C.D., Polman C.H., Hoogervorst E.L., von Bergmann K., and Lutjohann D. Decreased levels of brain specific 24S-hydroxycholesterol and cholesterol precursors in serum of multiple sclerosis patients. Neurosci. Lett. 347 (2003) 159-162
    • (2003) Neurosci. Lett. , vol.347 , pp. 159-162
    • Teunissen, C.E.1    Dijkstra, C.D.2    Polman, C.H.3    Hoogervorst, E.L.4    von Bergmann, K.5    Lutjohann, D.6
  • 50
    • 34248186478 scopus 로고    scopus 로고
    • 24S-Hydroxycholesterol in relation to disease manifestation of acute experimental autoimmune encephalomyelitis
    • Teunissen C.E., Floris S., Sonke K.E., Dijkstra C.D., DeVries H.E., and Lutjohann D. 24S-Hydroxycholesterol in relation to disease manifestation of acute experimental autoimmune encephalomyelitis. Neurosci. Res. 85 (2007) 1499-1505
    • (2007) Neurosci. Res. , vol.85 , pp. 1499-1505
    • Teunissen, C.E.1    Floris, S.2    Sonke, K.E.3    Dijkstra, C.D.4    DeVries, H.E.5    Lutjohann, D.6
  • 52
    • 34548777515 scopus 로고    scopus 로고
    • Progressive dysfunction of the cholesterol biosynthesis pathway in the R6/2 mouse model of Huntington's disease
    • Valenza M., Leoni V., Tarditi A., Mariotti C., Björkhem I., Di Donato S., and Catteano E. Progressive dysfunction of the cholesterol biosynthesis pathway in the R6/2 mouse model of Huntington's disease. Neurobiol. Dis. 28 (2007) 133-142
    • (2007) Neurobiol. Dis. , vol.28 , pp. 133-142
    • Valenza, M.1    Leoni, V.2    Tarditi, A.3    Mariotti, C.4    Björkhem, I.5    Di Donato, S.6    Catteano, E.7
  • 53
    • 42049122331 scopus 로고    scopus 로고
    • ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain
    • Wang N., Yvan-Charvet L., Lutjohann D., Mulder M., Vabmierlo T., Kim T.W., and Tall A.R. ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain. FASEB J. 22 (2008) 1073-1082
    • (2008) FASEB J. , vol.22 , pp. 1073-1082
    • Wang, N.1    Yvan-Charvet, L.2    Lutjohann, D.3    Mulder, M.4    Vabmierlo, T.5    Kim, T.W.6    Tall, A.R.7
  • 55
    • 0033772113 scopus 로고    scopus 로고
    • Decreased prevalence of Alzheimer's disease associated with HMG CoA reductase inhibitors
    • Wolozin B., Kellman W., Ruosseau P., Celesia G.G., and Siegel G. Decreased prevalence of Alzheimer's disease associated with HMG CoA reductase inhibitors. Arch. Neurol. 57 (2000) 1439-1443
    • (2000) Arch. Neurol. , vol.57 , pp. 1439-1443
    • Wolozin, B.1    Kellman, W.2    Ruosseau, P.3    Celesia, G.G.4    Siegel, G.5
  • 56
    • 0141459395 scopus 로고    scopus 로고
    • Quantitation of two pathways for cholesterol excretion in normal mice and mice with neurodegeneration
    • Xie C., Lund E.G., Turley S.D., Russell D.W., and Dietschy J.M. Quantitation of two pathways for cholesterol excretion in normal mice and mice with neurodegeneration. J. Lipid Res. 44 (2003) 1780-1789
    • (2003) J. Lipid Res. , vol.44 , pp. 1780-1789
    • Xie, C.1    Lund, E.G.2    Turley, S.D.3    Russell, D.W.4    Dietschy, J.M.5
  • 57
    • 0141533183 scopus 로고    scopus 로고
    • Dehydroepiandrosterone 7-hydroxylase CYP7B1: predominant expression in primate hippocampus and reduced expression in Alzheimer's disease
    • Yau J.L., Rasmuson S., Andrew R., Graham M., Noble J., Olson T., Fuchs E., Lathe R., and Seckl J.R. Dehydroepiandrosterone 7-hydroxylase CYP7B1: predominant expression in primate hippocampus and reduced expression in Alzheimer's disease. Neuroscience 121 (2003) 307-314
    • (2003) Neuroscience , vol.121 , pp. 307-314
    • Yau, J.L.1    Rasmuson, S.2    Andrew, R.3    Graham, M.4    Noble, J.5    Olson, T.6    Fuchs, E.7    Lathe, R.8    Seckl, J.R.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.