High hepatic SCD1 activity is associated with low liver fat content in healthy subjects under a lipogenic diet

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 12, 2012, Pages

  Silbernagel, Günther ^a   Kovarova, Marketa ^b   Cegan, Alexander ^b   Machann, Jürgen ^a   Schick, Fritz ^a   Lehmann, Rainer ^a   Häring, Hans Ulrich ^a   Stefan, Norbert ^a   Schleicher, Erwin ^a   Fritsche, Andreas ^a   Peter, Andreas ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF PARDUBICE   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE 1; FATTY ACID; LIPID; MONOSACCHARIDE; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; VERY LOW DENSITY LIPOPROTEIN TRIGLYCERIDE;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME ACTIVITY; FATTY LIVER; FEMALE; HUMAN; LIPID LIVER LEVEL; LIPID STORAGE; LIPOGENESIS; MALE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SUGAR INTAKE;

ADULT; DIET, ATHEROGENIC; DIETARY CARBOHYDRATES; DIETARY FATS; ENZYME ACTIVATION; FEMALE; HEALTH; HUMANS; INDIVIDUALITY; LIPID METABOLISM; LIPOGENESIS; LIPOPROTEINS, VLDL; LIVER; MALE; STEAROYL-COA DESATURASE; TRIGLYCERIDES;

EID: 84870755708     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-2152     Document Type: Article

References (20)

1. Targher G, Marra F, Marchesini G 2008 Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon? Diabetologia 51:1947-1953
2. Farese Jr J, Zechner R, Newgard CB, Walther TC 2012 The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance. Cell Metab 15:570-573
3. Hudgins LC, Hellerstein M, Seidman C, Neese R, Diakun J, Hirsch J 1996 Human fatty acid synthesis is stimulated by a eucaloric low fat, high carbohydrate diet. J Clin Invest 97:2081-2091 (Pubitemid 26143963)
4. Hodson L, Frayn KN 2011 Hepatic fatty acid partitioning. Curr Opin Lipidol 22:216-224
5. Cnop M, Foufelle F, Velloso LA 2012 Endoplasmic reticulum stress, obesity and diabetes. Trends Mol Med 18:59-68
6. Brookheart RT, Michel CI, Schaffer JE 2009 As a matter of fat. Cell Metab 10:9-12
7. Peter A, Weigert C, Staiger H, Machicao F, Schick F, Machann J, Stefan N, Thamer C, Häring HU, Schleicher E 2009 Individual stearoyl-coA desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo. Diabetes 58:1757-1765
8. Li ZZ, Berk M, McIntyre TM, Feldstein AE 2009 Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. J Biol Chem 284:5637-5644
9. Hotamisligil GS 2010 Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140:900-917
10. Collins JM, Neville MJ, Hoppa MB, Frayn KN 2010 De novo lipogenesis and stearoyl-CoA desaturase are coordinately regulated in the human adipocyte and protect against palmitate-induced cell injury. J Biol Chem 285:6044-6052
11. Silbernagel G, Machann J, Unmuth S, Schick F, Stefan N, Häring HU, Fritsche A 2011 Effects of 4-week very-high-fructose/glucose diets on insulin sensitivity, visceral fat and intrahepatic lipids: an exploratory trial. Br J Nutr 106:79-86
12. Kantartzis K, Peter A, Machicao F, Machann J, Wagner S, Königsrainer I, Königsrainer A, Schick F, Fritsche A, Häring HU, Stefan N 2009 Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene. Diabetes 58:2616-2623
13. Peter A, Cegan A, Wagner S, Lehmann R, Stefan N, Königsrainer A, Königsrainer I, Häring HU, Schleicher E 2009 Hepatic lipid composition and stearoyl-coenzyme A desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios. Clin Chem 55:2113-2120
14. Chong MF, Hodson L, Bickerton AS, Roberts R, Neville M, Karpe F, Frayn KN, Fielding BA 2008 Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding. Am J Clin Nutr 87:817-823 (Pubitemid 351549224)
15. Ferre P, Foufelle F 2010 Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c. Diabetes Obes Metab 12(Suppl 2):83-92
16. Alkhouri N, Dixon LJ, Feldstein AE 2009 Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal. Expert Rev Gastroenterol Hepatol 3:445-451
17. Stefan N, Peter A, Cegan A, Staiger H, Machann J, Schick F, Claussen CD, Fritsche A, Häring HU, Schleicher E 2008 Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans. Diabetologia 51:648-656
18. Ntambi JM, Miyazaki M, Dobrzyn A 2004 Regulation of stearoyl- CoA desaturase expression. Lipids 39:1061-1065 (Pubitemid 40129048)
19. Puri P, Mirshahi F, Cheung O, Natarajan R, Maher JW, Kellum JM, Sanyal AJ 2008 Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology 134:568-576 (Pubitemid 351173040)
20. Caviglia JM, Gayet C, Ota T, Hernandez-Ono A, Conlon DM, Jiang H, Fisher EA, Ginsberg HN 2011 Different fatty acids inhibit apolipoprotein B100 secretion by different pathways: unique roles for endoplasmic reticulum stress, ceramide, and autophagy. J Lipid Res 52:1636-1651