Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio

Free Radical Biology and Medicine

Volumn 46, Issue 10, 2009, Pages 1386-1391

  Emerling, Brooke M ^a   Weinberg, Frank ^a   Snyder, Colleen ^a   Burgess, Zach ^a   Mutlu, Gökhan M ^a   Viollet, Benoit ^b,c   Budinger, G R Scott ^a   Chandel, Navdeep S ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b INSTITUT COCHIN   (France)

^c INSERM   (France)

Author keywords

AMP activated kinase; Free radicals; Hypoxia; LKB1; Mitochondria; Reactive oxygen species

Indexed keywords

ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; HYDROGEN PEROXIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MANGANESE N,N' ETHYLENEBIS(3 METHOXYSALICYLIDENEAMINE); MITOCHONDRIAL DNA; PROTEIN KINASE LKB1; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ELECTRON TRANSPORT; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYPOXIA; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANOXIA; ANTIOXIDANTS; CATALYTIC DOMAIN; CELL LINE; ELECTRON TRANSPORT COMPLEX III; FIBROBLASTS; HYDROGEN PEROXIDE; MICE; MITOCHONDRIA; MUTATION; ORGANOMETALLIC COMPOUNDS; OXIDATIVE PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; SALICYLATES;

METAZOA;

EID: 64449087671     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2009.02.019     Document Type: Article

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