Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis

Journal of Gastroenterology

Volumn 47, Issue 8, 2012, Pages 924-935

  Okada, Kosuke ^a   Warabi, Eiji ^a   Sugimoto, Hirokazu ^a   Horie, Masaki ^a   Tokushige, Katsutoshi ^b   Ueda, Tetsuya ^c   Harada, Nobuhiko ^d   Taguchi, Keiko ^e   Hashimoto, Etsuko ^b   Itoh, Ken ^d   Ishii, Tetsuro ^a   Utsunomiya, Hirotoshi ^f   Yamamoto, Masayuki ^e   Shoda, Junichi ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c LSI MEDIENCE CORPORATION   (Japan)

^d HIROSAKI UNIVERSITY   (Japan)

^e TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Iron metabolism; Keap1 gene knockdown mouse; Methionine and choline deficient diet; Nrf2 gene knockout mouse

Indexed keywords

4 HYDROXYNONENAL; CHOLINE; IRON; MALONALDEHYDE; METHIONINE; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FATTY LIVER; GENE ACTIVATION; GENE CONTROL; INFLAMMATION; IRON METABOLISM; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; WILD TYPE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTICARCINOGENIC AGENTS; CHOLINE DEFICIENCY; CYTOSKELETAL PROTEINS; DISEASE MODELS, ANIMAL; FATTY LIVER; GENE EXPRESSION REGULATION; IRON; LIVER; MALE; METHIONINE; MICE; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; REAL-TIME POLYMERASE CHAIN REACTION; THIOCYANATES;

EID: 84867570924     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-012-0552-9     Document Type: Article

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