메뉴 건너뛰기




Volumn 7, Issue 2, 2012, Pages

Liver-specific expression of transcriptionally active srebp-1c is associated with fatty liver and increased visceral fat mass

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; INSULIN; MONOUNSATURATED FATTY ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; ACYL COENZYME A DESATURASE; ACYLTRANSFERASE; CYTOKINE; FATTY ACID ELONGASES; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 84857383028     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031812     Document Type: Article
Times cited : (135)

References (66)
  • 1
    • 0036182137 scopus 로고    scopus 로고
    • Lipotoxic diseases
    • Unger RH, (2002) Lipotoxic diseases. Annu Rev Med 53: 19-36.
    • (2002) Annu Rev Med , vol.53 , pp. 19-36
    • Unger, R.H.1
  • 2
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, et al. (2005) Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin. Invest 115: 1343-1351.
    • (2005) J Clin. Invest , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5
  • 3
    • 43249092409 scopus 로고    scopus 로고
    • Hepatic triglyceride synthesis and nonalcoholic fatty liver disease
    • Choi SS, Diehl AM, (2008) Hepatic triglyceride synthesis and nonalcoholic fatty liver disease. Curr Opin Lipidol 19: 295-300.
    • (2008) Curr Opin Lipidol , vol.19 , pp. 295-300
    • Choi, S.S.1    Diehl, A.M.2
  • 4
    • 57649214103 scopus 로고    scopus 로고
    • Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)
    • Musso G, Gambino R, Cassader M, (2009) Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). Prog Lipid 48: 1-26.
    • (2009) Prog Lipid , vol.48 , pp. 1-26
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 5
    • 0032726283 scopus 로고    scopus 로고
    • Effects of a low-fat, high carbohydrate diet on VLDL-triglyceride assembly, production and clearance
    • Parks ER, Krauss CM, Neese PR, Hellerstein M, (1999) Effects of a low-fat, high carbohydrate diet on VLDL-triglyceride assembly, production and clearance. J Clin. Invest 104: 1087-1096.
    • (1999) J Clin. Invest , vol.104 , pp. 1087-1096
    • Parks, E.R.1    Krauss, C.M.2    Neese, P.R.3    Hellerstein, M.4
  • 6
    • 0036089126 scopus 로고    scopus 로고
    • Dietary carbohydrate's effect on lipogenesis and the relationship of lipogenesis to blood insulin and glucose concentrations
    • Parks E, (2002) Dietary carbohydrate's effect on lipogenesis and the relationship of lipogenesis to blood insulin and glucose concentrations. Br J Nutr 87: S247-S253.
    • (2002) Br J Nutr , vol.87
    • Parks, E.1
  • 7
    • 0030938195 scopus 로고    scopus 로고
    • Hepatic and whole body fat synthesis in humans during carbohydrate overfeeding
    • Aarsland A, Chinkes D, Wolfe RR, (1997) Hepatic and whole body fat synthesis in humans during carbohydrate overfeeding. Am J Clin. Nutr 65: 1174-1182.
    • (1997) Am J Clin. Nutr , vol.65 , pp. 1174-1182
    • Aarsland, A.1    Chinkes, D.2    Wolfe, R.R.3
  • 8
    • 44449096155 scopus 로고    scopus 로고
    • Dietary sugars stimulate fatty acid synthesis in adults
    • Parks EJ, Skokan LE, Timlin MT, Dingfelder CS, (2008) Dietary sugars stimulate fatty acid synthesis in adults. J Nutr 138: 1039-1046.
    • (2008) J Nutr , vol.138 , pp. 1039-1046
    • Parks, E.J.1    Skokan, L.E.2    Timlin, M.T.3    Dingfelder, C.S.4
  • 9
    • 0037216466 scopus 로고    scopus 로고
    • Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets
    • Schwarz JM, Linfoot P, Dare D, Aghajanian K, (2003) Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets. Am J Clin Nutr 77: 43-50.
    • (2003) Am J Clin Nutr , vol.77 , pp. 43-50
    • Schwarz, J.M.1    Linfoot, P.2    Dare, D.3    Aghajanian, K.4
  • 10
    • 0033995287 scopus 로고    scopus 로고
    • Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects
    • Hudgins LC, Hellerstein MK, Seidman CE, Neese RA, Tremaroli JD, et al. (2000) Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects. J Lipid Res 41: 595-604.
    • (2000) J Lipid Res , vol.41 , pp. 595-604
    • Hudgins, L.C.1    Hellerstein, M.K.2    Seidman, C.E.3    Neese, R.A.4    Tremaroli, J.D.5
  • 11
    • 42249115045 scopus 로고    scopus 로고
    • Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding
    • Chong MF, Hodson L, Bickerton AS, Roberts R, Neville M, et al. (2008) Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding. Am J Clin. Nutr 87: 817-823.
    • (2008) Am J Clin. Nutr , vol.87 , pp. 817-823
    • Chong, M.F.1    Hodson, L.2    Bickerton, A.S.3    Roberts, R.4    Neville, M.5
  • 13
    • 21344443664 scopus 로고    scopus 로고
    • Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men
    • Faeh D, Minehira K, Schwarz JM, Periasamy R, Park S, et al. (2005) Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men. Diabetes 54: 1907-1913.
    • (2005) Diabetes , vol.54 , pp. 1907-1913
    • Faeh, D.1    Minehira, K.2    Schwarz, J.M.3    Periasamy, R.4    Park, S.5
  • 14
    • 43049170503 scopus 로고    scopus 로고
    • Fructose consumption as a risk factor for non-alcoholic fatty liver disease
    • Ouyang X, Cirillo P, Sautin Y, McCall S, Bruchette JL, et al. (2008) Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J Hepatol 48: 993-999.
    • (2008) J Hepatol , vol.48 , pp. 993-999
    • Ouyang, X.1    Cirillo, P.2    Sautin, Y.3    McCall, S.4    Bruchette, J.L.5
  • 15
    • 60649109152 scopus 로고    scopus 로고
    • A sweet path to insulin resistance through PGC-1b
    • Hernandez C, Lin JD, (2009) A sweet path to insulin resistance through PGC-1b. Cell Metab 9: 215-216.
    • (2009) Cell Metab , vol.9 , pp. 215-216
    • Hernandez, C.1    Lin, J.D.2
  • 16
    • 77952567958 scopus 로고    scopus 로고
    • Environmental and genetic determinants of fatty liver in humans
    • Kantartzis K, Schick F, Häring HU, Stefan N, (2010) Environmental and genetic determinants of fatty liver in humans. Dig Dis 28: 169-178.
    • (2010) Dig Dis , vol.28 , pp. 169-178
    • Kantartzis, K.1    Schick, F.2    Häring, H.U.3    Stefan, N.4
  • 17
    • 0142027805 scopus 로고    scopus 로고
    • Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
    • Horton JD, Shah NA, Warrington JA, Anderson NN, Park SW, et al. (2003) Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc. Natl. Acad. Sci USA.100: 12027-12032.
    • (2003) Proc. Natl. Acad. Sci , vol.USA.100 , pp. 12027-12032
    • Horton, J.D.1    Shah, N.A.2    Warrington, J.A.3    Anderson, N.N.4    Park, S.W.5
  • 18
    • 18444391229 scopus 로고    scopus 로고
    • SREBP-1 as a transcriptional integrator of circadian and nutritional cues in the liver
    • Brewer M, Lange D, Baler R, Anzulovich A, (2005) SREBP-1 as a transcriptional integrator of circadian and nutritional cues in the liver. J Biol Rhythms 20: 195-205.
    • (2005) J Biol Rhythms , vol.20 , pp. 195-205
    • Brewer, M.1    Lange, D.2    Baler, R.3    Anzulovich, A.4
  • 19
    • 0033570119 scopus 로고    scopus 로고
    • Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus
    • Shimomura I, Bashmakov Y, Horton JD, (1999) Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J Biol Chem 274: 30028-30032.
    • (1999) J Biol Chem , vol.274 , pp. 30028-30032
    • Shimomura, I.1    Bashmakov, Y.2    Horton, J.D.3
  • 20
    • 77952863834 scopus 로고    scopus 로고
    • Genetic control of de novo lipogenesis: role in diet-induced obesity
    • Strable MS, Ntambi JM, (2010) Genetic control of de novo lipogenesis: role in diet-induced obesity. Crit Rev Biochem Mol Biol 45: 199-214.
    • (2010) Crit Rev Biochem Mol Biol , vol.45 , pp. 199-214
    • Strable, M.S.1    Ntambi, J.M.2
  • 21
    • 40549135297 scopus 로고    scopus 로고
    • Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
    • Postic C, Girard J, (2008) Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest 118: 829-838.
    • (2008) J Clin Invest , vol.118 , pp. 829-838
    • Postic, C.1    Girard, J.2
  • 22
    • 0032567445 scopus 로고    scopus 로고
    • Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver
    • Shimomura I, Shimano H, Korn BS, Bashmakov Y, Horton JD, (1998) Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver. J Biol Chem 273: 35299-35306.
    • (1998) J Biol Chem , vol.273 , pp. 35299-35306
    • Shimomura, I.1    Shimano, H.2    Korn, B.S.3    Bashmakov, Y.4    Horton, J.D.5
  • 23
    • 0030907175 scopus 로고    scopus 로고
    • Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
    • Shimano H, Horton JD, Shimomura I, Hammer RE, Brown MS, et al. (1997) Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J Clin Invest 99: 846-854.
    • (1997) J Clin Invest , vol.99 , pp. 846-854
    • Shimano, H.1    Horton, J.D.2    Shimomura, I.3    Hammer, R.E.4    Brown, M.S.5
  • 24
    • 44649111219 scopus 로고    scopus 로고
    • SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease
    • Kohjima M, Higuchi N, Kato M, Kotoh K, Yoshimoto T, et al. (2008) SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease. Int J Mol Med 21: 507-511.
    • (2008) Int J Mol Med , vol.21 , pp. 507-511
    • Kohjima, M.1    Higuchi, N.2    Kato, M.3    Kotoh, K.4    Yoshimoto, T.5
  • 25
    • 53349153430 scopus 로고    scopus 로고
    • Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease
    • Higuchi N, Kato M, Shundo Y, Tajiri H, Tanaka M, et al. (2008) Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease. Hepatol Res 38: 1122-1129.
    • (2008) Hepatol Res , vol.38 , pp. 1122-1129
    • Higuchi, N.1    Kato, M.2    Shundo, Y.3    Tajiri, H.4    Tanaka, M.5
  • 26
    • 34347406521 scopus 로고    scopus 로고
    • SREBP-1c transcription factor and lipid homeostasis: clinical perspective
    • Ferré P, Foufelle F, (2007) SREBP-1c transcription factor and lipid homeostasis: clinical perspective. Horm Res 68: 72-82.
    • (2007) Horm Res , vol.68 , pp. 72-82
    • Ferré, P.1    Foufelle, F.2
  • 27
    • 0028820299 scopus 로고
    • Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection
    • Hua X, Sakai J, Ho YK, Goldstein JL, Brown MS, (1995) Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection. J Biol Chem 270: 29422-29427.
    • (1995) J Biol Chem , vol.270 , pp. 29422-29427
    • Hua, X.1    Sakai, J.2    Ho, Y.K.3    Goldstein, J.L.4    Brown, M.S.5
  • 28
    • 0030961960 scopus 로고    scopus 로고
    • Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells
    • Shimomura I, Shimano H, Horton JD, Goldstein JL, Brown MS, (1997) Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J Clin Invest 99: 838-845.
    • (1997) J Clin Invest , vol.99 , pp. 838-845
    • Shimomura, I.1    Shimano, H.2    Horton, J.D.3    Goldstein, J.L.4    Brown, M.S.5
  • 29
    • 0027490174 scopus 로고
    • SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene
    • Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, et al. (1993) SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell 75: 187-197.
    • (1993) Cell , vol.75 , pp. 187-197
    • Yokoyama, C.1    Wang, X.2    Briggs, M.R.3    Admon, A.4    Wu, J.5
  • 30
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton JD, Goldstein JL, Brown MS, (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109: 1125-1131.
    • (2002) J Clin Invest , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 31
    • 66349134748 scopus 로고    scopus 로고
    • Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL
    • Brown MS, Goldstein JL, (2009) Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. J Lipid Res 50: S15-S27.
    • (2009) J Lipid Res , vol.50
    • Brown, M.S.1    Goldstein, J.L.2
  • 33
    • 24644463295 scopus 로고    scopus 로고
    • Schoenheimer effect explained-feedback regulation of cholesterol synthesis in mice mediated by Insig proteins
    • Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, et al. (2005) Schoenheimer effect explained-feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest 115: 2489-2498.
    • (2005) J Clin Invest , vol.115 , pp. 2489-2498
    • Engelking, L.J.1    Liang, G.2    Hammer, R.E.3    Takaishi, K.4    Kuriyama, H.5
  • 34
    • 19944430411 scopus 로고    scopus 로고
    • Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP
    • Lin J, Yang R, Tarr PT, Wu PH, Handschin C, et al. (2005) Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell 120: 261-273.
    • (2005) Cell , vol.120 , pp. 261-273
    • Lin, J.1    Yang, R.2    Tarr, P.T.3    Wu, P.H.4    Handschin, C.5
  • 35
    • 34047269605 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat
    • Sampath H, Miyazaki M, Dobrzyn A, Ntambi JM, (2007) Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat. J Biol Chem 282: 2483-2493.
    • (2007) J Biol Chem , vol.282 , pp. 2483-2493
    • Sampath, H.1    Miyazaki, M.2    Dobrzyn, A.3    Ntambi, J.M.4
  • 36
    • 0033636780 scopus 로고    scopus 로고
    • Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
    • Shimomura I, Matsuda M, Hammer RE, Bashmakov Y, Brown MS, et al. (2000) Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell 6: 77-86.
    • (2000) Mol Cell , vol.6 , pp. 77-86
    • Shimomura, I.1    Matsuda, M.2    Hammer, R.E.3    Bashmakov, Y.4    Brown, M.S.5
  • 38
    • 33748111665 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: cytokine- adipokine interplay and regulation of insulin resistance
    • Tilg H, Hotamisligil GS, (2006) Nonalcoholic fatty liver disease: cytokine- adipokine interplay and regulation of insulin resistance. Gastroenterology 131: 934-945.
    • (2006) Gastroenterology , vol.131 , pp. 934-945
    • Tilg, H.1    Hotamisligil, G.S.2
  • 39
    • 80051552944 scopus 로고    scopus 로고
    • Hepatic steatosis, obesity, and the metabolic syndrome are independently and additively associated with increased systemic inflammation
    • Ndumele CE, Nasir K, Conceiçao RD, Carvalho JA, Blumenthal RS, Santos RD, (2011) Hepatic steatosis, obesity, and the metabolic syndrome are independently and additively associated with increased systemic inflammation. Arterioscler Thromb Vasc Biol 31: 1927-32.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 1927-1932
    • Ndumele, C.E.1    Nasir, K.2    Conceiçao, R.D.3    Carvalho, J.A.4    Blumenthal, R.S.5    Santos, R.D.6
  • 40
    • 0024371539 scopus 로고
    • Cell-specific expression of mouse albumin promoter. Evidence for cell-specific DNA elements within the proximal promoter region and cis-acting DNA elements upstream of -160
    • Izban MG, Papaconstantinou J, (1989) Cell-specific expression of mouse albumin promoter. Evidence for cell-specific DNA elements within the proximal promoter region and cis-acting DNA elements upstream of -160. J Biol. Chem 264: 9171-9179.
    • (1989) J Biol. Chem , vol.264 , pp. 9171-9179
    • Izban, M.G.1    Papaconstantinou, J.2
  • 41
    • 0036187031 scopus 로고    scopus 로고
    • Opening chromatin
    • Lomvardas S, Thanos D, (2002) Opening chromatin. Mol Cell 2002 9: 209-211.
    • (2002) Mol Cell , vol.9 , pp. 209-211
    • Lomvardas, S.1    Thanos, D.2
  • 42
    • 0023202468 scopus 로고
    • The regulation of albumin and alpha-fetoprotein gene expression in mammals
    • Nahon JL, (1987) The regulation of albumin and alpha-fetoprotein gene expression in mammals. Biochimie 69: 445-459.
    • (1987) Biochimie , vol.69 , pp. 445-459
    • Nahon, J.L.1
  • 43
    • 0028822706 scopus 로고
    • Expression of serum albumin and of alphafetoprotein in murine normal and neoplastic primitive embryonic structures
    • Trojan J, Naval X, Johnson T, Lafarge-Frayssinet C, et al. (1995) Expression of serum albumin and of alphafetoprotein in murine normal and neoplastic primitive embryonic structures. Mol Reprod. Dev 42: 369-378.
    • (1995) Mol Reprod. Dev , vol.42 , pp. 369-378
    • Trojan, J.1    Naval, X.2    Johnson, T.3    Lafarge-Frayssinet, C.4
  • 44
    • 0030998776 scopus 로고    scopus 로고
    • Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression
    • Hanson RW, Reshef L, (1997) Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Annu. Rev. Biochem 66: 581-611.
    • (1997) Annu. Rev. Biochem , vol.66 , pp. 581-611
    • Hanson, R.W.1    Reshef, L.2
  • 45
    • 41149102818 scopus 로고    scopus 로고
    • Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans
    • Stefan N, Peter A, Cegan A, Staiger H, Machann J, et al. (2008) Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans. Diabetologia 51: 648-656.
    • (2008) Diabetologia , vol.51 , pp. 648-656
    • Stefan, N.1    Peter, A.2    Cegan, A.3    Staiger, H.4    Machann, J.5
  • 46
    • 77953190989 scopus 로고    scopus 로고
    • Glycerol-3-phosphate acyltransferase 1 deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity
    • Wendel AA, Li LO, Li Y, Cline GW, Shulman GI, et al. (2010) Glycerol-3-phosphate acyltransferase 1 deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity. Diabetes 59: 1321-1329.
    • (2010) Diabetes , vol.59 , pp. 1321-1329
    • Wendel, A.A.1    Li, L.O.2    Li, Y.3    Cline, G.W.4    Shulman, G.I.5
  • 47
    • 0034443707 scopus 로고    scopus 로고
    • Intracellular assembly of VLDL: two major steps in separate cell compartments
    • Olofsson SO, Stillemark-Billton P, Asp L, (2000) Intracellular assembly of VLDL: two major steps in separate cell compartments. Trends Cardiovasc Med 10: 338-345.
    • (2000) Trends Cardiovasc Med , vol.10 , pp. 338-345
    • Olofsson, S.O.1    Stillemark-Billton, P.2    Asp, L.3
  • 48
    • 84857438384 scopus 로고    scopus 로고
    • Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury
    • Björkegren J, Beigneux A, Bergo MO, Maher JJ, Young SG, (1999) Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury. J Clin Invest 103: 1287-1298.
    • (1999) J Clin Invest , vol.103 , pp. 1287-1298
    • Björkegren, J.1    Beigneux, A.2    Bergo, M.O.3    Maher, J.J.4    Young, S.G.5
  • 49
    • 84857376207 scopus 로고    scopus 로고
    • Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice
    • Raabe M, Véniant MM, Sullivan MA, Zlot CH, Björkegren J, et al. (2002) Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice. J Biol Chem 277: 5476-5483.
    • (2002) J Biol Chem , vol.277 , pp. 5476-5483
    • Raabe, M.1    Véniant, M.M.2    Sullivan, M.A.3    Zlot, C.H.4    Björkegren, J.5
  • 50
    • 53149101726 scopus 로고    scopus 로고
    • Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice
    • Minehira K, Young SG, Villanueva CJ, Yetukuri L, Oresic M, et al. (2008) Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J Lipid Res 49: 2038-2044.
    • (2008) J Lipid Res , vol.49 , pp. 2038-2044
    • Minehira, K.1    Young, S.G.2    Villanueva, C.J.3    Yetukuri, L.4    Oresic, M.5
  • 51
    • 54249147362 scopus 로고    scopus 로고
    • Adipose inflammation, insulin resistance, and cardiovascular disease
    • Shah A, Mehta N, Reilly MP, (2008) Adipose inflammation, insulin resistance, and cardiovascular disease. JPEN J Parenter Enteral Nutr 32: 638-644.
    • (2008) JPEN J Parenter Enteral Nutr , vol.32 , pp. 638-644
    • Shah, A.1    Mehta, N.2    Reilly, M.P.3
  • 52
    • 80052531958 scopus 로고    scopus 로고
    • Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans
    • Meissburger B, Stachorski L, Röder E, Rudofsky G, Wolfrum C, (2011) Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans. Diabetologia 54: 1468-1479.
    • (2011) Diabetologia , vol.54 , pp. 1468-1479
    • Meissburger, B.1    Stachorski, L.2    Röder, E.3    Rudofsky, G.4    Wolfrum, C.5
  • 53
    • 0038823617 scopus 로고    scopus 로고
    • Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation
    • Chavey C, Mari B, Monthouel MN, Bonnafous S, Anglard P, et al. (2003) Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation. J Biol Chem 278: 11888-11896.
    • (2003) J Biol Chem , vol.278 , pp. 11888-11896
    • Chavey, C.1    Mari, B.2    Monthouel, M.N.3    Bonnafous, S.4    Anglard, P.5
  • 54
    • 34248187585 scopus 로고    scopus 로고
    • Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice
    • Herbach N, Rathkolb B, Kemter E, Pichl L, Klaften M, et al. (2007) Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice. Diabetes 56: 1268-1276.
    • (2007) Diabetes , vol.56 , pp. 1268-1276
    • Herbach, N.1    Rathkolb, B.2    Kemter, E.3    Pichl, L.4    Klaften, M.5
  • 55
    • 0036063777 scopus 로고    scopus 로고
    • Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
    • Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, et al. (2002) Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8: 731-737.
    • (2002) Nat Med , vol.8 , pp. 731-737
    • Maeda, N.1    Shimomura, I.2    Kishida, K.3    Nishizawa, H.4    Matsuda, M.5
  • 56
    • 33847399236 scopus 로고    scopus 로고
    • Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue
    • Moloney F, Toomey S, Noone E, Nugent A, Allan B, et al. (2007) Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue. Diabetes 56: 574-582.
    • (2007) Diabetes , vol.56 , pp. 574-582
    • Moloney, F.1    Toomey, S.2    Noone, E.3    Nugent, A.4    Allan, B.5
  • 57
    • 33845516684 scopus 로고    scopus 로고
    • Treatment of spontaneously hypertensive rats with rosiglitazone and/or enalapril restores balance between vasodilator and vasoconstrictor actions of insulin with simultaneous improvement in hypertension and insulin resistance
    • Potenza MA, Marasciulo FL, Tarquinio M, Quon MJ, Montagnani M, (2006) Treatment of spontaneously hypertensive rats with rosiglitazone and/or enalapril restores balance between vasodilator and vasoconstrictor actions of insulin with simultaneous improvement in hypertension and insulin resistance. Diabetes 55: 3594-3603.
    • (2006) Diabetes , vol.55 , pp. 3594-3603
    • Potenza, M.A.1    Marasciulo, F.L.2    Tarquinio, M.3    Quon, M.J.4    Montagnani, M.5
  • 58
    • 20844439184 scopus 로고    scopus 로고
    • Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice
    • Verreth W, De Keyzer D, Pelat M, Verhamme P, Ganame J, et al. (2004) Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice. Circulation 110: 3259-3269.
    • (2004) Circulation , vol.110 , pp. 3259-3269
    • Verreth, W.1    De Keyzer, D.2    Pelat, M.3    Verhamme, P.4    Ganame, J.5
  • 59
    • 40449113180 scopus 로고    scopus 로고
    • Evaluation of glucose homeostasis. Curr Protoc Mol Biol
    • Unit 29B.3
    • Heikkinen S, Argmann CA, Champy MF, Auwerx J, (2007) Evaluation of glucose homeostasis. Curr Protoc Mol Biol. Chapter 29: Unit 29B.3.
    • (2007) Chapter , vol.29
    • Heikkinen, S.1    Argmann, C.A.2    Champy, M.F.3    Auwerx, J.4
  • 60
    • 60849128827 scopus 로고    scopus 로고
    • Surrogate measures of insulin resistance: of rats, mice, and men
    • Mather K, (2009) Surrogate measures of insulin resistance: of rats, mice, and men. Am J Physiol Endocrinol Metab 296: 398-399.
    • (2009) Am J Physiol Endocrinol Metab , vol.296 , pp. 398-399
    • Mather, K.1
  • 61
    • 63249121641 scopus 로고    scopus 로고
    • Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver
    • Kotronen A, Seppanen-Laakso T, Westerbacka J, Kiviluoto T, Arola J, et al. (2009) Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver. Diabetes 58: 203-208.
    • (2009) Diabetes , vol.58 , pp. 203-208
    • Kotronen, A.1    Seppanen-Laakso, T.2    Westerbacka, J.3    Kiviluoto, T.4    Arola, J.5
  • 62
    • 47849087880 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: an overview of current insights in pathogenesis, diagnosis and treatment
    • Schreuder TC, Verwer BJ, van Nieuwkerk CM, Mulder CJ, (2008) Nonalcoholic fatty liver disease: an overview of current insights in pathogenesis, diagnosis and treatment. World J Gastroenterol 14: 2474-2486.
    • (2008) World J Gastroenterol , vol.14 , pp. 2474-2486
    • Schreuder, T.C.1    Verwer, B.J.2    van Nieuwkerk, C.M.3    Mulder, C.J.4
  • 63
    • 70349322563 scopus 로고    scopus 로고
    • Mammalian hibernation: differential gene expression and novel application of epigenetic controls
    • Morin P Jr, Storey KB, (2009) Mammalian hibernation: differential gene expression and novel application of epigenetic controls. Int J Dev Biol 53: 433-442.
    • (2009) Int J Dev Biol , vol.53 , pp. 433-442
    • Morin Jr., P.1    Storey, K.B.2
  • 64
    • 0023339694 scopus 로고
    • An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice
    • Pinkert CA, Ornitz DM, Brinster RL, Palmiter RD, (1987) An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice. Genes Dev 3: 268-276.
    • (1987) Genes Dev , vol.3 , pp. 268-276
    • Pinkert, C.A.1    Ornitz, D.M.2    Brinster, R.L.3    Palmiter, R.D.4
  • 65
    • 77958471996 scopus 로고    scopus 로고
    • Phosphorylation of sterol regulatory element-binding protein (SREBP)-1a links growth hormone action to lipid metabolism in hepatocytes
    • Kotzka J, Knebel B, Avci H, Jacob S, Nitzgen U, et al. (2010) Phosphorylation of sterol regulatory element-binding protein (SREBP)-1a links growth hormone action to lipid metabolism in hepatocytes. Atherosclerosis 213: 156-165.
    • (2010) Atherosclerosis , vol.213 , pp. 156-165
    • Kotzka, J.1    Knebel, B.2    Avci, H.3    Jacob, S.4    Nitzgen, U.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.