-
1
-
-
79952662483
-
The integral role of mTOR in lipid metabolism
-
Soliman, G.A. The integral role of mTOR in lipid metabolism. Cell Cycle 2011, 10, 861-862.
-
(2011)
Cell Cycle
, vol.10
, pp. 861-862
-
-
Soliman, G.A.1
-
2
-
-
70350418625
-
mTOR signaling at a glance
-
Laplante, M.; Sabatini, D.M. mTOR signaling at a glance. J. Cell Sci. 2009, 122, 3589-3594.
-
(2009)
J. Cell Sci
, vol.122
, pp. 3589-3594
-
-
Laplante, M.1
Sabatini, D.M.2
-
3
-
-
79952104568
-
mTOR couples cellular nutrient sensing to organismal metabolic homeostasis
-
Howell, J.J.; Manning, B.D. mTOR couples cellular nutrient sensing to organismal metabolic homeostasis. Trends Endocrinol. Metab. 2011, 22, 94-102.
-
(2011)
Trends Endocrinol. Metab
, vol.22
, pp. 94-102
-
-
Howell, J.J.1
Manning, B.D.2
-
4
-
-
79955779584
-
mTOR links oncogenic signaling to tumor cell metabolism
-
Yecies, J.L.; Manning, B.D. mTOR links oncogenic signaling to tumor cell metabolism. J. Mol. Med. 2011, 89, 221-228.
-
(2011)
J. Mol. Med
, vol.89
, pp. 221-228
-
-
Yecies, J.L.1
Manning, B.D.2
-
5
-
-
20544451118
-
The mammalian target of rapamycin signaling network and gene regulation
-
Soliman, G.A. The mammalian target of rapamycin signaling network and gene regulation. Curr. Opin. Lipidol. 2005, 16, 317-323.
-
(2005)
Curr. Opin. Lipidol
, vol.16
, pp. 317-323
-
-
Soliman, G.A.1
-
6
-
-
77952007543
-
Mammalian target of rapamycin (mTOR): Conducting the cellular signaling symphony
-
Foster, K.G.; Fingar, D.C. Mammalian target of rapamycin (mTOR): Conducting the cellular signaling symphony. J. Biol. Chem. 2010, 285, 14071-14077.
-
(2010)
J. Biol. Chem
, vol.285
, pp. 14071-14077
-
-
Foster, K.G.1
Fingar, D.C.2
-
7
-
-
0028561918
-
Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue
-
Stan, R.; McLaughlin, M.M.; Cafferkey, R.; Johnson, R.K.; Rosenberg, M.; Livi, G.P. Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue. J. Biol. Chem. 1994, 269, 32027-32030.
-
(1994)
J. Biol. Chem
, vol.269
, pp. 32027-32030
-
-
Stan, R.1
McLaughlin, M.M.2
Cafferkey, R.3
Johnson, R.K.4
Rosenberg, M.5
Livi, G.P.6
-
8
-
-
0028344699
-
Yeast TOR (DRR) proteins: Amino-acid sequence alignment and identification of structural motifs
-
Cafferkey, R.; McLaughlin, M.M.; Young, P.R.; Johnson, R.K.; Livi, G.P. Yeast TOR (DRR) proteins: Amino-acid sequence alignment and identification of structural motifs. Gene 1994, 141, 133-136.
-
(1994)
Gene
, vol.141
, pp. 133-136
-
-
Cafferkey, R.1
McLaughlin, M.M.2
Young, P.R.3
Johnson, R.K.4
Livi, G.P.5
-
9
-
-
0029662156
-
The Drosophila p70s6k homolog exhibits conserved regulatory elements and rapamycin sensitivity
-
Stewart, M.J.; Berry, C.O.; Zilberman, F.; Thomas, G.; Kozma, S.C. The Drosophila p70s6k homolog exhibits conserved regulatory elements and rapamycin sensitivity. Proc. Natl. Acad. Sci. USA 1996, 93, 10791-10796.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 10791-10796
-
-
Stewart, M.J.1
Berry, C.O.2
Zilberman, F.3
Thomas, G.4
Kozma, S.C.5
-
10
-
-
33748934979
-
mTORC2 caught in a SINful Akt
-
Polak, P.; Hall, M.N. mTORC2 caught in a SINful Akt. Dev. Cell 2006, 11, 433-434.
-
(2006)
Dev. Cell
, vol.11
, pp. 433-434
-
-
Polak, P.1
Hall, M.N.2
-
11
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger, S.; Loewith, R.; Hall, M.N. TOR signaling in growth and metabolism. Cell 2006, 124, 471-484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
12
-
-
33750058023
-
Upstream of the mammalian target of rapamycin: Do all roads pass through mTOR?
-
Corradetti, M.N.; Guan, K.L. Upstream of the mammalian target of rapamycin: Do all roads pass through mTOR? Oncogene 2006, 25, 6347-6360.
-
(2006)
Oncogene
, vol.25
, pp. 6347-6360
-
-
Corradetti, M.N.1
Guan, K.L.2
-
13
-
-
77952755857
-
Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast
-
Staschke, K.A.; Dey, S.; Zaborske, J.M.; Palam, L.R.; McClintick, J.N.; Pan, T.; Edenberg, H.J.; Wek, R.C. Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast. J. Biol. Chem. 2010, 285, 16893-16911.
-
(2010)
J. Biol. Chem
, vol.285
, pp. 16893-16911
-
-
Staschke, K.A.1
Dey, S.2
Zaborske, J.M.3
Palam, L.R.4
McClintick, J.N.5
Pan, T.6
Edenberg, H.J.7
Wek, R.C.8
-
14
-
-
0032403058
-
The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease
-
Schmidt, A.; Beck, T.; Koller, A.; Kunz, J.; Hall, M.N. The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease. EMBO J. 1998, 17, 6924-6931.
-
(1998)
EMBO J
, vol.17
, pp. 6924-6931
-
-
Schmidt, A.1
Beck, T.2
Koller, A.3
Kunz, J.4
Hall, M.N.5
-
15
-
-
70450204007
-
An emerging role of mTOR in lipid biosynthesis
-
Laplante, M.; Sabatini, D.M. An emerging role of mTOR in lipid biosynthesis. Curr. Biol. 2009, 19, R1046-R1052.
-
(2009)
Curr. Biol
, vol.19
-
-
Laplante, M.1
Sabatini, D.M.2
-
16
-
-
77955483125
-
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
-
Duvel, K.; Yecies, J.L.; Menon, S.; Raman, P.; Lipovsky, A.I.; Souza, A.L.; Triantafellow, E.; Ma, Q.; Gorski, R.; Cleaver, S. et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol. Cell 2010, 39, 171-183.
-
(2010)
Mol. Cell
, vol.39
, pp. 171-183
-
-
Duvel, K.1
Yecies, J.L.2
Menon, S.3
Raman, P.4
Lipovsky, A.I.5
Souza, A.L.6
Triantafellow, E.7
Ma, Q.8
Gorski, R.9
Cleaver, S.10
-
17
-
-
79952320231
-
The evolving role of mTOR inhibition in transplantation tolerance
-
McMahon, G.; Weir, M.R.; Li, X.C.; Mandelbrot, D.A. The evolving role of mTOR inhibition in transplantation tolerance. J. Am. Soc. Nephrol. 2011, 22, 408-415.
-
(2011)
J. Am. Soc. Nephrol
, vol.22
, pp. 408-415
-
-
McMahon, G.1
Weir, M.R.2
Li, X.C.3
Mandelbrot, D.A.4
-
18
-
-
84864025307
-
Pancreatic neuroendocrine and carcinoid tumors: What's new, what's old, and what's different?
-
Reidy-Lagunes, D.; Thornton, R. Pancreatic neuroendocrine and carcinoid tumors: What's new, what's old, and what's different? Curr. Oncol. Rep. 2012, 14, 249-256.
-
(2012)
Curr. Oncol. Rep
, vol.14
, pp. 249-256
-
-
Reidy-Lagunes, D.1
Thornton, R.2
-
19
-
-
84255191433
-
Well-differentiated pancreatic neuroendocrine carcinoma in tuberous sclerosis--Case report and review of the literature
-
Arva, N.C.; Pappas, J.G.; Bhatla, T.; Raetz, E.A.; Macari, M.; Ginsburg, H.B.; Hajdu, C.H. Well-differentiated pancreatic neuroendocrine carcinoma in tuberous sclerosis--Case report and review of the literature. Am. J. Surg. Pathol. 2012, 36, 149-153.
-
(2012)
Am. J. Surg. Pathol
, vol.36
, pp. 149-153
-
-
Arva, N.C.1
Pappas, J.G.2
Bhatla, T.3
Raetz, E.A.4
Macari, M.5
Ginsburg, H.B.6
Hajdu, C.H.7
-
20
-
-
33646140851
-
Rapamycin, an mTOR inhibitor, disrupts triglyceride metabolism in guinea pigs
-
Aggarwal, D.; Fernandez, M.L.; Soliman, G.A. Rapamycin, an mTOR inhibitor, disrupts triglyceride metabolism in guinea pigs. Metab. Clin. Exp. 2006, 55, 794-802.
-
(2006)
Metab. Clin. Exp
, vol.55
, pp. 794-802
-
-
Aggarwal, D.1
Fernandez, M.L.2
Soliman, G.A.3
-
21
-
-
77951166692
-
Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage
-
Chakrabarti, P.; English, T.; Shi, J.; Smas, C.M.; Kandror, K.V. Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage. Diabetes 2010, 59, 775-781.
-
(2010)
Diabetes
, vol.59
, pp. 775-781
-
-
Chakrabarti, P.1
English, T.2
Shi, J.3
Smas, C.M.4
Kandror, K.V.5
-
22
-
-
84871260456
-
Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes
-
doi:10.1371/journal.pone.0036616
-
Ogmundsdottir, M.H.; Heublein, S.; Kazi, S.; Reynolds, B.; Visvalingam, S.M.; Shaw, M.K.; Goberdhan, D.C. Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes. PLoS One 2012, 7, e36616, doi:10.1371/journal.pone.0036616.
-
(2012)
PLoS One
, vol.7
-
-
Ogmundsdottir, M.H.1
Heublein, S.2
Kazi, S.3
Reynolds, B.4
Visvalingam, S.M.5
Shaw, M.K.6
Goberdhan, D.C.7
-
23
-
-
84874105202
-
mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state
-
Cang, C.; Zhou, Y.; Navarro, B.; Seo, Y.J.; Aranda, K.; Shi, L.; Battaglia-Hsu, S.; Nissim, I.; Clapham, D.E.; Ren, D. mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state. Cell 2013, 152, 778-790.
-
(2013)
Cell
, vol.152
, pp. 778-790
-
-
Cang, C.1
Zhou, Y.2
Navarro, B.3
Seo, Y.J.4
Aranda, K.5
Shi, L.6
Battaglia-Hsu, S.7
Nissim, I.8
Clapham, D.E.9
Ren, D.10
-
24
-
-
84859388578
-
Regulation of immune responses by mTOR
-
Powell, J.D.; Pollizzi, K.N.; Heikamp, E.B.; Horton, M.R. Regulation of immune responses by mTOR. Ann. Rev. Immunol. 2012, 30, 39-68.
-
(2012)
Ann. Rev. Immunol
, vol.30
, pp. 39-68
-
-
Powell, J.D.1
Pollizzi, K.N.2
Heikamp, E.B.3
Horton, M.R.4
-
25
-
-
33644556146
-
Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin
-
Colombetti, S.; Basso, V.; Mueller, D.L.; Mondino, A. Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin. J. Immunol. 2006, 176, 2730-2738.
-
(2006)
J. Immunol
, vol.176
, pp. 2730-2738
-
-
Colombetti, S.1
Basso, V.2
Mueller, D.L.3
Mondino, A.4
-
26
-
-
77957054466
-
The mammalian target of rapamycin: Linking T cell differentiation, function, and metabolism
-
Powell, J.D.; Delgoffe, G.M. The mammalian target of rapamycin: Linking T cell differentiation, function, and metabolism. Immunity 2010, 33, 301-311.
-
(2010)
Immunity
, vol.33
, pp. 301-311
-
-
Powell, J.D.1
Delgoffe, G.M.2
-
27
-
-
74649085700
-
The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin
-
Rao, R.R.; Li, Q.; Odunsi, K.; Shrikant, P.A. The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin. Immunity 2010, 32, 67-78.
-
(2010)
Immunity
, vol.32
, pp. 67-78
-
-
Rao, R.R.1
Li, Q.2
Odunsi, K.3
Shrikant, P.A.4
-
28
-
-
77956815868
-
Fine-tuning CD8(+) T cell functional responses: MTOR acts as a rheostat for regulating CD8(+) T cell proliferation, survival and differentiation?
-
Rao, R.R.; Li, Q.; Shrikant, P.A. Fine-tuning CD8(+) T cell functional responses: mTOR acts as a rheostat for regulating CD8(+) T cell proliferation, survival and differentiation? Cell Cycle 2010, 9, 2996-3001.
-
(2010)
Cell Cycle
, vol.9
, pp. 2996-3001
-
-
Rao, R.R.1
Li, Q.2
Shrikant, P.A.3
-
29
-
-
74649086985
-
The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation
-
Gulen, M.F.; Kang, Z.; Bulek, K.; Youzhong, W.; Kim, T.W.; Chen, Y.; Altuntas, C.Z.; Sass Bak-Jensen, K.; McGeachy, M.J.; Do, J.S. et al. The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity 2010, 32, 54-66.
-
(2010)
Immunity
, vol.32
, pp. 54-66
-
-
Gulen, M.F.1
Kang, Z.2
Bulek, K.3
Youzhong, W.4
Kim, T.W.5
Chen, Y.6
Altuntas, C.Z.7
Sass Bak-Jensen, K.8
McGeachy, M.J.9
Do, J.S.10
-
30
-
-
77955485057
-
Loss of single immunoglobulin interlukin-1 receptor-related molecule leads to enhanced colonic polyposis in Apc(min) mice
-
Xiao, H.; Yin, W.; Khan, M.A.; Gulen, M.F.; Zhou, H.; Sham, H.P.; Jacobson, K.; Vallance, B.A.; Li, X. Loss of single immunoglobulin interlukin-1 receptor-related molecule leads to enhanced colonic polyposis in Apc(min) mice. Gastroenterology 2010, 139, 574-585.
-
(2010)
Gastroenterology
, vol.139
, pp. 574-585
-
-
Xiao, H.1
Yin, W.2
Khan, M.A.3
Gulen, M.F.4
Zhou, H.5
Sham, H.P.6
Jacobson, K.7
Vallance, B.A.8
Li, X.9
-
31
-
-
0038433304
-
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
-
Garami, A.; Zwartkruis, F.J.; Nobukuni, T.; Joaquin, M.; Roccio, M.; Stocker, H.; Kozma, S.C.; Hafen, E.; Bos, J.L.; Thomas, G. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol. Cell 2003, 11, 1457-1466.
-
(2003)
Mol. Cell
, vol.11
, pp. 1457-1466
-
-
Garami, A.1
Zwartkruis, F.J.2
Nobukuni, T.3
Joaquin, M.4
Roccio, M.5
Stocker, H.6
Kozma, S.C.7
Hafen, E.8
Bos, J.L.9
Thomas G10
-
32
-
-
0038304516
-
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
-
Stocker, H.; Radimerski, T.; Schindelholz, B.; Wittwer, F.; Belawat, P.; Daram, P.; Breuer, S.; Thomas, G.; Hafen, E. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat. Cell Biol. 2003, 5, 559-565.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 559-565
-
-
Stocker, H.1
Radimerski, T.2
Schindelholz, B.3
Wittwer, F.4
Belawat, P.5
Daram, P.6
Breuer, S.7
Thomas, G.8
Hafen, E.9
-
33
-
-
16544383044
-
The mTOR/S6K signalling pathway: The role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb
-
discussion 154-149, 265-148
-
Nobukini, T.; Thomas, G. The mTOR/S6K signalling pathway: The role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb. Novartis Found. Symp. 2004, 262, 148-154; discussion 154-149, 265-148.
-
(2004)
Novartis Found. Symp
, vol.262
, pp. 148-154
-
-
Nobukini, T.1
Thomas, G.2
-
34
-
-
0036501277
-
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
-
Kwiatkowski, D.J.; Zhang, H.; Bandura, J.L.; Heiberger, K.M.; Glogauer, M.; el-Hashemite, N.; Onda, H. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum. Mol. Genet. 2002, 11, 525-534.
-
(2002)
Hum. Mol. Genet
, vol.11
, pp. 525-534
-
-
Kwiatkowski, D.J.1
Zhang, H.2
Bandura, J.L.3
Heiberger, K.M.4
Glogauer, M.5
El-Hashemite, N.6
Onda, H.7
-
35
-
-
27744588780
-
Tuberous sclerosis: A GAP at the crossroads of multiple signaling pathways
-
Kwiatkowski, D.J.; Manning, B.D. Tuberous sclerosis: A GAP at the crossroads of multiple signaling pathways. Hum. Mol. Genet. 2005, 14, R251-R258.
-
(2005)
Hum. Mol. Genet
, vol.14
-
-
Kwiatkowski, D.J.1
Manning, B.D.2
-
36
-
-
33748153690
-
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
-
Inoki, K.; Ouyang, H.; Zhu, T.; Lindvall, C.; Wang, Y.; Zhang, X.; Yang, Q.; Bennett, C.; Harada, Y.; Stankunas, K. et al. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 2006, 126, 955-968.
-
(2006)
Cell
, vol.126
, pp. 955-968
-
-
Inoki, K.1
Ouyang, H.2
Zhu, T.3
Lindvall, C.4
Wang, Y.5
Zhang, X.6
Yang, Q.7
Bennett, C.8
Harada, Y.9
Stankunas, K.10
-
37
-
-
80052736325
-
Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway
-
Yoshida, S.; Hong, S.; Suzuki, T.; Nada, S.; Mannan, A.M.; Wang, J.; Okada, M.; Guan, K.L.; Inoki, K. Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway. J. Biol. Chem. 2011, 286, 32651-32660.
-
(2011)
J. Biol. Chem
, vol.286
, pp. 32651-32660
-
-
Yoshida, S.1
Hong, S.2
Suzuki, T.3
Nada, S.4
Mannan, A.M.5
Wang, J.6
Okada, M.7
Guan, K.L.8
Inoki, K.9
-
38
-
-
33646485688
-
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity
-
Yang, Q.; Inoki, K.; Kim, E.; Guan, K.L. TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Proc. Natl. Acad. Sci. USA 2006, 103, 6811-6816.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 6811-6816
-
-
Yang, Q.1
Inoki, K.2
Kim, E.3
Guan, K.L.4
-
39
-
-
4544220704
-
Absence of S6K1 protects against age-and diet-induced obesity while enhancing insulin sensitivity
-
Um, S.H.; Frigerio, F.; Watanabe, M.; Picard, F.; Joaquin, M.; Sticker, M.; Fumagalli, S.; Allegrini, P.R.; Kozma, S.C.; Auwerx, J. et al. Absence of S6K1 protects against age-and diet-induced obesity while enhancing insulin sensitivity. Nature 2004, 431, 200-205.
-
(2004)
Nature
, vol.431
, pp. 200-205
-
-
Um, S.H.1
Frigerio, F.2
Watanabe, M.3
Picard, F.4
Joaquin, M.5
Sticker, M.6
Fumagalli, S.7
Allegrini, P.R.8
Kozma, S.C.9
Auwerx, J.10
-
40
-
-
79961165137
-
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
-
Peterson, T.R.; Sengupta, S.S.; Harris, T.E.; Carmack, A.E.; Kang, S.A.; Balderas, E.; Guertin, D.A.; Madden, K.L.; Carpenter, A.E.; Finck, B.N. et al. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell 2011, 146, 408-420.
-
(2011)
Cell
, vol.146
, pp. 408-420
-
-
Peterson, T.R.1
Sengupta, S.S.2
Harris, T.E.3
Carmack, A.E.4
Kang, S.A.5
Balderas, E.6
Guertin, D.A.7
Madden, K.L.8
Carpenter, A.E.9
Finck, B.N.10
-
41
-
-
84872272443
-
Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex
-
Kim, S.G.; Hoffman, G R.; Poulogiannis, G.; Buel, G.R.; Jang, Y.J.; Lee, K.W.; Kim, B.Y.; Erikson, R.L.; Cantley, L.C.; Choo, A.Y. et al. Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. Mol. Cell 2013, 49, 172-185.
-
(2013)
Mol. Cell
, vol.49
, pp. 172-185
-
-
Kim, S.G.1
Hoffman, G.R.2
Poulogiannis, G.3
Buel, G.R.4
Jang, Y.J.5
Lee, K.W.6
Kim, B.Y.7
Erikson, R.L.8
Cantley, L.C.9
Choo, A.Y.10
-
42
-
-
77954235821
-
Targeting mTOR: Prospects for mTOR complex 2 inhibitors in cancer therapy
-
Sparks, C.A.; Guertin, D.A. Targeting mTOR: Prospects for mTOR complex 2 inhibitors in cancer therapy. Oncogene 2010, 29, 3733-3744.
-
(2010)
Oncogene
, vol.29
, pp. 3733-3744
-
-
Sparks, C.A.1
Guertin, D.A.2
-
43
-
-
28844434558
-
mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
-
Hresko, R.C.; Mueckler, M. mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J. Biol. Chem. 2005, 280, 40406-40416.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 40406-40416
-
-
Hresko, R.C.1
Mueckler, M.2
-
44
-
-
79954576972
-
Transcriptional control of cellular metabolism by mTOR signaling
-
Yecies, J.L.; Manning, B.D. Transcriptional control of cellular metabolism by mTOR signaling. Cancer Res. 2011, 71, 2815-2820.
-
(2011)
Cancer Res
, vol.71
, pp. 2815-2820
-
-
Yecies, J.L.1
Manning, B.D.2
-
45
-
-
84868019043
-
Cancer cell metabolism: One hallmark, many faces
-
Cantor, J.R.; Sabatini, D.M. Cancer cell metabolism: One hallmark, many faces. Cancer Discov. 2012, 2, 881-898.
-
(2012)
Cancer Discov
, vol.2
, pp. 881-898
-
-
Cantor, J.R.1
Sabatini, D.M.2
-
46
-
-
84858130387
-
The effect of hydrogen peroxide on cancer cells and on embryonic cells
-
Warburg, O. The effect of hydrogen peroxide on cancer cells and on embryonic cells. Acta Unio Int. Contra Cancrum 1958, 14, 55-57.
-
(1958)
Acta Unio Int. Contra Cancrum
, vol.14
, pp. 55-57
-
-
Warburg, O.1
-
47
-
-
77952280516
-
Anergic T cells are metabolically anergic
-
Zheng, Y.; Delgoffe, G.M.; Meyer, C.F.; Chan, W.; Powell, J.D. Anergic T cells are metabolically anergic. J. Immunol. 2009, 183, 6095-6101.
-
(2009)
J. Immunol
, vol.183
, pp. 6095-6101
-
-
Zheng, Y.1
Delgoffe, G.M.2
Meyer, C.F.3
Chan, W.4
Powell, J.D.5
-
48
-
-
67650553603
-
mTOR: Taking cues from the immune microenvironment
-
Delgoffe, G.M.; Powell, J.D. mTOR: Taking cues from the immune microenvironment. Immunology 2009, 127, 459-465.
-
(2009)
Immunology
, vol.127
, pp. 459-465
-
-
Delgoffe, G.M.1
Powell, J.D.2
-
49
-
-
0033104824
-
Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation
-
Powell, J.D.; Lerner, C.G.; Schwartz, R.H. Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation. J. Immunol. 1999, 162, 2775-2784.
-
(1999)
J. Immunol
, vol.162
, pp. 2775-2784
-
-
Powell, J.D.1
Lerner, C.G.2
Schwartz, R.H.3
-
50
-
-
1842424727
-
The novel cyclophilin binding compound, sanglifehrin A, disassociates G1 cell cycle arrest from tolerance induction
-
Allen, A.; Zheng, Y.; Gardner, L.; Safford, M.; Horton, M.R.; Powell, J.D. The novel cyclophilin binding compound, sanglifehrin A, disassociates G1 cell cycle arrest from tolerance induction. J. Immunol. 2004, 172, 4797-4803.
-
(2004)
J. Immunol
, vol.172
, pp. 4797-4803
-
-
Allen, A.1
Zheng, Y.2
Gardner, L.3
Safford, M.4
Horton, M.R.5
Powell, J.D.6
-
51
-
-
0035889885
-
Antagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal anergy: Enhanced cell cycle progression promotes recall antigen responsiveness
-
Vanasek, T.L.; Khoruts, A.; Zell, T.; Mueller, D.L. Antagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal anergy: Enhanced cell cycle progression promotes recall antigen responsiveness. J. Immunol. 2001, 167, 5636-5644.
-
(2001)
J. Immunol
, vol.167
, pp. 5636-5644
-
-
Vanasek, T.L.1
Khoruts, A.2
Zell, T.3
Mueller, D.L.4
-
52
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay, N.; Sonenberg, N. Upstream and downstream of mTOR. Genes Dev. 2004, 18, 1926-1945.
-
(2004)
Genes Dev
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
53
-
-
0041344629
-
Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons
-
Lekmine, F.; Uddin, S.; Sassano, A.; Parmar, S.; Brachmann, S.M.; Majchrzak, B.; Sonenberg, N.; Hay, N.; Fish, E.N.; Platanias, L.C. Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons. J. Biol. Chem. 2003, 278, 27772-27780.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 27772-27780
-
-
Lekmine, F.1
Uddin, S.2
Sassano, A.3
Parmar, S.4
Brachmann, S.M.5
Majchrzak, B.6
Sonenberg, N.7
Hay, N.8
Fish, E.N.9
Platanias, L.C.10
-
54
-
-
0032520009
-
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway
-
Gingras, A.C.; Kennedy, S.G.; O'Leary, M.A.; Sonenberg, N.; Hay, N. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev. 1998, 12, 502-513.
-
(1998)
Genes Dev
, vol.12
, pp. 502-513
-
-
Gingras, A.C.1
Kennedy, S.G.2
O'Leary, M.A.3
Sonenberg, N.4
Hay, N.5
-
55
-
-
0345732640
-
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
-
Fingar, D.C.; Richardson, C.J.; Tee, A.R.; Cheatham, L.; Tsou, C.; Blenis, J. mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol. Cell. Biol. 2004, 24, 200-216.
-
(2004)
Mol. Cell. Biol
, vol.24
, pp. 200-216
-
-
Fingar, D.C.1
Richardson, C.J.2
Tee, A.R.3
Cheatham, L.4
Tsou, C.5
Blenis, J.6
-
56
-
-
2342545519
-
Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
-
Fingar, D.C.; Blenis, J. Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004, 23, 3151-3171.
-
(2004)
Oncogene
, vol.23
, pp. 3151-3171
-
-
Fingar, D.C.1
Blenis, J.2
-
57
-
-
33751348056
-
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
-
Guertin, D.A.; Stevens, D.M.; Thoreen, C.C.; Burds, A.A.; Kalaany, N.Y.; Moffat, J.; Brown, M.; Fitzgerald, K.J.; Sabatini, D.M. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev. Cell 2006, 11, 859-871.
-
(2006)
Dev. Cell
, vol.11
, pp. 859-871
-
-
Guertin, D.A.1
Stevens, D.M.2
Thoreen, C.C.3
Burds, A.A.4
Kalaany, N.Y.5
Moffat, J.6
Brown, M.7
Fitzgerald, K.J.8
Sabatini, D.M.9
-
58
-
-
80052443549
-
Perspectives on the role of mTORC2 in B lymphocyte development, immunity and tumorigenesis
-
Lazorchak, A.S.; Su, B. Perspectives on the role of mTORC2 in B lymphocyte development, immunity and tumorigenesis. Protein Cell 2011, 2, 523-530.
-
(2011)
Protein Cell
, vol.2
, pp. 523-530
-
-
Lazorchak, A.S.1
Su, B.2
-
59
-
-
84865503043
-
Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2
-
Yuan, M.; Pino, E.; Wu, L.; Kacergis, M.; Soukas, A.A. Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2. J. Biol. Chem. 2012, 287, 29579-29588.
-
(2012)
J. Biol. Chem
, vol.287
, pp. 29579-29588
-
-
Yuan, M.1
Pino, E.2
Wu, L.3
Kacergis, M.4
Soukas, A.A.5
-
60
-
-
33750044901
-
Ribosome biogenesis and cell growth: MTOR coordinates transcription by all three classes of nuclear RNA polymerases
-
Mayer, C.; Grummt, I. Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases. Oncogene 2006, 25, 6384-6391.
-
(2006)
Oncogene
, vol.25
, pp. 6384-6391
-
-
Mayer, C.1
Grummt, I.2
-
61
-
-
77951911260
-
Coordinated control of the gene expression machinery
-
White, R.J.; Sharrocks, A.D. Coordinated control of the gene expression machinery. Trends Genet 2010, 26, 214-220.
-
(2010)
Trends Genet
, vol.26
, pp. 214-220
-
-
White, R.J.1
Sharrocks, A.D.2
-
62
-
-
0042823530
-
mTOR signaling to translation
-
Gingras, A.C.; Raught, B.; Sonenberg, N. mTOR signaling to translation. Curr. Top. Microbiol. Immunol. 2004, 279, 169-197.
-
(2004)
Curr. Top. Microbiol. Immunol
, vol.279
, pp. 169-197
-
-
Gingras, A.C.1
Raught, B.2
Sonenberg, N.3
-
63
-
-
0041821475
-
Role of mTOR signalling in the control of translation initiation and elongation by nutrients
-
Proud, C.G. Role of mTOR signalling in the control of translation initiation and elongation by nutrients. Curr. Top. Microbiol. Immunol. 2004, 279, 215-244.
-
(2004)
Curr. Top. Microbiol. Immunol
, vol.279
, pp. 215-244
-
-
Proud, C.G.1
-
64
-
-
3242892160
-
The multifaceted role of mTOR in cellular stress responses
-
Proud, C.G. The multifaceted role of mTOR in cellular stress responses. DNA Repair 2004, 3, 927-934.
-
(2004)
DNA Repair
, vol.3
, pp. 927-934
-
-
Proud, C.G.1
-
65
-
-
33645863768
-
Transcriptional regulation of metabolism
-
Desvergne, B.; Michalik, L.; Wahli, W. Transcriptional regulation of metabolism. Physiol. Rev. 2006, 86, 465-514.
-
(2006)
Physiol. Rev
, vol.86
, pp. 465-514
-
-
Desvergne, B.1
Michalik, L.2
Wahli, W.3
-
66
-
-
48649107600
-
The mammalian target of rapamycin pathway and its role in molecular nutrition regulation
-
Lian, J.; Yan, X.H.; Peng, J.; Jiang, S.W. The mammalian target of rapamycin pathway and its role in molecular nutrition regulation. Mol. Nutr. Food Res. 2008, 52, 393-399.
-
(2008)
Mol. Nutr. Food Res
, vol.52
, pp. 393-399
-
-
Lian, J.1
Yan, X.H.2
Peng, J.3
Jiang, S.W.4
-
67
-
-
0036310982
-
The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation
-
Peng, T.; Golub, T.R.; Sabatini, D.M. The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation. Mol. Cell. Biol. 2002, 22, 5575-5584.
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 5575-5584
-
-
Peng, T.1
Golub, T.R.2
Sabatini, D.M.3
-
68
-
-
35248816945
-
The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes
-
Brown, N.F.; Stefanovic-Racic, M.; Sipula, I.J.; Perdomo, G. The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes. Metabolism 2007, 56, 1500-1507.
-
(2007)
Metabolism
, vol.56
, pp. 1500-1507
-
-
Brown, N.F.1
Stefanovic-Racic, M.2
Sipula, I.J.3
Perdomo, G.4
-
69
-
-
50049116472
-
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
-
Porstmann, T.; Santos, C.R.; Griffiths, B.; Cully, M.; Wu, M.; Leevers, S.; Griffiths, J.R.; Chung, Y.L.; Schulze, A. SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab. 2008, 8, 224-236.
-
(2008)
Cell Metab
, vol.8
, pp. 224-236
-
-
Porstmann, T.1
Santos, C.R.2
Griffiths, B.3
Cully, M.4
Wu, M.5
Leevers, S.6
Griffiths, J.R.7
Chung, Y.L.8
Schulze, A.9
-
70
-
-
66249090283
-
Role of thePI3-kinase/mTor pathway in the regulation of the stearoyl CoA desaturase (SCD1) gene expression by insulin in liver
-
Mauvoisin, D.; Rocque, G.; Arfa, O.; Radenne, A.; Boissier, P.; Mounier, C. Role of thePI3-kinase/mTor pathway in the regulation of the stearoyl CoA desaturase (SCD1) gene expression by insulin in liver. J. Cell Commun. Signal. 2007, 1, 113-125.
-
(2007)
J. Cell Commun. Signal
, vol.1
, pp. 113-125
-
-
Mauvoisin, D.1
Rocque, G.2
Arfa, O.3
Radenne, A.4
Boissier, P.5
Mounier, C.6
-
71
-
-
77953200528
-
Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism
-
Kumar, A.; Lawrence, J.C., Jr.; Jung, D.Y.; Ko, H.J.; Keller, S.R.; Kim, J.K.; Magnuson, M.A.; Harris, T.E. Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes 2010, 59, 1397-1406.
-
(2010)
Diabetes
, vol.59
, pp. 1397-1406
-
-
Kumar, A.1
Lawrence Jr., J.C.2
Jung, D.Y.3
Ko, H.J.4
Keller, S.R.5
Kim, J.K.6
Magnuson, M.A.7
Harris, T.E.8
-
72
-
-
4344595626
-
Regulation and role of autophagy in mammalian cells
-
Meijer, A.J.; Codogno, P. Regulation and role of autophagy in mammalian cells. Int. J. Biochem. Cell Biol. 2004, 36, 2445-2462.
-
(2004)
Int. J. Biochem. Cell Biol
, vol.36
, pp. 2445-2462
-
-
Meijer, A.J.1
Codogno, P.2
-
73
-
-
33947495259
-
Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells
-
Iwamaru, A.; Kondo, Y.; Iwado, E.; Aoki, H.; Fujiwara, K.; Yokoyama, T.; Mills, G.B.; Kondo, S. Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells. Oncogene 2007, 26, 1840-1851.
-
(2007)
Oncogene
, vol.26
, pp. 1840-1851
-
-
Iwamaru, A.1
Kondo, Y.2
Iwado, E.3
Aoki, H.4
Fujiwara, K.5
Yokoyama, T.6
Mills, G.B.7
Kondo, S.8
-
74
-
-
0035856949
-
Insulin signalling and the regulation of glucose and lipid metabolism
-
Saltiel, A.R.; Kahn, C.R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001, 414, 799-806.
-
(2001)
Nature
, vol.414
, pp. 799-806
-
-
Saltiel, A.R.1
Kahn, C.R.2
-
75
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
Zhong, H.; Chiles, K.; Feldser, D.; Laughner, E.; Hanrahan, C.; Georgescu, M.M.; Simons, J.W.; Semenza, G.L. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics. Cancer Res. 2000, 60, 1541-1545.
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
Laughner, E.4
Hanrahan, C.5
Georgescu, M.M.6
Simons, J.W.7
Semenza, G.L.8
-
76
-
-
0036789574
-
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
-
Hudson, C.C.; Liu, M.; Chiang, G.G.; Otterness, D.M.; Loomis, D.C.; Kaper, F.; Giaccia, A.J.; Abraham, R.T. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol. Cell. Biol. 2002, 22, 7004-7014.
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 7004-7014
-
-
Hudson, C.C.1
Liu, M.2
Chiang, G.G.3
Otterness, D.M.4
Loomis, D.C.5
Kaper, F.6
Giaccia, A.J.7
Abraham, R.T.8
-
77
-
-
0345491599
-
Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation
-
Hu, C.J.; Wang, L.Y.; Chodosh, L.A.; Keith, B.; Simon, M.C. Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation. Mol. Cell. Biol. 2003, 23, 9361-9374.
-
(2003)
Mol. Cell. Biol
, vol.23
, pp. 9361-9374
-
-
Hu, C.J.1
Wang, L.Y.2
Chodosh, L.A.3
Keith, B.4
Simon, M.C.5
-
78
-
-
62749083679
-
Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets
-
Liu, H.; Remedi, M.S.; Pappan, K.L.; Kwon, G.; Rohatgi, N.; Marshall, C.A.; McDaniel, M.L. Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets. Diabetes 2009, 58, 663-672.
-
(2009)
Diabetes
, vol.58
, pp. 663-672
-
-
Liu, H.1
Remedi, M.S.2
Pappan, K.L.3
Kwon, G.4
Rohatgi, N.5
Marshall, C.A.6
McDaniel, M.L.7
-
79
-
-
0032511090
-
Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires phosphatidylinositol 3-kinase
-
Wagle, A.; Jivraj, S.; Garlock, G.L.; Stapleton, S.R. Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires phosphatidylinositol 3-kinase. J. Biol. Chem. 1998, 273, 14968-14974.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 14968-14974
-
-
Wagle, A.1
Jivraj, S.2
Garlock, G.L.3
Stapleton, S.R.4
-
80
-
-
62749096589
-
Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms
-
Dunlop, E.A.; Tee, A.R. Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms. Cell Signal. 2009, 21, 827-835.
-
(2009)
Cell Signal
, vol.21
, pp. 827-835
-
-
Dunlop, E.A.1
Tee, A.R.2
-
81
-
-
77149154335
-
Adenosine 5′-monophosphate-activated protein kinase-mammalian target of rapamycin cross talk regulates brown adipocyte differentiation
-
Vila-Bedmar, R.; Lorenzo, M.; Fernandez-Veledo, S. Adenosine 5′-monophosphate-activated protein kinase-mammalian target of rapamycin cross talk regulates brown adipocyte differentiation. Endocrinology 2010, 151, 980-992.
-
(2010)
Endocrinology
, vol.151
, pp. 980-992
-
-
Vila-Bedmar, R.1
Lorenzo, M.2
Fernandez-Veledo, S.3
-
82
-
-
79960349522
-
mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression
-
Ekim, B.; Magnuson, B.; Acosta-Jaquez, H.A.; Keller, J.A.; Feener, E.P.; Fingar, D.C. mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression. Mol. Cell. Biol. 2011, 31, 2787-2801.
-
(2011)
Mol. Cell. Biol
, vol.31
, pp. 2787-2801
-
-
Ekim, B.1
Magnuson, B.2
Acosta-Jaquez, H.A.3
Keller, J.A.4
Feener, E.P.5
Fingar, D.C.6
-
83
-
-
66049138419
-
Rosiglitazone-induced heart remodelling is associated with enhanced turnover of myofibrillar protein and mTOR activation
-
Festuccia, W.T.; Laplante, M.; Brule, S.; Houde, V.P.; Achouba, A.; Lachance, D.; Pedrosa, M.L.; Silva, M.E.; Guerra-Sa, R.; Couet, J. et al. Rosiglitazone-induced heart remodelling is associated with enhanced turnover of myofibrillar protein and mTOR activation. J. Mol. Cell. Cardiol. 2009, 47, 85-95.
-
(2009)
J. Mol. Cell. Cardiol
, vol.47
, pp. 85-95
-
-
Festuccia, W.T.1
Laplante, M.2
Brule, S.3
Houde, V.P.4
Achouba, A.5
Lachance, D.6
Pedrosa, M.L.7
Silva, M.E.8
Guerra-Sa, R.9
Couet, J.10
-
84
-
-
52049106904
-
Cell growth control: MTOR takes on fat
-
Powers, T. Cell growth control: mTOR takes on fat. Mol. Cell 2008, 31, 775-776.
-
(2008)
Mol. Cell
, vol.31
, pp. 775-776
-
-
Powers, T.1
-
85
-
-
78651067054
-
mTORC1 inhibition via rapamycin promotes triacylglycerol lipolysis and release of free fatty acids in 3T3-L1 adipocytes
-
Soliman, G.A.; Acosta-Jaquez, H.A.; Fingar, D.C. mTORC1 inhibition via rapamycin promotes triacylglycerol lipolysis and release of free fatty acids in 3T3-L1 adipocytes. Lipids 2010, 45, 1089-1100.
-
(2010)
Lipids
, vol.45
, pp. 1089-1100
-
-
Soliman, G.A.1
Acosta-Jaquez, H.A.2
Fingar, D.C.3
-
86
-
-
42449104351
-
mTOR inhibition by rapamycin prevents β-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
-
Fraenkel, M.; Ketzinel-Gilad, M.; Ariav, Y.; Pappo, O.; Karaca, M.; Castel, J.; Berthault, M.F.; Magnan, C.; Cerasi, E.; Kaiser, N. et al. mTOR inhibition by rapamycin prevents β-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes. Diabetes 2008, 57, 945-957.
-
(2008)
Diabetes
, vol.57
, pp. 945-957
-
-
Fraenkel, M.1
Ketzinel-Gilad, M.2
Ariav, Y.3
Pappo, O.4
Karaca, M.5
Castel, J.6
Berthault, M.F.7
Magnan, C.8
Cerasi, E.9
Kaiser, N.10
-
87
-
-
70350309323
-
Balancing needs and means: The dilemma of the beta-cell in the modern world
-
Leibowitz, G.; Kaiser, N.; Cerasi, E. Balancing needs and means: The dilemma of the beta-cell in the modern world. Diabetes Obes. Metab. 2009, 11 (Suppl. 4), 1-9.
-
(2009)
Diabetes Obes. Metab
, vol.11
, Issue.4 SUPPL.
, pp. 1-9
-
-
Leibowitz, G.1
Kaiser, N.2
Cerasi, E.3
-
88
-
-
0035225871
-
Regulation of translation initiation by amino acids in eukaryotic cells
-
Kimball, S.R. Regulation of translation initiation by amino acids in eukaryotic cells. Prog. Mol. Subcell Biol. 2001, 26, 155-184.
-
(2001)
Prog. Mol. Subcell Biol
, vol.26
, pp. 155-184
-
-
Kimball, S.R.1
-
89
-
-
0037303916
-
Nutrient-sensing mTOR-mediated pathway regulates leptin production in isolated rat adipocytes
-
Roh, C.; Han, J.; Tzatsos, A.; Kandror, K.V. Nutrient-sensing mTOR-mediated pathway regulates leptin production in isolated rat adipocytes. Am. J. Physiol. Endocrinol. Metab. 2003, 284, E322-E330.
-
(2003)
Am. J. Physiol. Endocrinol. Metab
, vol.284
-
-
Roh, C.1
Han, J.2
Tzatsos, A.3
Kandror, K.V.4
-
90
-
-
0346366448
-
mTOR integrates amino acid-and energy-sensing pathways
-
Tokunaga, C.; Yoshino, K.; Yonezawa, K. mTOR integrates amino acid-and energy-sensing pathways. Biochem. Biophys. Res. Commun. 2004, 313, 443-446.
-
(2004)
Biochem. Biophys. Res. Commun
, vol.313
, pp. 443-446
-
-
Tokunaga, C.1
Yoshino, K.2
Yonezawa, K.3
-
91
-
-
0041821468
-
Raptor and mTOR: Subunits of a nutrient-sensitive complex
-
Kim, D.H.; Sabatini, D.M. Raptor and mTOR: Subunits of a nutrient-sensitive complex. Curr. Top. Microbiol. Immunol. 2004, 279, 259-270.
-
(2004)
Curr. Top. Microbiol. Immunol
, vol.279
, pp. 259-270
-
-
Kim, D.H.1
Sabatini, D.M.2
-
92
-
-
2442463314
-
Molecular mechanisms through which amino acids mediate signaling through the mammalian target of rapamycin
-
Kimball, S.R.; Jefferson, L.S. Molecular mechanisms through which amino acids mediate signaling through the mammalian target of rapamycin. Curr. Opin. Clin. Nutr. Metab. Care 2004, 7, 39-44.
-
(2004)
Curr. Opin. Clin. Nutr. Metab. Care
, vol.7
, pp. 39-44
-
-
Kimball, S.R.1
Jefferson, L.S.2
-
93
-
-
26844555799
-
Oral administration of branched-chain amino acids activates the mTOR signal in cirrhotic rat liver
-
Matsumura, T.; Morinaga, Y.; Fujitani, S.; Takehana, K.; Nishitani, S.; Sonaka, I. Oral administration of branched-chain amino acids activates the mTOR signal in cirrhotic rat liver. Hepatol. Res. 2005, 33, 27-32.
-
(2005)
Hepatol. Res
, vol.33
, pp. 27-32
-
-
Matsumura, T.1
Morinaga, Y.2
Fujitani, S.3
Takehana, K.4
Nishitani, S.5
Sonaka, I.6
-
94
-
-
0346365561
-
Pharmacological activities of branched-chain amino acids: Specificity of tissue and signal transduction
-
Nishitani, S.; Ijichi, C.; Takehana, K.; Fujitani, S.; Sonaka, I. Pharmacological activities of branched-chain amino acids: Specificity of tissue and signal transduction. Biochem. Biophys. Res. Commun. 2004, 313, 387-389.
-
(2004)
Biochem. Biophys. Res. Commun
, vol.313
, pp. 387-389
-
-
Nishitani, S.1
Ijichi, C.2
Takehana, K.3
Fujitani, S.4
Sonaka, I.5
-
95
-
-
80053563760
-
Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model
-
Roscic, A.; Baldo, B.; Crochemore, C.; Marcellin, D.; Paganetti, P. Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model. J. Neurochem. 2011, 119, 398-407.
-
(2011)
J. Neurochem
, vol.119
, pp. 398-407
-
-
Roscic, A.1
Baldo, B.2
Crochemore, C.3
Marcellin, D.4
Paganetti, P.5
-
96
-
-
0004112842
-
-
12th ed.; Wiley-Blackwell: Hoboken, NJ, USA
-
Delves, P.J.; Maitin, S.; Burton, D.R.; Roitt, I.M. Roitt's Essential Immunology, 12th ed.; Wiley-Blackwell: Hoboken, NJ, USA, 2011.
-
(2011)
Roitt's Essential Immunology
-
-
Delves, P.J.1
Maitin, S.2
Burton, D.R.3
Roitt, I.M.4
-
97
-
-
84860237060
-
Regulation and function of mTOR signalling in T cell fate decisions
-
Chi, H. Regulation and function of mTOR signalling in T cell fate decisions. Nat. Rev. Immunol. 2012, 12, 325-338.
-
(2012)
Nat. Rev. Immunol
, vol.12
, pp. 325-338
-
-
Chi, H.1
-
98
-
-
74549167783
-
Regulation of adaptive immunity by the innate immune system
-
Iwasaki, A.; Medzhitov, R. Regulation of adaptive immunity by the innate immune system. Science 2010, 327, 291-295.
-
(2010)
Science
, vol.327
, pp. 291-295
-
-
Iwasaki, A.1
Medzhitov, R.2
-
99
-
-
77958126087
-
A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation
-
Haidinger, M.; Poglitsch, M.; Geyeregger, R.; Kasturi, S.; Zeyda, M.; Zlabinger, G.J.; Pulendran, B.; Horl, W.H.; Saemann, M.D.; Weichhart, T. A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation. J. Immunol. 2010, 185, 3919-3931.
-
(2010)
J. Immunol
, vol.185
, pp. 3919-3931
-
-
Haidinger, M.1
Poglitsch, M.2
Geyeregger, R.3
Kasturi, S.4
Zeyda, M.5
Zlabinger, G.J.6
Pulendran, B.7
Horl, W.H.8
Saemann, M.D.9
Weichhart, T.10
-
100
-
-
84873560535
-
p38alpha senses environmental stress to control innate immune responses via mechanistic target of rapamycin
-
Katholnig, K.; Kaltenecker, C.C.; Hayakawa, H.; Rosner, M.; Lassnig, C.; Zlabinger, G.J.; Gaestel, M.; Muller, M.; Hengstschlager, M.; Horl, W.H. et al. p38alpha senses environmental stress to control innate immune responses via mechanistic target of rapamycin. J. Immunol. 2013, 190, 1519-1527.
-
(2013)
J. Immunol
, vol.190
, pp. 1519-1527
-
-
Katholnig, K.1
Kaltenecker, C.C.2
Hayakawa, H.3
Rosner, M.4
Lassnig, C.5
Zlabinger, G.J.6
Gaestel, M.7
Muller, M.8
Hengstschlager, M.9
Horl, W.H.10
-
101
-
-
80052963911
-
Targeting the dysregulated mammalian target of rapamycin pathway in organ transplantation: Killing 2 Birds With 1 Stone
-
Haidinger, M.; Werzowa, J.; Weichhart, T.; Saemann, M.D. Targeting the dysregulated mammalian target of rapamycin pathway in organ transplantation: Killing 2 birds with 1 stone. Transplant. Rev. 2011, 25, 145-153.
-
(2011)
Transplant. Rev
, vol.25
, pp. 145-153
-
-
Haidinger, M.1
Werzowa, J.2
Weichhart, T.3
Saemann, M.D.4
-
102
-
-
72449147738
-
The multifunctional role of mTOR in innate immunity: Implications for transplant immunity
-
Saemann, M.D.; Haidinger, M.; Hecking, M.; Horl, W.H.; Weichhart, T. The multifunctional role of mTOR in innate immunity: Implications for transplant immunity. Am. J. Transplant. 2009, 9, 2655-2661.
-
(2009)
Am. J. Transplant
, vol.9
, pp. 2655-2661
-
-
Saemann, M.D.1
Haidinger, M.2
Hecking, M.3
Horl, W.H.4
Weichhart, T.5
-
103
-
-
56749156696
-
The PI3K/Akt/mTOR pathway in innate immune cells: Emerging therapeutic applications
-
Weichhart, T.; Saemann, M.D. The PI3K/Akt/mTOR pathway in innate immune cells: Emerging therapeutic applications. Ann. Rheum. Dis. 2008, 67 (Suppl. 3), 370-374.
-
(2008)
Ann. Rheum. Dis
, vol.67
, Issue.3 SUPPL.
, pp. 370-374
-
-
Weichhart, T.1
Saemann, M.D.2
-
104
-
-
0038036797
-
Rapamycin inhibits IL-4--Induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo
-
Hackstein, H.; Taner, T.; Zahorchak, A.F.; Morelli, A.E.; Logar, A.J.; Gessner, A.; Thomson, A.W. Rapamycin inhibits IL-4--Induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo. Blood 2003, 101, 4457-4463.
-
(2003)
Blood
, vol.101
, pp. 4457-4463
-
-
Hackstein, H.1
Taner, T.2
Zahorchak, A.F.3
Morelli, A.E.4
Logar, A.J.5
Gessner, A.6
Thomson, A.W.7
-
105
-
-
0036682957
-
Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells
-
Hackstein, H.; Taner, T.; Logar, A.J.; Thomson, A.W. Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells. Blood 2002, 100, 1084-1087.
-
(2002)
Blood
, vol.100
, pp. 1084-1087
-
-
Hackstein, H.1
Taner, T.2
Logar, A.J.3
Thomson, A.W.4
-
106
-
-
0037439786
-
Rapamycin impairs antigen uptake of human dendritic cells
-
Monti, P.; Mercalli, A.; Leone, B.E.; Valerio, D.C.; Allavena, P.; Piemonti, L. Rapamycin impairs antigen uptake of human dendritic cells. Transplantation 2003, 75, 137-145.
-
(2003)
Transplantation
, vol.75
, pp. 137-145
-
-
Monti, P.1
Mercalli, A.2
Leone, B.E.3
Valerio, D.C.4
Allavena, P.5
Piemonti, L.6
-
107
-
-
77958470125
-
Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling
-
Sathaliyawala, T.; O'Gorman, W.E.; Greter, M.; Bogunovic, M.; Konjufca, V.; Hou, Z.E.; Nolan, G.P.; Miller, M.J.; Merad, M.; Reizis, B. Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling. Immunity 2010, 33, 597-606.
-
(2010)
Immunity
, vol.33
, pp. 597-606
-
-
Sathaliyawala, T.1
O'Gorman, W.E.2
Greter, M.3
Bogunovic, M.4
Konjufca, V.5
Hou, Z.E.6
Nolan, G.P.7
Miller, M.J.8
Merad, M.9
Reizis, B.10
-
108
-
-
34249805413
-
Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance
-
Turnquist, H.R.; Raimondi, G.; Zahorchak, A.F.; Fischer, R.T.; Wang, Z.; Thomson, A.W. Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance. J. Immunol. 2007, 178, 7018-7031.
-
(2007)
J. Immunol
, vol.178
, pp. 7018-7031
-
-
Turnquist, H.R.1
Raimondi, G.2
Zahorchak, A.F.3
Fischer, R.T.4
Wang, Z.5
Thomson, A.W.6
-
109
-
-
84861157347
-
Cutting edge: MTORC1 in intestinal CD11c+ CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production
-
Ohtani, M.; Hoshii, T.; Fujii, H.; Koyasu, S.; Hirao, A.; Matsuda, S. Cutting edge: mTORC1 in intestinal CD11c+ CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production. J. Immunol. 2012, 188, 4736-4740.
-
(2012)
J. Immunol
, vol.188
, pp. 4736-4740
-
-
Ohtani, M.1
Hoshii, T.2
Fujii, H.3
Koyasu, S.4
Hirao, A.5
Matsuda, S.6
-
110
-
-
54949109311
-
The TSC-mTOR signaling pathway regulates the innate inflammatory response
-
Weichhart, T.; Costantino, G.; Poglitsch, M.; Rosner, M.; Zeyda, M.; Stuhlmeier, K.M.; Kolbe, T.; Stulnig, T.M.; Horl, W.H.; Hengstschlager, M. et al. The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity 2008, 29, 565-577.
-
(2008)
Immunity
, vol.29
, pp. 565-577
-
-
Weichhart, T.1
Costantino, G.2
Poglitsch, M.3
Rosner, M.4
Zeyda, M.5
Stuhlmeier, K.M.6
Kolbe, T.7
Stulnig, T.M.8
Horl, W.H.9
Hengstschlager, M.10
-
111
-
-
84879303627
-
The peripheral NK cell repertoire after kidney transplantation is modulated by different immunosuppressive drugs
-
doi:10.3389/fimmu.2013.00046
-
Neudoerfl, C.; Mueller, B.J.; Blume, C.; Daemen, K.; Stevanovic-Meyer, M.; Keil, J.; Lehner, F.; Haller, H.; Falk, C.S. The peripheral NK cell repertoire after kidney transplantation is modulated by different immunosuppressive drugs. Front. Immunol. 2013, 4, 46, doi:10.3389/fimmu.2013.00046.
-
(2013)
Front. Immunol
, vol.4
, pp. 46
-
-
Neudoerfl, C.1
Mueller, B.J.2
Blume, C.3
Daemen, K.4
Stevanovic-Meyer, M.5
Keil, J.6
Lehner, F.7
Haller, H.8
Falk, C.S.9
-
112
-
-
84555187749
-
Mammalian target of rapamycin: A signaling kinase for every aspect of cellular life
-
Weichhart, T. Mammalian target of rapamycin: A signaling kinase for every aspect of cellular life. Methods Mol. Biol. 2012, 821, 1-14.
-
(2012)
Methods Mol. Biol
, vol.821
, pp. 1-14
-
-
Weichhart, T.1
-
113
-
-
65349159281
-
Immunoregulatory functions of mTOR inhibition
-
Thomson, A.W.; Turnquist, H.R.; Raimondi, G. Immunoregulatory functions of mTOR inhibition. Nat. Rev. Immunol. 2009, 9, 324-337.
-
(2009)
Nat. Rev. Immunol
, vol.9
, pp. 324-337
-
-
Thomson, A.W.1
Turnquist, H.R.2
Raimondi, G.3
-
114
-
-
84879316492
-
Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1 and regulatory T cell induction
-
doi:10.1182/blood-2012-08-448290
-
Rosborough, B.R.; Raich-Regue, D.; Matta, B.M.; Lee, K.; Gan, B.; Depinho, R.A.; Hackstein, H.; Boothby, M.; Turnquist, H.R.; Thomson, A.W. Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1 and regulatory T cell induction. Blood 2013, doi:10.1182/blood-2012-08-448290.
-
(2013)
Blood
-
-
Rosborough, B.R.1
Raich-Regue, D.2
Matta, B.M.3
Lee, K.4
Gan, B.5
Depinho, R.A.6
Hackstein, H.7
Boothby, M.8
Turnquist, H.R.9
Thomson, A.W.10
-
115
-
-
58149352480
-
Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells
-
Schmitz, F.; Heit, A.; Dreher, S.; Eisenacher, K.; Mages, J.; Haas, T.; Krug, A.; Janssen, K.P.; Kirschning, C.J.; Wagner, H. Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells. Eur. J. Immunol. 2008, 38, 2981-2992.
-
(2008)
Eur. J. Immunol
, vol.38
, pp. 2981-2992
-
-
Schmitz, F.1
Heit, A.2
Dreher, S.3
Eisenacher, K.4
Mages, J.5
Haas, T.6
Krug, A.7
Janssen, K.P.8
Kirschning, C.J.9
Wagner, H.10
-
116
-
-
84865130666
-
The mTOR-inhibitor rapamycin mediates proteinuria in nephrotoxic serum nephritis by activating the innate immune response
-
Kirsch, A.H.; Riegelbauer, V.; Tagwerker, A.; Rudnicki, M.; Rosenkranz, A.R.; Eller, K. The mTOR-inhibitor rapamycin mediates proteinuria in nephrotoxic serum nephritis by activating the innate immune response. Am. J. Physiol. Ren. Physiol. 2012, 303, F569-F575.
-
(2012)
Am. J. Physiol. Ren. Physiol
, vol.303
-
-
Kirsch, A.H.1
Riegelbauer, V.2
Tagwerker, A.3
Rudnicki, M.4
Rosenkranz, A.R.5
Eller, K.6
-
117
-
-
0025132636
-
Suppression of B cell activation by cyclosporin A, FK506 and rapamycin
-
Wicker, L.S.; Boltz, R.C., Jr.; Matt, V.; Nichols, E.A.; Peterson, L.B.; Sigal, N.H. Suppression of B cell activation by cyclosporin A, FK506 and rapamycin. Eur. J. Immunol. 1990, 20, 2277-2283.
-
(1990)
Eur. J. Immunol
, vol.20
, pp. 2277-2283
-
-
Wicker, L.S.1
Boltz Jr., R.C.2
Matt, V.3
Nichols, E.A.4
Peterson, L.B.5
Sigal, N.H.6
-
118
-
-
0025734876
-
Inhibition of T and B lymphocyte proliferation by rapamycin
-
Kay, J.E.; Kromwel, L.; Doe, S.E.; Denyer, M. Inhibition of T and B lymphocyte proliferation by rapamycin. Immunology 1991, 72, 544-549.
-
(1991)
Immunology
, vol.72
, pp. 544-549
-
-
Kay, J.E.1
Kromwel, L.2
Doe, S.E.3
Denyer, M.4
-
119
-
-
0028093139
-
Inhibition of human B lymphocyte cell cycle progression and differentiation by rapamycin
-
Aagaard-Tillery, K.M.; Jelinek, D.F. Inhibition of human B lymphocyte cell cycle progression and differentiation by rapamycin. Cell. Immunol. 1994, 156, 493-507.
-
(1994)
Cell. Immunol
, vol.156
, pp. 493-507
-
-
Aagaard-Tillery, K.M.1
Jelinek, D.F.2
-
120
-
-
0033152319
-
Involvement of a rapamycin-sensitive pathway in CD40-mediated activation of murine B cells in vitro
-
Sakata, A.; Kuwahara, K.; Ohmura, T.; Inui, S.; Sakaguchi, N. Involvement of a rapamycin-sensitive pathway in CD40-mediated activation of murine B cells in vitro. Immunol. Lett. 1999, 68, 301-309.
-
(1999)
Immunol. Lett
, vol.68
, pp. 301-309
-
-
Sakata, A.1
Kuwahara, K.2
Ohmura, T.3
Inui, S.4
Sakaguchi, N.5
-
121
-
-
35348852627
-
Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli
-
Donahue, A.C.; Fruman, D.A. Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli. Eur. J. Immunol. 2007, 37, 2923-2936.
-
(2007)
Eur. J. Immunol
, vol.37
, pp. 2923-2936
-
-
Donahue, A.C.1
Fruman, D.A.2
-
122
-
-
79251569252
-
Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production
-
Zhang, S.; Readinger, J.A.; DuBois, W.; Janka-Junttila, M.; Robinson, R.; Pruitt, M.; Bliskovsky, V.; Wu, J.Z.; Sakakibara, K.; Patel, J. et al. Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production. Blood 2011, 117, 1228-1238.
-
(2011)
Blood
, vol.117
, pp. 1228-1238
-
-
Zhang, S.1
Readinger, J.A.2
Dubois, W.3
Janka-Junttila, M.4
Robinson, R.5
Pruitt, M.6
Bliskovsky, V.7
Wu, J.Z.8
Sakakibara, K.9
Patel, J.10
-
123
-
-
79960724234
-
Direct activation of mTOR in B lymphocytes confers impairment in B-cell maturation andloss of marginal zone B cells
-
Benhamron, S.; Tirosh, B. Direct activation of mTOR in B lymphocytes confers impairment in B-cell maturation andloss of marginal zone B cells. Eur. J. Immunol. 2011, 41, 2390-2396.
-
(2011)
Eur. J. Immunol
, vol.41
, pp. 2390-2396
-
-
Benhamron, S.1
Tirosh, B.2
-
124
-
-
33846895443
-
The PI3K p110delta is required for down-regulation of RAG expression in immature B cells
-
Llorian, M.; Stamataki, Z.; Hill, S.; Turner, M.; Martensson, I.L. The PI3K p110delta is required for down-regulation of RAG expression in immature B cells. J. Immunol. 2007, 178, 1981-1985.
-
(2007)
J. Immunol
, vol.178
, pp. 1981-1985
-
-
Llorian, M.1
Stamataki, Z.2
Hill, S.3
Turner, M.4
Martensson, I.L.5
-
125
-
-
0038281331
-
Proliferation and survival of activated B cells requires sustained antigen receptor engagement and phosphoinositide 3-kinase activation
-
Donahue, A.C.; Fruman, D.A. Proliferation and survival of activated B cells requires sustained antigen receptor engagement and phosphoinositide 3-kinase activation. J. Immunol. 2003, 170, 5851-5860.
-
(2003)
J. Immunol
, vol.170
, pp. 5851-5860
-
-
Donahue, A.C.1
Fruman, D.A.2
-
126
-
-
9244263536
-
Frontline: The p85alpha isoform of phosphoinositide 3-kinase is essential for a subset of B cell receptor-initiated signaling responses
-
Hess, K.L.; Donahue, A.C.; Ng, K.L.; Moore, T.I.; Oak, J.; Fruman, D.A. Frontline: The p85alpha isoform of phosphoinositide 3-kinase is essential for a subset of B cell receptor-initiated signaling responses. Eur. J. Immunol. 2004, 34, 2968-2976.
-
(2004)
Eur. J. Immunol
, vol.34
, pp. 2968-2976
-
-
Hess, K.L.1
Donahue, A.C.2
Ng, K.L.3
Moore, T.I.4
Oak, J.5
Fruman, D.A.6
-
127
-
-
78851469165
-
Protein synthesis in plasma cells is regulated by crosstalk between endoplasmic reticulum stress and mTOR signaling
-
Goldfinger, M.; Shmuel, M.; Benhamron, S.; Tirosh, B. Protein synthesis in plasma cells is regulated by crosstalk between endoplasmic reticulum stress and mTOR signaling. Eur. J. Immunol. 2011, 41, 491-502.
-
(2011)
Eur. J. Immunol
, vol.41
, pp. 491-502
-
-
Goldfinger, M.1
Shmuel, M.2
Benhamron, S.3
Tirosh, B.4
-
128
-
-
84861157343
-
Mammalian target of rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells
-
Waickman, A.T.; Powell, J.D. Mammalian target of rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells. J. Immunol. 2012, 188, 4721-4729.
-
(2012)
J. Immunol
, vol.188
, pp. 4721-4729
-
-
Waickman, A.T.1
Powell, J.D.2
-
129
-
-
78149248752
-
Duration of antigen receptor signaling determines T-cell tolerance or activation
-
Katzman, S.D.; O'Gorman, W.E.; Villarino, A.V.; Gallo, E.; Friedman, R.S.; Krummel, M.F.; Nolan, G.P.; Abbas, A.K. Duration of antigen receptor signaling determines T-cell tolerance or activation. Proc. Natl. Acad. Sci. USA 2010, 107, 18085-18090.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 18085-18090
-
-
Katzman, S.D.1
O'Gorman, W.E.2
Villarino, A.V.3
Gallo, E.4
Friedman, R.S.5
Krummel, M.F.6
Nolan, G.P.7
Abbas, A.K.8
-
130
-
-
33749144276
-
Rapamycin and dendritic cells: Keep on movin'
-
Hackstein, H. Rapamycin and dendritic cells: Keep on movin'. Transplantation 2006, 82, 739-740.
-
(2006)
Transplantation
, vol.82
, pp. 739-740
-
-
Hackstein, H.1
-
131
-
-
80051997049
-
The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
-
Yang, K.; Neale, G.; Green, D.R.; He, W.; Chi, H. The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function. Nat. Immunol. 2011, 12, 888-897.
-
(2011)
Nat. Immunol
, vol.12
, pp. 888-897
-
-
Yang, K.1
Neale, G.2
Green, D.R.3
He, W.4
Chi, H.5
-
132
-
-
84857398190
-
TSC1/2 signaling complex is essential for peripheral naive CD8+ T cell survival and homeostasis in mice
-
doi:10.1371/journal.pone.0030592
-
Zhang, L.; Zhang, H.; Li, L.; Xiao, Y.; Rao, E.; Miao, Z.; Chen, H.; Sun, L.; Li, H.; Liu, G. et al. TSC1/2 signaling complex is essential for peripheral naive CD8+ T cell survival and homeostasis in mice. PLoS One 2012, 7, e30592, doi:10.1371/journal.pone.0030592.
-
(2012)
PLoS One
, vol.7
-
-
Zhang, L.1
Zhang, H.2
Li, L.3
Xiao, Y.4
Rao, E.5
Miao, Z.6
Chen, H.7
Sun, L.8
Li, H.9
Liu, G.10
-
133
-
-
0141927222
-
Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer
-
Gao, N.; Zhang, Z.; Jiang, B.H.; Shi, X. Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer. Biochem. Biophys. Res. Commun. 2003, 310, 1124-1132.
-
(2003)
Biochem. Biophys. Res. Commun
, vol.310
, pp. 1124-1132
-
-
Gao, N.1
Zhang, Z.2
Jiang, B.H.3
Shi, X.4
-
134
-
-
4043050174
-
G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells
-
Gao, N.; Flynn, D.C.; Zhang, Z.; Zhong, X.S.; Walker, V.; Liu, K.J.; Shi, X.; Jiang, B.H. G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells. Am. J. Physiol. Cell Physiol. 2004, 287, C281-C291.
-
(2004)
Am. J. Physiol. Cell Physiol
, vol.287
-
-
Gao, N.1
Flynn, D.C.2
Zhang, Z.3
Zhong, X.S.4
Walker, V.5
Liu, K.J.6
Shi, X.7
Jiang, B.H.8
-
135
-
-
34548014737
-
Revving the engine: Signal transduction fuels T cell activation
-
Jones, R.G.; Thompson, C.B. Revving the engine: Signal transduction fuels T cell activation. Immunity 2007, 27, 173-178.
-
(2007)
Immunity
, vol.27
, pp. 173-178
-
-
Jones, R.G.1
Thompson, C.B.2
-
136
-
-
65549130605
-
Foxp3 processing by proprotein convertases and control of regulatory T cell function
-
De Zoeten, E.F.; Lee, I.; Wang, L.; Chen, C.; Ge, G.; Wells, A.D.; Hancock, W.W.; Ozkaynak, E. Foxp3 processing by proprotein convertases and control of regulatory T cell function. J. Biol. Chem. 2009, 284, 5709-5716.
-
(2009)
J. Biol. Chem
, vol.284
, pp. 5709-5716
-
-
de Zoeten, E.F.1
Lee, I.2
Wang, L.3
Chen, C.4
Ge, G.5
Wells, A.D.6
Hancock, W.W.7
Ozkaynak, E.8
-
137
-
-
77952472919
-
The biology of FoxP3: A key player in immune suppression during infections, autoimmune diseases and cancer
-
Mercer, F.; Unutmaz, D. The biology of FoxP3: A key player in immune suppression during infections, autoimmune diseases and cancer. Adv. Exp. Med. Biol. 2009, 665, 47-59.
-
(2009)
Adv. Exp. Med. Biol
, vol.665
, pp. 47-59
-
-
Mercer, F.1
Unutmaz, D.2
-
138
-
-
20444373376
-
Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
-
Battaglia, M.; Stabilini, A.; Roncarolo, M.G. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 2005, 105, 4743-4748.
-
(2005)
Blood
, vol.105
, pp. 4743-4748
-
-
Battaglia, M.1
Stabilini, A.2
Roncarolo, M.G.3
-
139
-
-
33845379986
-
Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients
-
Battaglia, M.; Stabilini, A.; Migliavacca, B.; Horejs-Hoeck, J.; Kaupper, T.; Roncarolo, M.G. Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients. J. Immunol. 2006, 177, 8338-8347.
-
(2006)
J. Immunol
, vol.177
, pp. 8338-8347
-
-
Battaglia, M.1
Stabilini, A.2
Migliavacca, B.3
Horejs-Hoeck, J.4
Kaupper, T.5
Roncarolo, M.G.6
-
140
-
-
51849122220
-
Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells
-
Monti, P.; Scirpoli, M.; Maffi, P.; Piemonti, L.; Secchi, A.; Bonifacio, E.; Roncarolo, M.G.; Battaglia, M. Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells. Diabetes 2008, 57, 2341-2347.
-
(2008)
Diabetes
, vol.57
, pp. 2341-2347
-
-
Monti, P.1
Scirpoli, M.2
Maffi, P.3
Piemonti, L.4
Secchi, A.5
Bonifacio, E.6
Roncarolo, M.G.7
Battaglia, M.8
-
141
-
-
46949088630
-
De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR
-
Kang, J.; Huddleston, S.J.; Fraser, J.M.; Khoruts, A. De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR. J. Leukoc. Biol. 2008, 83, 1230-1239.
-
(2008)
J. Leukoc. Biol
, vol.83
, pp. 1230-1239
-
-
Kang, J.1
Huddleston, S.J.2
Fraser, J.M.3
Khoruts, A.4
-
142
-
-
35748956420
-
Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells
-
Kopf, H.; de la Rosa, G.M.; Howard, O.M.; Chen, X. Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells. Int. Immunopharmacol. 2007, 7, 1819-1824.
-
(2007)
Int. Immunopharmacol
, vol.7
, pp. 1819-1824
-
-
Kopf, H.1
de la Rosa, G.M.2
Howard, O.M.3
Chen, X.4
-
143
-
-
38049177784
-
Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells
-
Zeiser, R.; Leveson-Gower, D.B.; Zambricki, E.A.; Kambham, N.; Beilhack, A.; Loh, J.; Hou, J.Z.; Negrin, R.S. Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells. Blood 2008, 111, 453-462.
-
(2008)
Blood
, vol.111
, pp. 453-462
-
-
Zeiser, R.1
Leveson-Gower, D.B.2
Zambricki, E.A.3
Kambham, N.4
Beilhack, A.5
Loh, J.6
Hou, J.Z.7
Negrin, R.S.8
-
144
-
-
79952985551
-
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
-
Delgoffe, G.M.; Pollizzi, K.N.; Waickman, A.T.; Heikamp, E.; Meyers, D.J.; Horton, M.R.; Xiao, B.; Worley, P.F.; Powell, J.D. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat. Immunol. 2011, 12, 295-303.
-
(2011)
Nat. Immunol
, vol.12
, pp. 295-303
-
-
Delgoffe, G.M.1
Pollizzi, K.N.2
Waickman, A.T.3
Heikamp, E.4
Meyers, D.J.5
Horton, M.R.6
Xiao, B.7
Worley, P.F.8
Powell, J.D.9
-
145
-
-
79960369458
-
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
-
Shi, L.Z.; Wang, R.; Huang, G.; Vogel, P.; Neale, G.; Green, D.R.; Chi, H. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J. Exp. Med. 2011, 208, 1367-1376.
-
(2011)
J. Exp. Med
, vol.208
, pp. 1367-1376
-
-
Shi, L.Z.1
Wang, R.2
Huang, G.3
Vogel, P.4
Neale, G.5
Green, D.R.6
Chi, H.7
-
146
-
-
84876950862
-
Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM and ATR
-
Liu, Q.; Xu, C.; Kirubakaran, S.; Zhang, X.; Hur, W.; Liu, Y.; Kwiatkowski, N.P.; Wang, J.; Westover, K.D.; Gao, P. et al. Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM and ATR. Cancer Res. 2013, 73, 2574-2586.
-
(2013)
Cancer Res
, vol.73
, pp. 2574-2586
-
-
Liu, Q.1
Xu, C.2
Kirubakaran, S.3
Zhang, X.4
Hur, W.5
Liu, Y.6
Kwiatkowski, N.P.7
Wang, J.8
Westover, K.D.9
Gao, P.10
-
147
-
-
67749091321
-
Infectious tolerance via the consumption of essential amino acids and mTOR signaling
-
Cobbold, S.P.; Adams, E.; Farquhar, C.A.; Nolan, K.F.; Howie, D.; Lui, K.O.; Fairchild, P.J.; Mellor, A.L.; Ron, D.; Waldmann, H. Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc. Natl. Acad. Sci. USA 2009, 106, 12055-12060.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 12055-12060
-
-
Cobbold, S.P.1
Adams, E.2
Farquhar, C.A.3
Nolan, K.F.4
Howie, D.5
Lui, K.O.6
Fairchild, P.J.7
Mellor, A.L.8
Ron, D.9
Waldmann, H.10
-
148
-
-
78049287331
-
mTOR signalling and metabolic regulation of T cell differentiation
-
Peter, C.; Waldmann, H.; Cobbold, S.P. mTOR signalling and metabolic regulation of T cell differentiation. Curr. Opin. Immunol. 2010, 22, 655-661.
-
(2010)
Curr. Opin. Immunol
, vol.22
, pp. 655-661
-
-
Peter, C.1
Waldmann, H.2
Cobbold, S.P.3
-
149
-
-
77954417145
-
PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors
-
Merkenschlager, M.; von Boehmer, H. PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors. J. Exp. Med. 2010, 207, 1347-1350.
-
(2010)
J. Exp. Med
, vol.207
, pp. 1347-1350
-
-
Merkenschlager, M.1
von Boehmer, H.2
-
150
-
-
45549098562
-
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
-
Sauer, S.; Bruno, L.; Hertweck, A.; Finlay, D.; Leleu, M.; Spivakov, M.; Knight, Z.A.; Cobb, B.S.; Cantrell, D.; O'Connor, E. et al. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc. Natl. Acad. Sci. USA 2008, 105, 7797-7802.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 7797-7802
-
-
Sauer, S.1
Bruno, L.2
Hertweck, A.3
Finlay, D.4
Leleu, M.5
Spivakov, M.6
Knight, Z.A.7
Cobb, B.S.8
Cantrell, D.9
O'Connor, E.10
-
151
-
-
66949173728
-
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
-
Delgoffe, G.M.; Kole, T.P.; Zheng, Y.; Zarek, P.E.; Matthews, K.L.; Xiao, B.; Worley, P.F.; Kozma, S.C.; Powell, J.D. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 2009, 30, 832-844.
-
(2009)
Immunity
, vol.30
, pp. 832-844
-
-
Delgoffe, G.M.1
Kole, T.P.2
Zheng, Y.3
Zarek, P.E.4
Matthews, K.L.5
Xiao, B.6
Worley, P.F.7
Kozma, S.C.8
Powell, J.D.9
-
152
-
-
84865301337
-
mTOR, metabolism, and the regulation of T-cell differentiation and function
-
Waickman, A.T.; Powell, J.D. mTOR, metabolism, and the regulation of T-cell differentiation and function. Immunol. Rev. 2012, 249, 43-58.
-
(2012)
Immunol. Rev
, vol.249
, pp. 43-58
-
-
Waickman, A.T.1
Powell, J.D.2
-
153
-
-
77953897189
-
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
-
Lee, K.; Gudapati, P.; Dragovic, S.; Spencer, C.; Joyce, S.; Killeen, N.; Magnuson, M.A.; Boothby, M. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity 2010, 32, 743-753.
-
(2010)
Immunity
, vol.32
, pp. 743-753
-
-
Lee, K.1
Gudapati, P.2
Dragovic, S.3
Spencer, C.4
Joyce, S.5
Killeen, N.6
Magnuson, M.A.7
Boothby, M.8
-
154
-
-
84555189464
-
Exploring functional in vivo consequences of the selective genetic ablation of mTOR signaling in T helper lymphocytes
-
Delgoffe, G.M.; Powell, J.D. Exploring functional in vivo consequences of the selective genetic ablation of mTOR signaling in T helper lymphocytes. Methods Mol. Biol. 2012, 821, 317-327.
-
(2012)
Methods Mol. Biol
, vol.821
, pp. 317-327
-
-
Delgoffe, G.M.1
Powell, J.D.2
-
155
-
-
77958140465
-
Cutting edge: Expression of the transcription factor E74-like factor 4 is regulated by the mammalian target of rapamycin pathway in CD8+ T cells
-
Yamada, T.; Gierach, K.; Lee, P.H.; Wang, X.; Lacorazza, H.D. Cutting edge: Expression of the transcription factor E74-like factor 4 is regulated by the mammalian target of rapamycin pathway in CD8+ T cells. J. Immunol. 2010, 185, 3824-3828.
-
(2010)
J. Immunol
, vol.185
, pp. 3824-3828
-
-
Yamada, T.1
Gierach, K.2
Lee, P.H.3
Wang, X.4
Lacorazza, H.D.5
-
156
-
-
77951678634
-
The role of mTOR in memory CD8 T-cell differentiation
-
Araki, K.; Youngblood, B.; Ahmed, R. The role of mTOR in memory CD8 T-cell differentiation. Immunol. Rev. 2010, 235, 234-243.
-
(2010)
Immunol. Rev
, vol.235
, pp. 234-243
-
-
Araki, K.1
Youngblood, B.2
Ahmed, R.3
-
157
-
-
79954623272
-
A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity
-
Li, Q.; Rao, R.R.; Araki, K.; Pollizzi, K.; Odunsi, K.; Powell, J.D.; Shrikant, P.A. A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity. Immunity 2011, 34, 541-553.
-
(2011)
Immunity
, vol.34
, pp. 541-553
-
-
Li, Q.1
Rao, R.R.2
Araki, K.3
Pollizzi, K.4
Odunsi, K.5
Powell, J.D.6
Shrikant, P.A.7
-
158
-
-
84875392326
-
mTORC1 regulates CD8+ T-cell glucose metabolism and function independently of PI3K and PKB
-
Finlay, D.K. mTORC1 regulates CD8+ T-cell glucose metabolism and function independently of PI3K and PKB. Biochem. Soc. Trans. 2013, 41, 681-686.
-
(2013)
Biochem. Soc. Trans
, vol.41
, pp. 681-686
-
-
Finlay, D.K.1
-
159
-
-
75749119313
-
Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration
-
Finlay, D.; Cantrell, D. Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration. Ann. N. Y. Acad. Sci. 2010, 1183, 149-157.
-
(2010)
Ann. N. Y. Acad. Sci
, vol.1183
, pp. 149-157
-
-
Finlay, D.1
Cantrell, D.2
-
160
-
-
84871861969
-
PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells
-
Finlay, D.K.; Rosenzweig, E.; Sinclair, L.V.; Feijoo-Carnero, C.; Hukelmann, J.L.; Rolf, J.; Panteleyev, A.A.; Okkenhaug, K.; Cantrell, D.A. PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells. J. Exp. Med. 2012, 209, 2441-2453.
-
(2012)
J. Exp. Med
, vol.209
, pp. 2441-2453
-
-
Finlay, D.K.1
Rosenzweig, E.2
Sinclair, L.V.3
Feijoo-Carnero, C.4
Hukelmann, J.L.5
Rolf, J.6
Panteleyev, A.A.7
Okkenhaug, K.8
Cantrell, D.A.9
-
161
-
-
84875610850
-
Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells
-
Kurebayashi, Y.; Nagai, S.; Ikejiri, A.; Koyasu, S. Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells. Genes Cells Devoted Mol. Cell. Mech. 2013, 18, 247-265.
-
(2013)
Genes Cells Devoted Mol. Cell. Mech
, vol.18
, pp. 247-265
-
-
Kurebayashi, Y.1
Nagai, S.2
Ikejiri, A.3
Koyasu, S.4
-
162
-
-
84857542440
-
Dynamic regulation of Th17 differentiation by oxygen concentrations
-
Ikejiri, A.; Nagai, S.; Goda, N.; Kurebayashi, Y.; Osada-Oka, M.; Takubo, K.; Suda, T.; Koyasu, S. Dynamic regulation of Th17 differentiation by oxygen concentrations. Int. Immunol. 2012, 24, 137-146.
-
(2012)
Int. Immunol
, vol.24
, pp. 137-146
-
-
Ikejiri, A.1
Nagai, S.2
Goda, N.3
Kurebayashi, Y.4
Osada-Oka, M.5
Takubo, K.6
Suda, T.7
Koyasu, S.8
-
163
-
-
78649348967
-
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
-
Sengupta, S.; Peterson, T.R.; Sabatini, D.M. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol. Cell 2010, 40, 310-322.
-
(2010)
Mol. Cell
, vol.40
, pp. 310-322
-
-
Sengupta, S.1
Peterson, T.R.2
Sabatini, D.M.3
-
164
-
-
2942724235
-
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
-
Majumder, P.K.; Febbo, P.G.; Bikoff, R.; Berger, R.; Xue, Q.; McMahon, L.M.; Manola, J.; Brugarolas, J.; McDonnell, T.J.; Golub, T.R. et al. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat. Med. 2004, 10, 594-601.
-
(2004)
Nat. Med
, vol.10
, pp. 594-601
-
-
Majumder, P.K.1
Febbo, P.G.2
Bikoff, R.3
Berger, R.4
Xue, Q.5
McMahon, L.M.6
Manola, J.7
Brugarolas, J.8
McDonnell, T.J.9
Golub, T.R.10
-
165
-
-
10044276783
-
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
-
Brugarolas, J.; Lei, K.; Hurley, R.L.; Manning, B.D.; Reiling, J.H.; Hafen, E.; Witters, L.A.; Ellisen, L.W.; Kaelin, W.G. Jr. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev. 2004, 18, 2893-2904.
-
(2004)
Genes Dev
, vol.18
, pp. 2893-2904
-
-
Brugarolas, J.1
Lei, K.2
Hurley, R.L.3
Manning, B.D.4
Reiling, J.H.5
Hafen, E.6
Witters, L.A.7
Ellisen, L.W.8
Kaelin Jr., W.G.9
-
166
-
-
67650074206
-
mTOR regulates memory CD8 T-cell differentiation
-
Araki, K.; Turner, A.P.; Shaffer, V.O.; Gangappa, S.; Keller, S.A.; Bachmann, M.F.; Larsen, C.P.; Ahmed, R. mTOR regulates memory CD8 T-cell differentiation. Nature 2009, 460, 108-112.
-
(2009)
Nature
, vol.460
, pp. 108-112
-
-
Araki, K.1
Turner, A.P.2
Shaffer, V.O.3
Gangappa, S.4
Keller, S.A.5
Bachmann, M.F.6
Larsen, C.P.7
Ahmed, R.8
-
167
-
-
79956142389
-
Characterization of the metabolic phenotype of rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cells
-
doi:10.1371/journal.pone.0020107
-
He, S.; Kato, K.; Jiang, J.; Wahl, D.R.; Mineishi, S.; Fisher, E.M.; Murasko, D.M.; Glick, G.D.; Zhang, Y. Characterization of the metabolic phenotype of rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cells. PLoS One 2011, 6, e20107, doi:10.1371/journal.pone.0020107.
-
(2011)
PLoS One
, vol.6
-
-
He, S.1
Kato, K.2
Jiang, J.3
Wahl, D.R.4
Mineishi, S.5
Fisher, E.M.6
Murasko, D.M.7
Glick, G.D.8
Zhang, Y.9
-
168
-
-
67650096912
-
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
-
Pearce, E.L.; Walsh, M.C.; Cejas, P.J.; Harms, G.M.; Shen, H.; Wang, L.S.; Jones, R.G.; Choi, Y. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 2009, 460, 103-107.
-
(2009)
Nature
, vol.460
, pp. 103-107
-
-
Pearce, E.L.1
Walsh, M.C.2
Cejas, P.J.3
Harms, G.M.4
Shen, H.5
Wang, L.S.6
Jones, R.G.7
Choi, Y.8
-
169
-
-
78049268109
-
Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival
-
Hand, T.W.; Cui, W.; Jung, Y.W.; Sefik, E.; Joshi, N.S.; Chandele, A.; Liu, Y.; Kaech, S.M. Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival. Proc. Natl. Acad. Sci. USA 2010, 107, 16601-16606.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 16601-16606
-
-
Hand, T.W.1
Cui, W.2
Jung, Y.W.3
Sefik, E.4
Joshi, N.S.5
Chandele, A.6
Liu, Y.7
Kaech, S.M.8
-
170
-
-
79951670258
-
Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines
-
Wang, Y.; Wang, X.Y.; Subjeck, J.R.; Shrikant, P.A.; Kim, H.L. Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines. Br. J. Cancer 2011, 104, 643-652.
-
(2011)
Br. J. Cancer
, vol.104
, pp. 643-652
-
-
Wang, Y.1
Wang, X.Y.2
Subjeck, J.R.3
Shrikant, P.A.4
Kim, H.L.5
-
171
-
-
79951986439
-
Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques
-
Turner, A.P.; Shaffer, V.O.; Araki, K.; Martens, C.; Turner, P.L.; Gangappa, S.; Ford, M.L.; Ahmed, R.; Kirk, A.D.; Larsen, C.P. Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques. Am. J. Transplant. 2011, 11, 613-618.
-
(2011)
Am. J. Transplant
, vol.11
, pp. 613-618
-
-
Turner, A.P.1
Shaffer, V.O.2
Araki, K.3
Martens, C.4
Turner, P.L.5
Gangappa, S.6
Ford, M.L.7
Ahmed, R.8
Kirk, A.D.9
Larsen, C.P.10
-
172
-
-
84857026191
-
Rapamycin generates graft-homing murine suppressor CD8(+) T cells that confer donor-specific graft protection
-
El Essawy, B.; Putheti, P.; Gao, W.; Strom, T.B. Rapamycin generates graft-homing murine suppressor CD8(+) T cells that confer donor-specific graft protection. Cell Transplant. 2011, 20, 1759-1769.
-
(2011)
Cell Transplant
, vol.20
, pp. 1759-1769
-
-
El Essawy, B.1
Putheti, P.2
Gao, W.3
Strom, T.B.4
-
173
-
-
77956893188
-
Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses
-
Ferrer, I.R.; Wagener, M.E.; Robertson, J.M.; Turner, A.P.; Araki, K.; Ahmed, R.; Kirk, A.D.; Larsen, C.P.; Ford, M.L. Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses. J. Immunol. 2010, 185, 2004-2008.
-
(2010)
J. Immunol
, vol.185
, pp. 2004-2008
-
-
Ferrer, I.R.1
Wagener, M.E.2
Robertson, J.M.3
Turner, A.P.4
Araki, K.5
Ahmed, R.6
Kirk, A.D.7
Larsen, C.P.8
Ford, M.L.9
-
174
-
-
33846909503
-
A role for mammalian target of rapamycin in regulating T cell activation versus anergy
-
Zheng, Y.; Collins, S.L.; Lutz, M.A.; Allen, A.N.; Kole, T.P.; Zarek, P.E.; Powell, J.D. A role for mammalian target of rapamycin in regulating T cell activation versus anergy. J. Immunol. 2007, 178, 2163-2170.
-
(2007)
J. Immunol
, vol.178
, pp. 2163-2170
-
-
Zheng, Y.1
Collins, S.L.2
Lutz, M.A.3
Allen, A.N.4
Kole, T.P.5
Zarek, P.E.6
Powell, J.D.7
-
175
-
-
13144256708
-
Rapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survival
-
Taner, T.; Hackstein, H.; Wang, Z.; Morelli, A.E.; Thomson, A.W. Rapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survival. Am. J. Transplant. 2005, 5, 228-236.
-
(2005)
Am. J. Transplant
, vol.5
, pp. 228-236
-
-
Taner, T.1
Hackstein, H.2
Wang, Z.3
Morelli, A.E.4
Thomson, A.W.5
-
176
-
-
58149292274
-
Impact of mammalian target of rapamycin inhibition on lymphoid homing and tolerogenic function of nanoparticle-labeled dendritic cells following allogeneic hematopoietic cell transplantation
-
Reichardt, W.; Durr, C.; von Elverfeldt, D.; Juttner, E.; Gerlach, U.V.; Yamada, M.; Smith, B.; Negrin, R.S.; Zeiser, R. Impact of mammalian target of rapamycin inhibition on lymphoid homing and tolerogenic function of nanoparticle-labeled dendritic cells following allogeneic hematopoietic cell transplantation. J. Immunol. 2008, 181, 4770-4779.
-
(2008)
J. Immunol
, vol.181
, pp. 4770-4779
-
-
Reichardt, W.1
Durr, C.2
von Elverfeldt, D.3
Juttner, E.4
Gerlach, U.V.5
Yamada, M.6
Smith, B.7
Negrin, R.S.8
Zeiser, R.9
-
177
-
-
77957659746
-
Everolimus: A proliferation signal inhibitor with clinical applications in organ transplantation, oncology, and cardiology
-
Gabardi, S.; Baroletti, S.A. Everolimus: A proliferation signal inhibitor with clinical applications in organ transplantation, oncology, and cardiology. Pharmacotherapy 2010, 30, 1044-1056.
-
(2010)
Pharmacotherapy
, vol.30
, pp. 1044-1056
-
-
Gabardi, S.1
Baroletti, S.A.2
-
178
-
-
77957583305
-
Efficacy and safety of de novo or early everolimus with low cyclosporine in deceased-donor kidney transplant recipients at specified risk of delayed graft function: 12-Month results of a randomized, multicenter trial
-
Dantal, J.; Berthoux, F.; Moal, M.C.; Rostaing, L.; Legendre, C.; Genin, R.; Toupance, O.; Moulin, B.; Merville, P.; Rerolle, J.P. et al. Efficacy and safety of de novo or early everolimus with low cyclosporine in deceased-donor kidney transplant recipients at specified risk of delayed graft function: 12-Month results of a randomized, multicenter trial. Transpl. Int. 2010, 23, 1084-1093.
-
(2010)
Transpl. Int
, vol.23
, pp. 1084-1093
-
-
Dantal, J.1
Berthoux, F.2
Moal, M.C.3
Rostaing, L.4
Legendre, C.5
Genin, R.6
Toupance, O.7
Moulin, B.8
Merville, P.9
Rerolle, J.P.10
-
179
-
-
57649088471
-
Fifteen years of clinical studies and clinical practice in renal transplantation: Reviewing outcomes with de novo use of sirolimus in combination with cyclosporine
-
Kahan, B.D. Fifteen years of clinical studies and clinical practice in renal transplantation: Reviewing outcomes with de novo use of sirolimus in combination with cyclosporine. Transpl. Proc. 2008, 40 (Suppl. 10), S17-S20.
-
(2008)
Transpl. Proc
, vol.40
, Issue.10 SUPPL.
-
-
Kahan, B.D.1
-
180
-
-
19444369860
-
Rapamycin inhibits human in stent restenosis vascular smooth muscle cells independently of pRB phosphorylation and p53
-
Rosner, D.; McCarthy, N.; Bennett, M. Rapamycin inhibits human in stent restenosis vascular smooth muscle cells independently of pRB phosphorylation and p53. Cardiovasc. Res. 2005, 66, 601-610.
-
(2005)
Cardiovasc. Res
, vol.66
, pp. 601-610
-
-
Rosner, D.1
McCarthy, N.2
Bennett, M.3
-
181
-
-
59749096847
-
Therapeutic targeting of mTOR in tuberous sclerosis
-
Sampson, J.R. Therapeutic targeting of mTOR in tuberous sclerosis. Biochem. Soc. Trans. 2009, 37, 259-264.
-
(2009)
Biochem. Soc. Trans
, vol.37
, pp. 259-264
-
-
Sampson, J.R.1
-
182
-
-
0035886214
-
Effect of sirolimus on the metabolism of apoB100-containing lipoproteins in renal transplant patients
-
Hoogeveen, R.C.; Ballantyne, C.M.; Pownall, H.J.; Opekun, A.R.; Hachey, D.L.; Jaffe, J.S.; Oppermann, S.; Kahan, B.D.; Morrisett, J.D. Effect of sirolimus on the metabolism of apoB100-containing lipoproteins in renal transplant patients. Transplantation 2001, 72, 1244-1250.
-
(2001)
Transplantation
, vol.72
, pp. 1244-1250
-
-
Hoogeveen, R.C.1
Ballantyne, C.M.2
Pownall, H.J.3
Opekun, A.R.4
Hachey, D.L.5
Jaffe, J.S.6
Oppermann, S.7
Kahan, B.D.8
Morrisett, J.D.9
-
183
-
-
0034075822
-
Therapeutic drug monitoring of sirolimus: Correlations with efficacy and toxicity
-
Kahan, B.D.; Napoli, K.L.; Kelly, P.A.; Podbielski, J.; Hussein, I.; Urbauer, D.L.; Katz, S.H.; van Buren, C.T. Therapeutic drug monitoring of sirolimus: Correlations with efficacy and toxicity. Clin. Transplant. 2000, 14, 97-109.
-
(2000)
Clin. Transplant
, vol.14
, pp. 97-109
-
-
Kahan, B.D.1
Napoli, K.L.2
Kelly, P.A.3
Podbielski, J.4
Hussein, I.5
Urbauer, D.L.6
Katz, S.H.7
van Buren, C.T.8
-
184
-
-
0042768010
-
Dyslipidemia in renal transplant recipients treated with a sirolimus and cyclosporine-based immunosuppressive regimen: Incidence, risk factors, progression, and prognosis
-
Chueh, S.C.; Kahan, B.D. Dyslipidemia in renal transplant recipients treated with a sirolimus and cyclosporine-based immunosuppressive regimen: Incidence, risk factors, progression, and prognosis. Transplantation 2003, 76, 375-382.
-
(2003)
Transplantation
, vol.76
, pp. 375-382
-
-
Chueh, S.C.1
Kahan, B.D.2
-
185
-
-
0037181426
-
Exposure-response relationships for everolimus in de novo kidney transplantation: Defining a therapeutic range
-
Kovarik, J.M.; Kaplan, B.; Tedesco Silva, H.; Kahan, B.D.; Dantal, J.; Vitko, S.; Boger, R.; Rordorf, C. Exposure-response relationships for everolimus in de novo kidney transplantation: Defining a therapeutic range. Transplantation 2002, 73, 920-925.
-
(2002)
Transplantation
, vol.73
, pp. 920-925
-
-
Kovarik, J.M.1
Kaplan, B.2
Tedesco, S.H.3
Kahan, B.D.4
Dantal, J.5
Vitko, S.6
Boger, R.7
Rordorf, C.8
-
186
-
-
84865296997
-
Amino acid catabolism: A pivotal regulator of innate and adaptive immunity
-
McGaha, T.L.; Huang, L.; Lemos, H.; Metz, R.; Mautino, M.; Prendergast, G.C.; Mellor, A.L. Amino acid catabolism: A pivotal regulator of innate and adaptive immunity. Immunol. Rev. 2012, 249, 135-157.
-
(2012)
Immunol. Rev
, vol.249
, pp. 135-157
-
-
McGaha, T.L.1
Huang, L.2
Lemos, H.3
Metz, R.4
Mautino, M.5
Prendergast, G.C.6
Mellor, A.L.7
-
187
-
-
0036691215
-
Effects of sirolimus on plasma lipids, lipoprotein levels, and fatty acid metabolism in renal transplant patients
-
Morrisett, J.D.; Abdel-Fattah, G.; Hoogeveen, R.; Mitchell, E.; Ballantyne, C.M.; Pownall, H.J.; Opekun, A.R.; Jaffe, J.S.; Oppermann, S.; Kahan, B.D. Effects of sirolimus on plasma lipids, lipoprotein levels, and fatty acid metabolism in renal transplant patients. J. Lipid Res. 2002, 43, 1170-1180.
-
(2002)
J. Lipid Res
, vol.43
, pp. 1170-1180
-
-
Morrisett, J.D.1
Abdel-Fattah, G.2
Hoogeveen, R.3
Mitchell, E.4
Ballantyne, C.M.5
Pownall, H.J.6
Opekun, A.R.7
Jaffe, J.S.8
Oppermann, S.9
Kahan, B.D.10
-
188
-
-
81155162619
-
De-novo calcineurin-inhibitor-free immunosuppression with sirolimus and mycophenolate mofetil after heart transplantation: 5-Year results
-
Meiser, B.; Buchholz, S.; Kaczmarek, I. De-novo calcineurin-inhibitor-free immunosuppression with sirolimus and mycophenolate mofetil after heart transplantation: 5-Year results. Curr. Opin. Organ Transplant. 2011, 16, 522-528.
-
(2011)
Curr. Opin. Organ Transplant
, vol.16
, pp. 522-528
-
-
Meiser, B.1
Buchholz, S.2
Kaczmarek, I.3
-
189
-
-
58649114084
-
mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice
-
Guertin, D.A.; Stevens, D.M.; Saitoh, M.; Kinkel, S.; Crosby, K.; Sheen, J.H.; Mullholland, D.J.; Magnuson, M.A.; Wu, H.; Sabatini, D.M. mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell 2009, 15, 148-159.
-
(2009)
Cancer Cell
, vol.15
, pp. 148-159
-
-
Guertin, D.A.1
Stevens, D.M.2
Saitoh, M.3
Kinkel, S.4
Crosby, K.5
Sheen, J.H.6
Mullholland, D.J.7
Magnuson, M.A.8
Wu, H.9
Sabatini, D.M.10
-
190
-
-
68149096799
-
The pharmacology of mTOR inhibition
-
doi:10.1126/scisignal.267pe24
-
Guertin, D.A.; Sabatini, D.M. The pharmacology of mTOR inhibition. Sci. Signal. 2009, 2, pe24, doi:10.1126/scisignal.267pe24.
-
(2009)
Sci. Signal
, vol.2
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
191
-
-
34347220473
-
Defining the role of mTOR in cancer
-
Guertin, D.A.; Sabatini, D.M. Defining the role of mTOR in cancer. Cancer Cell 2007, 12, 9-22.
-
(2007)
Cancer Cell
, vol.12
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
192
-
-
84873076650
-
A phase I/II, non-randomized, feasibility/safety and efficacy study of the combination of everolimus, cetuximab and capecitabine in patients with advanced pancreatic cancer
-
Kordes, S.; Richel, D.J.; Klumpen, H.J.; Weterman, M.J.; Stevens, A.J.; Wilmink, J.W. A phase I/II, non-randomized, feasibility/safety and efficacy study of the combination of everolimus, cetuximab and capecitabine in patients with advanced pancreatic cancer. Investig. New Drugs 2013, 31, 85-91.
-
(2013)
Investig. New Drugs
, vol.31
, pp. 85-91
-
-
Kordes, S.1
Richel, D.J.2
Klumpen, H.J.3
Weterman, M.J.4
Stevens, A.J.5
Wilmink, J.W.6
-
193
-
-
84859417274
-
New strategies for advanced neuroendocrine tumors in the era of targeted therapy
-
Dong, M.; Phan, A.T.; Yao, J.C. New strategies for advanced neuroendocrine tumors in the era of targeted therapy. Clin. Cancer Res. 2012, 18, 1830-1836.
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 1830-1836
-
-
Dong, M.1
Phan, A.T.2
Yao, J.C.3
-
194
-
-
79960094413
-
mTOR inhibition, a potential novel approach for bronchial carcinoids
-
Dong, M.; Yao, J.C. mTOR inhibition, a potential novel approach for bronchial carcinoids. Endocr. Relat. Cancer 2011, 18, C15-C18.
-
(2011)
Endocr. Relat. Cancer
, vol.18
-
-
Dong, M.1
Yao, J.C.2
-
195
-
-
84877752542
-
Pancreatic neuroendocrine tumors: Signal pathways and targeted therapies
-
Peng, L.; Schwarz, R.E. Pancreatic neuroendocrine tumors: Signal pathways and targeted therapies. Curr. Mol. Med. 2013, 13, 333-339.
-
(2013)
Curr. Mol. Med
, vol.13
, pp. 333-339
-
-
Peng, L.1
Schwarz, R.E.2
-
196
-
-
59749091850
-
A complex interplay between Akt, TSC2 and the two mTOR complexes
-
Huang, J.; Manning, B.D. A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem. Soc. Trans. 2009, 37, 217-222.
-
(2009)
Biochem. Soc. Trans
, vol.37
, pp. 217-222
-
-
Huang, J.1
Manning, B.D.2
|