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Volumn 67, Issue SUPPL. 3, 2008, Pages

The PI3K/Akt/mTOR pathway in innate immune cells: Emerging therapeutic applications

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 5 (6 QUINOXALINYLMETHYLENE) 2,4 THIAZOLIDINEDIONE; 5 [5 (4 FLUORO 2 HYDROXYPHENYL)FURFURYLIDENE] 2,4 THIAZOLIDINEDIONE; AP 23573; AS 604850; EVEROLIMUS; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERFERON REGULATORY FACTOR 1; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 10; INTERLEUKIN 8; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PHOSPHATIDYLINOSITOL KINASE; RAPAMYCIN; TEMSIROLIMUS; UNCLASSIFIED DRUG; WORTMANNIN;

EID: 56749156696     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2008.098459     Document Type: Conference Paper
Times cited : (254)

References (75)
  • 1
    • 1342292522 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase: Diverse roles in immune cell activation
    • Deane JA, Fruman DA. Phosphoinositide 3-kinase: diverse roles in immune cell activation. Annu Rev Immunol 2004;22:563-98.
    • (2004) Annu Rev Immunol , vol.22 , pp. 563-598
    • Deane, J.A.1    Fruman, D.A.2
  • 2
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006;124:471-84.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 3
    • 0034234924 scopus 로고    scopus 로고
    • A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
    • Sekulic A, Hudson CC, Homme JL, Yin P, Otterness DM, Karnitz LM, et al. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res 2000;60:3504-13.
    • (2000) Cancer Res , vol.60 , pp. 3504-3513
    • Sekulic, A.1    Hudson, C.C.2    Homme, J.L.3    Yin, P.4    Otterness, D.M.5    Karnitz, L.M.6
  • 4
    • 2342565881 scopus 로고    scopus 로고
    • Advances in protein kinase B signalling: AKTion on multiple fronts
    • Brazil DP, Yang ZZ, Hemmings BA. Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem Sci 2004;29:233-42.
    • (2004) Trends Biochem Sci , vol.29 , pp. 233-242
    • Brazil, D.P.1    Yang, Z.Z.2    Hemmings, B.A.3
  • 5
    • 0037374815 scopus 로고    scopus 로고
    • The role of PI3K in immune cells
    • Koyasu S. The role of PI3K in immune cells. Nat Immunol 2003;4:313-9.
    • (2003) Nat Immunol , vol.4 , pp. 313-319
    • Koyasu, S.1
  • 6
    • 0038549067 scopus 로고    scopus 로고
    • PI3K in lymphocyte development, differentiation and activation
    • Okkenhaug K, Vanhaesebroeck B. PI3K in lymphocyte development, differentiation and activation. Nat Rev Immunol 2003;3:317-30.
    • (2003) Nat Rev Immunol , vol.3 , pp. 317-330
    • Okkenhaug, K.1    Vanhaesebroeck, B.2
  • 7
    • 2342472012 scopus 로고    scopus 로고
    • Towards an understanding of isoform specificity in phosphoinositide 3-kinase signalling in lymphocytes
    • Fruman DA. Towards an understanding of isoform specificity in phosphoinositide 3-kinase signalling in lymphocytes. Biochem Soc Trans 2004;32:315-9.
    • (2004) Biochem Soc Trans , vol.32 , pp. 315-319
    • Fruman, D.A.1
  • 8
    • 34548649547 scopus 로고    scopus 로고
    • Role of phosphoinositide 3-kinase in innate immunity
    • Hazeki K, Nigorikawa K, Hazeki O. Role of phosphoinositide 3-kinase in innate immunity. Biol Pharm Bull 2007;30:1617-23.
    • (2007) Biol Pharm Bull , vol.30 , pp. 1617-1623
    • Hazeki, K.1    Nigorikawa, K.2    Hazeki, O.3
  • 10
    • 0037312507 scopus 로고    scopus 로고
    • Tor signalling in bugs, brain and brawn
    • Jacinto E, Hall MN. Tor signalling in bugs, brain and brawn. Nat Rev Mol Cell Biol 2003;4:117-26.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 117-126
    • Jacinto, E.1    Hall, M.N.2
  • 11
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004;18:1926-45.
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 12
    • 0028598672 scopus 로고
    • RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex
    • Chiu MI, Katz H, Berlin V. RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. Proc Natl Acad Sci USA 1994;91:12574-8.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12574-12578
    • Chiu, M.I.1    Katz, H.2    Berlin, V.3
  • 13
    • 0028239893 scopus 로고
    • RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
    • Sabatini DM, Erdjument-Bromage H, Lui M, Tempst P, Snyder SH. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 1994;78:35-43.
    • (1994) Cell , vol.78 , pp. 35-43
    • Sabatini, D.M.1    Erdjument-Bromage, H.2    Lui, M.3    Tempst, P.4    Snyder, S.H.5
  • 14
    • 0037178781 scopus 로고    scopus 로고
    • Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
    • Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 2002;110:177-89.
    • (2002) Cell , vol.110 , pp. 177-189
    • Hara, K.1    Maruki, Y.2    Long, X.3    Yoshino, K.4    Oshiro, N.5    Hidayat, S.6
  • 15
    • 0037178786 scopus 로고    scopus 로고
    • mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002;110:163-75.
    • (2002) Cell , vol.110 , pp. 163-175
    • Kim, D.H.1    Sarbassov, D.D.2    Ali, S.M.3    King, J.E.4    Latek, R.R.5    Erdjument-Bromage, H.6
  • 16
    • 1942487890 scopus 로고    scopus 로고
    • Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function
    • Oshiro N, Yoshino K. Hidayat S, Tokunaga C, Hara K, Eguchi S, et al. Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function. Genes Cells 2004;9:359-66.
    • (2004) Genes Cells , vol.9 , pp. 359-366
    • Oshiro, N.1    Yoshino, K.2    Hidayat, S.3    Tokunaga, C.4    Hara, K.5    Eguchi, S.6
  • 17
    • 7944235758 scopus 로고    scopus 로고
    • Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    • Jacinto E, Loewith R, Schmidt A, Lin S, Ruegg MA, Hall A, et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 2004;6:1122-8.
    • (2004) Nat Cell Biol , vol.6 , pp. 1122-1128
    • Jacinto, E.1    Loewith, R.2    Schmidt, A.3    Lin, S.4    Ruegg, M.A.5    Hall, A.6
  • 18
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005;307:1098-101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 20
    • 0038643484 scopus 로고    scopus 로고
    • Rheb promotes cell growth as a component of the insulin/TOR signalling network
    • Saucedo LJ, Gao X, Chiarelli DA, Li L, Pan D, Edgar BA. Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat Cell Biol 2003;5:566-71.
    • (2003) Nat Cell Biol , vol.5 , pp. 566-571
    • Saucedo, L.J.1    Gao, X.2    Chiarelli, D.A.3    Li, L.4    Pan, D.5    Edgar, B.A.6
  • 22
    • 34547907805 scopus 로고    scopus 로고
    • Expanding mTOR signaling
    • Yang Q, Guan KL. Expanding mTOR signaling. Cell Res 2007;17:666-81.
    • (2007) Cell Res , vol.17 , pp. 666-681
    • Yang, Q.1    Guan, K.L.2
  • 23
    • 43149101490 scopus 로고    scopus 로고
    • The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners
    • Rosner M, Hanneder M, Siegel N, Valli A, Hengstschlager M. The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners. Mutat Res 2008;658:234-46.
    • (2008) Mutat Res , vol.658 , pp. 234-246
    • Rosner, M.1    Hanneder, M.2    Siegel, N.3    Valli, A.4    Hengstschlager, M.5
  • 24
    • 44949215822 scopus 로고    scopus 로고
    • The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
    • Huang J, Dibble CC, Matsuzaki M, Manning BD. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol 2008;28:4104-15.
    • (2008) Mol Cell Biol , vol.28 , pp. 4104-4115
    • Huang, J.1    Dibble, C.C.2    Matsuzaki, M.3    Manning, B.D.4
  • 25
    • 33344468233 scopus 로고    scopus 로고
    • Neutrophils and immunity: Challenges and opportunities
    • Nathan C. Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol 2006;6:173-82.
    • (2006) Nat Rev Immunol , vol.6 , pp. 173-182
    • Nathan, C.1
  • 29
    • 0030903025 scopus 로고    scopus 로고
    • Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases
    • Knall C, Worthen GS, Johnson GL. Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases. Proc Natl Acad Sci USA 1997;94:3052-7.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3052-3057
    • Knall, C.1    Worthen, G.S.2    Johnson, G.L.3
  • 30
    • 0033555720 scopus 로고    scopus 로고
    • Enhancement of chemotactic peptide-induced activation of phosphoinositide 3-kinase by granulocyte-macrophage colony-stimulating factor and its relation to the cytokine-mediated priming of neutrophil superoxide-anion production
    • Kodama T, Hazeki K. Hazeki O, Okada T, Ui M. Enhancement of chemotactic peptide-induced activation of phosphoinositide 3-kinase by granulocyte-macrophage colony-stimulating factor and its relation to the cytokine-mediated priming of neutrophil superoxide-anion production. Biochem J 1999;337(Pt 2):201-9.
    • (1999) Biochem J , vol.337 , Issue.PART 2 , pp. 201-209
    • Kodama, T.1    Hazeki, K.2    Hazeki, O.3    Okada, T.4    Ui, M.5
  • 31
    • 0034635452 scopus 로고    scopus 로고
    • Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation
    • Hirsch E, Katanaev VL, Garlanda C, Azzolino O, Pirola L, Silengo L, et al. Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science 2000;287:1049-53.
    • (2000) Science , vol.287 , pp. 1049-1053
    • Hirsch, E.1    Katanaev, V.L.2    Garlanda, C.3    Azzolino, O.4    Pirola, L.5    Silengo, L.6
  • 32
    • 4544346050 scopus 로고    scopus 로고
    • Activated polymorphonuclear leukocytes rapidly synthesize retinoic acid receptor-alpha: A mechanism for translational control of transcriptional events
    • Yost CC, Denis MM, Lindemann S, Rubner FJ, Marathe GK, Buerke M, et al. Activated polymorphonuclear leukocytes rapidly synthesize retinoic acid receptor-alpha: a mechanism for translational control of transcriptional events. J Exp Med 2004;200:671-80.
    • (2004) J Exp Med , vol.200 , pp. 671-680
    • Yost, C.C.1    Denis, M.M.2    Lindemann, S.3    Rubner, F.J.4    Marathe, G.K.5    Buerke, M.6
  • 33
    • 0346996709 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor is a chemoattractant cytokine for human neutrophils: Involvement of the ribosomal p70 S6 kinase signaling pathway
    • Gomez-Cambronero J, Horn J, Paul CC, Baumann MA. Granulocyte-macrophage colony-stimulating factor is a chemoattractant cytokine for human neutrophils: involvement of the ribosomal p70 S6 kinase signaling pathway. J Immunol 2003;171:6846-55.
    • (2003) J Immunol , vol.171 , pp. 6846-6855
    • Gomez-Cambronero, J.1    Horn, J.2    Paul, C.C.3    Baumann, M.A.4
  • 34
    • 33846581108 scopus 로고    scopus 로고
    • Role of mast cells in allergic and non-allergic immune responses: Comparison of human and murine data
    • Bischoff SC. Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data. Nat Rev Immunol 2007;7:93-104.
    • (2007) Nat Rev Immunol , vol.7 , pp. 93-104
    • Bischoff, S.C.1
  • 35
    • 0036195935 scopus 로고    scopus 로고
    • Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice
    • Fukao T, Yamada T, Tanabe M, Terauchi Y, Ota T, Takayama T, et al. Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice. Nat Immunol 2002;3:295-304.
    • (2002) Nat Immunol , vol.3 , pp. 295-304
    • Fukao, T.1    Yamada, T.2    Tanabe, M.3    Terauchi, Y.4    Ota, T.5    Takayama, T.6
  • 36
    • 7244232917 scopus 로고    scopus 로고
    • Essential role for the p110delta phosphoinositide 3-kinase in the allergic response
    • Ali K, Bilancio A, Thomas M, Pearce W, Gilfillan AM, Tkaczyk C, et al. Essential role for the p110delta phosphoinositide 3-kinase in the allergic response. Nature 2004;431:1007-11.
    • (2004) Nature , vol.431 , pp. 1007-1011
    • Ali, K.1    Bilancio, A.2    Thomas, M.3    Pearce, W.4    Gilfillan, A.M.5    Tkaczyk, C.6
  • 37
    • 42149091691 scopus 로고    scopus 로고
    • Isoform-specific functions of phosphoinositide 3-kinases: P110 delta but not p110 gamma promotes optimal allergic responses in vivo
    • Ali K, Camps M, Pearce WP, Ji H, Ruckle T, Kuehn N, et al. Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo. J Immunol 2008;180:2538-44.
    • (2008) J Immunol , vol.180 , pp. 2538-2544
    • Ali, K.1    Camps, M.2    Pearce, W.P.3    Ji, H.4    Ruckle, T.5    Kuehn, N.6
  • 38
    • 44449141488 scopus 로고    scopus 로고
    • Activation and function of the mTORC1 pathway in mast cells
    • Kim MS, Kuehn HS, Metcalfe DD, Gilfillan AM. Activation and function of the mTORC1 pathway in mast cells. J Immunol 2008;180:4586-95.
    • (2008) J Immunol , vol.180 , pp. 4586-4595
    • Kim, M.S.1    Kuehn, H.S.2    Metcalfe, D.D.3    Gilfillan, A.M.4
  • 39
    • 15244349785 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells in immunity
    • Colonna M, Trinchieri G, Liu YJ. Plasmacytoid dendritic cells in immunity. Nat Immunol 2004;5:1219-26.
    • (2004) Nat Immunol , vol.5 , pp. 1219-1226
    • Colonna, M.1    Trinchieri, G.2    Liu, Y.J.3
  • 40
    • 39549116503 scopus 로고    scopus 로고
    • PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation
    • Guiducci C, Ghirelli C, Marloie-Provost MA, Matray T, Coffman RL, Liu YJ, et al. PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation. J Exp Med 2008;205:315-22.
    • (2008) J Exp Med , vol.205 , pp. 315-322
    • Guiducci, C.1    Ghirelli, C.2    Marloie-Provost, M.A.3    Matray, T.4    Coffman, R.L.5    Liu, Y.J.6
  • 42
    • 22544445221 scopus 로고    scopus 로고
    • Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappaB activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4
    • Aksoy E, Vanden Berghe W, Detienne S, Amraoui Z, Fitzgerald KA, Haegeman G, et al. Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappaB activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4. Eur J Immunol 2005;35:2200-9.
    • (2005) Eur J Immunol , vol.35 , pp. 2200-2209
    • Aksoy, E.1    Vanden Berghe, W.2    Detienne, S.3    Amraoui, Z.4    Fitzgerald, K.A.5    Haegeman, G.6
  • 43
    • 0036707521 scopus 로고    scopus 로고
    • PI3K-mediated negative feedback regulation of IL-12 production in DCs
    • Fukao T, Tanabe M, Terauchi Y, Ota T, Matsuda S, Asano T, et al. PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat Immunol 2002;3:875-81.
    • (2002) Nat Immunol , vol.3 , pp. 875-881
    • Fukao, T.1    Tanabe, M.2    Terauchi, Y.3    Ota, T.4    Matsuda, S.5    Asano, T.6
  • 44
    • 0037199972 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells
    • Guha M, Mackman N. The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem 2002;277:32124-32.
    • (2002) J Biol Chem , vol.277 , pp. 32124-32132
    • Guha, M.1    Mackman, N.2
  • 45
    • 0346103719 scopus 로고    scopus 로고
    • Modulation of the phosphoinositide 3-kinase pathway alters innate resistance to polymicrobial sepsis
    • Williams DL, Li C, Ha T, Ozment-Skelton T, Kalbfleisch JH, Preiszner J, et al. Modulation of the phosphoinositide 3-kinase pathway alters innate resistance to polymicrobial sepsis. J Immunol 2004;172:449-56.
    • (2004) J Immunol , vol.172 , pp. 449-456
    • Williams, D.L.1    Li, C.2    Ha, T.3    Ozment-Skelton, T.4    Kalbfleisch, J.H.5    Preiszner, J.6
  • 46
    • 0038446051 scopus 로고    scopus 로고
    • Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide
    • Martin M, Schifferle RE, Cuesta N, Vogel SN, Katz J, Michalek SM. Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide. J Immunol 2003;171:717-25.
    • (2003) J Immunol , vol.171 , pp. 717-725
    • Martin, M.1    Schifferle, R.E.2    Cuesta, N.3    Vogel, S.N.4    Katz, J.5    Michalek, S.M.6
  • 47
    • 34250803183 scopus 로고    scopus 로고
    • Role of phosphatidylinositol-3 kinase in transcriptional regulation of TLR-induced IL-12 and IL-10 by Fc{gamma} receptor ligation in murine macrophages
    • Polumuri SK, Toshchakov VY, Vogel SN. Role of phosphatidylinositol-3 kinase in transcriptional regulation of TLR-induced IL-12 and IL-10 by Fc{gamma} receptor ligation in murine macrophages. J Immunol 2007;179:236-46.
    • (2007) J Immunol , vol.179 , pp. 236-246
    • Polumuri, S.K.1    Toshchakov, V.Y.2    Vogel, S.N.3
  • 48
    • 0141853300 scopus 로고    scopus 로고
    • Influence of immunosuppressive drugs on dendritic cells
    • Abe M, Thomson AW. Influence of immunosuppressive drugs on dendritic cells. Transpl Immunol 2003;11:357-65.
    • (2003) Transpl Immunol , vol.11 , pp. 357-365
    • Abe, M.1    Thomson, A.W.2
  • 49
    • 0142102521 scopus 로고    scopus 로고
    • Rapamycin inhibits GM-CSF-induced neutrophil migration
    • Gomez-Cambronero J. Rapamycin inhibits GM-CSF-induced neutrophil migration. FEBS Lett 2003;550:94-100.
    • (2003) FEBS Lett , vol.550 , pp. 94-100
    • Gomez-Cambronero, J.1
  • 50
    • 3142583168 scopus 로고    scopus 로고
    • Insulin receptor substrate-2-dependent interleukin-4 signaling in macrophages is impaired in two models of type 2 diabetes mellitus
    • Hartman ME, O'Connor JC, Godbout JP, Minor KD, Mazzocco VR, Freund GG. Insulin receptor substrate-2-dependent interleukin-4 signaling in macrophages is impaired in two models of type 2 diabetes mellitus. J Biol Chem 2004;279:28045-50.
    • (2004) J Biol Chem , vol.279 , pp. 28045-28050
    • Hartman, M.E.1    O'Connor, J.C.2    Godbout, J.P.3    Minor, K.D.4    Mazzocco, V.R.5    Freund, G.G.6
  • 51
    • 0037441902 scopus 로고    scopus 로고
    • Rapamycin specifically interfetes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression
    • Woltman AM, van der Kooij SW, Coffer PJ, Offringa R, Daha MR, van Kooten C. Rapamycin specifically interfetes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression. Blood 2003;101:1439-45.
    • (2003) Blood , vol.101 , pp. 1439-1445
    • Woltman, A.M.1    van der Kooij, S.W.2    Coffer, P.J.3    Offringa, R.4    Daha, M.R.5    van Kooten, C.6
  • 52
    • 0036842274 scopus 로고    scopus 로고
    • Flow cytometric detection of intracellular IL-12 release: In vitro effect of widely used immunosuppressants
    • Tsiavou A, Degiannis D, Hatziagelaki E, Koniavitou K, Raptis S. Flow cytometric detection of intracellular IL-12 release: in vitro effect of widely used immunosuppressants. Int Immunopharmacol 2002;2:1713- 20.
    • (2002) Int Immunopharmacol , vol.2 , pp. 1713-1720
    • Tsiavou, A.1    Degiannis, D.2    Hatziagelaki, E.3    Koniavitou, K.4    Raptis, S.5
  • 53
    • 0141640858 scopus 로고    scopus 로고
    • Negative regulation of interleukin-12 production by a rapamycin-sensitive signaling pathway: A brief communication
    • Uthaisangsook S, Day NK, Hitchcock R, Lerner A, James-Yarish M, Good RA, et al. Negative regulation of interleukin-12 production by a rapamycin-sensitive signaling pathway: a brief communication. Exp Biol Med (Maywood) 2003;228:1023-7.
    • (2003) Exp Biol Med (Maywood) , vol.228 , pp. 1023-1027
    • Uthaisangsook, S.1    Day, N.K.2    Hitchcock, R.3    Lerner, A.4    James-Yarish, M.5    Good, R.A.6
  • 54
    • 0032985486 scopus 로고    scopus 로고
    • Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1
    • Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP. Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1. Pflugers Arch 1999;437:538-46.
    • (1999) Pflugers Arch , vol.437 , pp. 538-546
    • Barcova, M.1    Speth, C.2    Kacani, L.3    Uberall, F.4    Stoiber, H.5    Dierich, M.P.6
  • 55
    • 0034008833 scopus 로고    scopus 로고
    • HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones
    • Speth C, Joebstl B, Barcova M, Dierich MP. HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones. AIDS 2000;14:629-36.
    • (2000) AIDS , vol.14 , pp. 629-636
    • Speth, C.1    Joebstl, B.2    Barcova, M.3    Dierich, M.P.4
  • 56
    • 0036828331 scopus 로고    scopus 로고
    • Different mechanisms are utilized by HIV-1 Nef and staphylococcal enterotoxin A to control and regulate interleukin-10 production
    • Tangsinmankong N, Day NK, Good RA, Haraguchi S. Different mechanisms are utilized by HIV-1 Nef and staphylococcal enterotoxin A to control and regulate interleukin-10 production. Immunol Lett 2002;84:97-101.
    • (2002) Immunol Lett , vol.84 , pp. 97-101
    • Tangsinmankong, N.1    Day, N.K.2    Good, R.A.3    Haraguchi, S.4
  • 59
    • 33745013651 scopus 로고    scopus 로고
    • Intracellular network of phosphatidylinositol 3-kinase, mammalian target of the rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen-activated protein kinases pathways for regulating mycobacteria-induced IL-23 expression in human macrophages
    • Yang CS, Song CH, Lee JS, Jung SB, Oh JH, Park J, et al. Intracellular network of phosphatidylinositol 3-kinase, mammalian target of the rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen-activated protein kinases pathways for regulating mycobacteria-induced IL-23 expression in human macrophages. Cell Microbiol 2006;8:1158-71.
    • (2006) Cell Microbiol , vol.8 , pp. 1158-1171
    • Yang, C.S.1    Song, C.H.2    Lee, J.S.3    Jung, S.B.4    Oh, J.H.5    Park, J.6
  • 60
    • 34548700597 scopus 로고    scopus 로고
    • Rapamycin: Something old, something new, sometimes borrowed and now renewed
    • Hartford CM, Ratain MJ. Rapamycin: something old, something new, sometimes borrowed and now renewed. Clin Pharmacol Ther 2007;82:381-8.
    • (2007) Clin Pharmacol Ther , vol.82 , pp. 381-388
    • Hartford, C.M.1    Ratain, M.J.2
  • 61
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • Fingar DC, Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004;23:3151-71.
    • (2004) Oncogene , vol.23 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 62
    • 38049169557 scopus 로고    scopus 로고
    • Efficacy of sirolimus in treating tuberous sclerosis and lymphangioleiomyomatosis
    • Paul E, Thiele E. Efficacy of sirolimus in treating tuberous sclerosis and lymphangioleiomyomatosis. N Engl J Med 2008;358:190- 2.
    • (2008) N Engl J Med , vol.358 , pp. 190-192
    • Paul, E.1    Thiele, E.2
  • 63
    • 0036174289 scopus 로고    scopus 로고
    • Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
    • Guba M, von Breitenbuch P, Steinbauer M, Koehl G, Flegel S, Hornung M, et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 2002;8:128-35.
    • (2002) Nat Med , vol.8 , pp. 128-135
    • Guba, M.1    von Breitenbuch, P.2    Steinbauer, M.3    Koehl, G.4    Flegel, S.5    Hornung, M.6
  • 65
    • 21344467016 scopus 로고    scopus 로고
    • Calcineurin inhibitor withdrawal from sitolimus-based therapy in kidney transplantation: A systematic review of randomized trials
    • Mulay AV, Hussain N, Fergusson D, Knoll GA. Calcineurin inhibitor withdrawal from sitolimus-based therapy in kidney transplantation: a systematic review of randomized trials. Am J Transplant 2005;5:1748-56.
    • (2005) Am J Transplant , vol.5 , pp. 1748-1756
    • Mulay, A.V.1    Hussain, N.2    Fergusson, D.3    Knoll, G.A.4
  • 66
    • 0742318923 scopus 로고    scopus 로고
    • Sirolimus-induced pneumonitis: Three cases and a review of the literature
    • Haydar AA, Denton M, West A, Rees J, Goldsmith DJ. Sirolimus-induced pneumonitis: three cases and a review of the literature. Am J Transplant 2004;4:137-9.
    • (2004) Am J Transplant , vol.4 , pp. 137-139
    • Haydar, A.A.1    Denton, M.2    West, A.3    Rees, J.4    Goldsmith, D.J.5
  • 68
    • 0034649707 scopus 로고    scopus 로고
    • Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipients
    • Singer SJ, Tiernan R, Sullivan EJ. Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipients. N Engl J Med 2000;343:1815-6.
    • (2000) N Engl J Med , vol.343 , pp. 1815-1816
    • Singer, S.J.1    Tiernan, R.2    Sullivan, E.J.3
  • 70
    • 28544432476 scopus 로고    scopus 로고
    • Anemia after late introduction of sirolimus may correlate with biochemical evidence of a chronic inflammatory state
    • Thaunat O, Beaumont C, Chatenoud L, Lechaton S, Mamzer-Bruneel MF, Varet B, et al. Anemia after late introduction of sirolimus may correlate with biochemical evidence of a chronic inflammatory state. Transplantation 2005;80:1212-9.
    • (2005) Transplantation , vol.80 , pp. 1212-1219
    • Thaunat, O.1    Beaumont, C.2    Chatenoud, L.3    Lechaton, S.4    Mamzer-Bruneel, M.F.5    Varet, B.6
  • 71
    • 33746637660 scopus 로고    scopus 로고
    • Current development of mTOR inhibitors as anticancer agents
    • Faivre S, Kroemer G, Raymond E. Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov 2006;5:671- 88.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 671-688
    • Faivre, S.1    Kroemer, G.2    Raymond, E.3
  • 72
  • 74
    • 24744435115 scopus 로고    scopus 로고
    • Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
    • Camps M, Ruckle T, Ji H, Ardissone V, Rintelen F, Shaw J, et al. Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med 2005;11:936-43.
    • (2005) Nat Med , vol.11 , pp. 936-943
    • Camps, M.1    Ruckle, T.2    Ji, H.3    Ardissone, V.4    Rintelen, F.5    Shaw, J.6
  • 75
    • 24744449495 scopus 로고    scopus 로고
    • PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
    • Barber DF, Bartolome A, Hernandez C, Flores JM, Redondo C, Fernandez-Arias C, et al. PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus. Nat Med 2005;11:933-5.
    • (2005) Nat Med , vol.11 , pp. 933-935
    • Barber, D.F.1    Bartolome, A.2    Hernandez, C.3    Flores, J.M.4    Redondo, C.5    Fernandez-Arias, C.6


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