Sirolimus enhances the magnitude and quality of viral-specific CD8 + T-cell responses to vaccinia virus vaccination in rhesus macaques

American Journal of Transplantation

Volumn 11, Issue 3, 2011, Pages 613-618

  Turner, A P ^a   Shaffer, V O ^a   Araki, K ^a   Martens, C ^a   Turner, P L ^a   Gangappa, S ^a   Ford, M L ^a   Ahmed, R ^a   Kirk, A D ^a   Larsen, Christian P ^a  

^a EMORY UNIVERSITY   (United States)

Author keywords

mTOR; Vaccine

Indexed keywords

RAPAMYCIN; TACROLIMUS; VACCINIA VACCINE;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ARTICLE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; EFFECTOR CELL; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; VACCINATION; VACCINIA VIRUS;

EID: 79951986439     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2010.03407.x     Document Type: Article

References (20)

1. 2008 Annual Report of the U.S. Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients: Transplant Data 1998-2007. U.S. Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation, Rockville, MD.
2. Gangappa S, Kapadia SB, Speck SH, Virgin HWt. Antibody to a lytic cycle viral protein decreases gammaherpesvirus latency in B-cell-deficient mice. J Virol 2002; 76: 11460-11468. (Pubitemid 35231302)
3. Halloran PF. Immunosuppressive drugs for kidney transplantation. N Engl J Med 2004; 351: 2715-2729. (Pubitemid 39665325)
4. Augustine JJ, Bodziak KA, Hricik DE. Use of sirolimus in solid organ transplantation. Drugs 2007; 67: 369-391. (Pubitemid 46425551)
5. Segundo DS, Ruiz JC, Izquierdo M et al. Calcineurin inhibitors, but not rapamycin, reduce percentages of CD4+CD25+FOXP3+ regulatory T cells in renal transplant recipients. Transplantation 2006; 82: 550-557. (Pubitemid 44290262)
6. Thomson AW, Turnquist HR, Raimondi G. Immunoregulatory functions of mTOR inhibition. Nat Rev Immunol 2009; 9: 324-337.
7. Hackstein H, Taner T, Logar AJ, Thomson AW. Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells. Blood 2002; 100: 1084-1087. (Pubitemid 34832646)
8. Cao W, Manicassamy S, Tang H et al. Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway. Nat Immunol 2008; 9: 1157-1164.
9. Ohtani M, Nagai S, Kondo S et al. Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells. Blood 2008; 112: 635-643.
10. Weichhart T, Costantino G, Poglitsch M et al. The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity 2008; 29: 565-577.
11. Demopoulos L, Polinsky M, Steele G et al. Reduced risk of cytomegalovirus infection in solid organ transplant recipients treated with sirolimus: A pooled analysis of clinical trials. Transplant Proc 2008; 40: 1407-1410. (Pubitemid 351853135)
12. Haririan A, Morawski K, West MS et al. Sirolimus exposure during the early post-transplant period reduces the risk of CMV infection relative to tacrolimus in renal allograft recipients. Clin Transplant 2007; 21: 466-471. (Pubitemid 47161822)
13. Marty FM, Bryar J, Browne SK et al. Sirolimus-based graft-versus-host disease prophylaxis protects against cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation: A cohort analysis. Blood 2007; 110: 490-500. (Pubitemid 47105386)
14. Araki K, Turner AP, Shaffer VO et al. mTOR regulates memory CD8 T cell differentiation. Nature 2009; 460: 108-112.
15. Pearce EL, Walsh MC, Cejas PJ et al. Enhancing CD8 T cell memory by modulating fatty acid metabolism. Nature 2009; 460: 103-107.
16. Karkhanis LU, Ross TM. Mucosal vaccine vectors: Replication-competent versus replication-deficient poxviruses. Curr Pharm Des 2007; 13: 2015-2023. (Pubitemid 47040501)
17. Seder RA, Darrah PA, Roederer M. T cell quality in memory and protection: Implications for vaccine design. Nat Rev Immunol 2008; 8: 247-258. (Pubitemid 351432801)
18. Pitcher CJ, Hagen SI, Walker JM et al. Development and homeostasis of T cell memory in rhesus macaque. J Immunol 2002; 168: 29-43. (Pubitemid 34014099)
19. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999; 401: 708-712.
20. Ferrer IR, Wagener ME, Robertson JM et al. Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses. J Immunol 2010; 185: 2004-2008.