Impact of mammalian target of rapamycin inhibition on lymphoid homing and tolerogenic function of nanoparticle-labeled dendritic cells following allogeneic hematopoietic cell transplantation

Journal of Immunology

Volumn 181, Issue 7, 2008, Pages 4770-4779

  Reichardt, Wilfried ^a   Dürr, Christoph ^a,b   Von Elverfeldt, Dominik ^a   Jüttner, Eva ^a   Gerlach, Ulrike V ^a   Yamada, Mayumi ^c   Smith, Benjie ^c   Negrin, Robert S ^c   Zeiser, Robert ^b,c  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR7; FC RECEPTOR; IMMUNOGLOBULIN G ANTIBODY; L SELECTIN; LUCIFERASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; DIAGNOSTIC AGENT; IMMUNOSUPPRESSIVE AGENT; IRON; NANOPARTICLE; OXIDE; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; SUPERPARAMAGNETIC IRON OXIDE;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BIOLUMINESCENCE; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DISEASE SEVERITY; ENDOCYTOSIS; GENOTYPE; GRAFT VERSUS HOST REACTION; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; IN VIVO STUDY; LYMPHOCYTE HOMING; LYMPHOCYTE PROLIFERATION; LYMPHOID CELL; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; ANIMAL; BAGG ALBINO MOUSE; BONE MARROW TRANSPLANTATION; C57BL MOUSE; CELL MOTION; CYTOLOGY; DRUG EFFECT; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOLOGY; LUMINESCENCE; LYMPHOID TISSUE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; TRANSPLANTATION;

ANIMALS; BONE MARROW TRANSPLANTATION; CELL MOVEMENT; DENDRITIC CELLS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNE TOLERANCE; IMMUNOSUPPRESSIVE AGENTS; IRON; LUMINESCENCE; LYMPHOID TISSUE; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; NANOPARTICLES; OXIDES; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; SIGNAL TRANSDUCTION; SIROLIMUS;

EID: 58149292274     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.7.4770     Document Type: Article

References (37)

1. Sprent, J., M. Schaefer, D. Lo, and R. Korngold. 1986. Properties of purified T cell subsets. II. In vivo responses to class I vs. class II H-2 differences. J. Exp. Med. 163: 998-1011. (Pubitemid 16082812)
2. + natural killer T cells with limited capacity for graftversus- host disease induction due to interferon γ production. Blood 97: 2923-2931.
3. Ruggeri, L., M. Capanni, E. Urbani, K. Perruccio, W. D. Shlomchik, A. Tosti, S. Posati, D. Rogaia, F. Frassoni, F. Aversa, et al. 2002. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295: 2097-2100. (Pubitemid 34229476)
4. + regulatory T cells preserve graft-vs-tumor activity while inhibiting graft-vs-host disease after bone marrow transplantation. Nat. Med. 9: 1144-1149.
5. Steinman, R. M., D. Hawiger, and M. C. Nussenzweig. 2003. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21: 685-689.
6. Tang, Q., J. Y. Adams, A. J. Tooley, M. Bi, B. T. Fife, P. Serra, P. Santamaria, R. M. Locksley, M. F. Krummel, and J. A. Bluestone. 2005. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat. Immunol. 7: 83-92. (Pubitemid 41823872)
7. Shlomchik, W. D., M. S. Couzens, C. B. Tang, J. McNiff, M. E. Robert, J. Liu, M. J. Shlomchik, and S. G. Emerson. 1999. Prevention of graft-versus-host disease by inactivation of host antigen-presenting cells. Science 285: 412-415.
8. Anderson, B. E., J. M. McNiff, D. Jain, B. R. Blazar, W. D. Shlomchik, and M. J. Shlomchik. 2005. Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ. Blood 105: 2227-2234.
9. + regulatory T cell function by calcineurin dependent interleukin-2 production. Blood 108: 390-399.
10. + regulatory T cells. Blood 105: 4743-4748.
11. + regulatory T cells of both healthy subjects and type 1 diabetic patients. J. Immunol. 177: 8338-8347.
12. + T regulatory cells and promote organ transplant tolerance. J. Immunol. 178: 7018-7031.
13. Hackstein, H., T. Taner, A. F. Zahorchak, A. E. Morelli, A. J. Logar, A. Gessner, and A. W. Thomson. 2003. Rapamycin inhibits IL-4-induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo. Blood 101: 4457-4463. (Pubitemid 36857814)
14. Hackstein, H., T. Taner, A. J. Logar, and A. W. Thomson. 2002. Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells. Blood 100: 1084-1087. (Pubitemid 34832646)
15. Monti, P., A. Mercalli, B. E. Leone, D. C. Valerio, P. Allavena, and L. Piemonti. 2003. Rapamycin impairs antigen uptake of human dendritic cells. Transplantation 75: 137-145. (Pubitemid 36139710)
16. Chiang, P. H., L. Wang, Y. Liang, X. Liang, S. Qian, J. J. Fung, C. A. Bonham, and L. Lu. 2002. Inhibition of IL-12 signaling Stat4/IFN-γpathway by rapamycin is associated with impaired dendritic (correction of dendritc) cell function. Transplant. Proc. 34: 1394-1395.
17. Woltman, A. M., J. W. de Fijter, S. W. Kamerling, S. W. van Der Kooij, L. C. Paul, M. R. Daha, and C. van Kooten. 2001. Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages. Blood 98: 174-180.
18. Woltman, A. M., S. W. van der Kooij, P. J. Coffer, R. Offringa, M. R. Daha, and C. van Kooten. 2003. Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression. Blood 101: 1439-1445.
19. Antin, J. H., H. T. Kim, C. Cutler, V. T. Ho, S. J. Lee, D. B. Miklos, E. P. Hochberg, C. J. Wu, E. P. Alyea, and R. J. Soiffer. 2003. Sirolimus, tacrolimus, and low-dose methotrexate for graft-versus-host disease prophylaxis in mismatched related donor or unrelated donor transplantation. Blood 102: 1601-1605.
20. Cutler, C., S. Li, V. T. Ho, J. Koreth, E. Alyea, R. J. Soiffer, and J. H. Antin. 2007. Extended follow-up of methotrexate-free immunosuppression using sirolimus and tacrolimus in related and unrelated donor peripheral blood stem cell transplantation. Blood 109: 3108-3114. (Pubitemid 46482114)
21. + regulatory T cells in prevention of acute graft versus host disease. Blood 109: 2225-2233.
22. Verdijk, P., T. W. Scheenen, W. J. Lesterhuis, G. Gambarota, A. A. Veltien, P. Walczak, N. M. Scharenborg, J. W. Bulte, C. J. Punt, A. Heerschap, et al. 2007. Sensitivity of magnetic resonance imaging of dendritic cells for in vivo tracking of cellular cancer vaccines. Int. J. Cancer 120: 978-984. (Pubitemid 46214296)
23. Cao, Y. A., A. J. Wagers, A. Beilhack, J. Dusich, M. H. Bachmann, R. S. Negrin, I. L. Weissman, and C. H. Contag. 2004. Shifting foci of hematopoiesis during reconstitution from single stem cells. Proc. Natl. Acad. Sci. USA 101: 221-226.
24. Beilhack, A., S. Schulz, J. Baker, G. F. Beilhack, C. B. Wieland, E. I. Herman, E. M. Baker, Y. A. Cao, C. H. Contag, and R. S. Negrin. 2005. In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T cell subsets. Blood 106: 1113-1122. (Pubitemid 41076462)
25. Phung, T. L., G. Eyiah-Mensah, R. K. O'Donnell, R. Bieniek, S. Shechter, K. Walsh, C. Kuperwasser, and L. E. Benjamin. 2007. Endothelial Akt signaling is rate-limiting for rapamycin inhibition of mouse mammary tumor progression. Cancer Res. 67: 5070-5075.
26. De Vries, I. J., W. J. Lesterhuis, J. O. Barentsz, P. Verdijk, J. H. van Krieken, O. C. Boerman, W. J. Oyen, J. J. Bonenkamp, J. B. Boezeman, and G. J. Adema. 2005. Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy. Nat. Biotechnol. 23: 1407-1413.
27. Ahrens, E. T., M. Feili-Hariri, H. Xu, G. Genove, and P. A. Morel. 2003. Receptor-mediated endocytosis of iron-oxide particles provides efficient labeling of dendritic cells for in vivo MR imaging. Magn. Reson. Med. 49: 1006-1013.
28. + T cells. Blood 111: 453-462.
29. Dieu, M. C., B. Vanbervliet, A. Vicari, J. M. Bridon, E. Oldham, S. Aït-Yahia, F. Brière, A. Zlotnik, S. Lebecque, and C. Caux. 1998. Selective recruitment for immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J. Exp. Med. 188: 373-386.
30. Ngo, V. N., H. L. Tang, and J. G. Cyster. 1998. Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells. J. Exp. Med. 188: 181-191.
31. Sica, G. L., I. H. Choi, G. Zhu, K. Tamada, S. D. Wang, H. Tamura, A. I. Chapoval, D. B. Flies, J. Bajorath, and L. Chen. 2003. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 18: 849-861. (Pubitemid 36776432)
32. Reddy, V., G. R. Hill, L. Pan, A. Gerbitz, T. Teshima, Y. Brinson, and J. L. Ferrara. 2000. G-CSF modulates cytokine profile of dendritic cells and decreases acute graft-versus-host disease through effects on the donor rather than the recipient. Blood 69: 691-693. (Pubitemid 30129614)
33. Xua, H., T. Chena, H. Q. Wanga, Y. B. Huaa, and W. W. Wu. 2007. Combination treatment with donor interleukin-12p35 silenced dendritic cells and cyclosporine induces long-term survival of intestinal allografts in rats. Transplant. Proc. 39: 286-288.
34. Sordi, V., G. Bianchi, C. Buracchi, A. Mercalli, F. Marchesi, G. D'Amico, C. H. Yang, W. Luini, A. Vecchi, A. Mantovani, et al. 2006. Differential effects of immunosuppressive drugs on chemokine receptor CCR7 in human monocytederived dendritic cells: selective up-regulation by rapamycin. Transplantation 82: 826-834. (Pubitemid 44470386)
35. Ferrara, J. L., K. R. Cooke, and T. Teshima. 2003. The pathophysiology of acute graft-versus-host disease. Int. J. Hematol. 78: 181-187.
36. + T cells after Fc γ RII-mediated uptake. J. Exp. Med. 203: 1629-1635.
37. Ahrens, E. T., R. Flores, H. Xu, and P. A. Morel. 2005. In vivo imaging platform for tracking immunotherapeutic cells. Nat. Biotechnol. 23: 983-987. (Pubitemid 41114032)