-
1
-
-
0037204949
-
B cell antigen receptor signaling: Roles in cell development and disease
-
Gauld, S. B., Dal Porto, J. M. and Cambier, J. C., B cell antigen receptor signaling: roles in cell development and disease. Science 2002. 296: 1641-1642.
-
(2002)
Science
, vol.296
, pp. 1641-1642
-
-
Gauld, S.B.1
Dal Porto, J.M.2
Cambier, J.C.3
-
2
-
-
0036884819
-
Regulation of B-cell fate by antigen-receptor signals
-
Niiro, H. and Clark, E. A., Regulation of B-cell fate by antigen-receptor signals. Nat. Rev. Immunol. 2002. 2: 945-956.
-
(2002)
Nat. Rev. Immunol.
, vol.2
, pp. 945-956
-
-
Niiro, H.1
Clark, E.A.2
-
3
-
-
1342321748
-
PI3K signaling controls cell fate at many points in B lymphocyte development and activation
-
Donahue, A. C. and Fruman, D. A., PI3K signaling controls cell fate at many points in B lymphocyte development and activation. Semin. Cell Dev. Biol. 2004. 15: 183-197.
-
(2004)
Semin. Cell Dev. Biol.
, vol.15
, pp. 183-197
-
-
Donahue, A.C.1
Fruman, D.A.2
-
4
-
-
0038549067
-
PI3K in lymphocyte development, differentiation and activation
-
Okkenhaug, K. and Vanhaesebroeck, B., PI3K in lymphocyte development, differentiation and activation. Nat. Rev. Immunol. 2003. 3: 317-330.
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 317-330
-
-
Okkenhaug, K.1
Vanhaesebroeck, B.2
-
5
-
-
0029882545
-
Phosphatidylinositol 3-kinase activation in normal human B lymphocytes
-
Aagaard-Tillery, K. M. and Jelinek, D. F., Phosphatidylinositol 3-kinase activation in normal human B lymphocytes. J. Immunol. 1996. 156: 4543-4554.
-
(1996)
J. Immunol.
, vol.156
, pp. 4543-4554
-
-
Aagaard-Tillery, K.M.1
Jelinek, D.F.2
-
7
-
-
0033556333
-
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α
-
Fruman, D. A., Snapper, S. B., Yballe, C. M., Davidson, L., Yu, J. Y., Alt, F. W. and Cantley, L. C., Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α. Science 1999. 283: 393-397.
-
(1999)
Science
, vol.283
, pp. 393-397
-
-
Fruman, D.A.1
Snapper, S.B.2
Yballe, C.M.3
Davidson, L.4
Yu, J.Y.5
Alt, F.W.6
Cantley, L.C.7
-
8
-
-
0033555829
-
Xid-like immunodeficiency in mice with disruption of the p85α subunit of phosphoinositide 3-kinase
-
Suzuki, H., Terauchi, Y., Fujiwara, M., Aizawa, S., Yazaki, Y., Kadowaki, T. and Koyasu, S., Xid-like immunodeficiency in mice with disruption of the p85α subunit of phosphoinositide 3-kinase. Science 1999. 283: 390-392.
-
(1999)
Science
, vol.283
, pp. 390-392
-
-
Suzuki, H.1
Terauchi, Y.2
Fujiwara, M.3
Aizawa, S.4
Yazaki, Y.5
Kadowaki, T.6
Koyasu, S.7
-
9
-
-
0037047590
-
Impaired B and T cell antigen receptor signaling in p110δ PI 3-kinase mutant mice
-
Okkenhaug, K., Bilancio, A., Farjot, G., Priddle, H., Sancho, S., Peskett, E., Pearce, W., Meek, S. E., Salpekar, A., Waterfield, M. D. et al., Impaired B and T cell antigen receptor signaling in p110δ PI 3-kinase mutant mice. Science 2002. 297: 1031-1034.
-
(2002)
Science
, vol.297
, pp. 1031-1034
-
-
Okkenhaug, K.1
Bilancio, A.2
Farjot, G.3
Priddle, H.4
Sancho, S.5
Peskett, E.6
Pearce, W.7
Meek, S.E.8
Salpekar, A.9
Waterfield, M.D.10
-
10
-
-
0037119630
-
A crucial role for the p110δ subunit of phosphatidylinositol 3-kinase in B cell development and activation
-
Clayton, E., Bardi, G., Bell, S. E., Chantry, D., Downes, C. P., Gray, A., Humphries, L. A., Rawlings, D., Reynolds, H., Vigorito, E. and Turner, M., A crucial role for the p110δ subunit of phosphatidylinositol 3-kinase in B cell development and activation. J. Exp. Med. 2002. 196: 753-763.
-
(2002)
J. Exp. Med.
, vol.196
, pp. 753-763
-
-
Clayton, E.1
Bardi, G.2
Bell, S.E.3
Chantry, D.4
Downes, C.P.5
Gray, A.6
Humphries, L.A.7
Rawlings, D.8
Reynolds, H.9
Vigorito, E.10
Turner, M.11
-
11
-
-
0037695593
-
Essential, nonredundant role for the phosphoinositide 3-kinase p110δ in signaling by the B-cell receptor complex
-
Jou, S. T., Carpino, N., Takahashi, Y., Piekorz, R., Chao, J. R., Wang, D. and Ihle, J. N., Essential, nonredundant role for the phosphoinositide 3-kinase p110δ in signaling by the B-cell receptor complex. Mol. Cell. Biol. 2002. 22: 8580-8591.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 8580-8591
-
-
Jou, S.T.1
Carpino, N.2
Takahashi, Y.3
Piekorz, R.4
Chao, J.R.5
Wang, D.6
Ihle, J.N.7
-
12
-
-
2442719040
-
Enhanced T cell proliferation in mice lacking the p85β subunit of phosphoinositide 3-kinase
-
Deane, J. A., Trifilo, M. J., Yballe, C. M., Choi, S., Lane, T. E. and Fruman, D. A., Enhanced T cell proliferation in mice lacking the p85β subunit of phosphoinositide 3-kinase. J. Immunol. 2004. 172: 6615-6625.
-
(2004)
J. Immunol.
, vol.172
, pp. 6615-6625
-
-
Deane, J.A.1
Trifilo, M.J.2
Yballe, C.M.3
Choi, S.4
Lane, T.E.5
Fruman, D.A.6
-
13
-
-
0034635452
-
Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation
-
Hirsch, E., Katanaev, V. L., Garlanda, C., Azzolino, O., Pirola, L., Silengo, L., Sozzani, S., Mantovani, A., Altruda, F. and Wymann, M. P., Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation. Science 2000. 287: 1049-1053.
-
(2000)
Science
, vol.287
, pp. 1049-1053
-
-
Hirsch, E.1
Katanaev, V.L.2
Garlanda, C.3
Azzolino, O.4
Pirola, L.5
Silengo, L.6
Sozzani, S.7
Mantovani, A.8
Altruda, F.9
Wymann, M.P.10
-
14
-
-
0034635221
-
Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant-mediated signal transduction
-
Li, Z., Jiang, H., Xie, W., Zhang, Z., Smrcka, A. V. and Wu, D., Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant-mediated signal transduction. Science 2000. 287: 1046-1049.
-
(2000)
Science
, vol.287
, pp. 1046-1049
-
-
Li, Z.1
Jiang, H.2
Xie, W.3
Zhang, Z.4
Smrcka, A.V.5
Wu, D.6
-
15
-
-
0034635264
-
Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration
-
Sasaki, T., Irie-Sasaki, J., Jones, R. G., Oliveira-dos-Santos, A. J., Stanford, W. L., Bolon, B., Wakeham, A., Itie, A., Bouchard, D., Kozieradzki, I. et al., Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration. Science 2000. 287: 1040-1046.
-
(2000)
Science
, vol.287
, pp. 1040-1046
-
-
Sasaki, T.1
Irie-Sasaki, J.2
Jones, R.G.3
Oliveira-dos-Santos, A.J.4
Stanford, W.L.5
Bolon, B.6
Wakeham, A.7
Itie, A.8
Bouchard, D.9
Kozieradzki, I.10
-
16
-
-
0031663503
-
Phosphoinositide kinases
-
Fruman, D. A., Meyers, R. E. and Cantley, L. C., Phosphoinositide kinases. Annu. Rev. Biochem. 1998. 67: 481-507.
-
(1998)
Annu. Rev. Biochem.
, vol.67
, pp. 481-507
-
-
Fruman, D.A.1
Meyers, R.E.2
Cantley, L.C.3
-
17
-
-
0037341617
-
PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction
-
Suzuki, H., Matsuda, S., Terauchi, Y., Fujiwara, M., Ohteki, T., Asano, T., Behrens, T. W., Kouro, T., Takatsu, K., Kadowaki, T. and Koyasu, S., PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction. Nat Immunol. 2003. 4: 280-286.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 280-286
-
-
Suzuki, H.1
Matsuda, S.2
Terauchi, Y.3
Fujiwara, M.4
Ohteki, T.5
Asano, T.6
Behrens, T.W.7
Kouro, T.8
Takatsu, K.9
Kadowaki, T.10
Koyasu, S.11
-
18
-
-
0033757592
-
Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α
-
Fruman, D. A., Mauvais-Jarvis, F., Pollard, D. A., Yballe, C. M., Brazil, D., Bronson, R. T., Kahn, C. R. and Cantley, L. C., Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α. Nat Genet. 2000. 26: 379-382.
-
(2000)
Nat. Genet.
, vol.26
, pp. 379-382
-
-
Fruman, D.A.1
Mauvais-Jarvis, F.2
Pollard, D.A.3
Yballe, C.M.4
Brazil, D.5
Bronson, R.T.6
Kahn, C.R.7
Cantley, L.C.8
-
19
-
-
0033712984
-
Xid-like phenotypes: A B cell signalosome takes shape
-
Fruman, D. A., Satterthwaite, A. B. and Witte, O. N., Xid-like phenotypes: a B cell signalosome takes shape. Immunity 2000. 13: 1-3.
-
(2000)
Immunity
, vol.13
, pp. 1-3
-
-
Fruman, D.A.1
Satterthwaite, A.B.2
Witte, O.N.3
-
20
-
-
1342342993
-
PDK1, the master regulator of AGC kinase signal transduction
-
Mora, A., Komander, D., van Aalten, D. M. F. and Alessi, D. R., PDK1, the master regulator of AGC kinase signal transduction. Semin. Cell Dev. Biol. 2004. 15: 161-170.
-
(2004)
Semin. Cell Dev. Biol.
, vol.15
, pp. 161-170
-
-
Mora, A.1
Komander, D.2
van Aalten, D.M.F.3
Alessi, D.R.4
-
21
-
-
1342321750
-
PI 3-kinase, Akt, and cell survival
-
Downward, J., PI 3-kinase, Akt, and cell survival. Semin. Cell Dev. Biol. 2004. 15: 177-182.
-
(2004)
Semin. Cell Dev. Biol.
, vol.15
, pp. 177-182
-
-
Downward, J.1
-
22
-
-
1342279422
-
PI3-kinase and TOR: PIKTORing cell growth
-
Richardson, C. J., Schalm, S. S. and Blenis, J., PI3-kinase and TOR: PIKTORing cell growth. Semin. Cell Dev. Biol. 2004. 15: 147-159.
-
(2004)
Semin. Cell Dev. Biol.
, vol.15
, pp. 147-159
-
-
Richardson, C.J.1
Schalm, S.S.2
Blenis, J.3
-
23
-
-
2342493308
-
Protein kinase C family functions in B-cell activation
-
Guo, B., Su, T. T. and Rawlings, D. J., Protein kinase C family functions in B-cell activation. Curr. Opin. Immunol. 2004. 16: 367-373.
-
(2004)
Curr. Opin. Immunol.
, vol.16
, pp. 367-373
-
-
Guo, B.1
Su, T.T.2
Rawlings, D.J.3
-
24
-
-
0037189571
-
Convergence of signaling pathways on the activation of ERK in B cells
-
Jacob, A., Cooney, D., Pradhan, M. and Coggeshall, K. M., Convergence of signaling pathways on the activation of ERK in B cells. J. Biol. Chem. 2002. 277: 23420-23426.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 23420-23426
-
-
Jacob, A.1
Cooney, D.2
Pradhan, M.3
Coggeshall, K.M.4
-
25
-
-
0038671744
-
BCR targets cyclin D2 via Btk and the p85α subunit of PI3-K to induce cell cycle progression in primary mouse B cells
-
Glassford, J., Soeiro, I., Skarell, S. M., Banerji, L., Holman, M., Klaus, G. G., Kadowaki, T., Koyasu, S. and Lam, E. W., BCR targets cyclin D2 via Btk and the p85α subunit of PI3-K to induce cell cycle progression in primary mouse B cells. Oncogene 2003. 22: 2248-2259.
-
(2003)
Oncogene
, vol.22
, pp. 2248-2259
-
-
Glassford, J.1
Soeiro, I.2
Skarell, S.M.3
Banerji, L.4
Holman, M.5
Klaus, G.G.6
Kadowaki, T.7
Koyasu, S.8
Lam, E.W.9
-
26
-
-
0034925066
-
RasGRP: The missing link for Ras activation in thymocytes
-
Hogquist, K., RasGRP: the missing link for Ras activation in thymocytes. Trends Immunol. 2001. 22: 69.
-
(2001)
Trends Immunol.
, vol.22
, pp. 69
-
-
Hogquist, K.1
-
27
-
-
0037124307
-
Protein kinase C β controls nuclear factor κB activation in B cells through selective regulation of the IκB kinase α
-
Saijo, K., Mecklenbrauker, I., Santana, A., Leitger, M., Schmedt, C. and Tarakhovsky, A., Protein kinase C β controls nuclear factor κB activation in B cells through selective regulation of the IκB kinase α. J. Exp. Med. 2002. 195: 1647-1652.
-
(2002)
J. Exp. Med.
, vol.195
, pp. 1647-1652
-
-
Saijo, K.1
Mecklenbrauker, I.2
Santana, A.3
Leitger, M.4
Schmedt, C.5
Tarakhovsky, A.6
-
28
-
-
0036344276
-
PKC-β controls IκB kinase lipid raft recruitment and activation in response to BCR signaling
-
Su, T. T., Guo, B., Kawakami, Y., Sommer, K., Chae, K., Humphries, L. A., Kato, R. M., Kang, S., Patrone, L., Wall, R. et al., PKC-β controls IκB kinase lipid raft recruitment and activation in response to BCR signaling. Nat. Immunol. 2002. 3: 780-786.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 780-786
-
-
Su, T.T.1
Guo, B.2
Kawakami, Y.3
Sommer, K.4
Chae, K.5
Humphries, L.A.6
Kato, R.M.7
Kang, S.8
Patrone, L.9
Wall, R.10
-
29
-
-
0037464468
-
AKT1/PKBα is recruited to lipid rafts and activated downstream of PKC isotypes in CD3-induced T cell signaling
-
Bauer, B., Jenny, M., Fresser, F., Uberall, F. and Baier, G., AKT1/PKBα is recruited to lipid rafts and activated downstream of PKC isotypes in CD3-induced T cell signaling. FEBS Lett. 2003. 541: 155-162.
-
(2003)
FEBS Lett.
, vol.541
, pp. 155-162
-
-
Bauer, B.1
Jenny, M.2
Fresser, F.3
Uberall, F.4
Baier, G.5
-
30
-
-
0029166374
-
Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-α-responsive elements
-
Lopez-Cabrera, M., Munoz, E., Blazquez, M. V., Ursa, M. A., Santis, A. G. and Sanchez-Madrid, F., Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-α-responsive elements. J. Biol. Chem. 1995. 270: 21545-21551.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 21545-21551
-
-
Lopez-Cabrera, M.1
Munoz, E.2
Blazquez, M.V.3
Ursa, M.A.4
Santis, A.G.5
Sanchez-Madrid, F.6
-
31
-
-
0028176488
-
Cyclosporin A sensitivity of the NF-κB site of the IL2Rα promoter in untransformed murine T cells
-
McCaffrey, P. G., Kim, P. K., Valge-Archer, V. E., Sen, R. and Rao, A., Cyclosporin A sensitivity of the NF-κB site of the IL2Rα promoter in untransformed murine T cells. Nucleic Acids Res. 1994. 22: 2134-2142.
-
(1994)
Nucleic Acids Res.
, vol.22
, pp. 2134-2142
-
-
McCaffrey, P.G.1
Kim, P.K.2
Valge-Archer, V.E.3
Sen, R.4
Rao, A.5
-
32
-
-
0035260351
-
Reactive oxygen species mediate tumor necrosis factor α-converting, enzyme-dependent ectodomain shedding induced by phorbol myristate acetate
-
Zhang, Z., Oliver, P., Lancaster, J. J., Schwarzenberger, P. O., Joshi, M. S., Cork, J. and Kolls, J. K., Reactive oxygen species mediate tumor necrosis factor α-converting, enzyme-dependent ectodomain shedding induced by phorbol myristate acetate. FASEB J. 2001. 15: 303-305.
-
(2001)
FASEB J.
, vol.15
, pp. 303-305
-
-
Zhang, Z.1
Oliver, P.2
Lancaster, J.J.3
Schwarzenberger, P.O.4
Joshi, M.S.5
Cork, J.6
Kolls, J.K.7
-
33
-
-
0037039320
-
Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes
-
Fruman, D. A., Ferl, G. Z., An, S. S., Donahue, A. C., Satterthwaite, A. B. and Witte, O. N., Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes. Proc. Natl. Acad. Sci. U S A 2002. 99: 359-364.
-
(2002)
Proc. Natl. Acad. Sci. U S A
, vol.99
, pp. 359-364
-
-
Fruman, D.A.1
Ferl, G.Z.2
An, S.S.3
Donahue, A.C.4
Satterthwaite, A.B.5
Witte, O.N.6
-
34
-
-
0345138995
-
BTK regulates Ptdlns-4,5-P2 synthesis: Importance for calcium signaling and PI3 K activity
-
Saito, K., Tolias, K. F., Saci, A., Koon, H. B., Humphries, L. A., Scharenberg, A., Rawlings, D. J., Kinet, J. P. and Carpenter, C. L., BTK regulates Ptdlns-4,5-P2 synthesis: importance for calcium signaling and PI3 K activity. Immunity 2003. 19: 669-678.
-
(2003)
Immunity
, vol.19
, pp. 669-678
-
-
Saito, K.1
Tolias, K.F.2
Saci, A.3
Koon, H.B.4
Humphries, L.A.5
Scharenberg, A.6
Rawlings, D.J.7
Kinet, J.P.8
Carpenter, C.L.9
-
35
-
-
0036536426
-
Protein kinase D: An intracellular traffic regulator on the move
-
Van Lint, J., Rykx, A., Maeda, Y., Vantus, T., Sturany, S., Malhotra, V., Vandenheede, J. R. and Seufferlein, T., Protein kinase D: an intracellular traffic regulator on the move. Trends Cell Biol. 2002. 12: 193-200.
-
(2002)
Trends Cell Biol.
, vol.12
, pp. 193-200
-
-
Van Lint, J.1
Rykx, A.2
Maeda, Y.3
Vantus, T.4
Sturany, S.5
Malhotra, V.6
Vandenheede, J.R.7
Seufferlein, T.8
-
36
-
-
0037413711
-
Protein kinase D mediates a stress-induced NF-κB activation and survival pathway
-
Storz, P. and Toker, A., Protein kinase D mediates a stress-induced NF-κB activation and survival pathway. EMBO J. 2003. 22: 109-120.
-
(2003)
EMBO J.
, vol.22
, pp. 109-120
-
-
Storz, P.1
Toker, A.2
-
37
-
-
2342622123
-
Optimal B cell proliferation requires phosphoinositide 3-kinase-dependent inactivation of FOXO transcription factors
-
In press
-
Yusuf, I., Zhu, X., Kharas, M. G., Chen, J. and Fruman, D. A., Optimal B cell proliferation requires phosphoinositide 3-kinase-dependent inactivation of FOXO transcription factors. Blood 2004. In press.
-
(2004)
Blood
-
-
Yusuf, I.1
Zhu, X.2
Kharas, M.G.3
Chen, J.4
Fruman, D.A.5
-
38
-
-
0029739626
-
Immunodeficiency in protein kinase Cβ-deficient mice
-
Leitges, M., Schmedt, C., Guinamard, R., Davoust, J., Schaal, S., Stabel, S. and Tarakhovsky, A., Immunodeficiency in protein kinase Cβ-deficient mice. Science 1996. 273: 788-791.
-
(1996)
Science
, vol.273
, pp. 788-791
-
-
Leitges, M.1
Schmedt, C.2
Guinamard, R.3
Davoust, J.4
Schaal, S.5
Stabel, S.6
Tarakhovsky, A.7
-
39
-
-
0038281331
-
Proliferation and survival of activated B cells requires sustained antigen receptor engagement and phosphoinositide 3-kinase activation
-
Donahue, A. C. and Fruman, D. A., Proliferation and survival of activated B cells requires sustained antigen receptor engagement and phosphoinositide 3-kinase activation. J. Immunol. 2003. 170: 5851-5860.
-
(2003)
J. Immunol.
, vol.170
, pp. 5851-5860
-
-
Donahue, A.C.1
Fruman, D.A.2
|