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Volumn 14, Issue 3, 2012, Pages 249-256

Pancreatic neuroendocrine and carcinoid tumors: What's new, what's old, and what's different?

Author keywords

Bland embolization; Carcinoid; Embolization; Everolimus; Gastrointestinal cancers; Neuroendocrine tumors; Pancreatic NETs; Streptozocin; Sunitinib; Temozolomide; Yttrium 90 spheres

Indexed keywords

ANGIOPEPTIN; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CAPECITABINE; CHLOROZOTOCIN; CYCLOPHOSPHAMIDE; DACARBAZINE; DOXORUBICIN; EVEROLIMUS; FLUOROURACIL; FOLINIC ACID; INDIUM 111; INTERFERON; LANREOTIDE Y 90; LUTETIUM 177; OCTREOTIDE; OCTREOTIDE LU 177; OXALIPLATIN; PEGINTERFERON ALPHA2B; PLACEBO; PLATINUM COMPLEX; SOMATOSTATIN DERIVATIVE; STREPTOZOCIN; SUNITINIB; TEMOZOLOMIDE; TEMSIROLIMUS; THALIDOMIDE; UNCLASSIFIED DRUG; YTTRIUM 90; ANGIOGENESIS INHIBITOR; DRUG DERIVATIVE; IMMUNOSUPPRESSIVE AGENT; INDOLE DERIVATIVE; MTOR PROTEIN, HUMAN; PYRROLE DERIVATIVE; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE; VASCULOTROPIN; YTTRIUM;

EID: 84864025307     PISSN: 15233790     EISSN: 15346269     Source Type: Journal    
DOI: 10.1007/s11912-012-0232-1     Document Type: Article
Times cited : (27)

References (60)
  • 1
    • 79851500081 scopus 로고    scopus 로고
    • Everolimus for advanced pancreatic neuroendocrine tumors
    • This randomized controlled phase III study showed that everolimus improves progression-free survival when compared to placebo in patients with progressive pancreatic NETs and led to its FDA approval in 2011
    • •• Yao JC, ShahMH, Ito T, et al. Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med. 2011;364:514-23. This randomized controlled phase III study showed that everolimus improves progression-free survival when compared to placebo in patients with progressive pancreatic NETs and led to its FDA approval in 2011.
    • (2011) N Engl J Med. , vol.364 , pp. 514-523
    • Yao, J.C.1    Shah, M.H.2    Ito, T.3
  • 2
    • 79851482955 scopus 로고    scopus 로고
    • Sunitinib malate for the treatment of pancreatic neuroendocrine tumors
    • This randomized controlled phase III study showed that sunitinib improves progression-free survival when compared to placebo in patients with progressive pancreatic NETs and led to its FDA approval in 2011
    • •• Raymond E, Dahan L, Raoul JL, et al. Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med. 2011;364:501-13. This randomized controlled phase III study showed that sunitinib improves progression-free survival when compared to placebo in patients with progressive pancreatic NETs and led to its FDA approval in 2011.
    • (2011) N Engl J Med. , vol.364 , pp. 501-513
    • Raymond, E.1    Dahan, L.2    Raoul, J.L.3
  • 4
    • 0036858598 scopus 로고    scopus 로고
    • Classification of lowgrade neuroendocrine tumors of midgut and unknown origin
    • Van Eeden S, Quadvlieg P, Babs G, et al. Classification of lowgrade neuroendocrine tumors of midgut and unknown origin. Hum Pathol. 2002;33:1126-32.
    • (2002) Hum Pathol , vol.33 , pp. 1126-1132
    • Van Eeden, S.1    Quadvlieg, P.2    Babs, G.3
  • 6
    • 0025933213 scopus 로고
    • Treatment of neuroendocrine carcinomas with combined etoposide and cisplatin: Evidence of major therapeutic activity in the anaplastic variants of these neoplasms
    • Moertel C, Kvols L, O'Connell M, Rubin J. Treatment of neuroendocrine carcinomas with combined etoposide and cisplatin: Evidence of major therapeutic activity in the anaplastic variants of these neoplasms. Cancer. 1991;68:227-32.
    • (1991) Cancer. , vol.68 , pp. 227-232
    • Moertel, C.1    Kvols, L.2    O'Connell, M.3    Rubin, J.4
  • 7
    • 80051619926 scopus 로고    scopus 로고
    • Prognostic validity of a novel American joint committee on cancer staging classification for pancreatic neuroendocrine tumors
    • Strosberg JR, Cheema A, Weber J, Han G, Coppola D, Kvols LK. Prognostic validity of a novel American Joint Committee on Cancer Staging Classification for Pancreatic Neuroendocrine Tumors. J Clin Oncol 2011.
    • (2011) J Clin Oncol
    • Strosberg, J.R.1    Cheema, A.2    Weber, J.3    Han, G.4    Coppola, D.5    Kvols, L.K.6
  • 8
    • 79952279828 scopus 로고    scopus 로고
    • DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors
    • Jiao Y, Shi C, Edil BH, et al. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science. 2011;331:1199-203.
    • (2011) Science , vol.331 , pp. 1199-1203
    • Jiao, Y.1    Shi, C.2    Edil, B.H.3
  • 9
    • 0028323620 scopus 로고
    • Gastrointestinal neuroendocrine tumors
    • Delcore R, Friesen SR. Gastrointestinal neuroendocrine tumors. J Am Coll Surg. 1994;178:187-211.
    • (1994) J Am Coll Surg , vol.178 , pp. 187-211
    • Delcore, R.1    Friesen, S.R.2
  • 10
    • 43749091955 scopus 로고    scopus 로고
    • Treatment with the radiolabeled somatostatin analog [177 Lu-DOTA 0, Tyr3] octreotate: Toxicity, efficacy, and survival
    • Kwekkeboom DJ, de Herder WW, Kam BL, et al. Treatment with the radiolabeled somatostatin analog [177 Lu-DOTA 0, Tyr3] octreotate: Toxicity, efficacy, and survival. J Clin Oncol: Official J Am Soc Clin Oncol. 2008;26:2124-30.
    • (2008) J Clin Oncol: Official J Am Soc Clin Oncol , vol.26 , pp. 2124-2130
    • Kwekkeboom, D.J.1    De Herder, W.W.2    Kam, B.L.3
  • 12
    • 73949094846 scopus 로고    scopus 로고
    • Treatment of advanced disease in patients with well-differentiated neuroendocrine tumors
    • Reidy DL, Tang LH, Saltz LB. Treatment of advanced disease in patients with well-differentiated neuroendocrine tumors. Nat Clin Pract Oncol. 2009;6:143-52.
    • (2009) Nat Clin Pract Oncol , vol.6 , pp. 143-152
    • Reidy, D.L.1    Tang, L.H.2    Saltz, L.B.3
  • 13
    • 33846451046 scopus 로고    scopus 로고
    • Aggressive surgery improves long-term survival in neuroendocrine pancreatic tumors: An institutional experience
    • Schurr P, Strate T, Rese K, et al. Aggressive surgery improves long-term survival in neuroendocrine pancreatic tumors: An institutional experience. Ann Surg. 2007;245:273-81.
    • (2007) Ann Surg , vol.245 , pp. 273-281
    • Schurr, P.1    Strate, T.2    Rese, K.3
  • 14
    • 20944445859 scopus 로고    scopus 로고
    • Neuroendocrine hepatic metastases: Does aggressive management improve survival?
    • Touzios J, Kiely J, Pitt S, et al. Neuroendocrine hepatic metastases: Does aggressive management improve survival? Ann Surg. 2005;241:776-83.
    • (2005) Ann Surg , vol.241 , pp. 776-783
    • Touzios, J.1    Kiely, J.2    Pitt, S.3
  • 15
    • 0037635397 scopus 로고    scopus 로고
    • Surgical treatment of neuroendocrine metastases to the liver: A plea for resection to increase survival
    • Sarmiento J, Heywood G, Rubin Jea. Surgical treatment of neuroendocrine metastases to the liver: A plea for resection to increase survival. J Am Coll Surg 2003;197.
    • (2003) J Am Coll Surg , vol.197
    • Sarmiento, J.1    Heywood, G.2    Jea, R.3
  • 16
    • 0034111079 scopus 로고    scopus 로고
    • Hepatic neuroendocrine metastases: Does intervention affect outcome?
    • Chamberlain R, Canes D, Brown K, et al. Hepatic neuroendocrine metastases: Does intervention affect outcome? J Am Coll Surg. 2000;190:432-45.
    • (2000) J Am Coll Surg , vol.190 , pp. 432-445
    • Chamberlain, R.1    Canes, D.2    Brown, K.3
  • 17
    • 0027536497 scopus 로고
    • Hepatic arterial chemoembolization in patients with liver metastases of endocrine tumors. A prospective phase II study in 24 patients
    • Ruszniewski P, Rougier P, Roche A, et al. Hepatic arterial chemoembolization in patients with liver metastases of endocrine tumors. A prospective phase II study in 24 patients. Cancer. 1993;71:2624-40.
    • (1993) Cancer. , vol.71 , pp. 2624-2640
    • Ruszniewski, P.1    Rougier, P.2    Roche, A.3
  • 18
    • 0032400854 scopus 로고    scopus 로고
    • Liver embolizations of patients with malignant neuroendocrine gastrointestinal tumors
    • Eriksson B, Larsson E, Skogseid B, et al. Liver embolizations of patients with malignant neuroendocrine gastrointestinal tumors. Cancer. 1998;83:2293-301.
    • (1998) Cancer , vol.83 , pp. 2293-2301
    • Eriksson, B.1    Larsson, E.2    Skogseid, B.3
  • 19
    • 0642276510 scopus 로고    scopus 로고
    • Hepatic Artery Embolization and chemoembolization for treatment of patients with metastatic carcinoid tumors: The MD Anderson Experience
    • Gupta S, Yao J, Ahrar K, et al. Hepatic Artery Embolization and chemoembolization for treatment of patients with metastatic carcinoid tumors: The MD Anderson Experience. Cancer. 2003;9:261-7.
    • (2003) Cancer. , vol.9 , pp. 261-267
    • Gupta, S.1    Yao, J.2    Ahrar, K.3
  • 20
    • 0027952532 scopus 로고
    • The management of patients with advanced carcinoid tumors and islet cell carcinomas
    • Moertel C, Johnson C, McKusick M, et al. The management of patients with advanced carcinoid tumors and islet cell carcinomas. Ann Intern Med. 1994;120:302-9.
    • (1994) Ann Intern Med , vol.120 , pp. 302-309
    • Moertel, C.1    Johnson, C.2    McKusick, M.3
  • 21
    • 44949120870 scopus 로고    scopus 로고
    • Radioembolization for unresectable neuroendocrine hepatic metastases using resin 90Y-microspheres: Early results in 148 patients
    • Kennedy AS, Dezarn WA, McNeillie P, et al. Radioembolization for unresectable neuroendocrine hepatic metastases using resin 90Y-microspheres: Early results in 148 patients. Am J Clin Oncol. 2008;31:271-9.
    • (2008) Am J Clin Oncol , vol.31 , pp. 271-279
    • Kennedy, A.S.1    Dezarn, W.A.2    McNeillie, P.3
  • 22
    • 44449085489 scopus 로고    scopus 로고
    • 90Y Radioembolization for metastatic neuroendocrine liver tumors: Preliminary results from a multi-institutional experience
    • Rhee TK, Lewandowski RJ, Liu DM, et al. 90Y Radioembolization for metastatic neuroendocrine liver tumors: Preliminary results from a multi-institutional experience. Ann Surg. 2008;247:1029-35.
    • (2008) Ann Surg , vol.247 , pp. 1029-1035
    • Rhee, T.K.1    Lewandowski, R.J.2    Liu, D.M.3
  • 23
    • 52049109269 scopus 로고    scopus 로고
    • Radioembolization with selective internal radiation microspheres for neuroendocrine liver metastases
    • King J, Quinn R, Glenn DM, et al. Radioembolization with selective internal radiation microspheres for neuroendocrine liver metastases. Cancer. 2008;113:921-9.
    • (2008) Cancer , vol.113 , pp. 921-929
    • King, J.1    Quinn, R.2    Glenn, D.M.3
  • 24
    • 77949347750 scopus 로고    scopus 로고
    • Radioembolization with yttrium microspheres for neuroendocrine tumour liver metastases
    • Cao CQ, Yan TD, Bester L, Liauw W, Morris DL. Radioembolization with yttrium microspheres for neuroendocrine tumour liver metastases. Br J Surg. 2010;97:537-43.
    • (2010) Br J Surg , vol.97 , pp. 537-543
    • Cao, C.Q.1    Yan, T.D.2    Bester, L.3    Liauw, W.4    Morris, D.L.5
  • 25
    • 0021924172 scopus 로고
    • Longterm treatment of a VIPoma with somatostatin analogue resulting in remission of symptoms and possible shrinkage of metastases
    • Kraenzlin ME, Ch'ng JL, Wood SM, Carr DH, Bloom SR. Longterm treatment of a VIPoma with somatostatin analogue resulting in remission of symptoms and possible shrinkage of metastases. Gastroenterology. 1985;88:185-7.
    • (1985) Gastroenterology , vol.88 , pp. 185-187
    • Kraenzlin, M.E.1    Ch'ng, J.L.2    Wood, S.M.3    Carr, D.H.4    Bloom, S.R.5
  • 26
    • 19744366733 scopus 로고    scopus 로고
    • Octreotide in insulinoma patients: Efficacy on hypoglycemia, relationships with Octreoscan scintigraphy and immunostaining with anti-sst2A and anti-sst5 antibodies
    • Vezzosi D, Bennet A, Rochaix P, et al. Octreotide in insulinoma patients: Efficacy on hypoglycemia, relationships with Octreoscan scintigraphy and immunostaining with anti-sst2A and anti-sst5 antibodies. Eur J Endocrinol. 2005;152:757-67.
    • (2005) Eur J Endocrinol , vol.152 , pp. 757-767
    • Vezzosi, D.1    Bennet, A.2    Rochaix, P.3
  • 27
    • 70350442637 scopus 로고    scopus 로고
    • Placebocontrolled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: A report from the PROMID Study Group
    • Rinke A, Muller HH, Schade-Brittinger C, et al. Placebocontrolled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: A report from the PROMID Study Group. J Clin Oncol. 2009;27:4656-63.
    • (2009) J Clin Oncol. , vol.27 , pp. 4656-4663
    • Rinke, A.1    Muller, H.H.2    Schade-Brittinger, C.3
  • 28
    • 84870774803 scopus 로고    scopus 로고
    • National Comprehensive Care Network Organizations, last accessioned Novemeber 21, 2011
    • National Comprehensive Care Network Organizations, www. nccn.org; last accessioned Novemeber 21, 2011.
  • 29
    • 19944434272 scopus 로고    scopus 로고
    • Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: Negative correlation of microvascular density and VEGF expression with tumour progression
    • Couvelard A, O'Toole D, Turley H, et al. Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: Negative correlation of microvascular density and VEGF expression with tumour progression. Br J Cancer. 2005;92:94-101.
    • (2005) Br J Cancer. , vol.92 , pp. 94-101
    • Couvelard, A.1    O'Toole, D.2    Turley, H.3
  • 30
    • 33846196448 scopus 로고    scopus 로고
    • Results of a phase II study with sunitinib malate (SU11248) in patients with advanced neuroendocrine tumours
    • Kulke M, Lenz H, Meropol N, et al. Results of a phase II study with sunitinib malate (SU11248) in patients with advanced neuroendocrine tumours. Eur J Canc 2005;Suppl.
    • (2005) Eur J Canc , Issue.SUPPL.
    • Kulke, M.1    Lenz, H.2    Meropol, N.3
  • 31
    • 49149114782 scopus 로고    scopus 로고
    • Activity of sunitinib in patients with advanced neuroendocrine tumors
    • Kulke MH, Lenz HJ, Meropol NJ, et al. Activity of sunitinib in patients with advanced neuroendocrine tumors. J Clin Oncol. 2008;26:3403-10.
    • (2008) J Clin Oncol , vol.26 , pp. 3403-3410
    • Kulke, M.H.1    Lenz, H.J.2    Meropol, N.J.3
  • 32
    • 33750510023 scopus 로고    scopus 로고
    • A phase II clinical and pharmacodynamic study trial of temsirolimus in advanced neuroendocrine tumors
    • Duran I, Kortmansky J, Singh D, et al. A phase II clinical and pharmacodynamic study trial of temsirolimus in advanced neuroendocrine tumors. Br J Canc. 2006;95:1148-54.
    • (2006) Br J Canc. , vol.95 , pp. 1148-1154
    • Duran, I.1    Kortmansky, J.2    Singh, D.3
  • 33
    • 52049125970 scopus 로고    scopus 로고
    • Efficacy of RAD001 (everolimus) and octreotide LAR in advanced low-to intermediategrade neuroendocrine tumors: Results of a phase II study
    • Yao JC, Phan AT, Chang DZ, et al. Efficacy of RAD001 (everolimus) and octreotide LAR in advanced low-to intermediategrade neuroendocrine tumors: Results of a phase II study. J Clin Oncol. 2008;26:4311-8.
    • (2008) J Clin Oncol , vol.26 , pp. 4311-4318
    • Yao, J.C.1    Phan, A.T.2    Chang, D.Z.3
  • 34
    • 0031906775 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor in digestive tumours
    • Terris B, Scoazec J, Rubbia L, et al. Expression of vascular endothelial growth factor in digestive tumours. Histopathology. 1998;32:133-8.
    • (1998) Histopathology , vol.32 , pp. 133-138
    • Terris, B.1    Scoazec, J.2    Rubbia, L.3
  • 35
    • 33947277038 scopus 로고    scopus 로고
    • Association Of VEGF expression with poor prognosis among patients with low-grade neuroendocrine carcinoma
    • Atlanta
    • Phan A, Wang L, Xie K, et al. Association of VEGF expression with poor prognosis among patients with low-grade neuroendocrine carcinoma. In: Annual Meeting of American Society of Clinical Oncology; 2006; Atlanta; 2006.
    • (2006) Annual Meeting Of American Society Of Clinical Oncology , vol.2006
    • Phan, A.1    Wang, L.2    Xie, K.3
  • 36
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotyn W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004;350:2335-42.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotyn, W.3
  • 37
    • 34250703190 scopus 로고    scopus 로고
    • A phase II study of temozolomide and bevacizumab in patients with advanced neuroendocrine tumors
    • Atlanta, GA
    • Kulke M, Stuart K, Earle C, et al. A phase II study of temozolomide and bevacizumab in patients with advanced neuroendocrine tumors. In: Proceedings ASCO 2006; Atlanta, GA; 2006.
    • (2006) Proceedings ASCO 2006
    • Kulke, M.1    Stuart, K.2    Earle, C.3
  • 38
    • 0034742565 scopus 로고    scopus 로고
    • The clinical value of [90YDOTA]-DPhe-Tyr-octreotide In the treatment of neuroendocrine tumours: A clinical phase II study
    • Walderr C, Pless M, Maecke H, et al. The clinical value of [90YDOTA]-dPhe-Tyr-octreotide in the treatment of neuroendocrine tumours: A clinical phase II study. Ann Oncol. 2001;12:941-5.
    • (2001) Ann Oncol. , vol.12 , pp. 941-945
    • Walderr, C.1    Pless, M.2    Maecke, H.3
  • 39
    • 0036250672 scopus 로고    scopus 로고
    • Tumor response and clinical benefit in neuroendocrine tumors after 7.4 GBq (90)Y-DOTATOC
    • Waldherr C, Pless M, Maecke H, et al. Tumor response and clinical benefit in neuroendocrine tumors after 7.4 GBq (90)Y-DOTATOC. J Nucl Med. 2002;43:610-6.
    • (2002) J Nucl Med. , Issue.43 , pp. 610-616
    • Waldherr, C.1    Pless, M.2    Maecke, H.3
  • 40
    • 0036231005 scopus 로고    scopus 로고
    • 111In-and 90Y-DOTALanreotide: Results and implications of the MAURITIUS trial
    • Virgolini I, Britton K, Buscombe J, et al. 111In-and 90Y-DOTALanreotide: Results and implications of the MAURITIUS trial. J Nucl Med. 2002;32:148-55.
    • (2002) J Nucl Med , vol.32 , pp. 148-155
    • Virgolini, I.1    Britton, K.2    Buscombe, J.3
  • 41
    • 33644616790 scopus 로고    scopus 로고
    • Survival and response after peptide receptor radionuclide therapy with [90Y-DOTA0, Tyr3] octreotide in patients with advanced gastroenteropancreatic neuroendocrine tumors
    • Valkema R, Pauwels S, Kvols L, et al. Survival and response after peptide receptor radionuclide therapy with [90Y-DOTA0, Tyr3] octreotide in patients with advanced gastroenteropancreatic neuroendocrine tumors. Semin Nucl Med. 2006;36:147.
    • (2006) Semin Nucl Med. , vol.36 , pp. 147
    • Valkema, R.1    Pauwels, S.2    Kvols, L.3
  • 42
    • 43749091955 scopus 로고    scopus 로고
    • Treatment with the radiolabeled somatostatin analog [177Lu-DOTA0, Tyr3]Octreotate: Toxicity, efficacy, and survival
    • Kwekkeboom D, Wouter W, de Herder B, et al. Treatment with the radiolabeled somatostatin analog [177Lu-DOTA0, Tyr3]Octreotate: Toxicity, efficacy, and survival. J Clin Oncol. 2008;26:2124-30.
    • (2008) J Clin Oncol. , vol.26 , pp. 2124-2130
    • Kwekkeboom, D.1    Wouter, W.2    De Herder, B.3
  • 43
    • 21044451724 scopus 로고    scopus 로고
    • Treatment with the radiolabeled somatostatin analogue [177Lu-DOTA° Tyr3]octreotate in patients with gastro-entero-pancreatic (GEP) tumors
    • Kwekkeboom J, Teunissen J, Bakker WH. Treatment with the radiolabeled somatostatin analogue [177Lu-DOTA° Tyr3]octreotate in patients with gastro-entero-pancreatic (GEP) tumors. J Clin Oncol. 2005;23:2754-62.
    • (2005) J Clin Oncol. , vol.23 , pp. 2754-2762
    • Kwekkeboom, J.1    Teunissen, J.2    Bakker, W.H.3
  • 44
    • 0026530547 scopus 로고
    • Streptozocin-doxorubicin, streptozocin-fluorouracil or chlorozotocin in the treatment of advanced islet-cell carcinoma
    • Moertel CG, Lefkopoulo M, Lipsitz S, Hahn RG, Klaassen D. Streptozocin-doxorubicin, streptozocin-fluorouracil or chlorozotocin in the treatment of advanced islet-cell carcinoma. N Engl J Med. 1992;326:519-23.
    • (1992) N Engl J Med , vol.326 , pp. 519-523
    • Moertel, C.G.1    Lefkopoulo, M.2    Lipsitz, S.3    Hahn, R.G.4    Klaassen, D.5
  • 45
    • 0033567934 scopus 로고    scopus 로고
    • Failure to confirm major objective antitumor activity for streptozocin and doxorubicin in the treatment of patients with advanced islet cell carcinoma
    • Cheng P, Saltz L. Failure to confirm major objective antitumor activity for streptozocin and doxorubicin in the treatment of patients with advanced islet cell carcinoma. Cancer. 1999;86:944-8.
    • (1999) Cancer , vol.86 , pp. 944-948
    • Cheng, P.1    Saltz, L.2
  • 46
    • 14644413806 scopus 로고    scopus 로고
    • Fluorouracil, doxorubicin, and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas
    • Kouvaraki MA, Ajani JA, Hoff P, et al. Fluorouracil, doxorubicin, and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas. J Clin Oncol. 2004;22:4762-71.
    • (2004) J Clin Oncol. , vol.22 , pp. 4762-4771
    • Kouvaraki, M.A.1    Ajani, J.A.2    Hoff, P.3
  • 47
    • 0034823957 scopus 로고    scopus 로고
    • Phase II trial of dacarbazine (DTIC) in advanced pancreatic islet cell carcinoma
    • Study of the Eastern Cooperative Oncology Group-E6282
    • Ramanathan R, Cnaan A, Hahn R, et al. Phase II trial of dacarbazine (DTIC) in advanced pancreatic islet cell carcinoma. Study of the Eastern Cooperative Oncology Group-E6282. Ann Oncol. 2001;12:1139-43.
    • (2001) Ann Oncol. , vol.12 , pp. 1139-1143
    • Ramanathan, R.1    Cnaan, A.2    Hahn, R.3
  • 48
    • 33644846851 scopus 로고    scopus 로고
    • Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors
    • Kulke M, Stuart K, Enzinger P, et al. Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors. J Clin Oncol. 2006;24:401-6.
    • (2006) J Clin Oncol. , vol.24 , pp. 401-406
    • Kulke, M.1    Stuart, K.2    Enzinger, P.3
  • 49
    • 38049008967 scopus 로고    scopus 로고
    • Phase II study of thalidomide in patients with metastatic carcinoid and islet cell tumors
    • Varker KA, Campbell J, Shah MH. Phase II study of thalidomide in patients with metastatic carcinoid and islet cell tumors. Cancer Chemother Pharmacol. 2008;61:661-8.
    • (2008) Cancer Chemother Pharmacol. , vol.61 , pp. 661-668
    • Varker, K.A.1    Campbell, J.2    Shah, M.H.3
  • 50
    • 34249818466 scopus 로고    scopus 로고
    • Temozolomide as monotherapy is effective in treatment of advanced malignant neuroendocrine tumors
    • Ekeblad S, Sundin A, Janson ET, et al. Temozolomide as monotherapy is effective in treatment of advanced malignant neuroendocrine tumors. Clin Cancer Res. 2007;13:2986-91.
    • (2007) Clin Cancer Res , vol.13 , pp. 2986-2991
    • Ekeblad, S.1    Sundin, A.2    Janson, E.T.3
  • 51
    • 78650993549 scopus 로고    scopus 로고
    • First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas
    • Strosberg JR, Fine RL, Choi J, et al. First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas. Cancer. 2011;117:268-75.
    • (2011) Cancer , vol.117 , pp. 268-275
    • Strosberg, J.R.1    Fine, R.L.2    Choi, J.3
  • 52
    • 68149155414 scopus 로고    scopus 로고
    • Gemcitabine and oxaliplatin combination chemotherapy for metastatic well-differentiated neuroendocrine carcinomas: A single-center experience
    • Cassier PA,Walter T, Eymard B, et al. Gemcitabine and oxaliplatin combination chemotherapy for metastatic well-differentiated neuroendocrine carcinomas: A single-center experience. Cancer. 2009;115:3392-9.
    • (2009) Cancer. , vol.115 , pp. 3392-3399
    • Cassier, P.A.1    Walter, T.2    Eymard, B.3
  • 53
    • 33847098794 scopus 로고    scopus 로고
    • Are capecitabine and oxaliplatin (XELOX) suitable treatments for progressing lowgrade and high-grade neuroendocrine tumours?
    • Bajetta E, Catena L, Procopio G, et al. Are capecitabine and oxaliplatin (XELOX) suitable treatments for progressing lowgrade and high-grade neuroendocrine tumours? Cancer Chemother Pharmacol. 2007;59:637-42.
    • (2007) Cancer Chemother Pharmacol. , vol.59 , pp. 637-642
    • Bajetta, E.1    Catena, L.2    Procopio, G.3
  • 54
    • 84870776964 scopus 로고    scopus 로고
    • Phase II trial of FOLFOX plus bevacizumab in advanced, progressive neuroendocrine tumors (abstract 216
    • Orlando, FL, confID053&abstractID010380
    • Bergsland E, Ko A, Tempero M, et al. Phase II trial of FOLFOX plus bevacizumab in advanced, progressive neuroendocrine tumors (abstract 216). Data presented at the 2008 ASCO Gastrointestinal Cancers Symposium, Orlando, FL 2008; http://www.asco.org/ ASCOv2/Meetings/Abstracts?&vmview0abst-detail- view&confID053&abstractID010380
    • (2008) Data Presented at the 2008 ASCO Gastrointestinal Cancers Symposium
    • Bergsland, E.1    Ko, A.2    Tempero, M.3
  • 55
    • 77954779889 scopus 로고    scopus 로고
    • A phase II study of capecitabine, oxaliplatin, and bevacizumab for metastatic or unresectable neuroendocrine tumors (abstract 4104)
    • Abstract available online at, abstractID054381 (Accessed on February 10 2011
    • Kunz P, Kuo T, Zahn J, et al. A phase II study of capecitabine, oxaliplatin, and bevacizumab for metastatic or unresectable neuroendocrine tumors (abstract 4104). J Clin Oncol 2010;28:326s Abstract available online at http://www.asco.org/ASCOv2/ Meetings/Abstracts?&vmview0abst-detail- view&confID074& abstractID054381 (Accessed on February 10, 2011).
    • (2010) J Clin Oncol , vol.28
    • Kunz, P.1    Kuo, T.2    Zahn, J.3
  • 56
    • 84870814827 scopus 로고    scopus 로고
    • Prediction of response to temozolamide (TMZ)-based therapy by loss of MGMT expression in patients with advanced neuroendocrine tumors (NET)
    • Chicago, IL
    • Kulke M, Frauenhoffer C, Hooshmand D, Ryan P, et al. Prediction of response to temozolamide (TMZ)-based therapy by loss of MGMT expression in patients with advanced neuroendocrine tumors (NET). In: Proceedings ASCO; 2007; Chicago, IL; 2007.
    • (2007) Proceedings ASCO , pp. 2007
    • Kulke, M.1    Frauenhoffer, C.2    Hooshmand, D.3    Ryan, P.4
  • 57
    • 0018740629 scopus 로고
    • Combination chemotherapy trials in metastatic carcinoid tumor and the malignant carcinoid syndrome
    • Moertel C, Hanley J. Combination chemotherapy trials in metastatic carcinoid tumor and the malignant carcinoid syndrome. Cancer Clin Trials. 1979;2:327-34.
    • (1979) Cancer Clin Trials , vol.2 , pp. 327-334
    • Moertel, C.1    Hanley, J.2
  • 58
    • 0021738889 scopus 로고
    • Streptozocin plus fluorouracil versus doxorubicin therapy for metastatic carcinoid tumor
    • Engstrom P, Lavin P, Moertel CG, et al. Streptozocin plus fluorouracil versus doxorubicin therapy for metastatic carcinoid tumor. J Clin Oncol. 1984;2:1255-59.
    • (1984) J Clin Oncol , vol.2 , pp. 1255-1259
    • Engstrom, P.1    Lavin, P.2    Moertel, C.G.3
  • 59
    • 0023502961 scopus 로고
    • A phase II trial of combination chemotherapy in patients with metastatic carcinoid tumors. A southwest oncology group study
    • Bukowski R, Johnson K, Peterson R, et al. A phase II trial of combination chemotherapy in patients with metastatic carcinoid tumors. A Southwest Oncology Group Study. Cancer. 1987;60:2891-5.
    • (1987) Cancer. , vol.60 , pp. 2891-2895
    • Bukowski, R.1    Johnson, K.2    Peterson, R.3
  • 60
    • 24644503671 scopus 로고    scopus 로고
    • Phase II/III study of doxorubicin with fluorouracil compared with streptozocin with fluorouracil or dacarbazine in teh treatment of advanced carcinoid tumors: Eastern Cooperative Oncology Group Study E1281
    • Sun W, Lipsitz S, Catalano P, et al. Phase II/III study of doxorubicin with fluorouracil compared with streptozocin with fluorouracil or dacarbazine in teh treatment of advanced carcinoid tumors: Eastern Cooperative Oncology Group Study E1281. J Clin Oncol. 2005;23:4897-904.
    • (2005) J Clin Oncol , vol.23 , pp. 4897-4904
    • Sun, W.1    Lipsitz, S.2    Catalano, P.3


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