-
1
-
-
78650510609
-
MTOR: From growth signal integration to cancer, diabetes and ageing
-
Zoncu, R., Efeyan, A. & Sabatini, D. M. mTOR: from growth signal integration to cancer, diabetes and ageing. Nature Rev. Mol. Cell Biol. 12, 21-35 (2011).
-
(2011)
Nature Rev. Mol. Cell Biol.
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
2
-
-
65349159281
-
Immunoregulatory functions of mTOR inhibition
-
Thomson, A. W., Turnquist, H. R. & Raimondi, G. Immunoregulatory functions of mTOR inhibition. Nature Rev. Immunol. 9, 324-337 (2009).
-
(2009)
Nature Rev. Immunol.
, vol.9
, pp. 324-337
-
-
Thomson, A.W.1
Turnquist, H.R.2
Raimondi, G.3
-
3
-
-
82555164917
-
TOR in the immune system
-
Araki, K., Ellebedy, A. H. & Ahmed, R. TOR in the immune system. Curr. Opin. Cell Biol. 23, 707-715 (2011).
-
(2011)
Curr. Opin. Cell Biol.
, vol.23
, pp. 707-715
-
-
Araki, K.1
Ellebedy, A.H.2
Ahmed, R.3
-
4
-
-
77957054466
-
The mammalian target of rapamycin: Linking T cell differentiation, function, and metabolism
-
Powell, J. D. & Delgoffe, G. M. The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism. Immunity 33, 301-311 (2010).
-
(2010)
Immunity
, vol.33
, pp. 301-311
-
-
Powell, J.D.1
Delgoffe, G.M.2
-
5
-
-
74549167783
-
Regulation of adaptive immunity by the innate immune system
-
Iwasaki, A. & Medzhitov, R. Regulation of adaptive immunity by the innate immune system. Science 327, 291-295 (2010).
-
(2010)
Science
, vol.327
, pp. 291-295
-
-
Iwasaki, A.1
Medzhitov, R.2
-
6
-
-
66949173728
-
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
-
Delgoffe, G. M. et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 30, 832-844 (2009).
-
(2009)
Immunity
, vol.30
, pp. 832-844
-
-
Delgoffe, G.M.1
-
7
-
-
80051997049
-
The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
-
Yang, K., Neale, G., Green, D. R., He, W. & Chi, H. The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function. Nature Immunol. 12, 888-897 (2011).
-
(2011)
Nature Immunol.
, vol.12
, pp. 888-897
-
-
Yang, K.1
Neale, G.2
Green, D.R.3
He, W.4
Chi, H.5
-
8
-
-
80051617288
-
The tuberous sclerosis complex-mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells
-
Wu, Q. et al. The tuberous sclerosis complex-mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells. J. Immunol. 187, 1106-1112 (2011).
-
(2011)
J. Immunol.
, vol.187
, pp. 1106-1112
-
-
Wu, Q.1
-
9
-
-
80054721266
-
Regulation of T-cell survival and mitochondrial homeostasis by TSC1
-
O'Brien, T. F. et al. Regulation of T-cell survival and mitochondrial homeostasis by TSC1. Eur. J. Immunol. 41, 3361-3370 (2011).
-
(2011)
Eur. J. Immunol.
, vol.41
, pp. 3361-3370
-
-
O'Brien, T.F.1
-
10
-
-
45849105156
-
The rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
DOI 10.1126/science.1157535
-
Sancak, Y. et al. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320, 1496-1501 (2008). (Pubitemid 351929429)
-
(2008)
Science
, vol.320
, Issue.5882
, pp. 1496-1501
-
-
Sancak, Y.1
Peterson, T.R.2
Shaul, Y.D.3
Lindquist, R.A.4
Thoreen, C.C.5
Bar-Peled, L.6
Sabatini, D.M.7
-
11
-
-
77951768486
-
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
-
Sancak, Y. et al. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141, 290-303 (2010).
-
(2010)
Cell
, vol.141
, pp. 290-303
-
-
Sancak, Y.1
-
12
-
-
42949139481
-
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
-
DOI 10.1016/j.molcel.2008.03.003, PII S109727650800169X
-
Gwinn, D. M. et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30, 214-226 (2008). (Pubitemid 351626684)
-
(2008)
Molecular Cell
, vol.30
, Issue.2
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
13
-
-
79952281400
-
Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1
-
Zheng, M. et al. Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nature Cell Biol. 13, 263-272 (2011).
-
(2011)
Nature Cell Biol.
, vol.13
, pp. 263-272
-
-
Zheng, M.1
-
14
-
-
80052403225
-
Phosphorylation of Raptor by p38β participates in arsenite-induced mammalian target of rapamycin complex 1 (mTORC1) activation
-
Wu, X. N. et al. Phosphorylation of Raptor by p38β participates in arsenite-induced mammalian target of rapamycin complex 1 (mTORC1) activation. J. Biol. Chem. 286, 31501-31511 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 31501-31511
-
-
Wu, X.N.1
-
15
-
-
79952293503
-
Activation of mTORC2 by association with the ribosome
-
Zinzalla, V., Stracka, D., Oppliger, W. & Hall, M. N. Activation of mTORC2 by association with the ribosome. Cell 144, 757-768 (2011).
-
(2011)
Cell
, vol.144
, pp. 757-768
-
-
Zinzalla, V.1
Stracka, D.2
Oppliger, W.3
Hall, M.N.4
-
16
-
-
78649712949
-
MTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
-
Oh, W. J. et al. mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J. 29, 3939-3951 (2010).
-
(2010)
EMBO J.
, vol.29
, pp. 3939-3951
-
-
Oh, W.J.1
-
17
-
-
79953307234
-
Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size
-
Saci, A., Cantley, L. C. & Carpenter, C. L. Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size. Mol. Cell 42, 50-61 (2011).
-
(2011)
Mol. Cell
, vol.42
, pp. 50-61
-
-
Saci, A.1
Cantley, L.C.2
Carpenter, C.L.3
-
18
-
-
77954104660
-
Dominant role of antigen dose in CD4+Foxp3+ regulatory T cell induction and expansion
-
Turner, M. S., Kane, L. P. & Morel, P. A. Dominant role of antigen dose in CD4+Foxp3+ regulatory T cell induction and expansion. J. Immunol. 183, 4895-4903 (2009).
-
(2009)
J. Immunol.
, vol.183
, pp. 4895-4903
-
-
Turner, M.S.1
Kane, L.P.2
Morel, P.A.3
-
19
-
-
78149248752
-
Duration of antigen receptor signaling determines T-cell tolerance or activation
-
Katzman, S. D. et al. Duration of antigen receptor signaling determines T-cell tolerance or activation. Proc. Natl Acad. Sci. USA 107, 18085-18090 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 18085-18090
-
-
Katzman, S.D.1
-
20
-
-
33644556146
-
Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin
-
Colombetti, S., Basso, V., Mueller, D. L. & Mondino, A. Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin. J. Immunol. 176, 2730-2738 (2006).
-
(2006)
J. Immunol.
, vol.176
, pp. 2730-2738
-
-
Colombetti, S.1
Basso, V.2
Mueller, D.L.3
Mondino, A.4
-
21
-
-
33846909503
-
A role for mammalian target of rapamycin in regulating T cell activation versus anergy
-
Zheng, Y. et al. A role for mammalian target of rapamycin in regulating T cell activation versus anergy. J. Immunol. 178, 2163-2170 (2007). (Pubitemid 46233414)
-
(2007)
Journal of Immunology
, vol.178
, Issue.4
, pp. 2163-2170
-
-
Zheng, Y.1
Coffins, S.L.2
Lutz, M.A.3
Allen, A.N.4
Kole, T.P.5
Zarek, P.E.6
Powell, J.D.7
-
22
-
-
77952280516
-
Anergic T cells are metabolically anergic
-
Zheng, Y., Delgoffe, G. M., Meyer, C. F., Chan, W. & Powell, J. D. Anergic T cells are metabolically anergic. J. Immunol. 183, 6095-6101 (2009).
-
(2009)
J. Immunol.
, vol.183
, pp. 6095-6101
-
-
Zheng, Y.1
Delgoffe, G.M.2
Meyer, C.F.3
Chan, W.4
Powell, J.D.5
-
23
-
-
79953185367
-
OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling
-
So, T., Choi, H. & Croft, M. OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling. J. Immunol. 186, 3547-3555 (2011).
-
(2011)
J. Immunol.
, vol.186
, pp. 3547-3555
-
-
So, T.1
Choi, H.2
Croft, M.3
-
24
-
-
73949088551
-
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
-
Francisco, L. M. et al. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J. Exp. Med. 206, 3015-3029 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 3015-3029
-
-
Francisco, L.M.1
-
25
-
-
41349093966
-
IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival
-
DOI 10.1182/blood-2007-06-096297
-
Wofford, J. A., Wieman, H. L., Jacobs, S. R., Zhao, Y. & Rathmell, J. C. IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. Blood 111, 2101-2111 (2008). (Pubitemid 351451522)
-
(2008)
Blood
, vol.111
, Issue.4
, pp. 2101-2111
-
-
Wofford, J.A.1
Wieman, H.L.2
Jacobs, S.R.3
Zhao, Y.4
Rathmell, J.C.5
-
26
-
-
0035892899
-
IL-7 enhances the survival and maintains the size of naive T cells
-
Rathmell, J. C., Farkash, E. A., Gao, W. & Thompson, C. B. IL-7 enhances the survival and maintains the size of naive T cells. J. Immunol. 167, 6869-6876 (2001). (Pubitemid 33144179)
-
(2001)
Journal of Immunology
, vol.167
, Issue.12
, pp. 6869-6876
-
-
Rathmell, J.C.1
Farkash, E.A.2
Gao, W.3
Thompson, C.B.4
-
27
-
-
74649085700
-
The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin
-
Rao, R. R., Li, Q., Odunsi, K. & Shrikant, P. A. The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin. Immunity 32, 67-78 (2010).
-
(2010)
Immunity
, vol.32
, pp. 67-78
-
-
Rao, R.R.1
Li, Q.2
Odunsi, K.3
Shrikant, P.A.4
-
28
-
-
26844490420
-
Sequence motifs in IL-4Rα mediating cell-cycle progression of primary lymphocytes
-
Stephenson, L. M., Park, D. S., Mora, A. L., Goenka, S. & Boothby, M. Sequence motifs in IL-4Rα mediating cell-cycle progression of primary lymphocytes. J. Immunol. 175, 5178-5185 (2005). (Pubitemid 41456402)
-
(2005)
Journal of Immunology
, vol.175
, Issue.8
, pp. 5178-5185
-
-
Stephenson, L.M.1
Park, D.-S.2
Mora, A.L.3
Goenka, S.4
Boothby, M.5
-
29
-
-
74649086985
-
The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation
-
Gulen, M. F. et al. The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity 32, 54-66 (2010).
-
(2010)
Immunity
, vol.32
, pp. 54-66
-
-
Gulen, M.F.1
-
30
-
-
79952985551
-
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
-
Delgoffe, G. M. et al. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nature Immunol. 12, 295-303 (2011).
-
(2011)
Nature Immunol.
, vol.12
, pp. 295-303
-
-
Delgoffe, G.M.1
-
31
-
-
36048963331
-
Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance
-
DOI 10.1073/pnas.0702596104
-
Zhou, J. et al. Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proc. Natl Acad. Sci. USA 104, 16158-16163 (2007). (Pubitemid 350099378)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.41
, pp. 16158-16163
-
-
Zhou, J.1
Wulfkuhle, J.2
Zhang, H.3
Gu, P.4
Yang, Y.5
Deng, J.6
Margolick, J.B.7
Liotta, L.A.8
Petricoin III, E.9
Zhang, Y.10
-
32
-
-
0032572722
-
Leptin modulates the T-cell immune response and reverses starvation- induced immunosuppression
-
DOI 10.1038/29795
-
Lord, G. M. et al. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394, 897-901 (1998). (Pubitemid 28410912)
-
(1998)
Nature
, vol.394
, Issue.6696
, pp. 897-901
-
-
Lord, G.M.1
Matarese, G.2
Howard, J.K.3
Baker, R.J.4
Bloom, S.R.5
Lechler, R.I.6
-
33
-
-
78650188983
-
An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness
-
Procaccini, C. et al. An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity 33, 929-941 (2010).
-
(2010)
Immunity
, vol.33
, pp. 929-941
-
-
Procaccini, C.1
-
34
-
-
33847312289
-
A key role of leptin in the control of regulatory T cell proliferation
-
DOI 10.1016/j.immuni.2007.01.011, PII S1074761307001410
-
De Rosa, V. et al. A key role of leptin in the control of regulatory T cell proliferation. Immunity 26, 241-255 (2007). (Pubitemid 46329441)
-
(2007)
Immunity
, vol.26
, Issue.2
, pp. 241-255
-
-
De Rosa, V.1
Procaccini, C.2
Cali, G.3
Pirozzi, G.4
Fontana, S.5
Zappacosta, S.6
La Cava, A.7
Matarese, G.8
-
35
-
-
78650667165
-
Leptin modulates the survival of autoreactive CD4+ T cells through the nutrient/energy-sensing mammalian target of rapamycin signaling pathway
-
Galgani, M. et al. Leptin modulates the survival of autoreactive CD4+ T cells through the nutrient/energy-sensing mammalian target of rapamycin signaling pathway. J. Immunol. 185, 7474-7479 (2010).
-
(2010)
J. Immunol.
, vol.185
, pp. 7474-7479
-
-
Galgani, M.1
-
36
-
-
67649185215
-
The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR
-
Liu, G. et al. The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nature Immunol. 10, 769-777 (2009).
-
(2009)
Nature Immunol.
, vol.10
, pp. 769-777
-
-
Liu, G.1
-
37
-
-
77958151145
-
The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells
-
Liu, G., Yang, K., Burns, S., Shrestha, S. & Chi, H. The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells. Nature Immunol. 11, 1047-1056 (2010).
-
(2010)
Nature Immunol.
, vol.11
, pp. 1047-1056
-
-
Liu, G.1
Yang, K.2
Burns, S.3
Shrestha, S.4
Chi, H.5
-
38
-
-
78149353783
-
When Toll-like receptor and T-cell receptor signals collide: A mechanism for enhanced CD8 T-cell effector function
-
Geng, D. et al. When Toll-like receptor and T-cell receptor signals collide: a mechanism for enhanced CD8 T-cell effector function. Blood 116, 3494-3504 (2010).
-
(2010)
Blood
, vol.116
, pp. 3494-3504
-
-
Geng, D.1
-
39
-
-
63849167957
-
A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection
-
Quigley, M., Martinez, J., Huang, X. & Yang, Y. A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection. Blood 113, 2256-2264 (2009).
-
(2009)
Blood
, vol.113
, pp. 2256-2264
-
-
Quigley, M.1
Martinez, J.2
Huang, X.3
Yang, Y.4
-
40
-
-
79953122463
-
Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88
-
Rahman, A. H. et al. Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88. Blood 117, 3123-3130 (2011).
-
(2011)
Blood
, vol.117
, pp. 3123-3130
-
-
Rahman, A.H.1
-
41
-
-
24944444760
-
Notch promotes survival of pre-T cells at the β-selection checkpoint by regulating cellular metabolism
-
DOI 10.1038/ni1234, PII N1234
-
Ciofani, M. & Zuniga-Pflucker, J. C. Notch promotes survival of pre-T cells at the β-selection checkpoint by regulating cellular metabolism. Nature Immunol. 6, 881-888 (2005). (Pubitemid 43090442)
-
(2005)
Nature Immunology
, vol.6
, Issue.9
, pp. 881-888
-
-
Ciofani, M.1
Zuniga-Pflucker, J.C.2
-
42
-
-
79956105098
-
Normal T cell homeostasis: The conversion of naive cells into memory-phenotype cells
-
Sprent, J. & Surh, C. D. Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells. Nature Immunol. 12, 478-484 (2011).
-
(2011)
Nature Immunol.
, vol.12
, pp. 478-484
-
-
Sprent, J.1
Surh, C.D.2
-
43
-
-
77953785070
-
The metabolic life and times of a T-cell
-
Michalek, R. D. & Rathmell, J. C. The metabolic life and times of a T-cell. Immunol. Rev. 236, 190-202 (2010).
-
(2010)
Immunol. Rev.
, vol.236
, pp. 190-202
-
-
Michalek, R.D.1
Rathmell, J.C.2
-
44
-
-
0034995242
-
T cell-specific loss of Pten leads to defects in central and peripheral tolerance
-
DOI 10.1016/S1074-7613(01)00134-0
-
Suzuki, A. et al. T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity 14, 523-534 (2001). (Pubitemid 32520864)
-
(2001)
Immunity
, vol.14
, Issue.5
, pp. 523-534
-
-
Suzuki, A.1
Yamaguchi, M.T.2
Ohteki, T.3
Sasaki, T.4
Kaisho, T.5
Kimura, Y.6
Yoshida, R.7
Wakeham, A.8
Higuchi, T.9
Fukumoto, M.10
Tsubata, T.11
Ohashi, P.S.12
Koyasu, S.13
Penninger, J.M.14
Nakano, T.15
Mak, T.W.16
-
45
-
-
41149097551
-
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
-
DOI 10.1073/pnas.0712059105
-
Xue, L., Nolla, H., Suzuki, A., Mak, T. W. & Winoto, A. Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice. Proc. Natl Acad. Sci. USA 105, 2022-2027 (2008). (Pubitemid 351439458)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.6
, pp. 2022-2027
-
-
Xue, L.1
Nolla, H.2
Suzuki, A.3
Mak, T.W.4
Winoto, A.5
-
46
-
-
40749131244
-
T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus
-
DOI 10.1038/sj.leu.2405056, PII 2405056
-
Hagenbeek, T. J. & Spits, H. T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus. Leukemia 22, 608-619 (2008). (Pubitemid 351386732)
-
(2008)
Leukemia
, vol.22
, Issue.3
, pp. 608-619
-
-
Hagenbeek, T.J.1
Spits, H.2
-
47
-
-
70449471819
-
Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes
-
Finlay, D. K. et al. Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes. J. Exp. Med. 206, 2441-2454 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 2441-2454
-
-
Finlay, D.K.1
-
48
-
-
79952120938
-
Suppression of leukemia development caused by PTEN loss
-
Guo, W. et al. Suppression of leukemia development caused by PTEN loss. Proc. Natl Acad. Sci. USA 108, 1409-1414 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 1409-1414
-
-
Guo, W.1
-
49
-
-
77954981351
-
Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice
-
Liu, X. et al. Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice. J. Clin. Invest. 120, 2497-2507 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 2497-2507
-
-
Liu, X.1
-
50
-
-
5444269438
-
The loss of PTEN allows TCR αβ lineage thymocytes to bypass IL-7 and pre-TCR-mediated signaling
-
DOI 10.1084/jem.20040495
-
Hagenbeek, T. J. et al. The loss of PTEN allows TCRαβ lineage thymocytes to bypass IL-7 and pre-TCR-mediated signaling. J. Exp. Med. 200, 883-894 (2004). (Pubitemid 39362924)
-
(2004)
Journal of Experimental Medicine
, vol.200
, Issue.7
, pp. 883-894
-
-
Hagenbeek, T.J.1
Naspetti, M.2
Malergue, F.3
Garcon, F.4
Nunes, J.A.5
Cleutjens, K.B.J.M.6
Trapman, J.7
Krimpenfort, P.8
Spits, H.9
-
51
-
-
34147139532
-
The Pten/PI3K pathway governs the homeostasis of Vα14iNKT cells
-
DOI 10.1182/blood-2006-07-038059
-
Kishimoto, H. et al. The Pten/PI3K pathway governs the homeostasis of Vα14 iNKT cells. Blood 109, 3316-3324 (2007). (Pubitemid 46572519)
-
(2007)
Blood
, vol.109
, Issue.8
, pp. 3316-3324
-
-
Kishimoto, H.1
Ohteki, T.2
Yajima, N.3
Kawahara, K.4
Natsui, M.5
Kawarasaki, S.6
Hamada, K.7
Horie, Y.8
Kubo, Y.9
Arase, S.10
Taniguchi, M.11
Vanhaesebroeck, B.12
Tak, W.M.13
Nakano, T.14
Koyasu, S.15
Sasaki, T.16
Suzuki, A.17
-
52
-
-
0032843540
-
Impaired Fas response and autoimmunity in Pten(+/-) mice
-
DOI 10.1126/science.285.5436.2122
-
Di Cristofano, A. et al. Impaired Fas response and autoimmunity in Pten +-mice. Science 285, 2122-2125 (1999). (Pubitemid 29451429)
-
(1999)
Science
, vol.285
, Issue.5436
, pp. 2122-2125
-
-
Di Cristofano, A.1
Kotsi, P.2
Peng, Y.F.3
Cordon-Cardo, C.4
Elkon, K.B.5
Pandolfi, P.P.6
-
53
-
-
45549098562
-
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
-
DOI 10.1073/pnas.0800928105
-
Sauer, S. et al. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc. Natl Acad. Sci. USA 105, 7797-7802 (2008). (Pubitemid 351872718)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.22
, pp. 7797-7802
-
-
Sauer, S.1
Bruno, L.2
Hertweck, A.3
Finlay, D.4
Leleu, M.5
Spivakov, M.6
Knight, Z.A.7
Cobb, B.S.8
Cantrell, D.9
O'Connor, E.10
Shokat, K.M.11
Fisher, A.G.12
Merkenschlager, M.13
-
54
-
-
39749163245
-
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes
-
DOI 10.1038/ni1575, PII NI1575
-
Xiao, C. et al. Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nature Immunol. 9, 405-414 (2008). (Pubitemid 351405110)
-
(2008)
Nature Immunology
, vol.9
, Issue.4
, pp. 405-414
-
-
Xiao, C.1
Srinivasan, L.2
Calado, D.P.3
Patterson, H.C.4
Zhang, B.5
Wang, J.6
Henderson, J.M.7
Kutok, J.L.8
Rajewsky, K.9
-
55
-
-
72849120988
-
MiR-19 is a key oncogenic component of mir-17-92
-
Olive, V. et al. miR-19 is a key oncogenic component of mir-17-92. Genes Dev. 23, 2839-2849 (2009).
-
(2009)
Genes Dev.
, vol.23
, pp. 2839-2849
-
-
Olive, V.1
-
56
-
-
81555196345
-
Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation
-
Jiang, S. et al. Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation. Blood 118, 5487-5497 (2011).
-
(2011)
Blood
, vol.118
, pp. 5487-5497
-
-
Jiang, S.1
-
57
-
-
74249122511
-
LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells
-
Tamas, P. et al. LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells. Eur. J. Immunol. 40, 242-253 (2010).
-
(2010)
Eur. J. Immunol.
, vol.40
, pp. 242-253
-
-
Tamas, P.1
-
58
-
-
73849112608
-
The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression
-
Cao, Y. et al. The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression. Cell Res. 20, 99-108 (2010).
-
(2010)
Cell Res.
, vol.20
, pp. 99-108
-
-
Cao, Y.1
-
59
-
-
79956132815
-
LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection
-
Cao, Y. et al. LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection. EMBO J. 30, 2083-2093 (2011).
-
(2011)
EMBO J.
, vol.30
, pp. 2083-2093
-
-
Cao, Y.1
-
60
-
-
80054726323
-
The liver kinase B1 is a central regulator of T cell development, activation, and metabolism
-
Maciver, N. J. et al. The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. J. Immunol. 187, 4187-4198 (2011).
-
(2011)
J. Immunol.
, vol.187
, pp. 4187-4198
-
-
MacIver, N.J.1
-
61
-
-
80052511813
-
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
-
Mihaylova, M. M. & Shaw, R. J. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nature Cell Biol. 13, 1016-1023 (2011).
-
(2011)
Nature Cell Biol.
, vol.13
, pp. 1016-1023
-
-
Mihaylova, M.M.1
Shaw, R.J.2
-
62
-
-
33745823168
-
2+ in T lymphocytes
-
DOI 10.1084/jem.20052469
-
Tamas, P. et al. Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes. J. Exp. Med. 203, 1665-1670 (2006). (Pubitemid 44036271)
-
(2006)
Journal of Experimental Medicine
, vol.203
, Issue.7
, pp. 1665-1670
-
-
Tamas, P.1
Hawley, S.A.2
Clarke, R.G.3
Mustard, K.J.4
Green, K.5
Hardie, D.G.6
Cantrell, D.A.7
-
63
-
-
44849141880
-
AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function
-
Mayer, A., Denanglaire, S., Viollet, B., Leo, O. & Andris, F. AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function. Eur. J. Immunol. 38, 948-956 (2008).
-
(2008)
Eur. J. Immunol.
, vol.38
, pp. 948-956
-
-
Mayer, A.1
Denanglaire, S.2
Viollet, B.3
Leo, O.4
Andris, F.5
-
64
-
-
33646376411
-
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
-
DOI 10.1038/nature04703, PII NATURE04703
-
Yilmaz, O. H. et al. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441, 475-482 (2006). (Pubitemid 44050144)
-
(2006)
Nature
, vol.441
, Issue.7092
, pp. 475-482
-
-
Yilmaz, O.H.1
Valdez, R.2
Theisen, B.K.3
Guo, W.4
Ferguson, D.O.5
Wu, H.6
Morrison, S.J.7
-
65
-
-
33646351002
-
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention
-
DOI 10.1038/nature04747, PII NATURE04747
-
Zhang, J. et al. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature 441, 518-522 (2006). (Pubitemid 44050154)
-
(2006)
Nature
, vol.441
, Issue.7092
, pp. 518-522
-
-
Zhang, J.1
Grindley, J.C.2
Yin, T.3
Jayasinghe, S.4
He, X.C.5
Ross, J.T.6
Haug, J.S.7
Rupp, D.8
Porter-Westpfahl, K.S.9
Wiedemann, L.M.10
Wu, H.11
Li, L.12
-
66
-
-
53349091768
-
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
-
Chen, C. et al. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J. Exp. Med. 205, 2397-2408 (2008).
-
(2008)
J. Exp. Med.
, vol.205
, pp. 2397-2408
-
-
Chen, C.1
-
67
-
-
58049196780
-
MTORC1-dependent and-independent regulation of stem cell renewal, differentiation, and mobilization
-
Gan, B. et al. mTORC1-dependent and-independent regulation of stem cell renewal, differentiation, and mobilization. Proc. Natl Acad. Sci. USA 105, 19384-19389 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 19384-19389
-
-
Gan, B.1
-
68
-
-
78649874959
-
Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
-
Gan, B. et al. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 468, 701-704 (2010).
-
(2010)
Nature
, vol.468
, pp. 701-704
-
-
Gan, B.1
-
69
-
-
78649851511
-
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
-
Gurumurthy, S. et al. The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature 468, 659-663 (2010).
-
(2010)
Nature
, vol.468
, pp. 659-663
-
-
Gurumurthy, S.1
-
70
-
-
78649811793
-
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
-
Nakada, D., Saunders, T. L. & Morrison, S. J. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 468, 653-658 (2010).
-
(2010)
Nature
, vol.468
, pp. 653-658
-
-
Nakada, D.1
Saunders, T.L.2
Morrison, S.J.3
-
71
-
-
67349241955
-
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
-
Peterson, T. R. et al. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 137, 873-886 (2009).
-
(2009)
Cell
, vol.137
, pp. 873-886
-
-
Peterson, T.R.1
-
72
-
-
48449101433
-
P53 target genes Sestrin1 and Sestrin2 connect genotoxic stress and mTOR signaling
-
Budanov, A. V. & Karin, M. p53 target genes Sestrin1 and Sestrin2 connect genotoxic stress and mTOR signaling. Cell 134, 451-460 (2008).
-
(2008)
Cell
, vol.134
, pp. 451-460
-
-
Budanov, A.V.1
Karin, M.2
-
73
-
-
33947264077
-
PRAS40 Is an Insulin-Regulated Inhibitor of the mTORC1 Protein Kinase
-
DOI 10.1016/j.molcel.2007.03.003, PII S1097276507001487
-
Sancak, Y. et al. PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol. Cell 25, 903-915 (2007). (Pubitemid 46436534)
-
(2007)
Molecular Cell
, vol.25
, Issue.6
, pp. 903-915
-
-
Sancak, Y.1
Thoreen, C.C.2
Peterson, T.R.3
Lindquist, R.A.4
Kang, S.A.5
Spooner, E.6
Carr, S.A.7
Sabatini, D.M.8
-
74
-
-
33847397874
-
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
-
DOI 10.1038/ncb1547, PII NCB1547
-
Vander Haar, E., Lee, S. I., Bandhakavi, S., Griffin, T. J. & Kim, D. H. Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nature Cell Biol. 9, 316-323 (2007). (Pubitemid 46344611)
-
(2007)
Nature Cell Biology
, vol.9
, Issue.3
, pp. 316-323
-
-
Haar, E.V.1
Lee, S.2
Bandhakavi, S.3
Griffin, T.J.4
Kim, D.-H.5
-
75
-
-
58449102260
-
Foxo1 links homing and survival of naive T cells by regulating L-selectin CCR7 and interleukin 7 receptor
-
Kerdiles, Y. M. et al. Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nature Immunol. 10, 176-184 (2009).
-
(2009)
Nature Immunol.
, vol.10
, pp. 176-184
-
-
Kerdiles, Y.M.1
-
76
-
-
62049086102
-
An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance
-
Ouyang, W., Beckett, O., Flavell, R. A. & Li, M. O. An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. Immunity 30, 358-371 (2009).
-
(2009)
Immunity
, vol.30
, pp. 358-371
-
-
Ouyang, W.1
Beckett, O.2
Flavell, R.A.3
Li, M.O.4
-
77
-
-
77953897189
-
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
-
Lee, K. et al. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity 32, 743-753 (2010).
-
(2010)
Immunity
, vol.32
, pp. 743-753
-
-
Lee, K.1
-
78
-
-
42449110816
-
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
-
DOI 10.1038/ni.1603, PII NI.1603
-
Sinclair, L. V. et al. Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking. Nature Immunol. 9, 513-521 (2008). (Pubitemid 351560520)
-
(2008)
Nature Immunology
, vol.9
, Issue.5
, pp. 513-521
-
-
Sinclair, L.V.1
Finlay, D.2
Feijoo, C.3
Cornish, G.H.4
Gray, A.5
Ager, A.6
Okkenhaug, K.7
Hagenbeek, T.J.8
Spits, H.9
Cantrell, D.A.10
-
79
-
-
79951745387
-
Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism
-
Macintyre, A. N. et al. Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism. Immunity 34, 224-236 (2011).
-
(2011)
Immunity
, vol.34
, pp. 224-236
-
-
MacIntyre, A.N.1
-
80
-
-
79954618943
-
Negative regulation of mTOR activation by diacylglycerol kinases
-
Gorentla, B. K., Wan, C. K. & Zhong, X. P. Negative regulation of mTOR activation by diacylglycerol kinases. Blood 117, 4022-4031 (2010).
-
(2010)
Blood
, vol.117
, pp. 4022-4031
-
-
Gorentla, B.K.1
Wan, C.K.2
Zhong, X.P.3
-
81
-
-
78049287331
-
MTOR signalling and metabolic regulation of T cell differentiation
-
Peter, C., Waldmann, H. & Cobbold, S. P. mTOR signalling and metabolic regulation of T cell differentiation. Curr. Opin. Immunol. 22, 655-661 (2010).
-
(2010)
Curr. Opin. Immunol.
, vol.22
, pp. 655-661
-
-
Peter, C.1
Waldmann, H.2
Cobbold, S.P.3
-
82
-
-
77951678634
-
The role of mTOR in memory CD8 T-cell differentiation
-
Araki, K., Youngblood, B. & Ahmed, R. The role of mTOR in memory CD8 T-cell differentiation. Immunol. Rev. 235, 234-243 (2010).
-
(2010)
Immunol. Rev.
, vol.235
, pp. 234-243
-
-
Araki, K.1
Youngblood, B.2
Ahmed, R.3
-
83
-
-
79151486083
-
Metabolism migration and memory in cytotoxic T cells
-
Finlay, D. & Cantrell, D. A. Metabolism, migration and memory in cytotoxic T cells. Nature Rev. Immunol. 11, 109-117 (2011).
-
(2011)
Nature Rev. Immunol.
, vol.11
, pp. 109-117
-
-
Finlay, D.1
Cantrell, D.A.2
-
84
-
-
77952313777
-
Differentiation of effector CD4 T cell populations
-
Zhu, J., Yamane, H. & Paul, W. E. Differentiation of effector CD4 T cell populations. Annu. Rev. Immunol. 28, 445-489 (2010).
-
(2010)
Annu. Rev. Immunol.
, vol.28
, pp. 445-489
-
-
Zhu, J.1
Yamane, H.2
Paul, W.E.3
-
85
-
-
79960369458
-
HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
-
Shi, L. Z. et al. HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J. Exp. Med. 208, 1367-1376 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, pp. 1367-1376
-
-
Shi, L.Z.1
-
86
-
-
80052277906
-
Control of TH17/Treg balance by hypoxia-inducible factor 1
-
Dang, E. V. et al. Control of TH17/Treg balance by hypoxia-inducible factor 1. Cell 146, 772-784 (2011).
-
(2011)
Cell
, vol.146
, pp. 772-784
-
-
Dang, E.V.1
-
87
-
-
0032143821
-
Helper T cell differentiation is controlled by the cell cycle
-
Bird, J. J. et al. Helper T cell differentiation is controlled by the cell cycle. Immunity 9, 229-237 (1998). (Pubitemid 28400036)
-
(1998)
Immunity
, vol.9
, Issue.2
, pp. 229-237
-
-
Bird, J.J.1
Brown, D.R.2
Mullen, A.C.3
Moskowitz, N.H.4
Mahowald, M.A.5
Sider, J.R.6
Gajewski, T.F.7
Wang, C.-R.8
Reiner, S.L.9
-
88
-
-
84255199079
-
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
-
Wang, R. et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 35, 871-882 (2011).
-
(2011)
Immunity
, vol.35
, pp. 871-882
-
-
Wang, R.1
-
89
-
-
34548014737
-
Revving the engine: Signal transduction fuels T cell activation
-
DOI 10.1016/j.immuni.2007.07.008, PII S1074761307003676
-
Jones, R. G. & Thompson, C. B. Revving the engine: signal transduction fuels T cell activation. Immunity 27, 173-178 (2007). (Pubitemid 47284920)
-
(2007)
Immunity
, vol.27
, Issue.2
, pp. 173-178
-
-
Jones, R.G.1
Thompson, C.B.2
-
90
-
-
77953534607
-
Metabolism in T cell activation and differentiation
-
Pearce, E. L. Metabolism in T cell activation and differentiation. Curr. Opin. Immunol. 22, 314-320 (2010).
-
(2010)
Curr. Opin. Immunol.
, vol.22
, pp. 314-320
-
-
Pearce, E.L.1
-
91
-
-
0036069699
-
The CD28 signaling pathway regulates glucose metabolism
-
DOI 10.1016/S1074-7613(02)00323-0
-
Frauwirth, K. A. et al. The CD28 signaling pathway regulates glucose metabolism. Immunity 16, 769-777 (2002). (Pubitemid 34786476)
-
(2002)
Immunity
, vol.16
, Issue.6
, pp. 769-777
-
-
Frauwirth, K.A.1
Riley, J.L.2
Harris, M.H.3
Parry, R.V.4
Rathmell, J.C.5
Plas, D.R.6
Elstrom, R.L.7
June, C.H.8
Thompson, C.B.9
-
92
-
-
84255188291
-
T cell Myc-tabolism
-
Rathmell, J. C. T cell Myc-tabolism. Immunity 35, 845-846 (2011).
-
(2011)
Immunity
, vol.35
, pp. 845-846
-
-
Rathmell, J.C.1
-
93
-
-
81055126129
-
Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation
-
Michalek, R. D. et al. Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation. Proc. Natl Acad. Sci. USA 108, 18348-18353 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 18348-18353
-
-
Michalek, R.D.1
-
94
-
-
34547580590
-
HIF and c-Myc: Sibling Rivals for Control of Cancer Cell Metabolism and Proliferation
-
DOI 10.1016/j.ccr.2007.07.006, PII S1535610807002048
-
Gordan, J. D., Thompson, C. B. & Simon, M. C. HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell 12, 108-113 (2007). (Pubitemid 47199124)
-
(2007)
Cancer Cell
, vol.12
, Issue.2
, pp. 108-113
-
-
Gordan, J.D.1
Thompson, C.B.2
Simon, M.C.3
-
95
-
-
37449024702
-
The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
-
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G. & Thompson, C. B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 7, 11-20 (2008).
-
(2008)
Cell Metab.
, vol.7
, pp. 11-20
-
-
Deberardinis, R.J.1
Lum, J.J.2
Hatzivassiliou, G.3
Thompson, C.B.4
-
96
-
-
67650096912
-
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
-
Pearce, E. L. et al. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 460, 103-107 (2009).
-
(2009)
Nature
, vol.460
, pp. 103-107
-
-
Pearce, E.L.1
-
97
-
-
79953172571
-
Cutting edge: Distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
-
Michalek, R. D. et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J. Immunol. 186, 3299-3303 (2011).
-
(2011)
J. Immunol.
, vol.186
, pp. 3299-3303
-
-
Michalek, R.D.1
-
98
-
-
66749107425
-
Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response
-
Sundrud, M. S. et al. Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science 324, 1334-1338 (2009).
-
(2009)
Science
, vol.324
, pp. 1334-1338
-
-
Sundrud, M.S.1
-
99
-
-
79551545978
-
Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation
-
Cui, G. et al. Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation. J. Clin. Invest. 121, 658-670 (2011).
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 658-670
-
-
Cui, G.1
-
100
-
-
77955483125
-
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
-
Duvel, K. et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol. Cell 39, 171-183 (2010).
-
(2010)
Mol. Cell
, vol.39
, pp. 171-183
-
-
Duvel, K.1
-
101
-
-
59049087460
-
Bidirectional transport of amino acids regulates mTOR and autophagy
-
Nicklin, P. et al. Bidirectional transport of amino acids regulates mTOR and autophagy. Cell 136, 521-534 (2009).
-
(2009)
Cell
, vol.136
, pp. 521-534
-
-
Nicklin, P.1
-
102
-
-
77953775808
-
Control of immune response by amino acid metabolism
-
Grohmann, U. & Bronte, V. Control of immune response by amino acid metabolism. Immunol. Rev. 236, 243-264 (2010).
-
(2010)
Immunol. Rev.
, vol.236
, pp. 243-264
-
-
Grohmann, U.1
Bronte, V.2
-
103
-
-
67749091321
-
Infectious tolerance via the consumption of essential amino acids and mTOR signaling
-
Cobbold, S. P. et al. Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc. Natl Acad. Sci. USA 106, 12055-12060 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 12055-12060
-
-
Cobbold, S.P.1
-
104
-
-
19344377474
-
GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase
-
DOI 10.1016/j.immuni.2005.03.013, PII S1074761305001081
-
Munn, D. H. et al. GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity 22, 633-642 (2005). (Pubitemid 40719198)
-
(2005)
Immunity
, vol.22
, Issue.5
, pp. 633-642
-
-
Munn, D.H.1
Sharma, M.D.2
Baban, B.3
Harding, H.P.4
Zhang, Y.5
Ron, D.6
Mellor, A.L.7
-
105
-
-
77953730386
-
Connecting the mechanisms of T-cell regulation: Dendritic cells as the missing link
-
Cobbold, S. P., Adams, E., Nolan, K. F., Regateiro, F. S. & Waldmann, H. Connecting the mechanisms of T-cell regulation: dendritic cells as the missing link. Immunol. Rev. 236, 203-218 (2010).
-
(2010)
Immunol. Rev.
, vol.236
, pp. 203-218
-
-
Cobbold, S.P.1
Adams, E.2
Nolan, K.F.3
Regateiro, F.S.4
Waldmann, H.5
-
106
-
-
80053922625
-
Metabolic flux and the regulation of mammalian cell growth
-
Locasale, J. W. & Cantley, L. C. Metabolic flux and the regulation of mammalian cell growth. Cell Metab. 14, 443-451 (2011).
-
(2011)
Cell Metab.
, vol.14
, pp. 443-451
-
-
Locasale, J.W.1
Cantley, L.C.2
-
107
-
-
79959333447
-
Spontaneous and aging-dependent development of arthritis in NADPH oxidase 2 deficiency through altered differentiation of CD11b+ and Th/Treg cells
-
Lee, K., Won, H. Y., Bae, M. A., Hong, J. H. & Hwang, E. S. Spontaneous and aging-dependent development of arthritis in NADPH oxidase 2 deficiency through altered differentiation of CD11b+ and Th/Treg cells. Proc. Natl Acad. Sci. USA 108, 9548-9553 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 9548-9553
-
-
Lee, K.1
Won, H.Y.2
Bae, M.A.3
Hong, J.H.4
Hwang, E.S.5
-
108
-
-
70349440053
-
The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice
-
Zhang, J. et al. The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice. J. Clin. Invest. 119, 3048-3058 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3048-3058
-
-
Zhang, J.1
-
109
-
-
0037662713
-
Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability
-
DOI 10.1042/BJ20021266
-
Beugnet, A., Tee, A. R., Taylor, P. M. & Proud, C. G. Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability. Biochem. J. 372, 555-566 (2003). (Pubitemid 36723901)
-
(2003)
Biochemical Journal
, vol.372
, Issue.2
, pp. 555-566
-
-
Beugnet, A.1
Tee, A.R.2
Taylor, P.M.3
Proud, C.G.4
-
110
-
-
77952562382
-
Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply
-
Choo, A. Y. et al. Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Mol. Cell 38, 487-499 (2010).
-
(2010)
Mol. Cell
, vol.38
, pp. 487-499
-
-
Choo, A.Y.1
-
111
-
-
77957122174
-
The engine driving the ship: Metabolic steering of cell proliferation and death
-
Buchakjian, M. R. & Kornbluth, S. The engine driving the ship: metabolic steering of cell proliferation and death. Nature Rev. Mol. Cell Biol. 11, 715-727 (2010).
-
(2010)
Nature Rev. Mol. Cell Biol.
, vol.11
, pp. 715-727
-
-
Buchakjian, M.R.1
Kornbluth, S.2
-
112
-
-
79952703288
-
Cell metabolism: An essential link between cell growth and apoptosis
-
Mason, E. F. & Rathmell, J. C. Cell metabolism: An essential link between cell growth and apoptosis. Biochim. Biophys. Acta 1813, 645-654 (2011).
-
(2011)
Biochim. Biophys. Acta
, vol.1813
, pp. 645-654
-
-
Mason, E.F.1
Rathmell, J.C.2
-
113
-
-
20444373376
-
Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
-
Battaglia, M., Stabilini, A. & Roncarolo, M. G. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 105, 4743-4748 (2005).
-
(2005)
Blood
, vol.105
, pp. 4743-4748
-
-
Battaglia, M.1
Stabilini, A.2
Roncarolo, M.G.3
-
114
-
-
33845915103
-
+ regulatory T cells cultured with rapamycin
-
Strauss, L. et al. Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin. J. Immunol. 178, 320-329 (2007). (Pubitemid 46033615)
-
(2007)
Journal of Immunology
, vol.178
, Issue.1
, pp. 320-329
-
-
Strauss, L.1
Whiteside, T.L.2
Knights, A.3
Bergmann, C.4
Knuth, A.5
Zippelius, A.6
-
115
-
-
38049177784
-
Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells
-
Zeiser, R. et al. Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells. Blood 111, 453-462 (2008).
-
(2008)
Blood
, vol.111
, pp. 453-462
-
-
Zeiser, R.1
-
116
-
-
67650105331
-
Differential responses of human regulatory T cells (Treg) and effector T cells to rapamycin
-
Strauss, L., Czystowska, M., Szajnik, M., Mandapathil, M. & Whiteside, T. L. Differential responses of human regulatory T cells (Treg) and effector T cells to rapamycin. PLoS ONE 4, e5994 (2009).
-
(2009)
PLoS ONE
, vol.4
-
-
Strauss, L.1
Czystowska, M.2
Szajnik, M.3
Mandapathil, M.4
Whiteside, T.L.5
-
118
-
-
33749345289
-
Rapamycin reduces disease activity and normalizes T cell activation-induced calcium fluxing in patients with systemic lupus erythematosus
-
DOI 10.1002/art.22085
-
Fernandez, D., Bonilla, E., Mirza, N., Niland, B. & Perl, A. Rapamycin reduces disease activity and normalizes T cell activation-induced calcium fluxing in patients with systemic lupus erythematosus. Arthritis Rheum. 54, 2983-2988 (2006). (Pubitemid 44497779)
-
(2006)
Arthritis and Rheumatism
, vol.54
, Issue.9
, pp. 2983-2988
-
-
Fernandez, D.1
Bonilla, E.2
Mirza, N.3
Niland, B.4
Perl, A.5
-
119
-
-
67650074206
-
MTOR regulates memory CD8 T-cell differentiation
-
Araki, K. et al. mTOR regulates memory CD8 T-cell differentiation. Nature 460, 108-112 (2009).
-
(2009)
Nature
, vol.460
, pp. 108-112
-
-
Araki, K.1
-
120
-
-
77956893188
-
Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses
-
Ferrer, I. R. et al. Cutting edge: rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses. J. Immunol. 185, 2004-2008 (2010).
-
(2010)
J. Immunol.
, vol.185
, pp. 2004-2008
-
-
Ferrer, I.R.1
-
121
-
-
79951986439
-
Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques
-
Turner, A. P. et al. Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques. Am. J. Transplant. 11, 613-618 (2011).
-
(2011)
Am. J. Transplant.
, vol.11
, pp. 613-618
-
-
Turner, A.P.1
-
122
-
-
79954623272
-
A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity
-
Li, Q. et al. A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity. Immunity 34, 541-553 (2011).
-
(2011)
Immunity
, vol.34
, pp. 541-553
-
-
Li, Q.1
-
123
-
-
79951670258
-
An mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines
-
Wang, Y., Wang, X. Y., Subjeck, J. R., Shrikant, P. A. & Kim, H. L. Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines. Br. J. Cancer. 104, 643-652 (2011).
-
(2011)
Br. J. Cancer.
, vol.104
, pp. 643-652
-
-
Wang, Y.1
Wang, X.Y.2
Subjeck, J.R.3
Shrikant, P.A.4
Temsirolimus, L.K.H.5
-
124
-
-
80355133234
-
Macrophage-mediated inflammation in metabolic disease
-
Chawla, A., Nguyen, K. D. & Goh, Y. P. Macrophage-mediated inflammation in metabolic disease. Nature Rev. Immunol. 11, 738-749 (2011).
-
(2011)
Nature Rev. Immunol.
, vol.11
, pp. 738-749
-
-
Chawla, A.1
Nguyen, K.D.2
Goh, Y.P.3
-
125
-
-
68349137821
-
Normalization of obesity-associated insulin resistance through immunotherapy
-
Winer, S. et al. Normalization of obesity-associated insulin resistance through immunotherapy. Nature Med. 15, 921-929 (2009).
-
(2009)
Nature Med.
, vol.15
, pp. 921-929
-
-
Winer, S.1
-
126
-
-
68349150756
-
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
-
Nishimura, S. et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nature Med. 15, 914-920 (2009).
-
(2009)
Nature Med.
, vol.15
, pp. 914-920
-
-
Nishimura, S.1
-
127
-
-
68349148211
-
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
-
Feuerer, M. et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nature Med. 15, 930-939 (2009).
-
(2009)
Nature Med.
, vol.15
, pp. 930-939
-
-
Feuerer, M.1
-
128
-
-
56249147509
-
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
-
Choo, A. Y., Yoon, S. O., Kim, S. G., Roux, P. P. & Blenis, J. Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc. Natl Acad. Sci. USA 105, 17414-17419 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 17414-17419
-
-
Choo, A.Y.1
Yoon, S.O.2
Kim, S.G.3
Roux, P.P.4
Blenis, J.5
-
129
-
-
32944457518
-
MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
DOI 10.1158/0008-5472.CAN-05-2925
-
O'Reilly, K. E. et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res. 66, 1500-1508 (2006). (Pubitemid 43259931)
-
(2006)
Cancer Research
, vol.66
, Issue.3
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.-B.3
Solit, D.4
Mills, G.B.5
Smith, D.6
Lane, H.7
Hofmann, F.8
Hicklin, D.J.9
Ludwig, D.L.10
Baselga, J.11
Rosen, N.12
-
130
-
-
80155142474
-
Rapamycin passes the torch: A new generation of mTOR inhibitors
-
Benjamin, D., Colombi, M., Moroni, C. & Hall, M. N. Rapamycin passes the torch: a new generation of mTOR inhibitors. Nature Rev. Drug Discov. 10, 868-880 (2011).
-
(2011)
Nature Rev. Drug Discov.
, vol.10
, pp. 868-880
-
-
Benjamin, D.1
Colombi, M.2
Moroni, C.3
Hall, M.N.4
-
131
-
-
54249162351
-
Targeted polypharmacology: Discovery of dual inhibitors of tyrosine and phosphoinositide kinases
-
Apsel, B. et al. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nature Chem. Biol. 4, 691-699 (2008).
-
(2008)
Nature Chem. Biol.
, vol.4
, pp. 691-699
-
-
Apsel, B.1
-
132
-
-
61349141302
-
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
-
Feldman, M. E. et al. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 7, e38 (2009).
-
(2009)
PLoS Biol.
, vol.7
-
-
Feldman, M.E.1
-
133
-
-
65549145048
-
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
-
Thoreen, C. C. et al. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J. Biol. Chem. 284, 8023-8032 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 8023-8032
-
-
Thoreen, C.C.1
-
134
-
-
77649286736
-
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E
-
Hsieh, A. C. et al. Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell 17, 249-261 (2010).
-
(2010)
Cancer Cell
, vol.17
, pp. 249-261
-
-
Hsieh, A.C.1
-
135
-
-
76349104427
-
Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor
-
Janes, M. R. et al. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nature Med. 16, 205-213 (2010).
-
(2010)
Nature Med.
, vol.16
, pp. 205-213
-
-
Janes, M.R.1
-
136
-
-
21244437079
-
5-Aminoimidazole-4-carboxamide ribonucleoside: A novel immunomodulator with therapeutic efficacy in experimental autoimmune encephalomyelitis
-
Nath, N. et al. 5-aminoimidazole-4-carboxamide ribonucleoside: a novel immunomodulator with therapeutic efficacy in experimental autoimmune encephalomyelitis. J. Immunol. 175, 566-574 (2005). (Pubitemid 40884363)
-
(2005)
Journal of Immunology
, vol.175
, Issue.1
, pp. 566-574
-
-
Nath, N.1
Giri, S.2
Prasad, R.3
Salem, M.L.4
Singh, A.K.5
Singh, I.6
-
137
-
-
67649196932
-
Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis
-
Nath, N. et al. Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis. J. Immunol. 182, 8005-8014 (2009).
-
(2009)
J. Immunol.
, vol.182
, pp. 8005-8014
-
-
Nath, N.1
-
138
-
-
79952696967
-
Apoptosis and autophagy in the regulation of T lymphocyte function
-
Dunkle, A. & He, Y. W. Apoptosis and autophagy in the regulation of T lymphocyte function. Immunol. Res. 49, 70-86 (2011).
-
(2011)
Immunol. Res.
, vol.49
, pp. 70-86
-
-
Dunkle, A.1
He, Y.W.2
-
139
-
-
79960453738
-
A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity
-
Haribhai, D. et al. A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity 35, 109-122 (2011).
-
(2011)
Immunity
, vol.35
, pp. 109-122
-
-
Haribhai, D.1
-
140
-
-
46949088630
-
De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR
-
DOI 10.1189/jlb.1207851
-
Kang, J., Huddleston, S. J., Fraser, J. M. & Khoruts, A. De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR. J. Leukoc. Biol. 83, 1230-1239 (2008). (Pubitemid 351960355)
-
(2008)
Journal of Leukocyte Biology
, vol.83
, Issue.5
, pp. 1230-1239
-
-
Kang, J.1
Huddleston, S.J.2
Fraser, J.M.3
Khoruts, A.4
-
141
-
-
34250156673
-
Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells
-
DOI 10.1111/j.1600-6143.2007.01842.x
-
Gao, W. et al. Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells. Am. J. Transplant. 7, 1722-1732 (2007). (Pubitemid 46905432)
-
(2007)
American Journal of Transplantation
, vol.7
, Issue.7
, pp. 1722-1732
-
-
Gao, W.1
Lu, Y.2
El Essawy, B.3
Oukka, M.4
Kuchroo, V.K.5
Strom, T.B.6
-
142
-
-
41149113441
-
+ cells
-
DOI 10.1084/jem.20071477
-
Haxhinasto, S., Mathis, D. & Benoist, C. The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J. Exp. Med. 205, 565-574 (2008). (Pubitemid 351439304)
-
(2008)
Journal of Experimental Medicine
, vol.205
, Issue.3
, pp. 565-574
-
-
Haxhinasto, S.1
Mathis, D.2
Benoist, C.3
-
143
-
-
30444434212
-
Novel roles of Akt and mTOR in suppressing TGF-β/ALK5-mediated Smad3 activation
-
DOI 10.1038/sj.emboj.7600917, PII 7600917
-
Song, K., Wang, H., Krebs, T. L. & Danielpour, D. Novel roles of Akt and mTOR in suppressing TGF-β/ALK5-mediated Smad3 activation. EMBO J. 25, 58-69 (2006). (Pubitemid 43077295)
-
(2006)
EMBO Journal
, vol.25
, Issue.1
, pp. 58-69
-
-
Song, K.1
Wang, H.2
Krebs, T.L.3
Danielpour, D.4
-
144
-
-
77953811224
-
Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells
-
Ouyang, W. et al. Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. Nature Immunol. 11, 618-627 (2010).
-
(2010)
Nature Immunol.
, vol.11
, pp. 618-627
-
-
Ouyang, W.1
-
145
-
-
77954395996
-
Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells
-
Harada, Y. et al. Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells. J. Exp. Med. 207, 1381-1391 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 1381-1391
-
-
Harada, Y.1
-
146
-
-
78650085394
-
Foxo transcription factors control regulatory T cell development and function
-
Kerdiles, Y. M. et al. Foxo transcription factors control regulatory T cell development and function. Immunity 33, 890-904 (2010).
-
(2010)
Immunity
, vol.33
, pp. 890-904
-
-
Kerdiles, Y.M.1
-
147
-
-
77954417145
-
PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors
-
Merkenschlager, M. & von Boehmer, H. PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors. J. Exp. Med. 207, 1347-1350 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 1347-1350
-
-
Merkenschlager, M.1
Von Boehmer, H.2
-
148
-
-
1642332084
-
Integration of smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
-
DOI 10.1016/S0092-8674(04)00298-3, PII S0092867404002983
-
Seoane, J., Le, H. V., Shen, L., Anderson, S. A. & Massague, J. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 117, 211-223 (2004). (Pubitemid 38496241)
-
(2004)
Cell
, vol.117
, Issue.2
, pp. 211-223
-
-
Seoane, J.1
Le, H.-V.2
Shen, L.3
Anderson, S.A.4
Massague, J.5
-
149
-
-
80051873375
-
CD8+ T cells: Foot soldiers of the immune system
-
Zhang, N. & Bevan, M. J. CD8+ T cells: foot soldiers of the immune system. Immunity 35, 161-168 (2011).
-
(2011)
Immunity
, vol.35
, pp. 161-168
-
-
Zhang, N.1
Bevan, M.J.2
-
150
-
-
84856183120
-
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
-
Van der Windt, G. J. et al. Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity 36, 68-78 (2012).
-
(2012)
Immunity
, vol.36
, pp. 68-78
-
-
Van Der Windt, G.J.1
-
151
-
-
78049268109
-
Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival
-
Hand, T. W. et al. Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival. Proc. Natl Acad. Sci. USA 107, 16601-16606 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 16601-16606
-
-
Hand, T.W.1
-
152
-
-
75749119313
-
Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration
-
Finlay, D. & Cantrell, D. Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration. Ann. NY Acad. Sci. 1183, 149-157 (2010).
-
(2010)
Ann. NY Acad. Sci.
, vol.1183
, pp. 149-157
-
-
Finlay, D.1
Cantrell, D.2
-
153
-
-
65749103365
-
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
-
Koch, M. A. et al. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nature Immunol. 10, 595-602 (2009).
-
(2009)
Nature Immunol.
, vol.10
, pp. 595-602
-
-
Koch, M.A.1
-
154
-
-
33750374196
-
T-bet controls pathogenicity of CTLs in the heart by separable effects on migration and effector activity
-
Taqueti, V. R. et al. T-bet controls pathogenicity of CTLs in the heart by separable effects on migration and effector activity. J. Immunol. 177, 5890-5901 (2006). (Pubitemid 44628802)
-
(2006)
Journal of Immunology
, vol.177
, Issue.9
, pp. 5890-5901
-
-
Taqueti, V.R.1
Grabie, N.2
Colvin, R.3
Pang, H.4
Jarolim, P.5
Luster, A.D.6
Glimcher, L.H.7
Lichtman, A.H.8
|