Rapamycin and dendritic cells: Keep on movin'

Transplantation

Volumn 82, Issue 6, 2006, Pages 739-740

  Hackstein, Holger ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN INHIBITOR; CORTICOSTEROID; CYCLOSPORIN; RAPAMYCIN; TACROLIMUS;

AUTOIMMUNE DISEASE; CELL DIFFERENTIATION; CELL FUNCTION; CELL MIGRATION; DENDRITIC CELL; DRUG EFFECT; DRUG EFFICACY; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT OUTCOME;

ANIMALS; DENDRITIC CELLS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MICE; RECEPTORS, CHEMOKINE; SIROLIMUS;

EID: 33749144276     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.tp.0000235438.11132.8f     Document Type: Note

References (6)

1. Hackstein H, Thomson AW. DC: emerging pharmacological targets of immunosuppressive drugs. Nat Rev Immunol 2004; 4(1): 24.
2. Randolph GJ, Angeli V, Swartz MA. Dendritic-cell trafficking to lymph nodes through lymphatic vessels. Nat Rev Immunol 2005; 5(8): 617.
3. Sehgal SN. Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression. Clin Biochem 1998; 31(5): 335.
4. Hackstein H, Taner T, Logar AJ, Thomson AW. Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived DC. Blood 2002; 100(3): 1084.
5. Lutz MB, Schuler G. Immature, semi-mature and fully mature DC: which signals induce tolerance or immunity? Trends Immunol 2002; 23(9): 445.
6. Taner T, Hackstein H, Wang Z, et al. Rapamycin-treated, alloantigen-pulsed host DC induce ag-specific T cell regulation and prolong graft survival. Am J Transplant 2005; 5(2): 228.