Antagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal anergy: Enhanced cell cycle progression promotes recall antigen responsiveness

Journal of Immunology

Volumn 167, Issue 10, 2001, Pages 5636-5644

  Vanasek, T L ^a   Khoruts, A ^a   Zell, T ^a   Mueller, D L ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2; RAPAMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN RECOGNITION; ARTICLE; CELL CYCLE; CYTOTOXIC T LYMPHOCYTE; IMMUNOREGULATION; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0035889885     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.10.5636     Document Type: Article

References (45)

1. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
2. Clonal expansion versus functional clonal inactivation: A costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy
3. The role of clonal anergy in the avoidance of autoimmunity: Inactivation of autocrine growth without loss of effector function
4. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo
5. + T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4
6. T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression
7. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
8. A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism
9. Functional responses and apoptosis of CD25 (IL-2Rα)-deficient T cells expressing a transgenic antigen receptor
10. CTLA-4 can function as a negative regulator of T cell activation
11. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
12. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
13. CD152 ligation by CD80 on T cells is required for the induction of unresponsiveness by costimulation-deficient antigen presentation
14. CTLA-4 regulates induction of anergy in vivo
15. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
16. CTLA-4-mediated inhibition of early events of T cell proliferation
17. Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation
18. Reversal of in vitro T cell clonal anergy by IL-2 stimulation
19. Prevention of T cell anergy by signaling through the γc chain of the IL-2 receptor
20. Immunopharmacology of rapamycin
21. low thymocytes in vivo
22. Peripheral immune tolerance blocks clonal expansion, but fails to prevent the differentiation of Th1 cells
23. The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody
24. Determination of lymphocyte division by flow cytometry
25. Rapamycin inhibits the generation of graft-versus-host disease- and graft-versus-leukemia-causing T cells by interfering with the production of Th1 or Th1 cytotoxic cytokines
26. Analysis of jun N-terminal kinase and p38 mitogen-activated protein kinase phosphorylation in CD4 T cells stimulated by antigen in vivo
27. + T cells persist in vivo following induction of peripheral tolerance
28. CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression
29. Interleukin-2 expression by a subpopulation of primary T cells is linked to enhanced memory/effector function
30. T cell effector function and anergy avoidance are quantitatively linked to cell division
31. T cell activation determined by T cell receptor number and tunable thresholds
32. The duration of antigenic stimulation determines the fate of naive and effector T cells
33. Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo
34. + T cell tolerance induction versus priming is independent of the rate and number of cell divisions
35. Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody
36. Transforming growth factor-β1 induces antigen-specific unresponsiveness in naive T cells
37. 1a phase of the cell cycle
38. Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation
39. Structure of the FKBP12-rapamycin complex interacting with binding domain of human FRAP
40. 1-arresting rapamycin-receptor complex
41. Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin
42. Maintenance of human T cell anergy: Blocking of IL-2 gene transcription by activated Rap1
43. A new group of conserved coactivators that increase the specificity of AP-1 transcription factors
44. Evidence for repression of interleukin 2 gene activation in anergic T cells
45. Induction of T cell anergy in the absence of CTLA-4/B7 interaction