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Volumn 185, Issue 7, 2010, Pages 3919-3931

A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN INHIBITOR; CD86 ANTIGEN; CYCLOSPORIN A; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PHOSPHATIDYLINOSITOL 3 KINASE; PREDNISONE; PROGRAMMED DEATH 1 LIGAND 1; RAPAMYCIN; STAT3 PROTEIN; TACROLIMUS; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE;

EID: 77958126087     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000296     Document Type: Article
Times cited : (183)

References (67)
  • 1
    • 0348135024 scopus 로고    scopus 로고
    • Dendritic-cell control of pathogen-driven T-cell polarization
    • Kapsenberg, M. L. 2003. Dendritic-cell control of pathogen-driven T-cell polarization. Nat. Rev. Immunol. 3:984-993.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 984-993
    • Kapsenberg, M.L.1
  • 2
    • 0036518287 scopus 로고    scopus 로고
    • Mouse and human dendritic cell subtypes
    • Shortman, K., and Y. J. Liu. 2002. Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. 2:151-161.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 151-161
    • Shortman, K.1    Liu, Y.J.2
  • 4
    • 48749085127 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells: Sensing nucleic acids in viral infection and autoimmune diseases
    • Gilliet, M., W. Cao, and Y. J. Liu. 2008. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat. Rev. Immunol. 8:594-606.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 594-606
    • Gilliet, M.1    Cao, W.2    Liu, Y.J.3
  • 5
    • 77952313777 scopus 로고    scopus 로고
    • Differentiation of effector CD4 T cell populations (*)
    • Zhu, J., H. Yamane, and W. E. Paul. 2010. Differentiation of effector CD4 T cell populations (*). Annu. Rev. Immunol. 28:445-489.
    • (2010) Annu. Rev. Immunol. , vol.28 , pp. 445-489
    • Zhu, J.1    Yamane, H.2    Paul, W.E.3
  • 6
    • 0029917705 scopus 로고    scopus 로고
    • Human CD14+ leukocytes acquire the phenotype and function of antigen-presenting dendritic cells when cultured in GM-CSF and IL-4
    • Kiertscher, S. M., and M. D. Roth. 1996. Human CD14+ leukocytes acquire the phenotype and function of antigen-presenting dendritic cells when cultured in GM-CSF and IL-4. J. Leukoc. Biol. 59:208-218.
    • (1996) J. Leukoc. Biol. , vol.59 , pp. 208-218
    • Kiertscher, S.M.1    Roth, M.D.2
  • 7
    • 0028289244 scopus 로고
    • Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
    • Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 179:1109-1118.
    • (1994) J. Exp. Med. , vol.179 , pp. 1109-1118
    • Sallusto, F.1    Lanzavecchia, A.2
  • 8
    • 38849141667 scopus 로고    scopus 로고
    • Differential development of murine dendritic cells by GM-CSF versus Flt3 ligand has implications for inflammation and trafficking
    • Xu, Y., Y. Zhan, A. M. Lew, S. H. Naik, and M. H. Kershaw. 2007. Differential development of murine dendritic cells by GM-CSF versus Flt3 ligand has implications for inflammation and trafficking. J. Immunol. 179:7577-7584.
    • (2007) J. Immunol. , vol.179 , pp. 7577-7584
    • Xu, Y.1    Zhan, Y.2    Lew, A.M.3    Naik, S.H.4    Kershaw, M.H.5
  • 10
    • 44449083407 scopus 로고    scopus 로고
    • Deacetylase activity is required for STAT5-dependent GM-CSF functional activity in macrophages and differentiation to dendritic cells
    • Sebastián, C., M. Serra, A. Yeramian, N. Serrat, J. Lloberas, and A. Celada. 2008. Deacetylase activity is required for STAT5-dependent GM-CSF functional activity in macrophages and differentiation to dendritic cells. J. Immunol. 180:5898-5906.
    • (2008) J. Immunol. , vol.180 , pp. 5898-5906
    • Sebastián, C.1    Serra, M.2    Yeramian, A.3    Serrat, N.4    Lloberas, J.5    Celada, A.6
  • 11
    • 34547907805 scopus 로고    scopus 로고
    • Expanding mTOR signaling
    • Yang, Q., and K. L. Guan. 2007. Expanding mTOR signaling. Cell Res. 17:666-681.
    • (2007) Cell. Res. , vol.17 , pp. 666-681
    • Yang, Q.1    Guan, K.L.2
  • 12
    • 34249679614 scopus 로고    scopus 로고
    • MTOR Complex1-S6K1 signaling: At the crossroads of obesity, diabetes and cancer
    • Dann, S. G., A. Selvaraj, and G. Thomas. 2007. mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends Mol. Med. 13:252-259.
    • (2007) Trends Mol. Med. , vol.13 , pp. 252-259
    • Dann, S.G.1    Selvaraj, A.2    Thomas, G.3
  • 13
    • 65449135649 scopus 로고    scopus 로고
    • The multiple facets of mTOR in immunity
    • Weichhart, T., and M. D. Säemann. 2009. The multiple facets of mTOR in immunity. Trends Immunol. 30:218-226.
    • (2009) Trends Immunol. , vol.30 , pp. 218-226
    • Weichhart, T.1    Säemann, M.D.2
  • 15
    • 3142587052 scopus 로고    scopus 로고
    • Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes
    • Brugarolas, J., and W. G. Kaelin, Jr. 2004. Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes. Cancer Cell 6:7-10.
    • (2004) Cancer Cell. , vol.6 , pp. 7-10
    • Brugarolas, J.1    Kaelin Jr., W.G.2
  • 19
    • 49149122236 scopus 로고    scopus 로고
    • Mammalian target of rapamycin and caspase inhibitors in polycystic kidney disease
    • Edelstein, C. L. 2008. Mammalian target of rapamycin and caspase inhibitors in polycystic kidney disease. Clin. J. Am. Soc. Nephrol. 3:1219-1226.
    • (2008) Clin. J. Am. Soc. Nephrol. , vol.3 , pp. 1219-1226
    • Edelstein, C.L.1
  • 21
    • 20444373376 scopus 로고    scopus 로고
    • Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    • Battaglia, M., A. Stabilini, and M. G. Roncarolo. 2005. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 105:4743-4748.
    • (2005) Blood , vol.105 , pp. 4743-4748
    • Battaglia, M.1    Stabilini, A.2    Roncarolo, M.G.3
  • 23
    • 0038036797 scopus 로고    scopus 로고
    • Rapamycin inhibits IL-4-induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo
    • Hackstein, H., T. Taner, A. F. Zahorchak, A. E. Morelli, A. J. Logar, A. Gessner, and A. W. Thomson. 2003. Rapamycin inhibits IL-4-induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo. Blood 101:4457-4463.
    • (2003) Blood , vol.101 , pp. 4457-4463
    • Hackstein, H.1    Taner, T.2    Zahorchak, A.F.3    Morelli, A.E.4    Logar, A.J.5    Gessner, A.6    Thomson, A.W.7
  • 25
    • 0035412393 scopus 로고    scopus 로고
    • Rapamycin induces apoptosis in monocyte-and CD34-derived dendritic cells but not in monocytes and macrophages
    • Woltman, A. M., J. W. de Fijter, S. W. Kamerling, S. W. van der Kooij, L. C. Paul, M. R. Daha, and C. van Kooten. 2001. Rapamycin induces apoptosis in monocyte-and CD34-derived dendritic cells but not in monocytes and macrophages. Blood 98:174-180.
    • (2001) Blood , vol.98 , pp. 174-180
    • Woltman, A.M.1    De Fijter, J.W.2    Kamerling, S.W.3    Van Der Kooij, S.W.4    Paul, L.C.5    Daha, M.R.6    Van Kooten, C.7
  • 26
    • 0037441902 scopus 로고    scopus 로고
    • Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression
    • Woltman, A. M., S. W. van der Kooij, P. J. Coffer, R. Offringa, M. R. Daha, and C. van Kooten. 2003. Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression. Blood 101:1439-1445.
    • (2003) Blood , vol.101 , pp. 1439-1445
    • Woltman, A.M.1    Van Der Kooij, S.W.2    Coffer, P.J.3    Offringa, R.4    Daha, M.R.5    Van Kooten, C.6
  • 27
    • 0036682957 scopus 로고    scopus 로고
    • Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells
    • Hackstein, H., T. Taner, A. J. Logar, and A. W. Thomson. 2002. Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells. Blood 100:1084-1087.
    • (2002) Blood , vol.100 , pp. 1084-1087
    • Hackstein, H.1    Taner, T.2    Logar, A.J.3    Thomson, A.W.4
  • 29
    • 0034649707 scopus 로고    scopus 로고
    • Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipients
    • Singer, S. J., R. Tiernan, and E. J. Sullivan. 2000. Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipients. N. Engl. J. Med. 343:1815-1816.
    • (2000) N. Engl. J. Med. , vol.343 , pp. 1815-1816
    • Singer, S.J.1    Tiernan, R.2    Sullivan, E.J.3
  • 30
    • 2942562298 scopus 로고    scopus 로고
    • Rapamycin-associated post-transplantation glomerulonephritis and its remission after reintroduction of calcineurin-inhibitor therapy
    • Dittrich, E., S. Schmaldienst, A. Soleiman, W. H. Hörl, and E. Pohanka. 2004. Rapamycin-associated post-transplantation glomerulonephritis and its remission after reintroduction of calcineurin-inhibitor therapy. Transpl. Int. 17:215-220.
    • (2004) Transpl. Int. , vol.17 , pp. 215-220
    • Dittrich, E.1    Schmaldienst, S.2    Soleiman, A.3    Hörl, W.H.4    Pohanka, E.5
  • 31
    • 27744569416 scopus 로고    scopus 로고
    • Post-transplantation proteinuria and sirolimus
    • Izzedine, H., I. Brocheriou, and C. Frances. 2005. Post-transplantation proteinuria and sirolimus. N. Engl. J. Med. 353:2088-2089.
    • (2005) N. Engl. J. Med. , vol.353 , pp. 2088-2089
    • Izzedine, H.1    Brocheriou, I.2    Frances, C.3
  • 33
    • 50949130076 scopus 로고    scopus 로고
    • Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharideinduced interleukin-12 production in dendritic cells
    • Ohtani, M., S. Nagai, S. Kondo, S. Mizuno, K. Nakamura, M. Tanabe, T. Takeuchi, S. Matsuda, and S. Koyasu. 2008. Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharideinduced interleukin-12 production in dendritic cells. Blood 112:635-643.
    • (2008) Blood , vol.112 , pp. 635-643
    • Ohtani, M.1    Nagai, S.2    Kondo, S.3    Mizuno, S.4    Nakamura, K.5    Tanabe, M.6    Takeuchi, T.7    Matsuda, S.8    Koyasu, S.9
  • 35
    • 33745013651 scopus 로고    scopus 로고
    • Intracellular network of phosphatidylinositol 3-kinase, mammalian target of the rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen-activated protein kinases pathways for regulating mycobacteria-induced IL-23 expression in human macrophages
    • Yang, C. S., C. H. Song, J. S. Lee, S. B. Jung, J. H. Oh, J. Park, H. J. Kim, J. K. Park, T. H. Paik, and E. K. Jo. 2006. Intracellular network of phosphatidylinositol 3-kinase, mammalian target of the rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen-activated protein kinases pathways for regulating mycobacteria-induced IL-23 expression in human macrophages. Cell. Microbiol. 8:1158-1171.
    • (2006) Cell. Microbiol. , vol.8 , pp. 1158-1171
    • Yang, C.S.1    Song, C.H.2    Lee, J.S.3    Jung, S.B.4    Oh, J.H.5    Park, J.6    Kim, H.J.7    Park, J.K.8    Paik, T.H.9    Jo, E.K.10
  • 37
    • 52549127241 scopus 로고    scopus 로고
    • Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI (3) K-mTOR-p70S6K pathway
    • Cao, W., S. Manicassamy, H. Tang, S. P. Kasturi, A. Pirani, N. Murthy, and B. Pulendran. 2008. Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI (3) K-mTOR-p70S6K pathway. Nat. Immunol. 9:1157-1164.
    • (2008) Nat. Immunol. , vol.9 , pp. 1157-1164
    • Cao, W.1    Manicassamy, S.2    Tang, H.3    Kasturi, S.P.4    Pirani, A.5    Murthy, N.6    Pulendran, B.7
  • 40
    • 17844385843 scopus 로고    scopus 로고
    • Inhibition of mammalian target of rapamycin potentiates thrombin-induced intercellular adhesion molecule-1 expression by accelerating and stabilizing NF-kappa B activation in endothelial cells
    • Minhajuddin, M., F. Fazal, K. M. Bijli, M. R. Amin, and A. Rahman. 2005. Inhibition of mammalian target of rapamycin potentiates thrombin-induced intercellular adhesion molecule-1 expression by accelerating and stabilizing NF-kappa B activation in endothelial cells. J. Immunol. 174:5823-5829.
    • (2005) J. Immunol. , vol.174 , pp. 5823-5829
    • Minhajuddin, M.1    Fazal, F.2    Bijli, K.M.3    Amin, M.R.4    Rahman, A.5
  • 42
    • 0037531635 scopus 로고    scopus 로고
    • Dendritic cell subset ratio in peripheral blood correlates with successful withdrawal of immunosuppression in liver transplant patients
    • Mazariegos, G. V., A. F. Zahorchak, J. Reyes, L. Ostrowski, B. Flynn, A. Zeevi, and A. W. Thomson. 2003. Dendritic cell subset ratio in peripheral blood correlates with successful withdrawal of immunosuppression in liver transplant patients. Am. J. Transplant. 3:689-696.
    • (2003) Am. J. Transplant. , vol.3 , pp. 689-696
    • Mazariegos, G.V.1    Zahorchak, A.F.2    Reyes, J.3    Ostrowski, L.4    Flynn, B.5    Zeevi, A.6    Thomson, A.W.7
  • 43
    • 0346734188 scopus 로고    scopus 로고
    • Dexamethasone inhibits IL-12p40 production in lipopolysaccharidestimulated human monocytic cells by down-regulating the activity of c-Jun. N-terminal kinase, the activation protein-1, and NF-kappa B transcription factors
    • Ma, W., K. Gee, W. Lim, K. Chambers, J. B. Angel, M. Kozlowski, and A. Kumar. 2004. Dexamethasone inhibits IL-12p40 production in lipopolysaccharidestimulated human monocytic cells by down-regulating the activity of c-Jun. N-terminal kinase, the activation protein-1, and NF-kappa B transcription factors. J. Immunol. 172:318-330.
    • (2004) J. Immunol. , vol.172 , pp. 318-330
    • Ma, W.1    Gee, K.2    Lim, W.3    Chambers, K.4    Angel, J.B.5    Kozlowski, M.6    Kumar, A.7
  • 45
    • 22644445634 scopus 로고    scopus 로고
    • Dexamethasone induces IL-10-producing monocyte-derived dendritic cells with durable immaturity
    • Xia, C. Q., R. Peng, F. Beato, and M. J. Clare-Salzler. 2005. Dexamethasone induces IL-10-producing monocyte-derived dendritic cells with durable immaturity. Scand. J. Immunol. 62:45-54.
    • (2005) Scand. J. Immunol. , vol.62 , pp. 45-54
    • Xia, C.Q.1    Peng, R.2    Beato, F.3    Clare-Salzler, M.J.4
  • 46
    • 33344457034 scopus 로고    scopus 로고
    • GILZ expression in human dendritic cells redirects their maturation and prevents antigen-specific T lymphocyte response
    • Cohen, N., E. Mouly, H. Hamdi, M. C. Maillot, M. Pallardy, V. Godot, F. Capel, A. Balian, S. Naveau, P. Galanaud, et al. 2006. GILZ expression in human dendritic cells redirects their maturation and prevents antigen-specific T lymphocyte response. Blood 107:2037-2044.
    • (2006) Blood , vol.107 , pp. 2037-2044
    • Cohen, N.1    Mouly, E.2    Hamdi, H.3    Maillot, M.C.4    Pallardy, M.5    Godot, V.6    Capel, F.7    Balian, A.8    Naveau, S.9    Galanaud, P.10
  • 47
    • 33750027383 scopus 로고    scopus 로고
    • Maturation-resistant dendritic cells induce hyporesponsiveness in alloreactive CD45RA+ and CD45RO+ T-cell populations
    • Woltman, A. M., S. W. van der Kooij, J. W. de Fijter, and C. van Kooten. 2006. Maturation-resistant dendritic cells induce hyporesponsiveness in alloreactive CD45RA+ and CD45RO+ T-cell populations. Am. J. Transplant. 6:2580-2591.
    • (2006) Am. J. Transplant. , vol.6 , pp. 2580-2591
    • Woltman, A.M.1    Van Der Kooij, S.W.2    De Fijter, J.W.3    Van Kooten, C.4
  • 48
    • 40049104756 scopus 로고    scopus 로고
    • High PD-L1/CD86 ratio on plasmacytoid dendritic cells correlates with elevated T-regulatory cells in liver transplant tolerance
    • Tokita, D., G. V. Mazariegos, A. F. Zahorchak, N. Chien, M. Abe, G. Raimondi, and A. W. Thomson. 2008. High PD-L1/CD86 ratio on plasmacytoid dendritic cells correlates with elevated T-regulatory cells in liver transplant tolerance. Transplantation 85:369-377.
    • (2008) Transplantation , vol.85 , pp. 369-377
    • Tokita, D.1    Mazariegos, G.V.2    Zahorchak, A.F.3    Chien, N.4    Abe, M.5    Raimondi, G.6    Thomson, A.W.7
  • 51
    • 33749139526 scopus 로고    scopus 로고
    • Differential effects of immunosuppressive drugs on chemokine receptor CCR7 in human monocyte-derived dendritic cells: Selective upregulation by rapamycin
    • Sordi, V., G. Bianchi, C. Buracchi, A. Mercalli, F. Marchesi, G. D'Amico, C. H. Yang, W. Luini, A. Vecchi, A. Mantovani, et al. 2006. Differential effects of immunosuppressive drugs on chemokine receptor CCR7 in human monocyte-derived dendritic cells: selective upregulation by rapamycin. Transplantation 82:826-834.
    • (2006) Transplantation , vol.82 , pp. 826-834
    • Sordi, V.1    Bianchi, G.2    Buracchi, C.3    Mercalli, A.4    Marchesi, F.5    D'Amico, G.6    Yang, C.H.7    Luini, W.8    Vecchi, A.9    Mantovani, A.10
  • 53
    • 56749156696 scopus 로고    scopus 로고
    • The PI3K/Akt/mTOR pathway in innate immune cells: Emerging therapeutic applications
    • Weichhart, T., and M. D. Säemann. 2008. The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications. Ann. Rheum. Dis. 67 (Suppl 3): iii70-iii74.
    • (2008) Ann. Rheum. Dis. , vol.67 , Issue.3 SUPPL.
    • Weichhart, T.1    Säemann, M.D.2
  • 54
    • 34249805413 scopus 로고    scopus 로고
    • Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance
    • Turnquist, H. R., G. Raimondi, A. F. Zahorchak, R. T. Fischer, Z. Wang, and A. W. Thomson. 2007. Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance. J. Immunol. 178:7018-7031.
    • (2007) J. Immunol. , vol.178 , pp. 7018-7031
    • Turnquist, H.R.1    Raimondi, G.2    Zahorchak, A.F.3    Fischer, R.T.4    Wang, Z.5    Thomson, A.W.6
  • 55
    • 72449147738 scopus 로고    scopus 로고
    • The multifunctional role of mTOR in innate immunity: Implications for transplant immunity
    • Säemann, M. D., M. Haidinger, M. Hecking, W. H. Hörl, and T. Weichhart. 2009. The multifunctional role of mTOR in innate immunity: implications for transplant immunity. Am. J. Transplant. 9:2655-2661.
    • (2009) Am. J. Transplant. , vol.9 , pp. 2655-2661
    • Säemann, M.D.1    Haidinger, M.2    Hecking, M.3    Hörl, W.H.4    Weichhart, T.5
  • 56
    • 62049084947 scopus 로고    scopus 로고
    • Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells
    • Jagannath, C., D. R. Lindsey, S. Dhandayuthapani, Y. Xu, R. L. Hunter, Jr., and N. T. Eissa. 2009. Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells. Nat. Med. 15:267-276.
    • (2009) Nat. Med. , vol.15 , pp. 267-276
    • Jagannath, C.1    Lindsey, D.R.2    Dhandayuthapani, S.3    Xu, Y.4    Hunter Jr., R.L.5    Eissa, N.T.6
  • 57
    • 0033849699 scopus 로고    scopus 로고
    • A flow cytometric immune function assay for human peripheral blood dendritic cells
    • Willmann, K., and J. F. Dunne. 2000. A flow cytometric immune function assay for human peripheral blood dendritic cells. J. Leukoc. Biol. 67:536-544.
    • (2000) J. Leukoc. Biol. , vol.67 , pp. 536-544
    • Willmann, K.1    Dunne, J.F.2
  • 58
    • 33644853807 scopus 로고    scopus 로고
    • A whole blood assay to assess peripheral blood dendritic cell function in response to Toll-like receptor stimulation
    • Ida, J. A., N. Shrestha, S. Desai, S. Pahwa, W. A. Hanekom, and P. A. Haslett. 2006. A whole blood assay to assess peripheral blood dendritic cell function in response to Toll-like receptor stimulation. J. Immunol. Methods 310:86-99.
    • (2006) J. Immunol. Methods , vol.310 , pp. 86-99
    • Ida, J.A.1    Shrestha, N.2    Desai, S.3    Pahwa, S.4    Hanekom, W.A.5    Haslett, P.A.6
  • 59
    • 0033959195 scopus 로고    scopus 로고
    • Surface and intracellular interleukin-2 receptor expression on various resting and activated populations involved in cell-mediated immunity in human peripheral blood
    • Hodge, S., G. Hodge, R. Flower, and P. Han. 2000. Surface and intracellular interleukin-2 receptor expression on various resting and activated populations involved in cell-mediated immunity in human peripheral blood. Scand. J. Immunol. 51:67-72.
    • (2000) Scand. J. Immunol. , vol.51 , pp. 67-72
    • Hodge, S.1    Hodge, G.2    Flower, R.3    Han, P.4
  • 60
    • 0042847309 scopus 로고    scopus 로고
    • Mechanism of ribosomal p70S6 kinase activation by granulocyte macrophage colony-stimulating factor in neutrophils: Cooperation of a MEK-related, THR421/SER424 kinase and a rapamycin-sensitive, m-TOR-related THR389 kinase
    • Lehman, J. A., V. Calvo, and J. Gomez-Cambronero. 2003. Mechanism of ribosomal p70S6 kinase activation by granulocyte macrophage colony-stimulating factor in neutrophils: cooperation of a MEK-related, THR421/SER424 kinase and a rapamycin-sensitive, m-TOR-related THR389 kinase. J. Biol. Chem. 278:28130-28138.
    • (2003) J. Biol. Chem. , vol.278 , pp. 28130-28138
    • Lehman, J.A.1    Calvo, V.2    Gomez-Cambronero, J.3
  • 61
    • 13144256708 scopus 로고    scopus 로고
    • Rapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survival
    • Taner, T., H. Hackstein, Z. Wang, A. E. Morelli, and A. W. Thomson. 2005. Rapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survival. Am. J. Transplant. 5:228-236.
    • (2005) Am. J. Transplant. , vol.5 , pp. 228-236
    • Taner, T.1    Hackstein, H.2    Wang, Z.3    Morelli, A.E.4    Thomson, A.W.5
  • 62
    • 12544252206 scopus 로고    scopus 로고
    • Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR)
    • Kusaba, H., P. Ghosh, R. Derin, M. Buchholz, C. Sasaki, K. Madara, and D. L. Longo. 2005. Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR). J. Biol. Chem. 280:1037-1043.
    • (2005) J. Biol. Chem. , vol.280 , pp. 1037-1043
    • Kusaba, H.1    Ghosh, P.2    Derin, R.3    Buchholz, M.4    Sasaki, C.5    Madara, K.6    Longo, D.L.7
  • 64
    • 0347480225 scopus 로고    scopus 로고
    • STAT3 is required for Flt3L-dependent dendritic cell differentiation
    • Laouar, Y., T. Welte, X. Y. Fu, and R. A. Flavell. 2003. STAT3 is required for Flt3L-dependent dendritic cell differentiation. Immunity 19:903-912.
    • (2003) Immunity , vol.19 , pp. 903-912
    • Laouar, Y.1    Welte, T.2    Fu, X.Y.3    Flavell, R.A.4
  • 65
    • 74949092824 scopus 로고    scopus 로고
    • Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade
    • Ma, J., Y. Meng, D. J. Kwiatkowski, X. Chen, H. Peng, Q. Sun, X. Zha, F. Wang, Y. Wang, Y. Jing, et al. 2010. Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J. Clin. Invest. 120:103-114.
    • (2010) J. Clin. Invest. , vol.120 , pp. 103-114
    • Ma, J.1    Meng, Y.2    Kwiatkowski, D.J.3    Chen, X.4    Peng, H.5    Sun, Q.6    Zha, X.7    Wang, F.8    Wang, Y.9    Jing, Y.10


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