The Receptor SIGIRR Suppresses Th17 Cell Proliferation via Inhibition of the Interleukin-1 Receptor Pathway and mTOR Kinase Activation

Immunity

Volumn 32, Issue 1, 2010, Pages 54-66

  Gulen, Muhammet F ^a,b   Kang, Zizhen ^a   Bulek, Katarzyna ^a   Youzhong, Wan ^a   Kim, Tae Whan ^a   Chen, Yi ^c   Altuntas, Cengiz Z ^a   Sass Bak Jensen, Kristian ^c   McGeachy, Mandy J ^c   Do, Jeong Su ^a   Xiao, Hui ^a   Delgoffe, Greg M ^d   Min, Booki ^a   Powell, Jonathan D ^d   Tuohy, Vincent K ^a   Cua, Daniel J ^c   Li, Xiaoxia ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CLEVELAND STATE UNIVERSITY   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

CELLIMMUNO; MOLIMMUNO

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; INTERLEUKIN 17; INTERLEUKIN 6; MAMMALIAN TARGET OF RAPAMYCIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; RECEPTOR PROTEIN; RECOMBINANT INTERLEUKIN 1; SINGLE IMMUNOGLOBULIN INTERLEUKIN 1 RELATED RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL EXPANSION; CELL LINEAGE; CELL MATURATION; CELL POLARITY; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GROWTH INHIBITION; IMMUNIZATION; IMMUNOPATHOGENESIS; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TH1 CELL; TH17 CELL; WILD TYPE;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELL SEPARATION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INTERLEUKIN-17; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, KNOCKOUT; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, INTERLEUKIN-1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER; TRANSFECTION;

EID: 74649086985     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2009.12.003     Document Type: Article

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