MTORC1 regulates CD8+ T-cell glucose metabolism and function independently of PI3K and PKB

Biochemical Society Transactions

Volumn 41, Issue 2, 2013, Pages 681-686

  Finlay, David K ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Cytotoxic T lymphocyte; Glycolysis; Hypoxia inducible factor 1a (HIF1a); Mammalian target of rapamycin complex 1 (mTORC1); Protein kinase B (PKB); Trafficking

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; T LYMPHOCYTE RECEPTOR;

CD8+ T LYMPHOCYTE; CELL GROWTH; CELL METABOLISM; CELL SURVIVAL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; LYMPHOCYTE FUNCTION; LYMPHOCYTE MIGRATION; LYMPHOCYTE PROLIFERATION; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; GLUCOSE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MULTIPROTEIN COMPLEXES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; TOR SERINE-THREONINE KINASES;

MAMMALIA;

EID: 84875392326     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20120359     Document Type: Review

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