-
1
-
-
0032033419
-
Cytokines induce the development of functionally heterogeneous T helper cell subsets
-
DOI 10.1016/S1074-7613(00)80533-6
-
O'Garra, A. 1998. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8: 275-283. (Pubitemid 28188888)
-
(1998)
Immunity
, vol.8
, Issue.3
, pp. 275-283
-
-
O'Garra, A.1
-
2
-
-
67650502393
-
Th9 and allergic disease
-
Soroosh, P., and T. A. Doherty. 2009. Th9 and allergic disease. Immunology 127: 450-458.
-
(2009)
Immunology
, vol.127
, pp. 450-458
-
-
Soroosh, P.1
Doherty, T.A.2
-
3
-
-
33646164439
-
Expanding the effector CD4 T-cell repertoire: The Th17 lineage
-
Harrington, L. E., P. R. Mangan, and C. T. Weaver. 2006. Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr. Opin. Immunol. 18: 349-356.
-
(2006)
Curr. Opin. Immunol.
, vol.18
, pp. 349-356
-
-
Harrington, L.E.1
Mangan, P.R.2
Weaver, C.T.3
-
4
-
-
79952675131
-
Follicular helper CD4 T cells (TFH)
-
Crotty, S. 2011. Follicular helper CD4 T cells (TFH). Annu. Rev. Immunol. 29: 621-663.
-
(2011)
Annu. Rev. Immunol.
, vol.29
, pp. 621-663
-
-
Crotty, S.1
-
5
-
-
79954486763
-
Regulatory T cells and Foxp3
-
Rudensky, A. Y. 2011. Regulatory T cells and Foxp3. Immunol. Rev. 241: 260-268.
-
(2011)
Immunol. Rev.
, vol.241
, pp. 260-268
-
-
Rudensky, A.Y.1
-
6
-
-
77953541634
-
Inflammatory cytokines as a third signal for T cell activation
-
Curtsinger, J. M., and M. F. Mescher. 2010. Inflammatory cytokines as a third signal for T cell activation. Curr. Opin. Immunol. 22: 333-340.
-
(2010)
Curr. Opin. Immunol.
, vol.22
, pp. 333-340
-
-
Curtsinger, J.M.1
Mescher, M.F.2
-
8
-
-
84859388578
-
Regulation of Immune Responses by mTOR
-
Powell, J. D., K. N. Pollizzi, E. B. Heikamp, and M. R. Horton. 2012. Regulation of Immune Responses by mTOR. Annu. Rev. Immunol. 30: 39-68.
-
(2012)
Annu. Rev. Immunol.
, vol.30
, pp. 39-68
-
-
Powell, J.D.1
Pollizzi, K.N.2
Heikamp, E.B.3
Horton, M.R.4
-
9
-
-
0028360374
-
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
-
Brown, E. J., M. W. Albers, T. B. Shin, K. Ichikawa, C. T. Keith, W. S. Lane, and S. L. Schreiber. 1994. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 369: 756-758.
-
(1994)
Nature
, vol.369
, pp. 756-758
-
-
Brown, E.J.1
Albers, M.W.2
Shin, T.B.3
Ichikawa, K.4
Keith, C.T.5
Lane, W.S.6
Schreiber, S.L.7
-
10
-
-
77949264184
-
Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation
-
Esposito, M., F. Ruffini, M. Bellone, N. Gagliani, M. Battaglia, G. Martino, and R. Furlan. 2010. Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation. J. Neuroimmunol. 220: 52-63.
-
(2010)
J. Neuroimmunol.
, vol.220
, pp. 52-63
-
-
Esposito, M.1
Ruffini, F.2
Bellone, M.3
Gagliani, N.4
Battaglia, M.5
Martino, G.6
Furlan, R.7
-
11
-
-
66949118919
-
Practical recommendations for the early use of m-TOR inhibitors (sirolimus) in renal transplantation
-
Campistol, J. M., P. Cockwell, F. Diekmann, D. Donati, L. Guirado, G. Herlenius, D. Mousa, J. Pratschke, and J. C. San Millán. 2009. Practical recommendations for the early use of m-TOR inhibitors (sirolimus) in renal transplantation. Transpl. Int. 22: 681-687.
-
(2009)
Transpl. Int.
, vol.22
, pp. 681-687
-
-
Campistol, J.M.1
Cockwell, P.2
Diekmann, F.3
Donati, D.4
Guirado, L.5
Herlenius, G.6
Mousa, D.7
Pratschke, J.8
San Millán, J.C.9
-
12
-
-
4644262759
-
Sirolimus for GVHD prophylaxis in allogeneic stem cell transplantation
-
DOI 10.1038/sj.bmt.1704604
-
Cutler, C., and J. H. Antin. 2004. Sirolimus for GVHD prophylaxis in allogeneic stem cell transplantation. Bone Marrow Transplant. 34: 471-476. (Pubitemid 39264035)
-
(2004)
Bone Marrow Transplantation
, vol.34
, Issue.6
, pp. 471-476
-
-
Cutler, C.1
Antin, J.H.2
-
13
-
-
70350418625
-
MTOR signaling at a glance
-
Laplante, M., and D. M. Sabatini. 2009. mTOR signaling at a glance. J. Cell Sci. 122: 3589-3594.
-
(2009)
J. Cell Sci.
, vol.122
, pp. 3589-3594
-
-
Laplante, M.1
Sabatini, D.M.2
-
14
-
-
0028237671
-
rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel ras-related protein
-
Yamagata, K., L. K. Sanders, W. E. Kaufmann, W. Yee, C. A. Barnes, D. Nathans, and P. F. Worley. 1994. rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein. J. Biol. Chem. 269: 16333-16339. (Pubitemid 24209331)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.23
, pp. 16333-16339
-
-
Yamagata, K.1
Sanders, L.K.2
Kaufmann, W.E.3
Yee, W.4
Barnes, C.A.5
Nathans, D.6
Worley, P.F.7
-
15
-
-
0038141979
-
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
-
DOI 10.1038/ncb999
-
Zhang, Y., X. Gao, L. J. Saucedo, B. Ru, B. A. Edgar, and D. Pan. 2003. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat. Cell Biol. 5: 578-581. (Pubitemid 36781094)
-
(2003)
Nature Cell Biology
, vol.5
, Issue.6
, pp. 578-581
-
-
Zhang, Y.1
Gao, X.2
Saucedo, L.J.3
Ru, B.4
Edgar, B.A.5
Pan, D.6
-
16
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
DOI 10.1038/ncb839
-
Inoki, K., Y. Li, T. Zhu, J. Wu, and K. L. Guan. 2002. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4: 648-657. (Pubitemid 34993700)
-
(2002)
Nature Cell Biology
, vol.4
, Issue.9
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.-L.5
-
17
-
-
79951745387
-
Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism
-
Macintyre, A. N., D. Finlay, G. Preston, L. V. Sinclair, C. M. Waugh, P. Tamas, C. Feijoo, K. Okkenhaug, and D. A. Cantrell. 2011. Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism. Immunity 34: 224-236.
-
(2011)
Immunity
, vol.34
, pp. 224-236
-
-
Macintyre, A.N.1
Finlay, D.2
Preston, G.3
Sinclair, L.V.4
Waugh, C.M.5
Tamas, P.6
Feijoo, C.7
Okkenhaug, K.8
Cantrell, D.A.9
-
18
-
-
33847397874
-
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
-
DOI 10.1038/ncb1547, PII NCB1547
-
Vander Haar, E., S. I. Lee, S. Bandhakavi, T. J. Griffin, and D. H. Kim. 2007. Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat. Cell Biol. 9: 316-323. (Pubitemid 46344611)
-
(2007)
Nature Cell Biology
, vol.9
, Issue.3
, pp. 316-323
-
-
Haar, E.V.1
Lee, S.2
Bandhakavi, S.3
Griffin, T.J.4
Kim, D.-H.5
-
19
-
-
0037662713
-
Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability
-
DOI 10.1042/BJ20021266
-
Beugnet, A., A. R. Tee, P. M. Taylor, and C. G. Proud. 2003. Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability. Biochem. J. 372: 555-566. (Pubitemid 36723901)
-
(2003)
Biochemical Journal
, vol.372
, Issue.2
, pp. 555-566
-
-
Beugnet, A.1
Tee, A.R.2
Taylor, P.M.3
Proud, C.G.4
-
20
-
-
36749081539
-
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex
-
DOI 10.1038/nature06322, PII NATURE06322
-
Cunningham, J. T., J. T. Rodgers, D. H. Arlow, F. Vazquez, V. K. Mootha, and P. Puigserver. 2007. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature 450: 736-740. (Pubitemid 350207689)
-
(2007)
Nature
, vol.450
, Issue.7170
, pp. 736-740
-
-
Cunningham, J.T.1
Rodgers, J.T.2
Arlow, D.H.3
Vazquez, F.4
Mootha, V.K.5
Puigserver, P.6
-
21
-
-
77953699711
-
Termination of autophagy and reformation of lysosomes regulated by mTOR
-
Yu, L., C. K. McPhee, L. Zheng, G. A. Mardones, Y. Rong, J. Peng, N. Mi, Y. Zhao, Z. Liu, F. Wan, et al. 2010. Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature 465: 942-946.
-
(2010)
Nature
, vol.465
, pp. 942-946
-
-
Yu, L.1
McPhee, C.K.2
Zheng, L.3
Mardones, G.A.4
Rong, Y.5
Peng, J.6
Mi, N.7
Zhao, Y.8
Liu, Z.9
Wan, F.10
-
22
-
-
79954576972
-
Transcriptional control of cellular metabolism by mTOR signaling
-
Yecies, J. L., and B. D. Manning. 2011. Transcriptional control of cellular metabolism by mTOR signaling. Cancer Res. 71: 2815-2820.
-
(2011)
Cancer Res.
, vol.71
, pp. 2815-2820
-
-
Yecies, J.L.1
Manning, B.D.2
-
23
-
-
78649348967
-
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
-
Sengupta, S., T. R. Peterson, and D. M. Sabatini. 2010. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol. Cell 40: 310-322.
-
(2010)
Mol. Cell
, vol.40
, pp. 310-322
-
-
Sengupta, S.1
Peterson, T.R.2
Sabatini, D.M.3
-
24
-
-
79952293503
-
Activation of mTORC2 by association with the ribosome
-
Zinzalla, V., D. Stracka, W. Oppliger, and M. N. Hall. 2011. Activation of mTORC2 by association with the ribosome. Cell 144: 757-768.
-
(2011)
Cell
, vol.144
, pp. 757-768
-
-
Zinzalla, V.1
Stracka, D.2
Oppliger, W.3
Hall, M.N.4
-
25
-
-
79952119614
-
ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor
-
Chen, C. H., T. Shaikenov, T. R. Peterson, R. Aimbetov, A. K. Bissenbaev, S. W. Lee, J. Wu, H. K. Lin, and D. Sarbassov. 2011. ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor. Sci. Signal. 4: ra10.
-
(2011)
Sci. Signal.
, vol.4
-
-
Chen, C.H.1
Shaikenov, T.2
Peterson, T.R.3
Aimbetov, R.4
Bissenbaev, A.K.5
Lee, S.W.6
Wu, J.7
Lin, H.K.8
Sarbassov, D.9
-
26
-
-
58649092475
-
MTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
-
García-Martínez, J. M., and D. R. Alessi. 2008. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem. J. 416: 375-385.
-
(2008)
Biochem. J.
, vol.416
, pp. 375-385
-
-
García-Martínez, J.M.1
Alessi, D.R.2
-
27
-
-
33751348056
-
Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCalpha, but Not S6K1
-
DOI 10.1016/j.devcel.2006.10.007, PII S153458070600459X
-
Guertin, D. A., D. M. Stevens, C. C. Thoreen, A. A. Burds, N. Y. Kalaany, J. Moffat, M. Brown, K. J. Fitzgerald, and D. M. Sabatini. 2006. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev. Cell 11: 859-871. (Pubitemid 44804279)
-
(2006)
Developmental Cell
, vol.11
, Issue.6
, pp. 859-871
-
-
Guertin, D.A.1
Stevens, D.M.2
Thoreen, C.C.3
Burds, A.A.4
Kalaany, N.Y.5
Moffat, J.6
Brown, M.7
Fitzgerald, K.J.8
Sabatini, D.M.9
-
28
-
-
79952985551
-
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
-
Delgoffe, G. M., K. N. Pollizzi, A. T. Waickman, E. Heikamp, D. J. Meyers, M. R. Horton, B. Xiao, P. F. Worley, and J. D. Powell. 2011. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat. Immunol. 12: 295-303.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 295-303
-
-
Delgoffe, G.M.1
Pollizzi, K.N.2
Waickman, A.T.3
Heikamp, E.4
Meyers, D.J.5
Horton, M.R.6
Xiao, B.7
Worley, P.F.8
Powell, J.D.9
-
29
-
-
77953897189
-
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
-
Lee, K., P. Gudapati, S. Dragovic, C. Spencer, S. Joyce, N. Killeen, M. A. Magnuson, and M. Boothby. 2010. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity 32: 743-753.
-
(2010)
Immunity
, vol.32
, pp. 743-753
-
-
Lee, K.1
Gudapati, P.2
Dragovic, S.3
Spencer, C.4
Joyce, S.5
Killeen, N.6
Magnuson, M.A.7
Boothby, M.8
-
30
-
-
66949173728
-
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
-
Delgoffe, G. M., T. P. Kole, Y. Zheng, P. E. Zarek, K. L. Matthews, B. Xiao, P. F. Worley, S. C. Kozma, and J. D. Powell. 2009. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 30: 832-844.
-
(2009)
Immunity
, vol.30
, pp. 832-844
-
-
Delgoffe, G.M.1
Kole, T.P.2
Zheng, Y.3
Zarek, P.E.4
Matthews, K.L.5
Xiao, B.6
Worley, P.F.7
Kozma, S.C.8
Powell, J.D.9
-
31
-
-
46949088630
-
De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR
-
DOI 10.1189/jlb.1207851
-
Kang, J., S. J. Huddleston, J. M. Fraser, and A. Khoruts. 2008. De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR. J. Leukoc. Biol. 83: 1230-1239. (Pubitemid 351960355)
-
(2008)
Journal of Leukocyte Biology
, vol.83
, Issue.5
, pp. 1230-1239
-
-
Kang, J.1
Huddleston, S.J.2
Fraser, J.M.3
Khoruts, A.4
-
33
-
-
38049177784
-
Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells
-
Zeiser, R., D. B. Leveson-Gower, E. A. Zambricki, N. Kambham, A. Beilhack, J. Loh, J. Z. Hou, and R. S. Negrin. 2008. Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells. Blood 111: 453-462.
-
(2008)
Blood
, vol.111
, pp. 453-462
-
-
Zeiser, R.1
Leveson-Gower, D.B.2
Zambricki, E.A.3
Kambham, N.4
Beilhack, A.5
Loh, J.6
Hou, J.Z.7
Negrin, R.S.8
-
34
-
-
45549098562
-
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
-
DOI 10.1073/pnas.0800928105
-
Sauer, S., L. Bruno, A. Hertweck, D. Finlay, M. Leleu, M. Spivakov, Z. A. Knight, B. S. Cobb, D. Cantrell, E. O'Connor, et al. 2008. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc. Natl. Acad. Sci. USA 105: 7797-7802. (Pubitemid 351872718)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.22
, pp. 7797-7802
-
-
Sauer, S.1
Bruno, L.2
Hertweck, A.3
Finlay, D.4
Leleu, M.5
Spivakov, M.6
Knight, Z.A.7
Cobb, B.S.8
Cantrell, D.9
O'Connor, E.10
Shokat, K.M.11
Fisher, A.G.12
Merkenschlager, M.13
-
35
-
-
79952931627
-
Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cells
-
Gabryšová, L., J. R. Christensen, X. Wu, A. Kissenpfennig, B. Malissen, and A. O'Garra. 2011. Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cells. Eur. J. Immunol. 41: 1242-1248.
-
(2011)
Eur. J. Immunol.
, vol.41
, pp. 1242-1248
-
-
Gabryšová, L.1
Christensen, J.R.2
Wu, X.3
Kissenpfennig, A.4
Malissen, B.5
O'Garra, A.6
-
36
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov, D. D., S. M. Ali, S. Sengupta, J. H. Sheen, P. P. Hsu, A. F. Bagley, A. L. Markhard, and D. M. Sabatini. 2006. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol. Cell 22: 159-168.
-
(2006)
Mol. Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
Markhard, A.L.7
Sabatini, D.M.8
-
37
-
-
80155142474
-
Rapamycin passes the torch: A new generation of mTOR inhibitors
-
Benjamin, D., M. Colombi, C. Moroni, and M. N. Hall. 2011. Rapamycin passes the torch: a new generation of mTOR inhibitors. Nat. Rev. Drug Discov. 10: 868-880.
-
(2011)
Nat. Rev. Drug Discov.
, vol.10
, pp. 868-880
-
-
Benjamin, D.1
Colombi, M.2
Moroni, C.3
Hall, M.N.4
-
38
-
-
77955483125
-
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
-
Düvel, K., J. L. Yecies, S. Menon, P. Raman, A. I. Lipovsky, A. L. Souza, E. Triantafellow, Q. Ma, R. Gorski, S. Cleaver, et al. 2010. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol. Cell 39: 171-183.
-
(2010)
Mol. Cell
, vol.39
, pp. 171-183
-
-
Düvel, K.1
Yecies, J.L.2
Menon, S.3
Raman, P.4
Lipovsky, A.I.5
Souza, A.L.6
Triantafellow, E.7
Ma, Q.8
Gorski, R.9
Cleaver, S.10
-
39
-
-
34548014737
-
Revving the Engine: Signal Transduction Fuels T Cell Activation
-
DOI 10.1016/j.immuni.2007.07.008, PII S1074761307003676
-
Jones, R. G., and C. B. Thompson. 2007. Revving the engine: signal transduction fuels T cell activation. Immunity 27: 173-178. (Pubitemid 47284920)
-
(2007)
Immunity
, vol.27
, Issue.2
, pp. 173-178
-
-
Jones, R.G.1
Thompson, C.B.2
-
40
-
-
27744519400
-
Fuel feeds function: Energy metabolism and the T-cell response
-
DOI 10.1038/nri1710, PII N1710
-
Fox, C. J., P. S. Hammerman, and C. B. Thompson. 2005. Fuel feeds function: energy metabolism and the T-cell response. Nat. Rev. Immunol. 5: 844-852. (Pubitemid 41581666)
-
(2005)
Nature Reviews Immunology
, vol.5
, Issue.11
, pp. 844-852
-
-
Fox, C.J.1
Hammerman, P.S.2
Thompson, C.B.3
-
41
-
-
77953534607
-
Metabolism in T cell activation and differentiation
-
Pearce, E. L. 2010. Metabolism in T cell activation and differentiation. Curr. Opin. Immunol. 22: 314-320.
-
(2010)
Curr. Opin. Immunol.
, vol.22
, pp. 314-320
-
-
Pearce, E.L.1
-
42
-
-
73349119966
-
MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells
-
Salmond, R. J., J. Emery, K. Okkenhaug, and R. Zamoyska. 2009. MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells. J. Immunol. 183: 7388-7397.
-
(2009)
J. Immunol.
, vol.183
, pp. 7388-7397
-
-
Salmond, R.J.1
Emery, J.2
Okkenhaug, K.3
Zamoyska, R.4
-
43
-
-
67650074206
-
MTOR regulates memory CD8 T-cell differentiation
-
Araki, K., A. P. Turner, V. O. Shaffer, S. Gangappa, S. A. Keller, M. F. Bachmann, C. P. Larsen, and R. Ahmed. 2009. mTOR regulates memory CD8 T-cell differentiation. Nature 460: 108-112.
-
(2009)
Nature
, vol.460
, pp. 108-112
-
-
Araki, K.1
Turner, A.P.2
Shaffer, V.O.3
Gangappa, S.4
Keller, S.A.5
Bachmann, M.F.6
Larsen, C.P.7
Ahmed, R.8
-
44
-
-
79956142389
-
Characterization of the metabolic phenotype of rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cells
-
He, S., K. Kato, J. Jiang, D. R. Wahl, S. Mineishi, E. M. Fisher, D. M. Murasko, G. D. Glick, and Y. Zhang. 2011. Characterization of the metabolic phenotype of rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cells. PLoS ONE 6: e20107.
-
(2011)
PLoS ONE
, vol.6
-
-
He, S.1
Kato, K.2
Jiang, J.3
Wahl, D.R.4
Mineishi, S.5
Fisher, E.M.6
Murasko, D.M.7
Glick, G.D.8
Zhang, Y.9
-
45
-
-
74649085700
-
The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin
-
Rao, R. R., Q. Li, K. Odunsi, and P. A. Shrikant. 2010. The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin. Immunity 32: 67-78.
-
(2010)
Immunity
, vol.32
, pp. 67-78
-
-
Rao, R.R.1
Li, Q.2
Odunsi, K.3
Shrikant, P.A.4
-
46
-
-
79954623272
-
A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity
-
Li, Q., R. R. Rao, K. Araki, K. Pollizzi, K. Odunsi, J. D. Powell, and P. A. Shrikant. 2011. A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity. Immunity 34: 541-553.
-
(2011)
Immunity
, vol.34
, pp. 541-553
-
-
Li, Q.1
Rao, R.R.2
Araki, K.3
Pollizzi, K.4
Odunsi, K.5
Powell, J.D.6
Shrikant, P.A.7
-
47
-
-
67650096912
-
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
-
Pearce, E. L., M. C. Walsh, P. J. Cejas, G. M. Harms, H. Shen, L. S. Wang, R. G. Jones, and Y. Choi. 2009. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 460: 103-107.
-
(2009)
Nature
, vol.460
, pp. 103-107
-
-
Pearce, E.L.1
Walsh, M.C.2
Cejas, P.J.3
Harms, G.M.4
Shen, H.5
Wang, L.S.6
Jones, R.G.7
Choi, Y.8
-
48
-
-
75749119313
-
Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration
-
Finlay, D., and D. Cantrell. 2010. Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration. Ann. N. Y. Acad. Sci. 1183: 149-157.
-
(2010)
Ann. N. Y. Acad. Sci.
, vol.1183
, pp. 149-157
-
-
Finlay, D.1
Cantrell, D.2
-
49
-
-
51549111249
-
FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase
-
Fabre, S., F. Carrette, J. Chen, V. Lang, M. Semichon, C. Denoyelle, V. Lazar, N. Cagnard, A. Dubart-Kupperschmitt, M. Mangeney, et al. 2008. FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase. J. Immunol. 181: 2980-2989.
-
(2008)
J. Immunol.
, vol.181
, pp. 2980-2989
-
-
Fabre, S.1
Carrette, F.2
Chen, J.3
Lang, V.4
Semichon, M.5
Denoyelle, C.6
Lazar, V.7
Cagnard, N.8
Dubart-Kupperschmitt, A.9
Mangeney, M.10
-
50
-
-
58449102260
-
Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor
-
Kerdiles, Y. M., D. R. Beisner, R. Tinoco, A. S. Dejean, D. H. Castrillon, R. A. DePinho, and S. M. Hedrick. 2009. Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat. Immunol. 10: 176-184.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 176-184
-
-
Kerdiles, Y.M.1
Beisner, D.R.2
Tinoco, R.3
Dejean, A.S.4
Castrillon, D.H.5
DePinho, R.A.6
Hedrick, S.M.7
-
51
-
-
79151486083
-
Metabolism, migration and memory in cytotoxic T cells
-
Finlay, D., and D. A. Cantrell. 2011. Metabolism, migration and memory in cytotoxic T cells. Nat. Rev. Immunol. 11: 109-117.
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 109-117
-
-
Finlay, D.1
Cantrell, D.A.2
-
52
-
-
42449110816
-
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
-
DOI 10.1038/ni.1603, PII NI.1603
-
Sinclair, L. V., D. Finlay, C. Feijoo, G. H. Cornish, A. Gray, A. Ager, K. Okkenhaug, T. J. Hagenbeek, H. Spits, and D. A. Cantrell. 2008. Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking. Nat. Immunol. 9: 513-521. (Pubitemid 351560520)
-
(2008)
Nature Immunology
, vol.9
, Issue.5
, pp. 513-521
-
-
Sinclair, L.V.1
Finlay, D.2
Feijoo, C.3
Cornish, G.H.4
Gray, A.5
Ager, A.6
Okkenhaug, K.7
Hagenbeek, T.J.8
Spits, H.9
Cantrell, D.A.10
-
53
-
-
33746334804
-
Kruppel-like factor 2 regulates thymocyte and T-cell migration
-
DOI 10.1038/nature04882, PII NATURE04882
-
Carlson, C. M., B. T. Endrizzi, J. Wu, X. Ding, M. A. Weinreich, E. R. Walsh, M. A. Wani, J. B. Lingrel, K. A. Hogquist, and S. C. Jameson. 2006. Kruppel-like factor 2 regulates thymocyte and T-cell migration. Nature 442: 299-302. (Pubitemid 44114904)
-
(2006)
Nature
, vol.442
, Issue.7100
, pp. 299-302
-
-
Carlson, C.M.1
Endrizzi, B.T.2
Wu, J.3
Ding, X.4
Weinreich, M.A.5
Walsh, E.R.6
Wani, M.A.7
Lingrel, J.B.8
Hogquist, K.A.9
Jameson, S.C.10
-
54
-
-
1642580757
-
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
-
DOI 10.1038/nature02284
-
Matloubian, M., C. G. Lo, G. Cinamon, M. J. Lesneski, Y. Xu, V. Brinkmann, M. L. Allende, R. L. Proia, and J. G. Cyster. 2004. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427: 355-360. (Pubitemid 38133663)
-
(2004)
Nature
, vol.427
, Issue.6972
, pp. 355-360
-
-
Matloubian, M.1
Lo, C.G.2
Cinamon, G.3
Lesneski, M.J.4
Xu, Y.5
Brinkmann, V.6
Allende, M.L.7
Proia, R.L.8
Cyster, J.G.9
-
55
-
-
79953172571
-
Cutting edge: Distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
-
Michalek, R. D., V. A. Gerriets, S. R. Jacobs, A. N. Macintyre, N. J. MacIver, E. F. Mason, S. A. Sullivan, A. G. Nichols, and J. C. Rathmell. 2011. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J. Immunol. 186: 3299-3303.
-
(2011)
J. Immunol.
, vol.186
, pp. 3299-3303
-
-
Michalek, R.D.1
Gerriets, V.A.2
Jacobs, S.R.3
Macintyre, A.N.4
MacIver, N.J.5
Mason, E.F.6
Sullivan, S.A.7
Nichols, A.G.8
Rathmell, J.C.9
-
56
-
-
0028839022
-
Immunological function of a defined T-cell population tolerized to low-affinity self antigens
-
Kawai, K., and P. S. Ohashi. 1995. Immunological function of a defined T-cell population tolerized to low-affinity self antigens. Nature 374: 68-69.
-
(1995)
Nature
, vol.374
, pp. 68-69
-
-
Kawai, K.1
Ohashi, P.S.2
-
57
-
-
0034850863
-
Weak TCR stimulation induces a calcium signal that triggers IL-4 synthesis, stronger TCR stimulation induces MAP kinases that control IFN-gamma production
-
DOI 10.1002/1521-4141(200108)31:8<2487::AID-IMMU2487>3.0.CO;2-L
-
Badou, A., M. Savignac, M. Moreau, C. Leclerc, G. Foucras, G. Cassar, P. Paulet, D. Lagrange, P. Druet, J. C. Guéry, and L. Pelletier. 2001. Weak TCR stimulation induces a calcium signal that triggers IL-4 synthesis, stronger TCR stimulation induces MAP kinases that control IFN-gamma production. Eur. J. Immunol. 31: 2487-2496. (Pubitemid 32785368)
-
(2001)
European Journal of Immunology
, vol.31
, Issue.8
, pp. 2487-2496
-
-
Badou, A.1
Savignac, M.2
Moreau, M.3
Leclerc, C.4
Foucras, G.5
Cassar, G.6
Paulet, P.7
Lagrange, D.8
Druet, P.9
Guery, J.-C.10
Pelletier, L.11
-
58
-
-
77955391804
-
TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
-
Gottschalk, R. A., E. Corse, and J. P. Allison. 2010. TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo. J. Exp. Med. 207: 1701-1711.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 1701-1711
-
-
Gottschalk, R.A.1
Corse, E.2
Allison, J.P.3
-
59
-
-
0028304998
-
Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation
-
Exley, M., L. Varticovski, M. Peter, J. Sancho, and C. Terhorst. 1994. Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation. J. Biol. Chem. 269: 15140-15146. (Pubitemid 24198359)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.21
, pp. 15140-15146
-
-
Exley, M.1
Varticovski, L.2
Peter, M.3
Sancho, J.4
Terhorst, C.5
-
60
-
-
0034613767
-
Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
-
Jonuleit, H., E. Schmitt, G. Schuler, J. Knop, and A. H. Enk. 2000. Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med. 192: 1213-1222.
-
(2000)
J. Exp. Med.
, vol.192
, pp. 1213-1222
-
-
Jonuleit, H.1
Schmitt, E.2
Schuler, G.3
Knop, J.4
Enk, A.H.5
-
61
-
-
78149248752
-
Duration of antigen receptor signaling determines T-cell tolerance or activation
-
Katzman, S. D., W. E. O'Gorman, A. V. Villarino, E. Gallo, R. S. Friedman, M. F. Krummel, G. P. Nolan, and A. K. Abbas. 2010. Duration of antigen receptor signaling determines T-cell tolerance or activation. Proc. Natl. Acad. Sci. USA 107: 18085-18090.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 18085-18090
-
-
Katzman, S.D.1
O'Gorman, W.E.2
Villarino, A.V.3
Gallo, E.4
Friedman, R.S.5
Krummel, M.F.6
Nolan, G.P.7
Abbas, A.K.8
-
62
-
-
0026332710
-
Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-kB-like response element
-
Verweij, C. L., M. Geerts, and L. A. Aarden. 1991. Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-kB-like response element. J. Biol. Chem. 266: 14179-14182. (Pubitemid 21907480)
-
(1991)
Journal of Biological Chemistry
, vol.266
, Issue.22
, pp. 14179-14182
-
-
Verweij, C.L.1
Geerts, M.2
Aarden, L.A.3
-
63
-
-
0035869402
-
Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo
-
Harada, Y., M. Tokushima, Y. Matsumoto, S. Ogawa, M. Otsuka, K. Hayashi, B. D. Weiss, C. H. June, and R. Abe. 2001. Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo. J. Immunol. 166: 3797-3803. (Pubitemid 32224904)
-
(2001)
Journal of Immunology
, vol.166
, Issue.6
, pp. 3797-3803
-
-
Harada, Y.1
Tokushima, M.2
Matsumoto, Y.3
Ogawa, S.4
Otsuka, M.5
Hayashi, K.6
Weiss, B.D.7
June, C.H.8
Abe, R.9
-
64
-
-
0035221568
-
H2 cytokines
-
DOI 10.1038/83144
-
Kane, L. P., P. G. Andres, K. C. Howland, A. K. Abbas, and A. Weiss. 2001. Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines. Nat. Immunol. 2: 37-44. (Pubitemid 33704951)
-
(2001)
Nature Immunology
, vol.2
, Issue.1
, pp. 37-44
-
-
Kane, L.P.1
Andres, P.G.2
Howland, K.C.3
Abbas, A.K.4
Weiss, A.5
-
65
-
-
33644556146
-
Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin
-
Colombetti, S., V. Basso, D. L. Mueller, and A. Mondino. 2006. Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin. J. Immunol. 176: 2730-2738.
-
(2006)
J. Immunol.
, vol.176
, pp. 2730-2738
-
-
Colombetti, S.1
Basso, V.2
Mueller, D.L.3
Mondino, A.4
-
66
-
-
0033016465
-
CD28 induces cell cycle progression by IL-2-independent down-regulation of p27(kip1) expression in human peripheral T lymphocytes
-
Boonen, G. J., A. M. van Dijk, L. F. Verdonck, R. A. van Lier, G. Rijksen, and R. H. Medema. 1999. CD28 induces cell cycle progression by IL-2-independent down-regulation of p27kip1 expression in human peripheral T lymphocytes. Eur. J. Immunol. 29: 789-798. (Pubitemid 29119058)
-
(1999)
European Journal of Immunology
, vol.29
, Issue.3
, pp. 789-798
-
-
Boonen, G.J.J.C.1
Van Dijk, A.M.C.2
Verdonck, L.F.3
Van Lier, R.A.W.4
Rijksen, G.5
Medema, R.H.6
-
67
-
-
0036069699
-
The CD28 signaling pathway regulates glucose metabolism
-
DOI 10.1016/S1074-7613(02)00323-0
-
Frauwirth, K. A., J. L. Riley, M. H. Harris, R. V. Parry, J. C. Rathmell, D. R. Plas, R. L. Elstrom, C. H. June, and C. B. Thompson. 2002. The CD28 signaling pathway regulates glucose metabolism. Immunity 16: 769-777. (Pubitemid 34786476)
-
(2002)
Immunity
, vol.16
, Issue.6
, pp. 769-777
-
-
Frauwirth, K.A.1
Riley, J.L.2
Harris, M.H.3
Parry, R.V.4
Rathmell, J.C.5
Plas, D.R.6
Elstrom, R.L.7
June, C.H.8
Thompson, C.B.9
-
68
-
-
49649098826
-
ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse
-
Fos, C., A. Salles, V. Lang, F. Carrette, S. Audebert, S. Pastor, M. Ghiotto, D. Olive, G. Bismuth, and J. A. Nunès. 2008. ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse. J. Immunol. 181: 1969-1977.
-
(2008)
J. Immunol.
, vol.181
, pp. 1969-1977
-
-
Fos, C.1
Salles, A.2
Lang, V.3
Carrette, F.4
Audebert, S.5
Pastor, S.6
Ghiotto, M.7
Olive, D.8
Bismuth, G.9
Nunès, J.A.10
-
69
-
-
0032534582
-
Ox-40 ligand: A potent costimulatory molecule for sustaining primary CD4 T cell responses
-
Gramaglia, I., A. D. Weinberg, M. Lemon, and M. Croft. 1998. Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses. J. Immunol. 161: 6510-6517. (Pubitemid 28562188)
-
(1998)
Journal of Immunology
, vol.161
, Issue.12
, pp. 6510-6517
-
-
Gramaglia, I.1
Weinberg, A.D.2
Lemon, M.3
Croft, M.4
-
70
-
-
67650290300
-
The role of OX40-mediated co-stimulation in T-cell activation and survival
-
Redmond, W. L., C. E. Ruby, and A. D. Weinberg. 2009. The role of OX40-mediated co-stimulation in T-cell activation and survival. Crit. Rev. Immunol. 29: 187-201.
-
(2009)
Crit. Rev. Immunol.
, vol.29
, pp. 187-201
-
-
Redmond, W.L.1
Ruby, C.E.2
Weinberg, A.D.3
-
71
-
-
84862908662
-
New insights on OX40 in the control of T cell immunity and immune tolerance in vivo
-
Xiao, X., W. Gong, G. Demirci, W. Liu, S. Spoerl, X. Chu, D. K. Bishop, L. A. Turka, and X. C. Li. 2012. New insights on OX40 in the control of T cell immunity and immune tolerance in vivo. J. Immunol. 188: 892-901.
-
(2012)
J. Immunol.
, vol.188
, pp. 892-901
-
-
Xiao, X.1
Gong, W.2
Demirci, G.3
Liu, W.4
Spoerl, S.5
Chu, X.6
Bishop, D.K.7
Turka, L.A.8
Li, X.C.9
-
72
-
-
79953185367
-
OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling
-
So, T., H. Choi, and M. Croft. 2011. OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling. J. Immunol. 186: 3547-3555.
-
(2011)
J. Immunol.
, vol.186
, pp. 3547-3555
-
-
So, T.1
Choi, H.2
Croft, M.3
-
73
-
-
33846399187
-
+ memory T cell survival and significantly increases recall responses
-
DOI 10.1002/eji.200636428
-
Ruby, C. E., W. L. Redmond, D. Haley, and A. D. Weinberg. 2007. Anti-OX40 stimulation in vivo enhances CD8+ memory T cell survival and significantly increases recall responses. Eur. J. Immunol. 37: 157-166. (Pubitemid 46128796)
-
(2007)
European Journal of Immunology
, vol.37
, Issue.1
, pp. 157-166
-
-
Ruby, C.E.1
Redmond, W.L.2
Haley, D.3
Weinberg, A.D.4
-
74
-
-
27144496045
-
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
-
DOI 10.1128/MCB.25.21.9543-9553.2005
-
Parry, R. V., J. M. Chemnitz, K. A. Frauwirth, A. R. Lanfranco, I. Braunstein, S. V. Kobayashi, P. S. Linsley, C. B. Thompson, and J. L. Riley. 2005. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol. Cell. Biol. 25: 9543-9553. (Pubitemid 41507854)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.21
, pp. 9543-9553
-
-
Parry, R.V.1
Chemnitz, J.M.2
Frauwirth, K.A.3
Lanfranco, A.R.4
Braunstein, I.5
Kobayashi, S.V.6
Linsley, P.S.7
Thompson, C.B.8
Riley, J.L.9
-
75
-
-
0033662376
-
The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A
-
Chuang, E., T. S. Fisher, R. W. Morgan, M. D. Robbins, J. M. Duerr, M. G. Vander Heiden, J. P. Gardner, J. E. Hambor, M. J. Neveu, and C. B. Thompson. 2000. The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A. Immunity 13: 313-322.
-
(2000)
Immunity
, vol.13
, pp. 313-322
-
-
Chuang, E.1
Fisher, T.S.2
Morgan, R.W.3
Robbins, M.D.4
Duerr, J.M.5
Vander Heiden, M.G.6
Gardner, J.P.7
Hambor, J.E.8
Neveu, M.J.9
Thompson, C.B.10
-
76
-
-
57349090212
-
CTLA-4 activation of phosphatidylinositol 3-kinase (PI 3-K) and protein kinase B (PKB/AKT) sustains T-cell anergy without cell death
-
Schneider, H., E. Valk, R. Leung, and C. E. Rudd. 2008. CTLA-4 activation of phosphatidylinositol 3-kinase (PI 3-K) and protein kinase B (PKB/AKT) sustains T-cell anergy without cell death. PLoS ONE 3: e3842.
-
(2008)
PLoS ONE
, vol.3
-
-
Schneider, H.1
Valk, E.2
Leung, R.3
Rudd, C.E.4
-
77
-
-
65349118810
-
PD-1 signaling in primary T cells
-
Riley, J. L. 2009. PD-1 signaling in primary T cells. Immunol. Rev. 229: 114-125.
-
(2009)
Immunol. Rev.
, vol.229
, pp. 114-125
-
-
Riley, J.L.1
-
78
-
-
0031562690
-
Activation-induced expression of human programmed death-1 gene in T- lymphocytes
-
DOI 10.1006/excr.1997.3493
-
Vibhakar, R., G. Juan, F. Traganos, Z. Darzynkiewicz, and L. R. Finger. 1997. Activation-induced expression of human programmed death-1 gene in T-lymphocytes. Exp. Cell Res. 232: 25-28. (Pubitemid 27172215)
-
(1997)
Experimental Cell Research
, vol.232
, Issue.1
, pp. 25-28
-
-
Vibhakar, R.1
Juan, G.2
Traganos, F.3
Darzynkiewicz, Z.4
Finger, L.R.5
-
79
-
-
3142688997
-
SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation
-
Chemnitz, J. M., R. V. Parry, K. E. Nichols, C. H. June, and J. L. Riley. 2004. SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation. J. Immunol. 173: 945-954. (Pubitemid 38924267)
-
(2004)
Journal of Immunology
, vol.173
, Issue.2
, pp. 945-954
-
-
Chemnitz, J.M.1
Parry, R.V.2
Nichols, K.E.3
June, C.H.4
Riley, J.L.5
-
80
-
-
4444317516
-
PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta
-
DOI 10.1016/j.febslet.2004.07.083, PII S0014579304009779
-
Sheppard, K. A., L. J. Fitz, J. M. Lee, C. Benander, J. A. George, J. Wooters, Y. Qiu, J. M. Jussif, L. L. Carter, C. R. Wood, and D. Chaudhary. 2004. PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta. FEBS Lett. 574: 37-41. (Pubitemid 39200891)
-
(2004)
FEBS Letters
, vol.574
, Issue.1-3
, pp. 37-41
-
-
Sheppard, K.-A.1
Fitz, L.J.2
Lee, J.M.3
Benander, C.4
George, J.A.5
Wooters, J.6
Qiu, Y.7
Jussif, J.M.8
Carter, L.L.9
Wood, C.R.10
Chaudhary, D.11
-
81
-
-
73949088551
-
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
-
Francisco, L. M., V. H. Salinas, K. E. Brown, V. K. Vanguri, G. J. Freeman, V. K. Kuchroo, and A. H. Sharpe. 2009. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J. Exp. Med. 206: 3015-3029.
-
(2009)
J. Exp. Med.
, vol.206
, pp. 3015-3029
-
-
Francisco, L.M.1
Salinas, V.H.2
Brown, K.E.3
Vanguri, V.K.4
Freeman, G.J.5
Kuchroo, V.K.6
Sharpe, A.H.7
-
82
-
-
33745888913
-
PTEN function in normal and neoplastic growth
-
DOI 10.1016/j.canlet.2005.11.042, PII S0304383505010219
-
Chow, L. M., and S. J. Baker. 2006. PTEN function in normal and neoplastic growth. Cancer Lett. 241: 184-196. (Pubitemid 44163047)
-
(2006)
Cancer Letters
, vol.241
, Issue.2
, pp. 184-196
-
-
Chow, L.M.L.1
Baker, S.J.2
-
83
-
-
0030010183
-
Immunopharmacology of rapamycin
-
DOI 10.1146/annurev.immunol.14.1.483
-
Abraham, R. T., and G. J. Wiederrecht. 1996. Immunopharmacology of rapamycin. Annu. Rev. Immunol. 14: 483-510. (Pubitemid 26130192)
-
(1996)
Annual Review of Immunology
, vol.14
, pp. 483-510
-
-
Abraham, R.T.1
Wiederrecht, G.J.2
-
84
-
-
1842424727
-
1 Cell Cycle Arrest from Tolerance Induction
-
Allen, A., Y. Zheng, L. Gardner, M. Safford, M. R. Horton, and J. D. Powell. 2004. The novel cyclophilin binding compound, sanglifehrin A, disassociates G1 cell cycle arrest from tolerance induction. J. Immunol. 172: 4797-4803. (Pubitemid 38456401)
-
(2004)
Journal of Immunology
, vol.172
, Issue.8
, pp. 4797-4803
-
-
Allen, A.1
Zheng, Y.2
Gardner, L.3
Safford, M.4
Horton, M.R.5
Powell, J.D.6
-
85
-
-
0033104824
-
Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation
-
Powell, J. D., C. G. Lerner, and R. H. Schwartz. 1999. Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation. J. Immunol. 162: 2775-2784. (Pubitemid 29309302)
-
(1999)
Journal of Immunology
, vol.162
, Issue.5
, pp. 2775-2784
-
-
Powell, J.D.1
Lerner, C.G.2
Schwartz, R.H.3
-
86
-
-
0035889885
-
Antagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal anergy: Enhanced cell cycle progression promotes recall antigen responsiveness
-
Vanasek, T. L., A. Khoruts, T. Zell, and D. L. Mueller. 2001. Antagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal anergy: enhanced cell cycle progression promotes recall antigen responsiveness. J. Immunol. 167: 5636-5644. (Pubitemid 33062753)
-
(2001)
Journal of Immunology
, vol.167
, Issue.10
, pp. 5636-5644
-
-
Vanasek, T.L.1
Khoruts, A.2
Zell, T.3
Mueller, D.L.4
-
87
-
-
59249103441
-
IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes
-
Duré, M., and F. Macian. 2009. IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes. Mol. Immunol. 46: 999-1006.
-
(2009)
Mol. Immunol.
, vol.46
, pp. 999-1006
-
-
Duré, M.1
Macian, F.2
-
88
-
-
26844490420
-
Sequence motifs in IL-4R alpha mediating cell-cycle progression of primary lymphocytes
-
Stephenson, L. M., D. S. Park, A. L. Mora, S. Goenka, and M. Boothby. 2005. Sequence motifs in IL-4R alpha mediating cell-cycle progression of primary lymphocytes. J. Immunol. 175: 5178-5185. (Pubitemid 41456402)
-
(2005)
Journal of Immunology
, vol.175
, Issue.8
, pp. 5178-5185
-
-
Stephenson, L.M.1
Park, D.-S.2
Mora, A.L.3
Goenka, S.4
Boothby, M.5
-
89
-
-
4544331713
-
Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells
-
DOI 10.1084/jem.20040789
-
Barata, J. T., A. Silva, J. G. Brandao, L. M. Nadler, A. A. Cardoso, and V. A. Boussiotis. 2004. Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells. J. Exp. Med. 200: 659-669. (Pubitemid 39258314)
-
(2004)
Journal of Experimental Medicine
, vol.200
, Issue.5
, pp. 659-669
-
-
Barata, J.T.1
Silva, A.2
Brandao, J.G.3
Nadler, L.M.4
Cardoso, A.A.5
Boussiotis, V.A.6
-
90
-
-
0035892899
-
IL-7 enhances the survival and maintains the size of naive T cells
-
Rathmell, J. C., E. A. Farkash, W. Gao, and C. B. Thompson. 2001. IL-7 enhances the survival and maintains the size of naive T cells. J. Immunol. 167: 6869-6876. (Pubitemid 33144179)
-
(2001)
Journal of Immunology
, vol.167
, Issue.12
, pp. 6869-6876
-
-
Rathmell, J.C.1
Farkash, E.A.2
Gao, W.3
Thompson, C.B.4
-
91
-
-
74649086985
-
The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation
-
Gulen, M. F., Z. Kang, K. Bulek, W. Youzhong, T. W. Kim, Y. Chen, C. Z. Altuntas, K. Sass Bak-Jensen, M. J. McGeachy, J. S. Do, et al. 2010. The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity 32: 54-66.
-
(2010)
Immunity
, vol.32
, pp. 54-66
-
-
Gulen, M.F.1
Kang, Z.2
Bulek, K.3
Youzhong, W.4
Kim, T.W.5
Chen, Y.6
Altuntas, C.Z.7
Sass Bak-Jensen, K.8
McGeachy, M.J.9
Do, J.S.10
-
92
-
-
0028982917
-
Interferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 39-kinase
-
Uddin, S., L. Yenush, X. J. Sun, M. E. Sweet, M. F. White, and L. C. Platanias. 1995. Interferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 39-kinase. J. Biol. Chem. 270: 15938-15941.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 15938-15941
-
-
Uddin, S.1
Yenush, L.2
Sun, X.J.3
Sweet, M.E.4
White, M.F.5
Platanias, L.C.6
-
93
-
-
0030043596
-
The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2
-
DOI 10.1074/jbc.271.1.278
-
Platanias, L. C., S. Uddin, A. Yetter, X. J. Sun, and M. F. White. 1996. The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2. J. Biol. Chem. 271: 278-282. (Pubitemid 26026590)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.1
, pp. 278-282
-
-
Platanias, L.C.1
Uddin, S.2
Yetter, A.3
Sun, X.-J.4
White, M.F.5
-
94
-
-
0037645144
-
A PI-3 kinase-dependent, Stat1-independent signaling pathway regulates interferon-stimulated monocyte adhesion
-
DOI 10.1189/jlb.1002508
-
Navarro, A., B. Anand-Apte, Y. Tanabe, G. Feldman, and A. C. Larner. 2003. A PI-3 kinase-dependent, Stat1-independent signaling pathway regulates interferon-stimulated monocyte adhesion. J. Leukoc. Biol. 73: 540-545. (Pubitemid 38040100)
-
(2003)
Journal of Leukocyte Biology
, vol.73
, Issue.4
, pp. 540-545
-
-
Navarro, A.1
Anand-Apte, B.2
Tanabe, Y.3
Feldman, G.4
Larner, A.C.5
-
95
-
-
0037298561
-
Development and characterisation of tetracycline-regulated phosphoinositide 3-kinase mutants: Assessing the role of multiple phosphoinositide 3-kinases in chemokine signaling
-
DOI 10.1016/S0022-1759(02)00416-7, PII S0022175902004167
-
Curnock, A. P., and S. G. Ward. 2003. Development and characterisation of tetracycline-regulated phosphoinositide 3-kinase mutants: assessing the role of multiple phosphoinositide 3-kinases in chemokine signaling. J. Immunol. Methods 273: 29-41. (Pubitemid 36078460)
-
(2003)
Journal of Immunological Methods
, vol.273
, Issue.1-2
, pp. 29-41
-
-
Curnock, A.P.1
Ward, S.G.2
-
96
-
-
0034635264
-
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration
-
Sasaki, T., J. Irie-Sasaki, R. G. Jones, A. J. Oliveira-dos-Santos, W. L. Stanford, B. Bolon, A. Wakeham, A. Itie, D. Bouchard, I. Kozieradzki, et al. 2000. Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science 287: 1040-1046.
-
(2000)
Science
, vol.287
, pp. 1040-1046
-
-
Sasaki, T.1
Irie-Sasaki, J.2
Jones, R.G.3
Oliveira-dos-Santos, A.J.4
Stanford, W.L.5
Bolon, B.6
Wakeham, A.7
Itie, A.8
Bouchard, D.9
Kozieradzki, I.10
-
97
-
-
19344367393
-
Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of rapamycin
-
DOI 10.1152/ajpheart.00561.2004
-
Sakakibara, K., B. Liu, S. Hollenbeck, and K. C. Kent. 2005. Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of rapamycin. Am. J. Physiol. Heart Circ. Physiol. 288: H2861-H2868. (Pubitemid 40720668)
-
(2005)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.288
, Issue.6
-
-
Sakakibara, K.1
Liu, B.2
Hollenbeck, S.3
Kent, K.C.4
-
98
-
-
0142102521
-
Rapamycin inhibits GM-CSF-induced neutrophil migration
-
DOI 10.1016/S0014-5793(03)00828-7
-
Gomez-Cambronero, J. 2003. Rapamycin inhibits GM-CSF-induced neutrophil migration. FEBS Lett. 550: 94-100. (Pubitemid 37281364)
-
(2003)
FEBS Letters
, vol.550
, Issue.1-3
, pp. 94-100
-
-
Gomez-Cambronero, J.1
-
99
-
-
80052608274
-
Involvement of mTOR in CXCL12 mediated T cell signaling and migration
-
Munk, R., P. Ghosh, M. C. Ghosh, T. Saito, M. Xu, A. Carter, F. Indig, D. D. Taub, and D. L. Longo. 2011. Involvement of mTOR in CXCL12 mediated T cell signaling and migration. PLoS ONE 6: e24667.
-
(2011)
PLoS ONE
, vol.6
-
-
Munk, R.1
Ghosh, P.2
Ghosh, M.C.3
Saito, T.4
Xu, M.5
Carter, A.6
Indig, F.7
Taub, D.D.8
Longo, D.L.9
-
100
-
-
46749115220
-
CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1
-
Murooka, T. T., R. Rahbar, L. C. Platanias, and E. N. Fish. 2008. CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1. Blood 111: 4892-4901.
-
(2008)
Blood
, vol.111
, pp. 4892-4901
-
-
Murooka, T.T.1
Rahbar, R.2
Platanias, L.C.3
Fish, E.N.4
-
101
-
-
2342444310
-
Leptin receptor signaling and the regulation of mammalian physiology
-
Myers, M. G., Jr. 2004. Leptin receptor signaling and the regulation of mammalian physiology. Recent Prog. Horm. Res. 59: 287-304.
-
(2004)
Recent Prog. Horm. Res.
, vol.59
, pp. 287-304
-
-
Myers Jr., M.G.1
-
102
-
-
0030828823
-
12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways
-
DOI 10.1007/s001250050832
-
Kellerer, M., M. Koch, E. Metzinger, J. Mushack, E. Capp, and H. U. Häring. 1997. Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia 40: 1358-1362. (Pubitemid 27469678)
-
(1997)
Diabetologia
, vol.40
, Issue.11
, pp. 1358-1362
-
-
Kellerer, M.1
Koch, M.2
Metzinger, E.3
Mushack, J.4
Capp, E.5
Haring, H.U.6
-
103
-
-
78650667165
-
Leptin modulates the survival of autoreactive CD4+ T cells through the nutrient/energy-sensing mammalian target of rapamycin signaling pathway
-
Galgani, M., C. Procaccini, V. De Rosa, F. Carbone, P. Chieffi, A. La Cava, and G. Matarese. 2010. Leptin modulates the survival of autoreactive CD4+ T cells through the nutrient/energy-sensing mammalian target of rapamycin signaling pathway. J. Immunol. 185: 7474-7479.
-
(2010)
J. Immunol.
, vol.185
, pp. 7474-7479
-
-
Galgani, M.1
Procaccini, C.2
De Rosa, V.3
Carbone, F.4
Chieffi, P.5
La Cava, A.6
Matarese, G.7
-
104
-
-
78650188983
-
An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness
-
Procaccini, C., V. De Rosa, M. Galgani, L. Abanni, G. Calì, A. Porcellini, F. Carbone, S. Fontana, T. L. Horvath, A. La Cava, and G. Matarese. 2010. An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity 33: 929-941.
-
(2010)
Immunity
, vol.33
, pp. 929-941
-
-
Procaccini, C.1
De Rosa, V.2
Galgani, M.3
Abanni, L.4
Calì, G.5
Porcellini, A.6
Carbone, F.7
Fontana, S.8
Horvath, T.L.9
La Cava, A.10
Matarese, G.11
-
105
-
-
67649185215
-
The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR
-
Liu, G., S. Burns, G. Huang, K. Boyd, R. L. Proia, R. A. Flavell, and H. Chi. 2009. The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nat. Immunol. 10: 769-777.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 769-777
-
-
Liu, G.1
Burns, S.2
Huang, G.3
Boyd, K.4
Proia, R.L.5
Flavell, R.A.6
Chi, H.7
-
106
-
-
77958151145
-
The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells
-
Liu, G., K. Yang, S. Burns, S. Shrestha, and H. Chi. 2010. The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells. Nat. Immunol. 11: 1047-1056.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 1047-1056
-
-
Liu, G.1
Yang, K.2
Burns, S.3
Shrestha, S.4
Chi, H.5
-
107
-
-
34250189127
-
Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor 1 transcription
-
Bai, A., H. Hu, M. Yeung, and J. Chen. 2007. Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor 1 transcription. J. Immunol. 178: 7632-7639. (Pubitemid 46898033)
-
(2007)
Journal of Immunology
, vol.178
, Issue.12
, pp. 7632-7639
-
-
Bai, A.1
Hu, H.2
Yeung, M.3
Chen, J.4
-
108
-
-
42949139481
-
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
-
DOI 10.1016/j.molcel.2008.03.003, PII S109727650800169X
-
Gwinn, D. M., D. B. Shackelford, D. F. Egan, M. M. Mihaylova, A. Mery, D. S. Vasquez, B. E. Turk, and R. J. Shaw. 2008. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 30: 214-226. (Pubitemid 351626684)
-
(2008)
Molecular Cell
, vol.30
, Issue.2
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
109
-
-
77952280516
-
Anergic T cells are metabolically anergic
-
Zheng, Y., G. M. Delgoffe, C. F. Meyer, W. Chan, and J. D. Powell. 2009. Anergic T cells are metabolically anergic. J. Immunol. 183: 6095-6101.
-
(2009)
J. Immunol.
, vol.183
, pp. 6095-6101
-
-
Zheng, Y.1
Delgoffe, G.M.2
Meyer, C.F.3
Chan, W.4
Powell, J.D.5
-
110
-
-
19444372415
-
AICAR suppresses IL-2 expression through inhibition of GSK-3 phosphorylation and NF-AT activation in Jurkat T cells
-
DOI 10.1016/j.bbrc.2005.04.126, PII S0006291X0500906X
-
Jhun, B. S., Y. T. Oh, J. Y. Lee, Y. Kong, K. S. Yoon, S. S. Kim, H. H. Baik, J. Ha, and I. Kang. 2005. AICAR suppresses IL-2 expression through inhibition of GSK-3 phosphorylation and NF-AT activation in Jurkat T cells. Biochem. Biophys. Res. Commun. 332: 339-346. (Pubitemid 40724983)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.332
, Issue.2
, pp. 339-346
-
-
Bong, S.J.1
Young, T.O.2
Jung, Y.L.3
Kong, Y.4
Yoon, K.-S.5
Sung, S.K.6
Hyung, H.B.7
Ha, J.8
Kang, I.9
-
111
-
-
21244437079
-
5-Aminoimidazole-4-carboxamide ribonucleoside: A novel immunomodulator with therapeutic efficacy in experimental autoimmune encephalomyelitis
-
Nath, N., S. Giri, R. Prasad, M. L. Salem, A. K. Singh, and I. Singh. 2005. 5-aminoimidazole-4-carboxamide ribonucleoside: a novel immunomodulator with therapeutic efficacy in experimental autoimmune encephalomyelitis. J. Immunol. 175: 566-574. (Pubitemid 40884363)
-
(2005)
Journal of Immunology
, vol.175
, Issue.1
, pp. 566-574
-
-
Nath, N.1
Giri, S.2
Prasad, R.3
Salem, M.L.4
Singh, A.K.5
Singh, I.6
-
112
-
-
48149109621
-
Modulation of the activities of AMP-activated protein kinase, protein kinase B, and mammalian target of rapamycin by limiting energy availability with 2-deoxyglucose
-
Jiang, W., Z. Zhu, and H. J. Thompson. 2008. Modulation of the activities of AMP-activated protein kinase, protein kinase B, and mammalian target of rapamycin by limiting energy availability with 2-deoxyglucose. Mol. Carcinog. 47: 616-628.
-
(2008)
Mol. Carcinog.
, vol.47
, pp. 616-628
-
-
Jiang, W.1
Zhu, Z.2
Thompson, H.J.3
-
113
-
-
17044422629
-
Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells
-
Cham, C. M., and T. F. Gajewski. 2005. Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells. J. Immunol. 174: 4670-4677.
-
(2005)
J. Immunol.
, vol.174
, pp. 4670-4677
-
-
Cham, C.M.1
Gajewski, T.F.2
-
114
-
-
33748153690
-
TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
-
DOI 10.1016/j.cell.2006.06.055, PII S0092867406010166
-
Inoki, K., H. Ouyang, T. Zhu, C. Lindvall, Y. Wang, X. Zhang, Q. Yang, C. Bennett, Y. Harada, K. Stankunas, et al. 2006. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126: 955-968. (Pubitemid 44310775)
-
(2006)
Cell
, vol.126
, Issue.5
, pp. 955-968
-
-
Inoki, K.1
Ouyang, H.2
Zhu, T.3
Lindvall, C.4
Wang, Y.5
Zhang, X.6
Yang, Q.7
Bennett, C.8
Harada, Y.9
Stankunas, K.10
Wang, C.-y.11
He, X.12
MacDougald, O.A.13
You, M.14
Williams, B.O.15
Guan, K.-L.16
-
115
-
-
10044276783
-
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
-
DOI 10.1101/gad.1256804
-
Brugarolas, J., K. Lei, R. L. Hurley, B. D. Manning, J. H. Reiling, E. Hafen, L. A. Witters, L. W. Ellisen, and W. G. Kaelin, Jr. 2004. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev. 18: 2893-2904. (Pubitemid 39602308)
-
(2004)
Genes and Development
, vol.18
, Issue.23
, pp. 2893-2904
-
-
Brugarolas, J.1
Lei, K.2
Hurley, R.L.3
Manning, B.D.4
Reiling, J.H.5
Hafen, E.6
Witters, L.A.7
Ellisen, L.W.8
Kaelin Jr., W.G.9
-
116
-
-
21744459535
-
Regulation of mTOR and cell growth in response to energy stress by REDD1
-
DOI 10.1128/MCB.25.14.5834-5845.2005
-
Sofer, A., K. Lei, C. M. Johannessen, and L. W. Ellisen. 2005. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol. Cell. Biol. 25: 5834-5845. (Pubitemid 40946541)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.14
, pp. 5834-5845
-
-
Sofer, A.1
Lei, K.2
Johannessen, C.M.3
Ellisen, L.W.4
-
117
-
-
38349056675
-
Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
-
DeYoung, M. P., P. Horak, A. Sofer, D. Sgroi, and L. W. Ellisen. 2008. Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev. 22: 239-251.
-
(2008)
Genes Dev.
, vol.22
, pp. 239-251
-
-
DeYoung, M.P.1
Horak, P.2
Sofer, A.3
Sgroi, D.4
Ellisen, L.W.5
-
118
-
-
0036789574
-
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
-
Hudson, C. C., M. Liu, G. G. Chiang, D. M. Otterness, D. C. Loomis, F. Kaper, A. J. Giaccia, and R. T. Abraham. 2002. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol. Cell. Biol. 22: 7004-7014.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 7004-7014
-
-
Hudson, C.C.1
Liu, M.2
Chiang, G.G.3
Otterness, D.M.4
Loomis, D.C.5
Kaper, F.6
Giaccia, A.J.7
Abraham, R.T.8
-
119
-
-
20444429440
-
TCR engagement increases hypoxia-inducible factor-1 alpha protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells
-
Nakamura, H., Y. Makino, K. Okamoto, L. Poellinger, K. Ohnuma, C. Morimoto, and H. Tanaka. 2005. TCR engagement increases hypoxia-inducible factor-1 alpha protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells. J. Immunol. 174: 7592-7599. (Pubitemid 40806263)
-
(2005)
Journal of Immunology
, vol.174
, Issue.12
, pp. 7592-7599
-
-
Nakamura, H.1
Makino, Y.2
Okamoto, K.3
Poellinger, L.4
Ohnuma, K.5
Morimoto, C.6
Tanaka, H.7
-
120
-
-
80052277906
-
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
-
Dang, E. V., J. Barbi, H. Y. Yang, D. Jinasena, H. Yu, Y. Zheng, Z. Bordman, J. Fu, Y. Kim, H. R. Yen, et al. 2011. Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell 146: 772-784.
-
(2011)
Cell
, vol.146
, pp. 772-784
-
-
Dang, E.V.1
Barbi, J.2
Yang, H.Y.3
Jinasena, D.4
Yu, H.5
Zheng, Y.6
Bordman, Z.7
Fu, J.8
Kim, Y.9
Yen, H.R.10
-
121
-
-
79960369458
-
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
-
Shi, L. Z., R. Wang, G. Huang, P. Vogel, G. Neale, D. R. Green, and H. Chi. 2011. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J. Exp. Med. 208: 1367-1376.
-
(2011)
J. Exp. Med.
, vol.208
, pp. 1367-1376
-
-
Shi, L.Z.1
Wang, R.2
Huang, G.3
Vogel, P.4
Neale, G.5
Green, D.R.6
Chi, H.7
-
122
-
-
45849105156
-
The rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
DOI 10.1126/science.1157535
-
Sancak, Y., T. R. Peterson, Y. D. Shaul, R. A. Lindquist, C. C. Thoreen, L. Bar-Peled, and D. M. Sabatini. 2008. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320: 1496-1501. (Pubitemid 351929429)
-
(2008)
Science
, vol.320
, Issue.5882
, pp. 1496-1501
-
-
Sancak, Y.1
Peterson, T.R.2
Shaul, Y.D.3
Lindquist, R.A.4
Thoreen, C.C.5
Bar-Peled, L.6
Sabatini, D.M.7
-
123
-
-
67749091321
-
Infectious tolerance via the consumption of essential amino acids and mTOR signaling
-
Cobbold, S. P., E. Adams, C. A. Farquhar, K. F. Nolan, D. Howie, K. O. Lui, P. J. Fairchild, A. L. Mellor, D. Ron, and H. Waldmann. 2009. Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc. Natl. Acad. Sci. USA 106: 12055-12060.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 12055-12060
-
-
Cobbold, S.P.1
Adams, E.2
Farquhar, C.A.3
Nolan, K.F.4
Howie, D.5
Lui, K.O.6
Fairchild, P.J.7
Mellor, A.L.8
Ron, D.9
Waldmann, H.10
-
124
-
-
0037423752
-
Inhibition of amino acid-mTOR signaling by a leucine derivative induces G1 arrest in Jurkat cells
-
DOI 10.1016/S0006-291X(02)03052-8
-
Hidayat, S., K. Yoshino, C. Tokunaga, K. Hara, M. Matsuo, and K. Yonezawa. 2003. Inhibition of amino acid-mTOR signaling by a leucine derivative induces G1 arrest in Jurkat cells. Biochem. Biophys. Res. Commun. 301: 417-423. (Pubitemid 36279255)
-
(2003)
Biochemical and Biophysical Research Communications
, vol.301
, Issue.2
, pp. 417-423
-
-
Hidayat, S.1
Yoshino, K.-I.2
Tokunaga, C.3
Hara, K.4
Matsuo, M.5
Yonezawa, K.6
|