Nutrient-sensing mTOR-mediated pathway regulates leptin production in isolated rat adipocytes

American Journal of Physiology - Endocrinology and Metabolism

Volumn 284, Issue 2 47-2, 2003, Pages

  Roh, Cecilia ^a   Han, Jianrong ^a   Tzatsos, Alexandros ^a   Kandror, Konstantin V ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Mammalian target of rapamycin

Indexed keywords

BINDING PROTEIN; DACTINOMYCIN; LEPTIN; LEUCINE; MESSENGER RNA; RAPAMYCIN; S6 KINASE;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CENTRIFUGATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FOOD DEPRIVATION; FOOD INTAKE; MALE; NONHUMAN; NUTRIENT; POSTPRANDIAL STATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN SYNTHESIS; PROTEIN TARGETING; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 0037303916     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00230.2002     Document Type: Article

References (36)

1. Ahima RS and Flier JS. Leptin. Annu Rev Physiol 62: 413-437, 2000.
2. Barr VA, Malide D, Zarnowski MJ, Taylor SI, and Cushman SW. Insulin stimulates both leptin secretion and production by rat white adipose tissue. Endocrinology 138: 4463-4472, 1997.
3. Becker DJ, Ongemba LN, Brichard V, Henquin JC, and Brichard SM. Diet- and diabetes-induced changes of ob gene expression in rat adipose tissue. FEBS Lett 371: 324-328, 1995.
4. Bradley RL and Cheatham B. Regulation of ob gene expression and leptin secretion by insulin and dexametasone in rat adipocytes. Diabetes 48: 272-278, 1999.
5. Dennis PB, Jaeschke A, Saitoh M, Fowler B, Kozma SC, and Thomas G. Mammalian TOR: a homeostatic ATP sensor. Science 294: 1102-1105, 2001.
6. Fain JN and Bahouth SW. Stimulation of leptin release by actinomycin D in rat adipocytes. Biochem Pharmacol 55: 1309-1314, 1998.
7. Fox HL, Kimball SR, Jefferson LS, and Lynch CJ. Amino acids stimulate phosphorylation of p70S6k and organization of rat adipocytes into multicellular clusters. Am J Physiol Cell Physiol 274: C206-C213, 1998.
8. Fox HL, Pham PT, Kimball SR, Jefferson LS, and Lynch CJ. Amino acid effects on translational repressor 4E-BP1 are mediated primarily by L-leucine in isolated adipocytes. Am J Physiol Cell Physiol 275: C1232-C1238, 1998.
9. Frederich RC, Lollmann B, Hamann A, Napolitano-Rosen A, Kahn BB, Lowell BB, and Flier JS. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J Clin Invest 96: 1658-1663, 1995.
10. Gerrits PM, Olson AL, and Pessin JE. Regulation of the GLUT4/muscle-fat glucose transporter mRNA in adipose tissue of insulin-deficient diabetic rats. J Biol Chem 268: 640-644, 1993.
11. Gingras AC, Raught B, and Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes Dev 15: 807-826, 2001.
12. Hu C, Pang S, Kong X, Velleca M, and Lawrence JC Jr. Molecular cloning and tissue distribution of PHAS-I, an intracellular target for insulin and growth factors. Proc Natl Acad Sci USA 91: 3730-3734, 1994.
13. Jefferson LS and Kimball SR. Amino acid regulation of gene expression. J Nutr 131: 2460S-2467S, 2001.
14. Kandror KV and Pilch PF. Compartmentalization of protein traffic in insulin-sensitive cells. Am J Physiol Endocrinol Metab 271: E1-E14, 1996.
15. Kandror KV, Yu L, and Pilch PF. The major protein of GLUT4-containing vesicles, gp160, has aminopeptidase activity. J Biol Chem 269: 30777-30780, 1994.
16. Keller SR, Scott HM, Mastick CC, Aebersold R, and Lienhard G. Cloning and characterization of a novel insulin-regulated membrane aminopeptidase from GLUT4 vesicles. J Biol Chem 270: 23612-23618, 1995.
17. Kloc M, Zearfoss NR, and Etkin LD. Mechanisms of subcellular mRNA localization. Cell 108: 533-544, 2002.
18. Kupriyanova TA, Kandror V, and Kandror KV. Isolation and characterization of the two major intracellular Glut4 storage compartments. J Biol Chem 277: 9133-9138, 2002.
19. Levy JR, Gyarmati J, Lesko JM, Adler RA, and Stevens W. Dual regulation of leptin secretion: intracellular energy and calcium dependence of regulated pathway. Am J Physiol Endocrinol Metab 278: E892-E901, 2000.
20. Levy JR, LeGall-Salmon E, Santos M, Pandak WM, and Stevens W. Effect of enteral versus parenteral nutrition on leptin gene expression and release into the circulation. Biochem Biophys Res Commun 237: 98-102, 1997.
21. Lin TA, Kong X, Haystead TA, Pause A, Belsham G, Sonenberg N, and Lawrence JC Jr. PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science 266: 653-656, 1994.
22. Lin TA, Kong X, Saltiel AR, Blackshear PJ, and Lawrence JC Jr. Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway. J Biol Chem 270: 18531-18538, 1995.
23. Lynch CJ. Role of leucine in the regulation of mTOR by amino acids: revelations from structure-activity studies. J Nutr 131: 861S-865S, 2001.
24. Maianu L, Keller SR, and Garvey WT. Adipocytes exhibit abnormal subcellular distribution and translocation of vesicles containing glucose transporter 4 and insulin-regulated aminopeptidase in type 2 diabetes mellitus: implications regarding defects in vesicle trafficking. J Clin Endocrinol Metab 86: 5450-5456, 2001.
25. Mueller WM, Gregoire FM, Stanhope KL, Mobbs CV, Mizuno TM, Warden CH, Stern JS, and Havel PJ. Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes. Endocrinology 139: 551-558, 1998.
26. Pause A, Belsham GJ, Gingras AC, Donze O, Lin TA, Lawrence JC Jr, and Sonenberg N. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature 371: 762-767, 1994.
27. Raught B, Gingras A-C, and Sonenberg N. The target of rapamycin (TOR) proteins. Proc Natl Acad Sci USA 98: 7037-7044, 2001.
28. Rodbell M. Metabolism of isolated fat cells. I. Effects of hormones on glucose metabolism and lipolysis. J Biol Chem 239: 375-385, 1964.
29. Rogi T, Tsujimoto M, Nakazato H, Mizutani S, and Tomoda Y. Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metalloprotease family. J Biol Chem 271: 56-61, 1996.
30. Roh C, Roduit R, Thorens B, Fried S, and Kandror KV. Lipoprotein lipase and leptin are accumulated in different secretory compartments in rat adipocytes. J Biol Chem 276: 35990-35994, 2001.
31. Roh C, Thoidis G, Farmer SR, and Kandror KV. Identification and characterization of leptin-containing intracellular compartment in rat adipose cells. Am J Physiol Endocrinol Metab 279: E893-E899, 2000.
32. Rohde J, Heitman J, and Cardenas ME. The TOR kinases link nutrient sensing to cell growth. J Biol Chem 276: 9583-9586, 2001.
33. Russell CD, Ricci MR, Brolin RE, Magill E, and Fried SK. Regulation of the leptin content of obese human adipose tissue. Am J Physiol Endocrinol Metab 280: E399-E404, 2001.
34. Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girard J, Staels B, and Auwerx J. Transient increase in obese gene expression after food intake or insulin administration. Nature 377:527-529, 1995.
35. Schmelzle T and Hall MN. TOR, a central controller of cell growth. Cell 103: 253-262, 2000,
36. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, and Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432, 1994.