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Volumn 37, Issue 10, 2007, Pages 2923-2936

Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli

Author keywords

B lymphocyte; Cell activation; Cell proliferation; Lipopolysaccharide; Signal transduction

Indexed keywords

B LYMPHOCYTE ANTIGEN RECEPTOR; LIPOPOLYSACCHARIDE; LYMPHOCYTE ANTIGEN RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; WORTMANNIN;

EID: 35348852627     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200737281     Document Type: Article
Times cited : (70)

References (69)
  • 1
    • 0942268727 scopus 로고    scopus 로고
    • Development and selection of marginal zone B cells
    • Lopes-Carvalho, T. and Kearney, J. F., Development and selection of marginal zone B cells. Immunol. Rev. 2004. 197: 192-205.
    • (2004) Immunol. Rev , vol.197 , pp. 192-205
    • Lopes-Carvalho, T.1    Kearney, J.F.2
  • 2
  • 3
    • 18844398045 scopus 로고    scopus 로고
    • Marginal zone B cells in lymphocyte activation and regulation
    • Lopes-Carvalho, T., Foote, J. and Kearney, J. F., Marginal zone B cells in lymphocyte activation and regulation. Curr. Opin. Immunol. 2005. 17: 244-250.
    • (2005) Curr. Opin. Immunol , vol.17 , pp. 244-250
    • Lopes-Carvalho, T.1    Foote, J.2    Kearney, J.F.3
  • 4
    • 0035887778 scopus 로고    scopus 로고
    • Unique signaling properties of B cell antigen receptor in mature and immature B cells: Implications for tolerance and activation
    • Benschop, R. J., Brandl, E., Chan, A. C. and Cambier, J. C., Unique signaling properties of B cell antigen receptor in mature and immature B cells: Implications for tolerance and activation. J. Immunol. 2001. 167: 4172-4179.
    • (2001) J. Immunol , vol.167 , pp. 4172-4179
    • Benschop, R.J.1    Brandl, E.2    Chan, A.C.3    Cambier, J.C.4
  • 5
    • 0344069651 scopus 로고    scopus 로고
    • Distinct signal thresholds for the unique antigen receptor-linked gene expression programs in mature and immature B cells
    • Benschop, R. J., Melamed, D., Nemazee, D. and Cambier, J. C., Distinct signal thresholds for the unique antigen receptor-linked gene expression programs in mature and immature B cells. J. Exp. Med. 1999. 190: 749-756.
    • (1999) J. Exp. Med , vol.190 , pp. 749-756
    • Benschop, R.J.1    Melamed, D.2    Nemazee, D.3    Cambier, J.C.4
  • 6
    • 0035284811 scopus 로고    scopus 로고
    • Antigen receptor proximal signaling in splenic B-2 cell subsets
    • Li, X., Martin, F., Oliver, A. M., Kearney, J. F. and Carter, R. H., Antigen receptor proximal signaling in splenic B-2 cell subsets. J. Immunol. 2001. 166: 3122-3129.
    • (2001) J. Immunol , vol.166 , pp. 3122-3129
    • Li, X.1    Martin, F.2    Oliver, A.M.3    Kearney, J.F.4    Carter, R.H.5
  • 7
    • 33744551665 scopus 로고    scopus 로고
    • Mouse follicular and marginal zone B cells show differential expression of Dnmt3a and sensitivity to 5′-azacytidine
    • Wang, Y., Zhang, P., Li, W., Hou, L., Wang, J., Liang, Y. and Han, H., Mouse follicular and marginal zone B cells show differential expression of Dnmt3a and sensitivity to 5′-azacytidine. Immunol. Lett. 2006. 105: 174-179.
    • (2006) Immunol. Lett , vol.105 , pp. 174-179
    • Wang, Y.1    Zhang, P.2    Li, W.3    Hou, L.4    Wang, J.5    Liang, Y.6    Han, H.7
  • 8
    • 33747856465 scopus 로고    scopus 로고
    • Identification of CD36 as a new surface marker of marginal zone B cells by transcriptomic analysis
    • Zhang, P., Li, W., Wang, Y., Hou, L., Xing, Y., Qin, H., Wang, J. et al., Identification of CD36 as a new surface marker of marginal zone B cells by transcriptomic analysis. Mol. Immunol. 2007. 44: 332-337.
    • (2007) Mol. Immunol , vol.44 , pp. 332-337
    • Zhang, P.1    Li, W.2    Wang, Y.3    Hou, L.4    Xing, Y.5    Qin, H.6    Wang, J.7
  • 9
    • 1342321748 scopus 로고    scopus 로고
    • PI3K signaling controls cell fate at many points in B lymphocyte development and activation
    • Donahue, A. C. and Fruman, D. A., PI3K signaling controls cell fate at many points in B lymphocyte development and activation. Semin. Cell Dev. Biol. 2004. 15: 183-197.
    • (2004) Semin. Cell Dev. Biol , vol.15 , pp. 183-197
    • Donahue, A.C.1    Fruman, D.A.2
  • 10
    • 0038281331 scopus 로고    scopus 로고
    • Proliferation and survival of activated B cells requires sustained antigen receptor engagement and phosphoinositide 3-kinase activation
    • Donahue, A. C. and Fruman, D. A., Proliferation and survival of activated B cells requires sustained antigen receptor engagement and phosphoinositide 3-kinase activation. J. Immunol. 2003. 170: 5851-5860.
    • (2003) J. Immunol , vol.170 , pp. 5851-5860
    • Donahue, A.C.1    Fruman, D.A.2
  • 11
    • 0033556333 scopus 로고    scopus 로고
    • Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha
    • Fruman, D. A., Snapper, S. B., Yballe, C. M., Davidson, L., Yu, J. Y., Alt, F. W. and Cantley, L. C., Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science 1999. 283: 393-397.
    • (1999) Science , vol.283 , pp. 393-397
    • Fruman, D.A.1    Snapper, S.B.2    Yballe, C.M.3    Davidson, L.4    Yu, J.Y.5    Alt, F.W.6    Cantley, L.C.7
  • 12
    • 30444439101 scopus 로고    scopus 로고
    • Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: Comparative analysis of genetic and pharmacologic interference with p110delta function in B cells
    • Bilancio, A., Okkenhaug, K., Camps, M., Emery, J. L., Ruckle, T., Rommel, C. and Vanhaesebroeck, B., Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: Comparative analysis of genetic and pharmacologic interference with p110delta function in B cells. Blood 2006. 107: 642-650.
    • (2006) Blood , vol.107 , pp. 642-650
    • Bilancio, A.1    Okkenhaug, K.2    Camps, M.3    Emery, J.L.4    Ruckle, T.5    Rommel, C.6    Vanhaesebroeck, B.7
  • 13
    • 0037119630 scopus 로고    scopus 로고
    • A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation
    • Clayton, E., Bardi, G., Bell, S. E., Chantry, D., Downes, C. P., Gray, A., Humphries, L. A. et al., A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J. Exp. Med. 2002. 196: 753-763.
    • (2002) J. Exp. Med , vol.196 , pp. 753-763
    • Clayton, E.1    Bardi, G.2    Bell, S.E.3    Chantry, D.4    Downes, C.P.5    Gray, A.6    Humphries, L.A.7
  • 14
    • 10844255780 scopus 로고    scopus 로고
    • Altered splenic B cell subset development in mice lacking phosphoinositide 3-kinase p85alpha
    • Donahue, A. C., Hess, K. L., Ng, K. L. and Fruman, D. A., Altered splenic B cell subset development in mice lacking phosphoinositide 3-kinase p85alpha. Int. Immunol. 2004. 16: 1789-1798.
    • (2004) Int. Immunol , vol.16 , pp. 1789-1798
    • Donahue, A.C.1    Hess, K.L.2    Ng, K.L.3    Fruman, D.A.4
  • 15
    • 9244263536 scopus 로고    scopus 로고
    • Frontline: The p85alpha isoform of phosphoinositide 3-kinase is essential for a subset of B cell receptor-initiated signaling responses
    • Hess, K. L., Donahue, A. C., Ng, K. L., Moore, T. I., Oak, J. and Fruman, D. A., Frontline: The p85alpha isoform of phosphoinositide 3-kinase is essential for a subset of B cell receptor-initiated signaling responses. Eur. J. Immunol. 2004. 34: 2968-2976.
    • (2004) Eur. J. Immunol , vol.34 , pp. 2968-2976
    • Hess, K.L.1    Donahue, A.C.2    Ng, K.L.3    Moore, T.I.4    Oak, J.5    Fruman, D.A.6
  • 16
    • 0037695593 scopus 로고    scopus 로고
    • Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex
    • Jou, S. T., Carpino, N., Takahashi, Y., Piekorz, R., Chao, J. R., Carpino, N., Wang, D. and Ihle, J. N., Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex. Mol. Cell. Biol. 2002. 22: 8580-8591.
    • (2002) Mol. Cell. Biol , vol.22 , pp. 8580-8591
    • Jou, S.T.1    Carpino, N.2    Takahashi, Y.3    Piekorz, R.4    Chao, J.R.5    Carpino, N.6    Wang, D.7    Ihle, J.N.8
  • 17
    • 0037047590 scopus 로고    scopus 로고
    • Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice
    • Okkenhaug, K., Bilancio, A., Farjot, G., Priddle, H., Sancho, S., Peskett, E., Pearce, W. et al., Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice. Science 2002. 297: 1031-1034.
    • (2002) Science , vol.297 , pp. 1031-1034
    • Okkenhaug, K.1    Bilancio, A.2    Farjot, G.3    Priddle, H.4    Sancho, S.5    Peskett, E.6    Pearce, W.7
  • 18
    • 0037341617 scopus 로고    scopus 로고
    • PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction
    • Suzuki, H., Matsuda, S., Terauchi, Y., Fujiwara, M., Ohteki, T., Asano, T., Behrens, T. W. et al., PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction. Nat. Immunol. 2003. 4: 280-286.
    • (2003) Nat. Immunol , vol.4 , pp. 280-286
    • Suzuki, H.1    Matsuda, S.2    Terauchi, Y.3    Fujiwara, M.4    Ohteki, T.5    Asano, T.6    Behrens, T.W.7
  • 19
    • 0033555829 scopus 로고    scopus 로고
    • Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase
    • Suzuki, H., Terauchi, Y., Fujiwara, M., Aizawa, S., Yazaki, Y., Kadowaki, T. and Koyasu, S., Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. Science 1999. 283: 390-392.
    • (1999) Science , vol.283 , pp. 390-392
    • Suzuki, H.1    Terauchi, Y.2    Fujiwara, M.3    Aizawa, S.4    Yazaki, Y.5    Kadowaki, T.6    Koyasu, S.7
  • 20
    • 1342303480 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase-dependent mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 and NF-kappa B signaling pathways are required for B cell antigen receptor-mediated cyclin D2 induction in mature B cells
    • Piatelli, M. J., Wardle, C., Blois, J., Doughty, C., Schram, B. R., Rothstein, T. L. and Chiles, T. C., Phosphatidylinositol 3-kinase-dependent mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 and NF-kappa B signaling pathways are required for B cell antigen receptor-mediated cyclin D2 induction in mature B cells. J. Immunol. 2004. 172: 2753-2762.
    • (2004) J. Immunol , vol.172 , pp. 2753-2762
    • Piatelli, M.J.1    Wardle, C.2    Blois, J.3    Doughty, C.4    Schram, B.R.5    Rothstein, T.L.6    Chiles, T.C.7
  • 21
    • 0028093139 scopus 로고
    • Inhibition of human B lymphocyte cell cycle progression and differentiation by rapamycin
    • Aagaard-Tillery, K. M. and Jelinek, D. F., Inhibition of human B lymphocyte cell cycle progression and differentiation by rapamycin. Cell. Immunol. 1994. 156: 493-507.
    • (1994) Cell. Immunol , vol.156 , pp. 493-507
    • Aagaard-Tillery, K.M.1    Jelinek, D.F.2
  • 24
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger, S., Loewith, R. and Hall, M. N., TOR signaling in growth and metabolism. Cell 2006. 124: 471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 25
    • 0032518467 scopus 로고    scopus 로고
    • 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
    • Alessi, D. R., Kozlowski, M. T., Weng, Q. P., Morrice, N. and Avruch, J., 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro. Curr. Biol. 1998. 8: 69-81.
    • (1998) Curr. Biol , vol.8 , pp. 69-81
    • Alessi, D.R.1    Kozlowski, M.T.2    Weng, Q.P.3    Morrice, N.4    Avruch, J.5
  • 26
    • 0036342294 scopus 로고    scopus 로고
    • Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
    • Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J. and Cantley, L. C., Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol. Cell 2002. 10: 151-162.
    • (2002) Mol. Cell , vol.10 , pp. 151-162
    • Manning, B.D.1    Tee, A.R.2    Logsdon, M.N.3    Blenis, J.4    Cantley, L.C.5
  • 27
    • 24744435392 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/extracellular signal-regulated kinase kinase, insulin growth factor-I, and serum
    • Wlodarski, P., Kasprzycka, M., Liu, X., Marzec, M., Robertson, E. S., Slupianek, A. and Wasik, M. A., Activation of mammalian target of rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/extracellular signal-regulated kinase kinase, insulin growth factor-I, and serum. Cancer Res. 2005. 65: 7800-7808.
    • (2005) Cancer Res , vol.65 , pp. 7800-7808
    • Wlodarski, P.1    Kasprzycka, M.2    Liu, X.3    Marzec, M.4    Robertson, E.S.5    Slupianek, A.6    Wasik, M.A.7
  • 28
    • 8744275597 scopus 로고    scopus 로고
    • The p110delta subunit of phosphoinositide 3-kinase is required for the lipopolysaccharide response of mouse B cells
    • Hebeis, B. J., Vigorito, E. and Turner, M., The p110delta subunit of phosphoinositide 3-kinase is required for the lipopolysaccharide response of mouse B cells. Biochem. Soc. Trans. 2004. 32: 789-791.
    • (2004) Biochem. Soc. Trans , vol.32 , pp. 789-791
    • Hebeis, B.J.1    Vigorito, E.2    Turner, M.3
  • 29
    • 14844351587 scopus 로고    scopus 로고
    • Coligation of the B cell receptor with complement receptor type 2 (CR2/ CD21) using its natural ligand C3dg: Activation without engagement of an inhibitory signaling pathway
    • Lyubchenko, T., dal Porto, J., Cambier, J. C. and Holers, V. M., Coligation of the B cell receptor with complement receptor type 2 (CR2/ CD21) using its natural ligand C3dg: Activation without engagement of an inhibitory signaling pathway. J. Immunol. 2005. 174: 3264-3272.
    • (2005) J. Immunol , vol.174 , pp. 3264-3272
    • Lyubchenko, T.1    dal Porto, J.2    Cambier, J.C.3    Holers, V.M.4
  • 30
    • 0035892228 scopus 로고    scopus 로고
    • Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation
    • Allman, D., Lindsley, R. C., Demuth, W., Rudd, K., Shinton, S. A. and Hardy, R. R., Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation. J. Immunol. 2001. 167: 6834-6840.
    • (2001) J. Immunol , vol.167 , pp. 6834-6840
    • Allman, D.1    Lindsley, R.C.2    Demuth, W.3    Rudd, K.4    Shinton, S.A.5    Hardy, R.R.6
  • 31
    • 0033526816 scopus 로고    scopus 로고
    • B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals
    • Loder, F., Mutschler, B., Ray, R. J., Paige, C. J., Sideras, P., Torres, R., Lamers, M. C. and Carsetti, R., B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J. Exp. Med. 1999. 190: 75-89.
    • (1999) J. Exp. Med , vol.190 , pp. 75-89
    • Loder, F.1    Mutschler, B.2    Ray, R.J.3    Paige, C.J.4    Sideras, P.5    Torres, R.6    Lamers, M.C.7    Carsetti, R.8
  • 32
    • 27744491859 scopus 로고    scopus 로고
    • Srivastava, B., Quinn, W. J., 3rd, Hazard, K., Erikson, J. and Allman, D., Characterization of marginal zone B cell precursors. J. Exp. Med. 2005. 202: 1225-1234.
    • Srivastava, B., Quinn, W. J., 3rd, Hazard, K., Erikson, J. and Allman, D., Characterization of marginal zone B cell precursors. J. Exp. Med. 2005. 202: 1225-1234.
  • 33
    • 0036498795 scopus 로고    scopus 로고
    • Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development
    • Su, T. T. and Rawlings, D. J., Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development. J. Immunol. 2002. 168: 2101-2110.
    • (2002) J. Immunol , vol.168 , pp. 2101-2110
    • Su, T.T.1    Rawlings, D.J.2
  • 34
    • 0032545343 scopus 로고    scopus 로고
    • The inositol phosphatase SHIP inhibits Akt/PKB activation in B cells
    • Aman, M. J., Lamkin, T. D., Okada, H., Kurosaki, T. and Ravichandran, K. S., The inositol phosphatase SHIP inhibits Akt/PKB activation in B cells. J. Biol. Chem. 1998. 273: 33922-33928.
    • (1998) J. Biol. Chem , vol.273 , pp. 33922-33928
    • Aman, M.J.1    Lamkin, T.D.2    Okada, H.3    Kurosaki, T.4    Ravichandran, K.S.5
  • 35
    • 0037189571 scopus 로고    scopus 로고
    • Convergence of signaling pathways on the activation of ERK in B cells
    • Jacob, A., Cooney, D., Pradhan, M. and Coggeshall, K. M., Convergence of signaling pathways on the activation of ERK in B cells. J. Biol. Chem. 2002. 277: 23420-23426.
    • (2002) J. Biol. Chem , vol.277 , pp. 23420-23426
    • Jacob, A.1    Cooney, D.2    Pradhan, M.3    Coggeshall, K.M.4
  • 36
    • 23444446774 scopus 로고    scopus 로고
    • Coordinate analysis of murine immune cell surface markers and intracellular phosphoproteins by flow cytometry
    • Krutzik, P. O., Clutter, M. R. and Nolan, G. P., Coordinate analysis of murine immune cell surface markers and intracellular phosphoproteins by flow cytometry. J. Immunol. 2005. 175: 2357-2365.
    • (2005) J. Immunol , vol.175 , pp. 2357-2365
    • Krutzik, P.O.1    Clutter, M.R.2    Nolan, G.P.3
  • 37
    • 23444432362 scopus 로고    scopus 로고
    • Characterization of the murine immunological signaling network with phosphospecific flow cytometry
    • Krutzik, P. O., Hale, M. B. and Nolan, G. P., Characterization of the murine immunological signaling network with phosphospecific flow cytometry. J. Immunol. 2005. 175: 2366-2373.
    • (2005) J. Immunol , vol.175 , pp. 2366-2373
    • Krutzik, P.O.1    Hale, M.B.2    Nolan, G.P.3
  • 38
    • 0036173143 scopus 로고    scopus 로고
    • Simultaneous measurement of multiple active kinase states using polychromatic flow cytometry
    • Perez, O. D. and Nolan, G. P., Simultaneous measurement of multiple active kinase states using polychromatic flow cytometry. Nat. Biotechnol. 2002. 20: 155-162.
    • (2002) Nat. Biotechnol , vol.20 , pp. 155-162
    • Perez, O.D.1    Nolan, G.P.2
  • 39
    • 33645318725 scopus 로고    scopus 로고
    • Phospho-proteomic immune analysis by flow cytometry: From mechanism to translational medicine at the single-cell level
    • Perez, O. D. and Nolan, G. P., Phospho-proteomic immune analysis by flow cytometry: From mechanism to translational medicine at the single-cell level. Immunol. Rev. 2006. 210: 208-228.
    • (2006) Immunol. Rev , vol.210 , pp. 208-228
    • Perez, O.D.1    Nolan, G.P.2
  • 40
    • 33746214828 scopus 로고    scopus 로고
    • Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry
    • Irish, J. M., Czerwinski, D. K., Nolan, G. P. and Levy, R., Kinetics of B cell receptor signaling in human B cell subsets mapped by phosphospecific flow cytometry. J. Immunol. 2006. 177: 1581-1589.
    • (2006) J. Immunol , vol.177 , pp. 1581-1589
    • Irish, J.M.1    Czerwinski, D.K.2    Nolan, G.P.3    Levy, R.4
  • 41
    • 35348812273 scopus 로고    scopus 로고
    • Measuring phosphorylated Akt and other phosphoinositide-3-kinase-regulated phosphoproteins in primary lymphocytes
    • Donahue, A. C. and Fruman, D. A., Measuring phosphorylated Akt and other phosphoinositide-3-kinase-regulated phosphoproteins in primary lymphocytes. Methods Enzymol. 2007. 434: 131-154.
    • (2007) Methods Enzymol , vol.434 , pp. 131-154
    • Donahue, A.C.1    Fruman, D.A.2
  • 42
    • 0037342166 scopus 로고    scopus 로고
    • Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function
    • Anzelon, A. N., Wu, H. and Rickert, R. C., Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat. Immunol. 2003. 4: 287-294.
    • (2003) Nat. Immunol , vol.4 , pp. 287-294
    • Anzelon, A.N.1    Wu, H.2    Rickert, R.C.3
  • 44
    • 0442309363 scopus 로고    scopus 로고
    • Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid
    • Kam, Y. and Exton, J. H., Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid. FASEB J. 2004. 18: 311-319.
    • (2004) FASEB J , vol.18 , pp. 311-319
    • Kam, Y.1    Exton, J.H.2
  • 45
    • 33646548305 scopus 로고    scopus 로고
    • The amino acid sensitive TOR pathway from yeast to mammals
    • Dann, S. G. and Thomas, G., The amino acid sensitive TOR pathway from yeast to mammals. FEBS Lett. 2006. 580: 2821-2829.
    • (2006) FEBS Lett , vol.580 , pp. 2821-2829
    • Dann, S.G.1    Thomas, G.2
  • 46
    • 0034986036 scopus 로고    scopus 로고
    • Antigen-receptor cross-linking and lipopolysaccharide trigger distinct phosphoinositide 3-kinase-dependent pathways to NF-kappa B activation in primary B cells
    • Bone, H. and Williams, N. A., Antigen-receptor cross-linking and lipopolysaccharide trigger distinct phosphoinositide 3-kinase-dependent pathways to NF-kappa B activation in primary B cells. Int. Immunol. 2001. 13: 807-816.
    • (2001) Int. Immunol , vol.13 , pp. 807-816
    • Bone, H.1    Williams, N.A.2
  • 48
    • 8444224619 scopus 로고    scopus 로고
    • Balancing Akt with S6K: Implications for both metabolic diseases and tumorigenesis
    • Manning, B. D., Balancing Akt with S6K: Implications for both metabolic diseases and tumorigenesis. J. Cell Biol. 2004. 167: 399-403.
    • (2004) J. Cell Biol , vol.167 , pp. 399-403
    • Manning, B.D.1
  • 49
    • 33847217892 scopus 로고    scopus 로고
    • A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation
    • Prabhu, S., Saadat, D., Zhang, M., Halbur, L., Fruehauf, J. P. and Ong, S. T., A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation. Oncogene 2007. 26: 1188-1200.
    • (2007) Oncogene , vol.26 , pp. 1188-1200
    • Prabhu, S.1    Saadat, D.2    Zhang, M.3    Halbur, L.4    Fruehauf, J.P.5    Ong, S.T.6
  • 50
    • 0033563309 scopus 로고    scopus 로고
    • high lymphocytes enriched in the splenic marginal zone generate effector cells more rapidly than the bulk of follicular B cells
    • high lymphocytes enriched in the splenic marginal zone generate effector cells more rapidly than the bulk of follicular B cells. J. Immunol. 1999. 162: 7198-7207.
    • (1999) J. Immunol , vol.162 , pp. 7198-7207
    • Oliver, A.M.1    Martin, F.2    Kearney, J.F.3
  • 51
    • 22144455025 scopus 로고    scopus 로고
    • Vav proteins are required for B-lymphocyte responses to LPS
    • Hebeis, B., Vigorito, E., Kovesdi, D. and Turner, M., Vav proteins are required for B-lymphocyte responses to LPS. Blood 2005. 106: 635-640.
    • (2005) Blood , vol.106 , pp. 635-640
    • Hebeis, B.1    Vigorito, E.2    Kovesdi, D.3    Turner, M.4
  • 52
    • 0030832150 scopus 로고    scopus 로고
    • Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses
    • Oliver, A. M., Martin, F., Gartland, G. L., Carter, R. H. and Kearney, J. F., Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses. Eur. J. Immunol. 1997. 27: 2366-2374.
    • (1997) Eur. J. Immunol , vol.27 , pp. 2366-2374
    • Oliver, A.M.1    Martin, F.2    Gartland, G.L.3    Carter, R.H.4    Kearney, J.F.5
  • 53
    • 33749685322 scopus 로고    scopus 로고
    • Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling
    • Omori, S. A., Cato, M. H., Anzelon-Mills, A., Puri, K. D., Shapiro-Shelef, M., Calame, K. and Rickert, R. C., Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling. Immunity 2006. 25: 545-557.
    • (2006) Immunity , vol.25 , pp. 545-557
    • Omori, S.A.1    Cato, M.H.2    Anzelon-Mills, A.3    Puri, K.D.4    Shapiro-Shelef, M.5    Calame, K.6    Rickert, R.C.7
  • 54
    • 0029882545 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase activation in normal human B lymphocytes
    • Aagaard-Tillery, K. M. and Jelinek, D. F., Phosphatidylinositol 3-kinase activation in normal human B lymphocytes. J. Immunol. 1996. 156: 4543-4554.
    • (1996) J. Immunol , vol.156 , pp. 4543-4554
    • Aagaard-Tillery, K.M.1    Jelinek, D.F.2
  • 55
    • 0019865787 scopus 로고
    • Marginal zones: The major B cell compartment of rat spleens
    • Kumararatne, D. S., Bazin, H. and MacLennan, I. C., Marginal zones: The major B cell compartment of rat spleens. Eur. J. Immunol. 1981. 11: 858-864.
    • (1981) Eur. J. Immunol , vol.11 , pp. 858-864
    • Kumararatne, D.S.1    Bazin, H.2    MacLennan, I.C.3
  • 56
    • 25444457577 scopus 로고    scopus 로고
    • hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
    • Byfield, M. P., Murray, J. T. and Backer, J. M., hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J. Biol. Chem. 2005. 280: 33076-33082.
    • (2005) J. Biol. Chem , vol.280 , pp. 33076-33082
    • Byfield, M.P.1    Murray, J.T.2    Backer, J.M.3
  • 57
    • 26444575415 scopus 로고    scopus 로고
    • Amino acids mediate mTOR/ raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
    • Nobukuni, T., Joaquin, M., Roccio, M., Dann, S. G., Kim, S. Y., Gulati, P., Byfield, M. P. et al., Amino acids mediate mTOR/ raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc. Natl. Acad. Sci. USA 2005. 102: 14238-14243.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 14238-14243
    • Nobukuni, T.1    Joaquin, M.2    Roccio, M.3    Dann, S.G.4    Kim, S.Y.5    Gulati, P.6    Byfield, M.P.7
  • 58
    • 15444378732 scopus 로고    scopus 로고
    • Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid
    • Avila-Flores, A., Santos, T., Rincon, E. and Merida, I., Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid. J. Biol. Chem. 2005. 280: 10091-10099.
    • (2005) J. Biol. Chem , vol.280 , pp. 10091-10099
    • Avila-Flores, A.1    Santos, T.2    Rincon, E.3    Merida, I.4
  • 59
    • 0036776168 scopus 로고    scopus 로고
    • A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling
    • Chen, J. and Fang, Y., A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling. Biochem. Pharmacol. 2002. 64: 1071-1077.
    • (2002) Biochem. Pharmacol , vol.64 , pp. 1071-1077
    • Chen, J.1    Fang, Y.2
  • 60
    • 0035976615 scopus 로고    scopus 로고
    • Phosphatidic acid-mediated mitogenic activation of mTOR signaling
    • Fang, Y., Vilella-Bach, M., Bachmann, R., Flanigan, A. and Chen, J., Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science 2001. 294: 1942-1945.
    • (2001) Science , vol.294 , pp. 1942-1945
    • Fang, Y.1    Vilella-Bach, M.2    Bachmann, R.3    Flanigan, A.4    Chen, J.5
  • 61
    • 33750813851 scopus 로고    scopus 로고
    • Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway
    • Tang, W., Yuan, J., Chen, X., Gu, X., Luo, K., Li, J., Wan, B. et al., Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway. J. Biochem. Mol. Biol. 2006. 39: 626-635.
    • (2006) J. Biochem. Mol. Biol , vol.39 , pp. 626-635
    • Tang, W.1    Yuan, J.2    Chen, X.3    Gu, X.4    Luo, K.5    Li, J.6    Wan, B.7
  • 63
    • 33144458615 scopus 로고    scopus 로고
    • Signaling roles of diacylglycerol kinases
    • Topham, M. K., Signaling roles of diacylglycerol kinases. J. Cell. Biochem. 2006. 97: 474-484.
    • (2006) J. Cell. Biochem , vol.97 , pp. 474-484
    • Topham, M.K.1
  • 64
    • 0037629646 scopus 로고    scopus 로고
    • Fukao, T. and Koyasu, S., PI3K and negative regulation of TLR signaling. Trends Immunol. 2003. 24: 358-363.
    • Fukao, T. and Koyasu, S., PI3K and negative regulation of TLR signaling. Trends Immunol. 2003. 24: 358-363.
  • 65
    • 33646471083 scopus 로고    scopus 로고
    • TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expression
    • Yu, Y., Nagai, S., Wu, H., Neish, A. S., Koyasu, S. and Gewirtz, A. T., TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expression. J. Immunol. 2006. 176: 6194-6201.
    • (2006) J. Immunol , vol.176 , pp. 6194-6201
    • Yu, Y.1    Nagai, S.2    Wu, H.3    Neish, A.S.4    Koyasu, S.5    Gewirtz, A.T.6
  • 66
    • 0033520020 scopus 로고    scopus 로고
    • Bacterial lipopolysaccharide induced B cell activation is mediated via a phosphatidylinositol 3-kinase dependent signaling pathway
    • Venkataraman, C., Shankar, G., Sen, G. and Bondada, S., Bacterial lipopolysaccharide induced B cell activation is mediated via a phosphatidylinositol 3-kinase dependent signaling pathway. Immunol. Lett. 1999. 69: 233-238.
    • (1999) Immunol. Lett , vol.69 , pp. 233-238
    • Venkataraman, C.1    Shankar, G.2    Sen, G.3    Bondada, S.4
  • 67
    • 0029831167 scopus 로고    scopus 로고
    • Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002
    • Brunn, G. J., Williams, J., Sabers, C., Wiederrecht, G., Lawrence, J. C., Jr. and Abraham, R. T., Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J. 1996. 15: 5256-5267.
    • (1996) EMBO J , vol.15 , pp. 5256-5267
    • Brunn, G.J.1    Williams, J.2    Sabers, C.3    Wiederrecht, G.4    Lawrence Jr., J.C.5    Abraham, R.T.6
  • 68
    • 33646383684 scopus 로고    scopus 로고
    • A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling
    • Knight, Z. A., Gonzalez, B., Feldman, M. E., Zunder, E. R., Goldenberg, D. D., Williams, O., Loewith, R. et al., A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell 2006. 125: 733-747.
    • (2006) Cell , vol.125 , pp. 733-747
    • Knight, Z.A.1    Gonzalez, B.2    Feldman, M.E.3    Zunder, E.R.4    Goldenberg, D.D.5    Williams, O.6    Loewith, R.7
  • 69
    • 0033712984 scopus 로고    scopus 로고
    • Xid-like phenotypes: A B cell signalosome takes shape
    • Fruman, D. A., Satterthwaite, A. B. and Witte, O. N., Xid-like phenotypes: A B cell signalosome takes shape. Immunity 2000. 13: 1-3.
    • (2000) Immunity , vol.13 , pp. 1-3
    • Fruman, D.A.1    Satterthwaite, A.B.2    Witte, O.N.3


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