PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells

Journal of Experimental Medicine

Volumn 209, Issue 13, 2012, Pages 2441-2453

  Finlay, David K ^a   Rosenzweig, Ella ^b   Sinclair, Linda V ^b   Carmen, Feijoo Carnero ^b   Hukelmann, Jens L ^b   Rolf, Julia ^b   Panteleyev, Andrey A ^b   Okkenhaug, Klaus ^c   Cantrell, Doreen A ^b  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER; HYPOXIA INDUCIBLE FACTOR 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B;

ANIMAL CELL; ARTICLE; CD8+ T LYMPHOCYTE; CELL METABOLISM; CONTROLLED STUDY; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE MIGRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL MOVEMENT; CHEMOKINES; GENE EXPRESSION REGULATION; GLUCOSE; GLYCOLYSIS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTERLEUKIN-2; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, TRANSGENIC; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, CHEMOKINE; TOR SERINE-THREONINE KINASES;

EID: 84871861969     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20112607     Document Type: Article

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