A phase I/II, non-randomized, feasibility/safety and efficacy study of the combination of everolimus, cetuximab and capecitabine in patients with advanced pancreatic cancer

Investigational New Drugs

Volumn 31, Issue 1, 2013, Pages 85-91

  Kordes, Sil ^a   Richel, Dick J ^a   Klümpen, Heinz Josef ^a   Weterman, Mariëtte J ^a   Stevens, Arnoldus J W M ^a   Wilmink, Johanna W ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Capecitabine; Cetuximab; Everolimus; Pancreatic cancer; Phase I; Phase II

Indexed keywords

CAPECITABINE; CETUXIMAB; DOXYCYCLINE; EVEROLIMUS; METRONIDAZOLE;

ADULT; ADVANCED CANCER; AGED; ANEMIA; ARTICLE; BRAIN INFARCTION; CANCER COMBINATION CHEMOTHERAPY; CANCER CONTROL; CANCER PATIENT; CANCER SURVIVAL; CHEMOTHERAPY INDUCED EMESIS; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOSE RESPONSE; DRUG DOSE ESCALATION; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG ERUPTION; DRUG SAFETY; DRUG WITHDRAWAL; FATIGUE; FEASIBILITY STUDY; FEMALE; HAND FOOT SYNDROME; HUMAN; HUMAN CELL; HYPERGLYCEMIA; HYPOKALEMIA; INFECTION; MALE; MAXIMUM TOLERATED DOSE; MUCOSA INFLAMMATION; MULTIPLE CYCLE TREATMENT; NEUTROPENIA; OPEN STUDY; OVERALL SURVIVAL; PANCREAS CANCER; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; SURVIVAL TIME; THROMBOCYTOPENIA; TREATMENT RESPONSE;

ADULT; AGED; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DEOXYCYTIDINE; FEASIBILITY STUDIES; FEMALE; FLUOROURACIL; HUMANS; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; SIROLIMUS; TREATMENT OUTCOME;

EID: 84873076650     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-012-9802-1     Document Type: Article

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