Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives

Molecular Aspects of Medicine

Volumn 34, Issue 4, 2013, Pages 782-812

  Milagro, F I ^a   Mansego, M L ^a   De Miguel, C ^a   Martinez J A ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

DNA methylation; Epigenetic biomarkers; Histone modifications; Hyperglycemia; Hypoxia; Inflammation; Oxidative stress; Polyphenols

Indexed keywords

AMINO ACID; BIOLOGICAL MARKER; CATECHIN; CURCUMIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ENDOCRINE DISRUPTOR; FATTY ACID; GENISTEIN; HISTONE DEACETYLASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR; METHYL GROUP; MINERAL; NEUROPEPTIDE; POLYPHENOL; RESVERATROL; TOXIC SUBSTANCE; TRICHOSTATIN A; VITAMIN;

CALORIC INTAKE; CALORIC RESTRICTION; CIRCADIAN RHYTHM; DIETARY INTAKE; DNA MODIFICATION; DRUG EFFECT; ENDOCRINE DISEASE; ENVIRONMENTAL FACTOR; ENVIRONMENTAL TEMPERATURE; EPIGENETICS; GENE EXPRESSION REGULATION; GENETIC SUSCEPTIBILITY; GENETIC TRAIT; HUMAN; HYPERGLYCEMIA; HYPOXIA; IMMUNOCOMPETENT CELL; INFECTION SENSITIVITY; INFLAMMATION; INHERITANCE; LACTATION; LIPID DIET; MENTAL STRESS; MICROBIOME; NONHUMAN; NUTRITIONAL HEALTH; OBESITY; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PHYSICAL ACTIVITY; PREGNANCY; PROTEIN EXPRESSION; PROTEIN RESTRICTION; REVIEW; SLEEP TIME; SOCIAL STATUS;

ANIMALS; CIRCADIAN RHYTHM; DIET; DNA METHYLATION; EPIGENESIS, GENETIC; HISTONES; HUMANS; HYPERGLYCEMIA; OBESITY; OXIDATIVE STRESS; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 84878106876     PISSN: 00982997     EISSN: 18729452     Source Type: Journal    
DOI: 10.1016/j.mam.2012.06.010     Document Type: Review

References (337)

1. S.H. Adams Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state Adv. Nutr. 2 2011 445 456
2. V. Adler, Z. Yin, K.D. Tew, and Z. Ronai Role of redox potential and reactive oxygen species in stress signaling Oncogene 18 1999 6104 6111
3. A.M. Akimzhanov, X.O. Yang, and C. Dong Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation J. Biol. Chem. 282 2007 5969 5972
4. T. Alenghat, K. Meyers, S.E. Mullican, K. Leitner, A. Adeniji-Adele, J. Avila, M. Bućan, R.S. Ahima, K.H. Kaestner, and M.A. Lazar Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology Nature 456 2008 997 1000
5. M.S. Al-Moundhri, M. Al-Nabhani, L. Tarantini, A. Baccarelli, and J.A. Rusiecki The prognostic significance of whole blood global and specific DNA methylation levels in gastric adenocarcinoma PLoS One 5 2010 e15585
6. L. Altucci, and H.G. Stunnenberg Time for epigenetics Int. J. Biochem. Cell Biol. 41 2009 2 3
7. S. Alvarez, J. Suela, A. Valencia, A. Fernández, M. Wunderlich, X. Agirre, F. Prósper, J.I. Martín-Subero, A. Maiques, F. Acquadro, S. Rodriguez Perales, M.J. Calasanz, J. Roman-Gómez, R. Siebert, J.C. Mulloy, J. Cervera, M.A. Sanz, M. Esteller, and J.C. Cigudosa DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia PLoS One 5 2010 e12197
8. M.D. Anway, A.S. Cupp, M. Uzumcu, and M.K. Skinner Epigenetic transgenerational actions of endocrine disruptors and male fertility Science 308 2005 1466 1469
9. M.D. Anway, and M.K. Skinner Epigenetic programming of the germ line: effects of endocrine disruptors on the development of transgenerational disease Reprod. Biomed. Online 16 2008 23 25
10. A. Baccarelli, M. Rienstra, and E.J. Benjamin Cardiovascular epigenetics: basic concepts and results from animal and human studies Circ. Cardiovasc. Genet. 3 2010 567 573
11. A. Baccarelli, R. Wright, V. Bollati, A. Litonjua, A. Zanobetti, L. Tarantini, D. Sparrow, P. Vokonas, and J. Schwartz Ischemic heart disease and stroke in relation to blood DNA methylation Epidemiology 21 2010 819 828
12. A. Baccarelli, R.O. Wright, V. Bollati, L. Tarantini, A.A. Litonjua, H.H. Suh, A. Zanobetti, D. Sparrow, P.S. Vokonas, and J. Schwartz Rapid DNA methylation changes after exposure to traffic particles Am. J. Respir. Crit. Care Med. 179 2009 572 578
13. L. Bäckdahla, A. Bushellb, and S. Beck Inflammatory signalling as mediator of epigenetic modulation in tissue-specific chronic inflammation Int. J. Biochem. Cell Biol. 41 2009 176 184
14. C.A. Baile, J.Y. Yang, S. Rayalam, D.L. Hartzell, C.Y. Lai, C. Andersen, and M.A. Della-Fera Effect of resveratrol on fat mobilization Ann. NY Acad. Sci. 1215 2011 40 47
15. G. Barbatelli, I. Murano, L. Madsen, Q. Hao, M. Jimenez, K. Kristiansen, J.P. Giacobino, R. De Matteis, and S. Cinti The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation Am. J. Physiol. Endocrinol. Metab. 298 2010 E1244 E1253
16. R. Barrès, M.E. Osler, J. Yan, A. Rune, T. Fritz, K. Caidahl, A. Krook, and J.R. Zierath Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density Cell Metab. 10 2009 189 198
17. F.J. Basterra-Gortari, L. Forga, M. Bes-Rastrollo, E. Toledo, J.A. Martínez, and M.A. Martínez-González Effect of smoking on body weight: longitudinal analysis of the SUN cohort Rev. Esp. Cardiol. 63 2010 20 27
18. G. Begum, A. Stevens, E.B. Smith, K. Connor, J.R. Challis, F. Bloomfield, and A. White Epigenetic changes in fetal hypothalamic energy regulating pathways are associated with maternal undernutrition and twinning FASEB J. 26 2012 1694 1703
19. S. Beyer, M.M. Kristensen, K.S. Jensen, J.V. Johansen, and P. Staller The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF J. Biol. Chem. 283 2008 36542 36552
20. S. Bo, G. Ciccone, M. Durazzo, L. Ghinamo, P. Villois, S. Canil, R. Gambino, M. Cassader, L. Gentile, and P. Cavallo-Perin Contributors to the obesity and hyperglycemia epidemics. A prospective study in a population-based cohort Int. J. Obes. 35 2011 1442 1449
21. G. Bocheva, and N. Boyadjieva Epigenetic regulation of fetal bone development and placental transfer of nutrients: progress for osteoporosis Interdiscip. Toxicol. 4 2011 167 172
22. V. Bollati, A. Baccarelli, S. Sartori, L. Tarantini, V. Motta, F. Rota, and G. Costa Epigenetic effects of shiftwork on blood DNA methylation Chronobiol. Int. 27 2010 1093 1104
23. Borgel, J., Guibert, S., Li, Y., Chiba, H., Schübeler, D., Sasaki, H., Forné, T., Weber, M., 2010. Targets and dynamics of promoter DNA methylation during early mouse development. Nat. Genet. 42, 1093-1100.
24. N. Borghol, M. Suderman, W. McArdle, A. Racine, M. Hallett, M. Pembrey, C. Hertzman, C. Power, and M. Szyf Associations with early-life socio-economic position in adult DNA methylation Int. J. Epidemiol. 41 2011 62 74
25. L. Bouchard, R. Rabasa-Lhoret, M. Faraj, M.E. Lavoie, J. Mill, L. Pérusse, and M.C. Vohl Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction Am. J. Clin. Nutr. 91 2010 309 320
26. Y. Boumber, and J.P. Issa Epigenetics in cancer: what's the future? Oncology 25 2011 220 226
27. D. Brasacchio, J. Okabe, C. Tikellis, A. Balcerczyk, P. George, E.K. Baker, A.C. Calkin, M. Brownlee, M.E. Cooper, and A. El-Osta Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail Diabetes 5 2009 1229 1236
28. C. Brigati, B. Banelli, A. di Vinci, I. Casciano, G. Allemanni, A. Forlani, L. Borzì, and M. Romani Inflammation, HIF-1, and the epigenetics that follows Mediators Inflamm. 2010 2010 263914
29. J.G. Bromer, Y. Zhou, M.B. Taylor, L. Doherty, and H.S. Taylor Bisphenol-A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response FASEB J. 24 2010 2273 2280
30. K.D. Bruce, F.R. Cagampang, M. Argenton, J. Zhang, P.L. Ethirajan, G.C. Burdge, A.C. Bateman, G.F. Clough, L. Poston, M.A. Hanson, J.M. McConnell, and C.D. Byrne Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression Hepatology 50 2009 1796 1808
31. L. Bujanda, E. Hijona, M. Larzabal, M. Beraza, P. Aldazabal, N. García-Urkia, C. Sarasqueta, A. Cosme, B. Irastorza, A. González, and J.I. Arenas Jr. Resveratrol inhibits nonalcoholic fatty liver disease in rats BMC Gastroenterol. 8 2008 40
32. S.J. Burke, J.J. Collier, and D.K. Scott CAMP prevents glucose-mediated modifications of histone H3 and recruitment of the RNA polymerase II holoenzyme to the L-PK gene promoter J. Mol. Biol. 392 2009 578 588
33. G.C. Burdge, K.A. Lillycrop, E.S. Phillips, J.L. Slater-Jefferies, A.A. Jackson, and M.A. Hanson Folic acid supplementation during the juvenile-pubertal period in rats modifies the phenotype and epigenotype induced by prenatal nutrition J. Nutr. 139 2009 1054 1060
34. C.E. Charron, P.C. Chou, D.J. Coutts, V. Kumar, M. To, K. Akashi, L. Pinhu, M. Griffiths, I.M. Adcock, P.J. Barnes, and K. Ito Hypoxia inducible factor 1α induces corticosteroid-insensitive inflammation via reduction of histone deacetylase-2 transcription J. Biol. Chem. 284 2009 36047 36054
35. P.C. Calder, N. Ahluwalia, F. Brouns, T. Buetler, K. Clement, K. Cunningham, K. Esposito, L.S. Jönsson, H. Kolb, M. Lansink, A. Marcos, A. Margioris, N. Matusheski, H. Nordmann, J. O'Brien, G. Pugliese, S. Rizkalla, C. Schalkwijk, J. Tuomilehto, J. Wärnberg, B. Watzl, and B.M. Winklhofer-Roob Dietary factors and low-grade inflammation in relation to overweight and obesity Br. J. Nutr. 106 2011 S5 S78
36. A. Camins, F.X. Sureda, F. Junyent, E. Verdaguer, J. Folch, C. Pelegri, J. Vilaplana, C. Beas-Zarate, and M. Pallàs Sirtuin activators: designing molecules to extend life span Biochim. Biophys. Acta 1799 2010 740 749
37. J. Campión, F. Milagro, and J.A. Martínez Epigenetics and obesity Prog. Mol. Biol. Transl. Sci. 94 2010 291 347
38. J. Campión, F.I. Milagro, D. Fernández, and J.A. Martínez Vitamin C supplementation influences body fat mass and steroidogenesis-related genes when fed a high-fat diet Int. J. Vitam. Nutr. Res. 78 2008 87 95
39. J. Campión, F.I. Milagro, E. Goyenechea, and J.A. Martínez TNF-alpha promoter methylation as a predictive biomarker for weight-loss response Obesity 17 2009 1293 1297
40. J. Campión, F.I. Milagro, and J.A. Martínez Individuality and epigenetics in obesity Obes. Rev. 10 2009 383 392
41. P.D. Cani, and N.M. Delzenne The gut microbiome as therapeutic target Pharmacol. Ther. 130 2011 202 212
42. L. Cao, E.Y. Choi, X. Liu, A. Martin, C. Wang, X. Xu, and M.J. During White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis Cell Metab. 14 2011 324 338
43. B.R. Carone, L. Fauquier, N. Habib, J.M. Shea, C.E. Hart, R. Li, C. Bock, C. Li, H. Gu, P.D. Zamore, A. Meissner, Z. Weng, H.A. Hofmann, N. Friedman, and O.J. Rando Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals Cell 143 2010 1084 1096
44. V. Ceccarelli, S. Racanicchi, M.P. Martelli, G. Nocentini, K. Fettucciari, C. Riccardi, P. Marconi, P. Di Nardo, F. Grignani, L. Binaglia, and A. Vecchini Eicosapentaenoic acid demethylates a single CpG that mediates expression of tumor suppressor CCAAT/enhancer-binding protein delta in U937 leukemia cells J. Biol. Chem. 286 2011 27092 27102
45. T.K. Chatterjee, G. Idelman, V. Blanco, A.L. Blomkalns, M.G. Piegore Jr., D.S. Weintraub, S. Kumar, S. Rajsheker, D. Manka, S.M. Rudich, Y. Tang, D.Y. Hui, R. Bassel-Duby, E.N. Olson, J.B. Lingrel, S.M. Ho, and N.L. Weintraub Histone deacetylase 9 is a negative regulator of adipogenic differentiation J. Biol. Chem. 286 2011 27836 27847
46. N. Chaudhary, K.K. Nakka, N. Maulik, and S. Chattopadhyay Epigenetic manifestation of metabolic syndrome and dietary management Antioxid. Redox Signal. 17 2012 254 281
47. S. Chen, and N. Sang Histone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors J. Biomed. Biotechnol. 2011 2011 197946
48. Y.K. Chen, C. Cheung, K.R. Reuhl, A.B. Liu, M.J. Lee, Y.P. Lu, and C.S. Yang Effects of green tea polyphenol (-)-epigallocatechin-3-gallate on newly developed high-fat/Western-style diet-induced obesity and metabolic syndrome in mice J. Agric. Food Chem. 59 2011 11862 11871
49. H. Chen, Y. Yan, T.L. Davidson, Y. Shinkai, and M. Costa Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells Cancer Res. 66 2006 9009 9016
50. Cheng, T.F., Choudhuri, S., Muldoon-Jacobs, K., 2012. Epigenetic targets of some toxicologically relevant metals: a review of the literature. J. Appl. Toxicol. (Epub ahead of print).
51. E.P. Chiang, Y.C. Wang, W.W. Chen, and F.Y. Tang Effects of insulin and glucose on cellular metabolic fluxes in homocysteine transsulfuration, remethylation, S-adenosylmethionine synthesis, and global deoxyribonucleic acid methylation J. Clin. Endocrinol. Metab. 94 2009 1017 1025
52. K.C. Choi, M.G. Jung, Y.H. Lee, J.C. Yoon, S.H. Kwon, H.B. Kang, M.J. Kim, J.H. Cha, Y.J. Kim, W.J. Jun, J.M. Lee, and H.G. Yoon Epigallocatechin-3- gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation Cancer Res. 69 2009 583 592
53. K.M. Choi, Y.S. Lee, D.M. Sin, S. Lee, M.K. Lee, Y.M. Lee, J.T. Hong, Y.P. Yun, and H.S. Yoo Sulforaphane inhibits mitotic clonal expansion during adipogenesis through cell cycle arrest Obesity 20 2012 1365 1371
54. Choi, S.W., Friso, S., 2010. Epigenetics: a new bridge between nutrition and health. Adv. Nutr. 1, 8-16.
55. B.C. Christensen, E.A. Houseman, C.J. Marsit, S. Zheng, M.R. Wrensch, J.L. Wiemels, H.H. Nelson, M.R. Karagas, J.F. Padbury, R. Bueno, D.J. Sugarbaker, R.F. Yeh, J.K. Wiencke, and K.T. Kelsey Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context PLoS Genet. 5 2009 e1000602
56. B.C. Christensen, and C.J. Marsit Epigenomics in environmental health Front. Genet. 2 2011 84
57. D.P. Christensen, M. Dahllöf, M. Lundh, D.N. Rasmussen, M.D. Nielsen, N. Billestrup, L.G. Grunnet, and T. Mandrup-Poulsen Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus Mol. Med. 17 2011 378 390
58. T.L. Chung, R.M. Brena, G. Kolle, S.M. Grimmond, B.P. Berman, P.W. Laird, M.F. Pera, and E.J. Wolvetang Vitamin C promotes widespread yet specific DNA demethylation of the epigenome in human embryonic stem cells Stem Cells 28 2010 1848 1855
59. W.N. Cooper, B. Khulan, S. Owens, C.E. Elks, V. Seidel, A.M. Prentice, G. Belteki, K.K. Ong, N.A. Affara, M. Constância, and D.B. Dunger DNA methylation profiling at imprinted loci after periconceptional micronutrient supplementation in humans: results of a pilot randomized controlled trial FASEB J. 26 2012 1782 1790
60. P. Cordero, J. Campion, F.I. Milagro, E. Goyenechea, T. Steemburgo, B.M. Javierre, and J.A. Martinez Leptin and TNF-alpha promoter methylation levels measured by MSP could predict the response to a low-calorie diet J. Physiol. Biochem. 67 2011 463 470
61. Cordero, P., Campion, J., Milagro, F.I., Martínez, J.A., 2011. Dietary supplementation with methyl donor groups could prevent nonalcoholic fatty liver. Hepatology 53, 2151-2152.
62. J.F. Costello, M. Krzywinski, and M.A. Marra A first look at entire human methylomes Nat. Biotechnol. 27 2009 1130 1132
63. O. Couvreur, J. Ferezou, D. Gripois, C. Serougne, D. Crépin, A. Aubourg, A. Gertler, C.M. Vacher, and M. Taouis Unexpected long-term protection of adult offspring born to high-fat fed dams against obesity induced by a sucrose-rich diet PLoS One 6 2011 e18043
64. Y.M. Coyle, X.J. Xie, C.M. Lewis, D. Bu, S. Milchgrub, and D.M. Euhus Role of physical activity in modulating breast cancer risk as defined by APC and RASSF1A promoter hypermethylation in nonmalignant breast tissue Cancer Epidemiol. Biomarkers Prev. 16 2007 192 196
65. K.S. Crider, E.P. Quinlivan, R.J. Berry, L. Hao, Z. Li, D. Maneval, T.P. Yang, S.A. Rasmussen, Q. Yang, J.H. Zhu, D.J. Hu, and L.B. Bailey Genomic DNA methylation changes in response to folic acid supplementation in a population-based intervention study among women of reproductive age PLoS One 6 2011 e28144
66. J.E. Cropley, C.M. Suter, K.B. Beckman, and D.I. Martin Germ-line epigenetic modification of the murine Avy allele by nutritional supplementation Proc. Nat. Acad. Sci. USA 103 2006 17308 17312
67. Z.C. Dang Dose-dependent effects of soy phyto-oestrogen genistein on adipocytes: mechanisms of action Obes. Rev. 10 2009 342 349
68. R.H. Dashwood, and E. Ho Dietary histone deacetylase inhibitors: from cells to mice to man Semin. Cancer Biol. 17 2007 363 369
69. L. Daxinger, and E. Whitelaw Understanding transgenerational epigenetic inheritance via the gametes in mammals Nat. Rev. Genet. 13 2012 153 162
70. F. De Santa, M.G. Totaro, E. Prosperini, S. Notarbartolo, G. Testa, and G. Natoli The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing Cell 130 2007 1083 1094
71. D. Deng, Z. Liu, and Y. Du Epigenetic alterations as cancer diagnostic, prognostic, and predictive biomarkers Adv. Genet. 71 2010 125 176
72. E.M. Dioum, J.K. Osborne, S. Goetsch, J. Russell, J.W. Schneider, and M.H. Cobb A small molecule differentiation inducer increases insulin production by pancreatic β cells Proc. Nat. Acad. Sci. USA 108 2011 20713 20718
73. W. Doerfler Epigenetic consequences of foreign DNA insertions: de novo methylation and global alterations of methylation patterns in recipient genomes Rev. Med. Virol. 21 2011 336 346
74. D.C. Dolinoy, J.R. Weidman, R.A. Waterland, and R.L. Jirtle Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome Environ. Health Perspect. 114 2006 567 572
75. J. Dong, E. Jimi, H. Zhong, M.S. Hayden, and S. Ghosh Repression of gene expression by unphosphorylated NF-kappaB p65 through epigenetic mechanisms Gene Dev. 22 2008 1159 1173
76. G.A. Dunn, and T.L. Bale Maternal high-fat diet effects on third-generation female body size via the paternal lineage Endocrinology 152 2011 2228 2236
77. G.A. Dunn, and T.L. Bale Maternal high-fat diet promotes body length increases and insulin insensitivity in second-generation mice Endocrinology 150 2009 4999 5009
78. F. Einstein, R.F. Thompson, T.D. Bhagat, M.J. Fazzari, A. Verma, N. Barzilai, and J.M. Greally Cytosine methylation dysregulation in neonates following intrauterine growth restriction PLoS One 5 2010 e8887
79. A. Ejaz, D. Wu, P. Kwan, and M. Meydani Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice J. Nutr. 139 2009 919 925
80. M.M. Elahi, F.R. Cagampang, D. Mukhtar, F.W. Anthony, S.K. Ohri, and M.A. Hanson Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice Br. J. Nutr. 102 2009 514 519
81. A. El-Osta, D. Brasacchio, D. Yao, A. Pocai, P.L. Jones, R.G. Roeder, M.E. Cooper, and M. Brownlee Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia J. Exp. Med. 205 2008 2409 2417
82. V.R. Elsner, G.A. Lovatel, K. Bertoldi, C. Vanzella, F.M. Santos, C. Spindler, E.F. de Almeida, P. Nardin, and I.R. Siqueira Effect of different exercise protocols on histone acetyltransferases and histone deacetylases activities in rat hippocampus Neuroscience 192 2011 580 587
83. S. Erener, M. Hesse, R. Kostadinova, and M.O. Hottiger Poly(ADP-ribose)polymerase-1 (PARP1) controls adipogenic gene expression and adipocyte function Mol. Endocrinol. 26 2012 79 86
84. T.E. Fandy, J.G. Herman, P. Kerns, A. Jiemjit, E.A. Sugar, S.H. Choi, A.S. Yang, T. Aucott, T. Dauses, R. Odchimar-Reissig, J. Licht, M.J. McConnell, C. Nasrallah, M.K. Kim, W. Zhang, Y. Sun, A. Murgo, I. Espinoza-Delgado, K. Oteiza, I. Owoeye, L.R. Silverman, S.D. Gore, and H.E. Carraway Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies Blood 114 2009 2764 2773
85. M.Z. Fang, Y. Wang, N. Ai, Z. Hou, Y. Sun, H. Lu, W. Welsh, and C.S. Yang Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines Cancer Res. 63 2003 7563 7570
86. Feinberg, A.P., Irizarry, R.A., Fradin, D., Aryee, M.J., Murakami, P., Aspelund, T., Eiriksdottir, G., Harris, T.B., Launer, L., Gudnason, V., Fallin, M.D., 2010. Personalized epigenomic signatures that are stable over time and covary with body mass index. Sci. Transl. Med. 2, 49ra67.
87. S. Feng, S.E. Jacobsen, and W. Reik Epigenetic reprogramming in plant and animal development Science 330 2010 622 627
88. H.M. Findeisen, K.J. Pearson, F. Gizard, Y. Zhao, H. Qing, K.L. Jones, D. Cohn, E.B. Heywood, R. de Cabo, and D. Bruemmer Oxidative stress accumulates in adipose tissue during aging and inhibits adipogenesis PLoS One 6 2011 e18532
89. C.G. Fraga, M. Galleano, S.V. Verstraeten, and P.I. Oteiza Basic biochemical mechanisms behind the health benefits of polyphenols Mol. Aspects Med. 31 2010 435 445
90. M.F. Fraga, E. Ballestar, M.F. Paz, S. Ropero, F. Setien, M.L. Ballestar, D. Heine-Suñer, J.C. Cigudosa, M. Urioste, J. Benitez, M. Boix-Chornet, A. Sanchez-Aguilera, C. Ling, E. Carlsson, P. Poulsen, A. Vaag, Z. Stephan, T.D. Spector, Y.Z. Wu, C. Plass, and M. Esteller Epigenetic differences arise during the lifetime of monozygotic twins Proc. Nat. Acad. Sci. U.S.A. 102 2005 10604 10609
91. K. Fujiki, F. Kano, K. Shiota, and M. Murata Expression of the peroxisome proliferator activated receptor gamma gene is repressed by DNA methylation in visceral adipose tissue of mouse models of diabetes BMC Biol. 7 2009 38
92. K. Fujiwara, N. Fujimoto, M. Tabata, K. Nishii, K. Matsuo, K. Hotta, T. Kozuki, M. Aoe, K. Kiura, H. Ueoka, and M. Tanimoto Identification of epigenetic aberrant promoter methylation in serum DNA is useful for early detection of lung cancer Clin. Cancer Res. 11 2005 1219 1225
93. H. Funato, S. Oda, J. Yokofujita, H. Igarashi, and M. Kuroda Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus PLoS One 6 2011 e18950
94. S. Furukawa, T. Fujita, M. Shimabukuro, M. Iwaki, Y. Yamada, Y. Nakajima, O. Nakayama, M. Makishima, M. Matsuda, and I. Shimomura Increased oxidative stress in obesity and its impact on metabolic syndrome J. Clin. Invest. 114 2004 1752 1761
95. P.S. Gambhir, and M.A. Phadke Is chromium from stainless steel utensils responsible for epidemic of type 2 diabetes? Med Hypotheses 77 2011 84 86
96. M. Garaulet, M.D. Corbalán, J.A. Madrid, E. Morales, J.C. Baraza, Y.C. Lee, and J.M. Ordovas CLOCK gene is implicated in weight reduction in obese patients participating in a dietary programme based on the Mediterranean diet Int. J. Obes. 34 2010 516 523
97. B.P. Gargari, V. Aghamohammadi, and A. Aliasgharzadeh Effect of folic acid supplementation on biochemical indices in overweight and obese men with type 2 diabetes Diabetes Res. Clin. Pract. 94 2011 33 38
98. J. Geisel, H. Schorr, M. Bodis, S. Isber, U. Hübner, J.P. Knapp, R. Obeid, and W. Herrmann The vegetarian lifestyle and DNA methylation Clin. Chem. Lab. Med. 43 2005 1164 1169
99. C. Gemma, S. Sookoian, G. Dieuzeide, S.I. García, T.F. Gianotti, C.D. González, and C.J. Pirola Methylation of TFAM gene promoter in peripheral white blood cells is associated with insulin resistance in adolescents Mol. Genet. Metab. 100 2010 83 87
100. T. Gerken, C.A. Girard, Y.C. Tung, C.J. Webby, V. Saudek, K.S. Hewitson, G.S. Yeo, M.A. McDonough, S. Cunliffe, L.A. McNeill, J. Galvanovskis, P. Rorsman, P. Robins, X. Prieur, A.P. Coll, M. Ma, Z. Jovanovic, I.S. Farooqi, B. Sedgwick, I. Barroso, T. Lindahl, C.P. Ponting, F.M. Ashcroft, S. O'Rahilly, and C.J. Schofield The obesity-associated FTO gene encodes a 2-oxoglutarate- dependent nucleic acid demethylase Science 318 2007 1469 1472
101. C.P. Gheorghe, R. Goyal, A. Mittal, and L.D. Longo Gene expression in the placenta: maternal stress and epigenetic responses Int. J. Dev. Biol. 54 2010 507 523
102. P.D. Gluckman, M.A. Hanson, T. Buklijas, F.M. Low, and A.S. Beedle Epigenetic mechanisms that underpin metabolic and cardiovascular diseases Nat. Rev. Endocrinol. 5 2009 401 408
103. K.M. Godfrey, A. Sheppard, P.D. Gluckman, K.A. Lillycrop, G.C. Burdge, C. McLean, J. Rodford, J.L. Slater-Jefferies, E. Garratt, S.R. Crozier, B.S. Emerald, C.R. Gale, H.M. Inskip, C. Cooper, and M.A. Hanson Epigenetic gene promoter methylation at birth is associated with child's later adiposity Diabetes 60 2011 1528 1534
104. L. Gong, Y.X. Pan, and H. Chen Gestational low protein diet in the rat mediates Igf2 gene expression in male offspring via altered hepatic DNA methylation Epigenetics 5 2010 619 626
105. A. Gore, M. Muralidhar, M.G. Espey, K. Degenhardt, and L.L. Mantell Hyperoxia sensing: from molecular mechanisms to significance in disease J. Immunotoxicol. 7 2010 239 254
106. C. Gregg, J. Zhang, B. Weissbourd, S. Luo, G.P. Schroth, D. Haig, and C. Dulac High-resolution analysis of parent-of-origin allelic expression in the mouse brain Science 329 2010 643 648
107. A. Groom, C. Potter, D.C. Swan, G. Fatemifar, D.M. Evans, S.M. Ring, V. Turcot, M.S. Pearce, N.D. Embleton, G. Davey Smith, J.C. Mathers, and C.L. Relton Postnatal growth and DNA methylation are associated with differential gene expression of the TACSTD2 gene and childhood fat mass Diabetes 61 2012 391 400
108. F. Grün, and B. Blumberg Endocrine disrupters as obesogens Mol. Cell. Endocrinol. 304 2009 19 29
109. A.L. Guerrerio, R.M. Colvin, A.K. Schwartz, J.P. Molleston, K.F. Murray, A. Diehl, P. Mohan, J.B. Schwimmer, J.E. Lavine, M.S. Torbenson, and A.O. Scheimann Choline intake in a large cohort of patients with nonalcoholic fatty liver disease Am. J. Clin. Nutr. 95 2012 892 900
110. C. Guerrero-Bosagna, M. Settles, B. Lucker, and M.K. Skinner Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome PLoS One 5 2010 e13100
111. F. Guerrero-Romero, H.E. Tamez-Perez, G. González-González, A.M. Salinas-Martínez, J. Montes-Villarreal, J.H. Treviño-Ortiz, and M. Rodríguez-Morán Oral magnesium supplementation improves insulin sensitivity in non-diabetic subjects with insulin resistance. A double-blind placebo-controlled randomized trial Diabetes Metab. 30 2004 253 258
112. R.K. Hall, X.L. Wang, L. George, S.R. Koch, and D.K. Granner Insulin represses phosphoenolpyruvate carboxykinase gene transcription by causing the rapid disruption of an active transcription complex: a potential epigenetic effect Mol. Endocrinol. 21 2007 550 563
113. B. Hanley, J. Dijane, M. Fewtrell, A. Grynberg, S. Hummel, C. Junien, B. Koletzko, S. Lewis, H. Renz, M. Symonds, M. Gros, L. Harthoorn, K. Mace, F. Samuels, and E.M. van Der Beek Metabolic imprinting, programming and epigenetics - a review of present priorities and future opportunities Br. J. Nutr. 104 2010 S1 S25
114. Hanson, M., Gluckman, P.,2011. Developmental origins of noncommunicable disease: population and public health implications. Am. J. Clin. Nutr. 94, 1754S-1758S.
115. M. Hanson, K.M. Godfrey, K.A. Lillycrop, G.C. Burdge, and P.D. Gluckman Developmental plasticity and developmental origins of non-communicable disease: theoretical considerations and epigenetic mechanisms Prog. Biophys. Mol. Biol. 106 2011 272 280
116. M.A. Hanson, F.M. Low, and P.D. Gluckman Epigenetic epidemiology: the rebirth of soft inheritance Ann. Nutr. Metab. 58 2011 8 15
117. M.J. Heerwagen, M.R. Miller, L.A. Barbour, and J.E. Friedman Maternal obesity and fetal metabolic programming: a fertile epigenetic soil Am. J. Physiol. Regul. Integr. Comp. Physiol. 299 2010 R711 R722
118. C. Heim, and E.B. Binder Current research trends in early life stress and depression: Review of human studies on sensitive periods, gene-environment interactions, and epigenetics Exp. Neurol. 233 2012 102 111
119. B.T. Heijmans, E.W. Tobi, A.D. Stein, H. Putter, G.J. Blauw, E.S. Susser, P.E. Slagboom, and L.H. Lumey Persistent epigenetic differences associated with prenatal exposure to famine in humans Proc. Nat. Acad. Sci. U.S.A. 105 2008 17046 17049
120. A. Hinney, C.I. Vogel, and J. Hebebrand From monogenic to polygenic obesity: recent advances Eur. Child Adolesc. Psychiatry 19 2010 297 310
121. J. Hirayama, S. Sahar, B. Grimaldi, T. Tamaru, K. Takamatsu, Y. Nakahata, and P. Sassone-Corsi CLOCK-mediated acetylation of BMAL1 controls circadian function Nature 450 2007 1086 1090
122. E. Ho, L.M. Beaver, D.E. Williams, and R.H. Dashwood Dietary factors and epigenetic regulation for prostate cancer prevention Adv. Nutr. 2 2011 497 510
123. R. Holliday The inheritance of epigenetic defects Science 238 1987 163 170
124. S.A. Hopkins, J.C. Baldi, W.S. Cutfield, L. McCowan, and P.L. Hofman Exercise training in pregnancy reduces offspring size without changes in maternal insulin sensitivity J. Clin. Endocrinol. Metab. 95 2010 2080 2088
125. N. Hosogai, A. Fukuhara, K. Oshima, Y. Miyata, S. Tanaka, K. Segawa, S. Furukawa, Y. Tochino, R. Komuro, M. Matsuda, and I. Shimomura Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation Diabetes 56 2007 901 911
126. G.S. Hotamisligil Endoplasmic reticulum stress and the inflammatory basis of metabolic disease Cell 140 2010 900 917
127. N. Houstis, E.D. Rosen, and E.S. Lander Reactive oxygen species have a causal role in multiple forms of insulin resistance Nature 440 2006 944 948
128. T.D. Howard, S.M. Ho, L. Zhang, J. Chen, W. Cui, R. Slager, S. Gray, G.A. Hawkins, M. Medvedovic, and J.D. Wagner Epigenetic changes with dietary soy in cynomolgus monkeys PLoS One 6 2011 e26791
129. G.J. Howie, D.M. Sloboda, T. Kamal, and M.H. Vickers Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet J. Physiol. 587 2009 905 915
130. R. Humeniuk, P.J. Mishra, J.R. Bertino, and D. Banerjee Molecular targets for epigenetic therapy of cancer Curr. Pharm. Biotechnol. 10 2009 161 165
131. T. Inagaki, M. Tachibana, K. Magoori, H. Kudo, T. Tanaka, M. Okamura, M. Naito, T. Kodama, Y. Shinkai, and J. Sakai Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice Genes Cells 14 2009 991 1001
132. L.B. Iversen, K. Strandberg-Larsen, E. Prescott, P. Schnohr, and N.H. Rod Psychosocial risk factors, weight changes and risk of obesity: the Copenhagen City Heart Study Eur. J. Epidemiol. 27 2012 119 130
133. A.B. Johnson, N. Denko, and M.C. Barton Hypoxia induces a novel signature of chromatin modifications and global repression of transcription Mutat. Res. 640 2008 174 179
134. P.L. Jones, G.J. Veenstra, P.A. Wade, D. Vermaak, S.U. Kass, N. Landsberger, J. Strouboulis, and A.P. Wolffe Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription Nat. Genet. 19 1998 187 191
135. J.C. Jones-Smith, P. Gordon-Larsen, A. Siddiqi, and B.M. Popkin Cross-national comparisons of time trends in overweight inequality by socioeconomic status among women using repeated cross-sectional surveys from 37 developing countries, 1989-2007 Am. J. Epidemiol. 173 2011 667 675
136. C. Jousse, L. Parry, S. Lambert-Langlais, A.C. Maurin, J. Averous, A. Bruhat, V. Carraro, J. Tost, P. Letteron, P. Chen, R. Jockers, J.M. Launay, J. Mallet, and P. Fafournoux Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome FASEB J. 25 2011 3271 3278
137. E.R. Kang, K. Iqbal, D.A. Tran, G.E. Rivas, P. Singh, G.P. Pfeifer, and P.E. Szabó Effects of endocrine disruptors on imprinted gene expression in the mouse embryo Epigenetics 6 2011 937 950
138. E.A. Karlsson, and M.A. Beck The burden of obesity on infectious disease Exp. Biol. Med. 235 2010 1412 1424
139. P.T. Katzmarzyk, L. Pérusse, D.C. Rao, and C. Bouchard Spousal resemblance and risk of 7-year increases in obesity and central adiposity in the Canadian population Obes. Res. 7 1999 545 551
140. R. Kellermayer, S.E. Dowd, R.A. Harris, A. Balasa, T.D. Schaible, R.D. Wolcott, N. Tatevian, R. Szigeti, Z. Li, J. Versalovic, and C.W. Smith Colonic mucosal DNA methylation, immune response, and microbiome patterns in Toll-like receptor 2-knockout mice FASEB J. 25 2011 1449 1460
141. K. Kempf, B. Rose, C. Herder, B. Haastert, A. Fusbahn-Laufenburg, A. Reifferscheid, W.A. Scherbaum, H. Kolb, and S. Martin The metabolic syndrome sensitizes leukocytes for glucose-induced immune gene expression J. Mol. Med. 85 2007 389 396
142. B. Khulan, W.N. Cooper, B. Skinner, J. Bauer, S. Owens, A.M. Prentice, G. Belteki, M. Constancia, D. Dunger, and N.A. Affar Periconceptional maternal micronutrient supplementation leads to widespread changes in the epigenome: a study of a unique resource in the Gambia Hum. Mol. Genet. 21 2012 2086 2101
143. B. Kiec-Wilk, A. Sliwa, M. Mikolajczyk, M.T. Malecki, and J.C. Mathers The CpG island methylation regulated expression of endothelial proangiogenic genes in response to β-carotene and arachidonic acid Nutr. Cancer 63 2011 1053 1063
144. J.K. Kim, M. Samaranayake, and S. Pradhan Epigenetic mechanisms in mammals Cell. Mol. Life Sci. 66 2009 596 612
145. K.C. Kim, S. Friso, and S.W. Choi DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging J. Nutr. Biochem. 20 2009 917 926
146. M. Kim, T.I. Long, K. Arakawa, R. Wang, M.C. Yu, and P.W. Laird DNA methylation as a biomarker for cardiovascular disease risk PLoS One 5 2010 e9692
147. S.J. Kim, C. Nian, and C.H. McIntosh Adipocyte expression of the glucose-dependent insulinotropic polypeptide receptor involves gene regulation by PPARγ and histone acetylation J. Lipid Res. 52 2011 759 770
148. Y.H. Kim, H.C. Lee, S.Y. Kim, Y.I. Yeom, K.J. Ryu, B.H. Min, D.H. Kim, H.J. Son, P.L. Rhee, J.J. Kim, J.C. Rhee, H.C. Kim, H.K. Chun, W.M. Grady, and Y.S. Kim Epigenomic analysis of aberrantly methylated genes in colorectal cancer identifies genes commonly affected by epigenetic alterations Ann. Surg. Oncol. 18 2011 2338 2347
149. K. Kimura, T. Yamada, M. Matsumoto, Y. Kido, T. Hosooka, S. Asahara, T. Matsuda, T. Ota, H. Watanabe, Y. Sai, K. Miyamoto, S. Kaneko, M. Kasuga, and H. Inoue Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation Diabetes 61 2012 61 73
150. N. Kleefstra, S.T. Houweling, F.G. Jansman, K.H. Groenier, R.O. Gans, B. Meyboom-de Jong, S.J. Bakker, and H.J. Bilo Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial Diabetes Care 29 2006 521 525
151. H. Kolb, and T. Mandrup-Poulsen The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation Diabetologia 53 2010 10 20
152. G. Konycheva, M.A. Dziadek, L.R. Ferguson, C.U. Krägeloh, M.W. Coolen, M. Davison, and B.H. Breier Dietary methyl donor deficiency during pregnancy in rats shapes learning and anxiety in offspring Nutr. Res. 31 2011 790 804
153. A. Korkmaz, E.J. Sanchez-Barcelo, D.X. Tan, and R.J. Reiter Role of melatonin in the epigenetic regulation of breast cancer Breast Cancer Res. Treat. 115 2009 13 27
154. Ku, C.S., Park, Y., Coleman, S.L., Lee, J., 2011. Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264.7 macrophages. J. Nutr. Biochem. (Epub ahead of print).
155. A. Kulkarni, K. Dangat, A. Kale, P. Sable, P. Chavan-Gautam, and S. Joshi Effects of altered maternal folic acid, vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats PLoS One 6 2011 e17706
156. A. Kuroda, T.A. Rauch, I. Todorov, H.T. Ku, I.H. Al-Abdullah, F. Kandeel, Y. Mullen, G.P. Pfeifer, and K. Ferreri Insulin gene expression is regulated by DNA methylation PLoS One 4 2009 e6953
157. J.C. Lai, J.Y. Wu, Y.W. Cheng, K.T. Yeh, T.C. Wu, C.Y. Chen, and H. Lee O6-Methylguanine-DNA methyltransferase hypermethylation modulated by 17beta-estradiol in lung cancer cells Anticancer Res. 29 2009 2535 2540
158. C. Lavebratt, M. Almgren, and T.J. Ekström Epigenetic regulation in obesity Int. J. Obes. 36 2011 757 765
159. J.H. Lee, K.A. Kim, K.B. Kwon, E.K. Kim, Y.R. Lee, M.Y. Song, J.H. Koo, S.O. Ka, J.W. Park, and B.H. Park Diallyl disulfide accelerates adipogenesis in 3T3-L1 cells Int. J. Mol. Med. 20 2007 59 64
160. M.S. Lee, I.H. Kim, C.T. Kim, and Y. Kim Reduction of body weight by dietary garlic is associated with an increase in uncoupling protein mRNA expression and activation of AMP-activated protein kinase in diet-induced obese mice J. Nutr. 141 2011 1947 1953
161. J. Legler, T. Hamers, M. van Eck van der Sluijs-van de Bor, G. Schoeters, L. van der Ven, M. Eggesbo, J. Koppe, M. Feinberg, and T. Trnovec The OBELIX project: early life exposure to endocrine disruptors and obesity Am. J. Clin. Nutr. 94 2011 1933S 1938S
162. Lenoir O, Flosseau K, Ma FX, Blondeau B, Mai A, Bassel-Duby R, Ravassard P, Olson EN, Haumaitre C, Scharfmann R. Specific control of pancreatic endocrine β- and δ-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9. Diabetes 60, 2861-2871.
163. E.C. Lewis, L. Blaabjerg, J. Størling, S.G. Ronn, P. Mascagni, C.A. Dinarello, and T. Mandrup-Poulsen The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet β cells in vivo and in vitro Mol. Med. 17 2011 369 377
164. C.C. Li, J.E. Cropley, M.J. Cowley, T. Preiss, D.I. Martin, and C.M. Suter A sustained dietary change increases epigenetic variation in isogenic mice PLoS Genet. 7 2011 e1001380
165. J. Li, J. Huang, J.S. Li, H. Chen, K. Huang, and L. Zheng Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets J Hepatol. 56 2011 900 907
166. Y. Li, M. Daniel, and T.O. Tollefsbol Epigenetic regulation of caloric restriction in aging BMC Med. 9 2011 98
167. Y. Li, and T.O. Tollefsbol Impact on DNA methylation in cancer prevention and therapy by bioactive dietary components Curr. Med. Chem. 17 2010 2141 2151
168. P.V. Licciardi, S.S. Wong, M.L. Tang, and T.C. Karagiannis Epigenome targeting by probiotic metabolites Gut Pathog. 2 2010 24
169. C.K. Lii, C.Y. Huang, H.W. Chen, M.Y. Chow, Y.R. Lin, C.S. Huang, and C.W. Tsai Diallyl trisulfide suppresses the adipogenesis of 3T3-L1 preadipocytes through ERK activation Food Chem. Toxicol. 50 2011 478 484
170. K.A. Lillycrop, E.S. Phillips, C. Torrens, M.A. Hanson, A.A. Jackson, and G.C. Burdge Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring Br. J. Nutr. 100 2008 278 282
171. S.O. Lim, J.M. Gu, M.S. Kim, H.S. Kim, Y.N. Park, C.K. Park, J.W. Cho, Y.M. Park, and G. Jung Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter Gastroenterology 135 2008 2128 2140
172. H.S. Lin, C.Y. Hu, H.Y. Chan, Y.Y. Liew, H.P. Huang, L. Lepescheux, E. Bastianelli, R. Baron, G. Rawadi, and P. Clément-Lacroix Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents Br. J. Pharmacol. 150 2007 862 872
173. Q. Lin, H. Ding, Z. Zheng, Z. Gu, J. Ma, L. Chen, P. Chan, and Y. Cai Promoter methylation analysis of seven clock genes in Parkinson's disease Neurosci. Lett. 507 2012 147 150
174. F.J. Lippl, S. Neubauer, S. Schipfer, N. Lichter, A. Tufman, B. Otto, and R. Fischer Hypobaric hypoxia causes body weight reduction in obese subjects Obesity 18 2010 675 681
175. B. Liu, Y. Lin, A. Darwanto, X. Song, G. Xu, and K. Zhang Identification and characterization of propionylation at histone H3 lysine 23 in mammalian cells J. Biol. Chem. 284 2009 32288 32295
176. F. Liu, J.K. Killian, M. Yang, R.L. Walker, J.A. Hong, M. Zhang, S. Davis, Y. Zhang, M. Hussain, S. Xi, M. Rao, P.A. Meltzer, and D.S. Schrump Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate Oncogene 29 2010 3650 3664
177. Q. Liu, L. Liu, Y. Zhao, J. Zhang, D. Wang, J. Chen, Y. He, J. Wu, Z. Zhang, and Z. Liu Hypoxia induces genomic DNA demethylation through the activation of HIF-1alpha and transcriptional upregulation of MAT2A in hepatoma cells Mol. Cancer Ther. 10 2011 1113 1123
178. F. Lizcano, C. Romero, and D. Vargas Regulation of adipogenesis by nuclear receptor PPARγ is modulated by the histone demethylase JMJD2C Genet. Mol. Biol. 34 2011 19 24
179. A. Lomba, J.A. Martínez, D.F. García-Díaz, L. Paternain, A. Marti, J. Campión, and F.I. Milagro Weight gain induced by an isocaloric pair-fed high fat diet: a nutriepigenetic study on FASN and NDUFB6 gene promoters Mol. Genet. Metab. 101 2010 273 278
180. K.N. Lopez, and J.D. Knudson Obesity: from the agricultural revolution to the contemporary pediatric epidemic Congenit. Heart Dis. 7 2012 189 199
181. J. Madrigano, A. Baccarelli, M.A. Mittleman, R.O. Wright, D. Sparrow, P.S. Vokonas, L. Tarantini, and J. Schwartz Prolonged exposure to particulate pollution, genes associated with glutathione pathways, and DNA methylation in a cohort of older men Environ. Health Perspect. 119 2011 977 982
182. C.A. Maloney, S.M. Hay, and W.D. Rees The effects of feeding rats diets deficient in folic acid and related methyl donors on the blood pressure and glucose tolerance of the offspring Br. J. Nutr. 101 2009 1333 1340
183. C.A. Maloney, S.M. Hay, L.E. Young, K.D. Sinclair, and W.D. Rees A methyl-deficient diet fed to rat dams during the peri-conception period programs glucose homeostasis in adult male but not female offspring J. Nutr. 141 2011 95 100
184. J. Mandl, T. Meszaros, G. Banhegyi, L. Hunyady, and M. Csala Endoplasmic reticulum: Nutrient sensor in physiology and pathology Trends Endocrinol. Metab. 20 2009 194 201
185. A. Martí, A. Marcos, and J.A. Martínez Obesity and immune function relationships Obes. Rev. 2 2001 131 140
186. M.S. Martin-Gronert, and S.E. Ozanne Mechanisms linking suboptimal early nutrition and increased risk of type 2 diabetes and obesity J. Nutr. 140 2010 662 666
187. J.A. Martinez, P. Cordero, J. Campion, and F.I. Milagro Interplay of early life nutritional programming on obesity, inflammation and epigenetic outcomes Proc. Nutr. Soc. 71 2012 276 283
188. C. Mattsson, and T. Olsson Estrogens and glucocorticoid hormones in adipose tissue metabolism Curr. Med. Chem. 14 2007 2918 2924
189. A. May, and T.J. Wang Biomarkers for cardiovascular disease: challenges and future directions Trends Mol. Med. 14 2008 261 267
190. E.J. McAllister, N.V. Dhurandhar, S.W. Keith, L.J. Aronne, J. Barger, M. Baskin, R.M. Benca, J. Biggio, M.M. Boggiano, J.C. Eisenmann, M. Elobeid, K.R. Fontaine, P. Gluckman, E.C. Hanlon, P. Katzmarzyk, A. Pietrobelli, D.T. Redden, D.M. Ruden, C. Wang, R.A. Waterland, S.M. Wright, and D.B. Allison Ten putative contributors to the obesity epidemic Crit. Rev. Food Sci. Nutr. 49 2011 868 913
191. S.L. McGee, E. Fairlie, A.P. Garnham, and M. Hargreaves Exercise-induced histone modifications in human skeletal muscle J. Physiol. 200587 2009 5951 5958
192. S.L. McGee, and M. Hargreaves Histone modifications and exercise adaptations J. Appl. Physiol. 110 2011 258 263
193. P.O. McGowan, A. Sasaki, A.C. D'Alessio, S. Dymov, B. Labonté, M. Szyf, G. Turecki, and M.J. Meaney Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse Nat. Neurosci. 12 2009 342 348
194. D. McGuinness, L.M. McGlynn, P.C. Johnson, A. Macintyre, G.D. Batty, H. Burns, J. Cavanagh, K.A. Deans, I. Ford, A. McConnachie, A. McGinty, J.S. McLean, K. Millar, C.J. Packard, N.A. Sattar, C. Tannahill, Y.N. Velupillai, and P.G. Shiels Socio-economic status is associated with epigenetic differences in the pSoBid cohort Int. J. Epidemiol. 41 2012 151 160
195. J.A. McKay, and J.C. Mathers Diet induced epigenetic changes and their implications for health Acta Physiol. 202 2011 103 118
196. R.G. McMurray, and A.C. Hackney Interactions of metabolic hormones, adipose tissue and exercise Sports Med. 35 2005 393 412
197. R. Medzhitov, and T. Horng Transcriptional control of the inflammatory response Nat. Rev. Immunol. 9 2009 692 703
198. S.M. Meeran, A. Ahmed, and T.O. Tollefsbol Epigenetic targets of bioactive dietary components for cancer prevention and therapy Clin. Epigenetics 1 2010 101 116
199. K.B. Michels, H.R. Harris, and L. Barault Birthweight, maternal weight trajectories and global DNA methylation of LINE-1 repetitive elements PLoS One 6 2011 e25254
200. F.I. Milagro, J. Campión, P. Cordero, E. Goyenechea, A.M. Gómez-Uriz, I. Abete, M.A. Zulet, and J.A. Martínez A dual epigenomic approach for the search of obesity biomarkers: DNA methylation in relation to diet-induced weight loss FASEB J. 25 2011 1378 1389
201. F.I. Milagro, J. Campión, D.F. García-Díaz, E. Goyenechea, L. Paternain, and J.A. Martínez High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats J. Physiol. Biochem. 65 2009 1 9
202. F.I. Milagro, J. Campion, and J.A. Martínez Weight gain induced by high-fat feeding involves increased liver oxidative stress Obesity 14 2006 1118 1123
203. M. Milanski, G. Degasperi, A. Coope, J. Morari, R. Denis, D.E. Cintra, D.M. Tsukumo, G. Anhe, M.E. Amaral, H.K. Takahashi, R. Curi, H.C. Oliveira, J.B. Carvalheira, S. Bordin, M.J. Saad, and L.A. Velloso Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity J. Neurosci. 29 2009 359 370
204. J. Miyawaki, K. Sakayama, H. Kato, H. Yamamoto, and H. Masuno Perinatal and postnatal exposure to bisphenol a increases adipose tissue mass and serum cholesterol level in mice J. Atheroscler. Thromb. 14 2007 245 252
205. J.C. Moreira, F. Dal-Pizzol, A.B. Rocha, F. Klamt, N.C. Ribeiro, C.J. Ferreira, and E.A. Bernard Retinol-induced changes in the phosphorylation levels of histones and high mobility group proteins from Sertoli cells Braz. J. Med. Biol. Res. 33 2000 287 293
206. A.L. Mosley, J.A. Corbett, and S. Ozcan Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1 Mol. Endocrinol. 18 2004 2279 2290
207. A.L. Mosley, and S. Ozcan Glucose regulates insulin gene transcription by hyperacetylation of histone h4 J. Biol. Chem. 278 2003 19660 19666
208. H.N. Na, and J.H. Nam Adenovirus 36 as an obesity agent maintains the obesity state by increasing MCP-1 and inducing inflammation J. Infect. Dis. 205 2012 914 922
209. J. Nanduri, V. Makarenko, V.D. Reddy, G. Yuan, A. Pawar, N. Wang, S.A. Khan, X. Zhang, B. Kinsman, Y.J. Peng, G.K. Kumar, A.P. Fox, L.A. Godley, G.L. Semenza, and N.R. Prabhakar Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis Proc. Nat. Acad. Sci. U.S.A. 109 2012 2515 2520
210. G. Negi, A. Kumar, and S.S. Sharma Nrf2 and NF-κB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes Curr. Neurovasc. Res. 8 2011 294 304
211. R.R. Newbold Impact of environmental endocrine disrupting chemicals on the development of obesity Hormones 9 2010 206 217
212. S.F. Ng, R.C. Lin, D.R. Laybutt, R. Barres, J.A. Owens, and M.J. Morris Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring Nature 467 2010 963 966
213. Y.F. Ni, J. Wang, X.L. Yan, F. Tian, J.B. Zhao, Y.J. Wang, and T. Jiang Histone deacetylase inhibitor, butyrate, attenuates lipopolysaccharide-induced acute lung injury in mice Respir Res. 11 2010 33
214. H. Nian, B. Delage, E. Ho, and R.H. Dashwood Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds Environ. Mol. Mutagen. 50 2009 213 221
215. F.H. Nielsen Magnesium, inflammation, and obesity in chronic disease Nutr. Rev. 68 2010 333 340
216. E. O'Dea, and A. Hoffmann The regulatory logic of the NF-kappaB signaling system Cold Spring Harb. Perspect. Biol. 2 2010 a000216
217. M. Okamura, T. Inagaki, T. Tanaka, and J. Sakai Role of histone methylation and demethylation in adipogenesis and obesity Organogenesis 6 2010 24 32
218. J.M. Olefsky IKKepsilon: A bridge between obesity and inflammation Cell 138 2009 834 836
219. A.S. Olsen, M.P. Sarras Jr., A. Leontovich, and R.V. Intine Heritable transmission of diabetic metabolic memory in zebrafish correlates with DNA hypomethylation and aberrant gene expression Diabetes 61 2012 485 491
220. I.J. Onakpoya, R. Perry, J. Zhang, and E. Ernst Efficacy of calcium supplementation for management of overweight and obesity: systematic review of randomized clinical trials Nutr. Rev. 69 2011 335 343
221. I.J. Padmavathi, K.R. Rao, L. Venu, M. Ganeshan, K.A. Kumar, Ch.N. Rao, N. Harishankar, A. Ismail, and M. Raghunath Chronic maternal dietary chromium restriction modulates visceral adiposity: probable uderlying mechanisms Diabetes 59 2010 98 104
222. K.C. Page, R.E. Malik, J.A. Ripple, and E.K. Anday Maternal and postweaning diet interaction alters hypothalamic gene expression and modulates response to a high-fat diet in male offspring Am. J. Physiol. Regul. Integr. Comp. Physiol. 297 2009 R1049 R1057
223. M. Palou, C. Picó, J.A. McKay, J. Sánchez, T. Priego, J.C. Mathers, and A. Palou Protective effects of leptin during the suckling period against later obesity may be associated with changes in promoter methylation of the hypothalamic pro-opiomelanocortin gene Br. J. Nutr. 106 2011 769 778
224. D.E. Pankevich, S.L. Teegarden, A.D. Hedin, C.L. Jensen, and T.L. Bale Caloric restriction experience reprograms stress and orexigenic pathways and promotes binge eating J. Neurosci. 30 2010 16399 16407
225. J.H. Park, D.A. Stoffers, R.D. Nicholls, and R.A. Simmons Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1 J. Clin. Invest. 118 2008 2316 2324
226. L.K. Park, S. Friso, and S.W. Choi Nutritional influences on epigenetics and age-related disease Proc. Nutr. Soc. 71 2012 75 83
227. M. Pasarica, and N.V. Dhurandhar Infectobesity: obesity of infectious origin Adv. Food Nutr. Res. 52 2007 61 102
228. T. Pentinat, M. Ramon-Krauel, J. Cebria, R. Diaz, and J.C. Jimenez-Chillaron Transgenerational inheritance of glucose intolerance in a mouse model of neonatal overnutrition Endocrinology 151 2010 5617 5623
229. V. Perissi, K. Jepsen, C.K. Glass, and M.G. Rosenfeld Deconstructing repression: evolving models of co-repressor action Nat. Rev. Genet. 11 2010 109 123
230. P. Pervanidou, and G.P. Chrousos Metabolic consequences of stress during childhood and adolescence Metabolism 61 2011 611 619
231. E. Peschke, and E. Mühlbauer New evidence for a role of melatonin in glucose regulation Best Pract. Res. Clin. Endocrinol. Metab. 24 2010 829 841
232. L. Pirola, A. Balcerczyk, J. Okabe, and A. El-Osta Epigenetic phenomena linked to diabetic complications Nat. Rev. Endocrinol. 6 2010 665 675
233. L. Pirola, A. Balcerczyk, R.W. Tothill, I. Haviv, A. Kaspi, S. Lunke, M. Ziemann, T. Karagiannis, S. Tonna, A. Kowalczyk, B. Beresford-Smith, G. Macintyre, M. Kelong, Z. Hongyu, J. Zhu, and A. El-Osta Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells Genome Res. 21 2011 1601 1615
234. A. Plagemann, K. Roepke, T. Harder, M. Brunn, A. Harder, M. Wittrock-Staar, T. Ziska, K. Schellong, E. Rodekamp, K. Melchior, and J.W. Dudenhausen Epigenetic malprogramming of the insulin receptor promoter due to developmental overfeeding J. Perinat. Med. 38 2010 393 400
235. I.P. Pogribny, V.P. Tryndyak, T.V. Bagnyukova, S. Melnyk, B. Montgomery, S.A. Ross, J.R. Latendresse, I. Rusyn, and F.A. Beland Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet J. Hepatol. 51 2009 176 186
236. P.J. Pollard, C. Loenarz, D.R. Mole, M.A. McDonough, J.M. Gleadle, C.J. Schofield, and P.J. Ratcliffe Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α Biochem J. 416 2008 387 394
237. P. Quintero, F.I. Milagro, J. Campión, and J.A. Martínez Impact of oxygen availability on body weight management Med. Hypotheses 74 2010 901 907
238. V.K. Rakyan, H. Beyan, T.A. Down, M.I. Hawa, S. Maslau, D. Aden, A. Daunay, F. Busato, C.A. Mein, B. Manfras, K.R. Dias, C.G. Bell, J. Tost, B.O. Boehm, S. Beck, and R.D. Leslie Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis PLoS Genet. 7 2011 e1002300
239. V.K. Rakyan, T.A. Down, D.J. Balding, and S. Beck Epigenome-wide association studies for common human diseases Nat. Rev. Genet. 12 2011 529 541
240. V.R. Ramirez-Carrozzi, D. Braas, D.M. Bhatt, C.S. Cheng, C. Hong, K.R. Doty, J.C. Black, A. Hoffmann, M. Carey, and S.T. Smale A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling Cell 138 2009 114 128
241. E. Ravussin, and J.E. Galgani The implication of brown adipose tissue for humans Annu. Rev. Nutr. 31 2011 33 47
242. S. Reuter, S.C. Gupta, B. Park, A. Goel, and B.B. Aggarwal Epigenetic changes induced by curcumin and other natural compounds Genes Nutr. 6 2011 93 108
243. R.M. Reynolds, C. Osmond, D.I. Phillips, and K.M. Godfrey Maternal BMI, parity, and pregnancy weight gain: influences on offspring adiposity in young adulthood J. Clin. Endocrinol. Metab. 95 2010 5365 5369
244. K. Rooney, and S.E. Ozanne Maternal over-nutrition and offspring obesity predisposition: targets for preventative interventions Int. J. Obes. 35 2011 883 890
245. S.A. Ross, and C.D. Davis MicroRNA, Nutrition, and Cancer Prevention Adv. Nutr. 2 2011 472 485
246. B.S. Rubin Bisphenol A: an endocrine disruptor with widespread exposure and multiple effects J. Steroid Biochem. Mol. Biol. 127 2011 27 34
247. N. Sakurai, K. Mochizuki, and T. Goda Modifications of histone H3 at lysine 9 on the adiponectin gene in 3T3-L1 adipocytes J. Nutr. Sci. Vitaminol. 55 2009 131 138
248. A.M. Samuelsson, P.A. Matthew, M. Argenton, M.R. Christie, J.M. McConnell, E.H. Jansen, A.H. Piersma, S.E. Ozanne, D.F. Twinn, C. Remacle, A. Rowlerson, L. Poston, and P.D. Taylor Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance. a novel murine model of developmental programming Hypertension 51 2008 383 392
249. C. Sapienza, J. Lee, J. Powell, O. Erinle, F. Yafai, J. Reichert, E.S. Siraj, and M. Madaio DNA methylation profiling identifies epigenetic differences between diabetes patients with ESRD and diabetes patients without nephropathy Epigenetics 6 2011 20 28
250. N. Sato, N. Yamakawa, M. Masuda, K. Sudo, I. Hatada, and M. Muramatsu Genome-wide DNA methylation analysis reveals phytoestrogen modification of promoter methylation patterns during embryonic stem cell differentiation PLoS One 6 2011 e19278
251. S. Schenk, M. Saberi, and J.M. Olefsky Insulin sensitivity: modulation by nutrients and inflammation J. Clin. Invest. 118 2008 2992 3002
252. Y. Seki, L. Williams, P.M. Vuguin, and M.J. Charron Minireview: Epigenetic programming of diabetes and obesity: Animal Models Endocrinology 153 2012 1031 1038
253. Y.M. Shah, S. Ito, K. Morimura, C. Chen, S.H. Yim, V.H. Haase, and F.J. Gonzalez Hypoxia-inducible Factor augments experimental colitis through an MIF-dependent inflammatory signalling cascade Gastroenterology 134 2008 2036 2048
254. S. Shahrzad, K. Bertrand, K. Minhas, and B.L. Coomber Induction of DNA hypomethylation by tumor hypoxia Epigenetics 2 2007 119 125
255. W. Shao, Z. Yu, Y. Chiang, Y. Yang, T. Chai, W. Foltz, H. Lu, I.G. Fantus, and T. Jin Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes PLoS One 7 2012 e28784
256. P. Sharma, J. Kumar, G. Garg, A. Kumar, A. Patowary, G. Karthikeyan, L. Ramakrishnan, V. Brahmachari, and S. Sengupta Detection of altered global DNA methylation in coronary artery disease patients DNA Cell Biol. 27 2008 357 365
257. S. Sharma, T.K. Kelly, and P.A. Jones Epigenetics in cancer Carcinogenesis 31 2010 27 36
258. S.H. Shin, B.H. Kim, J.J. Jang, K.S. Suh, and G.H. Kang Identification of novel methylation markers in hepatocellular carcinoma using a methylation array J. Korean Med. Sci. 25 2010 1152 1159
259. A. Shore, A. Karamitri, P. Kemp, J.R. Speakman, and M.A. Lomax Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue Diabetologia 53 2010 1164 1173
260. A.L. Siebel, A.Z. Fernandez, and A. El-Osta Glycemic memory associated epigenetic changes Biochem. Pharmacol. 80 2010 1853 1859
261. M. Siervo, J.C. Wells, and G. Cizza The contribution of psychosocial stress to the obesity epidemic: an evolutionary approach Horm. Metab. Res. 41 2009 261 270
262. K.D. Sinclair, C. Allegrucci, R. Singh, D.S. Gardner, S. Sebastian, J. Bispham, A. Thurston, J.F. Huntley, W.D. Rees, C.A. Maloney, R.G. Lea, J. Craigon, T.G. McEvoy, and L.E. Young DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status Proc. Nat. Acad. Sci. U.S.A. 104 2007 19351 19356
263. N. Singh, G. Sharma, V. Mishra, and R. Raghubir Hypoxia inducible factor-1: Its potential role in cerebral ischemia Cell Mol Neurobiol. 32 2012 491 507
264. G. Sohi, K. Marchand, A. Revesz, E. Arany, and D.B. Hardy Maternal protein restriction elevates cholesterol in adult rat offspring due to repressive changes in histone modifications at the cholesterol 7alpha-hydroxylase promoter Mol. Endocrinol. 25 2011 785 798
265. M.L. Soliman, and T.A. Rosenberger Acetate supplementation increases brain histone acetylation and inhibits histone deacetylase activity and expression Mol. Cell. Biochem. 352 2011 173 180
266. G. Solinas, and M. Karin JNK1 and IKK{beta}: Molecular links between obesity and metabolic dysfunction FASEB J. 24 2010 2596 2611
267. K.L. Spalding, E. Arner, P.O. Westermark, S. Bernard, B.A. Buchholz, O. Bergmann, L. Blomqvist, J. Hoffstedt, E. Naslund, T. Britton, H. Concha, M. Hassan, M. Ryden, J. Frisen, and P. Arner Dynamics of fat cell turnover in humans Nature 453 2008 783 787
268. J.R. Speakman, and S.E. Mitchell Caloric restriction Mol. Aspects Med. 32 2011 159 221
269. K. Spiegel, E. Tasali, R. Leproult, and E. Van Cauter Effects of poor and short sleep on glucose metabolism and obesity risk Nat. Rev. Endocrinol. 5 2009 253 261
270. N. Sreejayan, F. Dong, M.R. Kandadi, X. Yang, and J. Ren Chromium alleviates glucose intolerance, insulin resistance, and hepatic ER stress in obese mice Obesity 16 2008 1331 1337
271. A. Stathis, S.J. Hotte, E.X. Chen, H.W. Hirte, A.M. Oza, P. Moretto, S. Webster, A. Laughlin, L.A. Stayner, S. McGill, L. Wang, W.J. Zhang, I. Espinoza-Delgado, J.L. Holleran, M.J. Egorin, and L.L. Siu Phase I study of decitabine in combination with vorinostat in patients with advanced solid tumors and non-Hodgkin's lymphomas Clin. Cancer Res. 17 2011 1582 1590
272. A. Stevens, G. Begum, A. Cook, K. Connor, C. Rumball, M. Oliver, J. Challis, F. Bloomfield, and A. White Epigenetic changes in the hypothalamic proopiomelanocortin and glucocorticoid receptor genes in the ovine fetus after periconceptional undernutrition Endocrinology 151 2010 3652 3664
273. C.P. Stewart, P. Christian, K.J. Schulze, S.C. Leclerq, K.P. West Jr., and S.K. Khatry Antenatal micronutrient supplementation reduces metabolic syndrome in 6- to 8-year-old children in rural Nepal J. Nutr. 139 2009 1575 1581
274. K.E. Sullivan, A.B. Reddy, K. Dietzmann, A.R. Suriano, V.P. Kocieda, M. Stewart, and M. Bhatia Epigenetic regulation of tumor necrosis factor alpha Mol. Cell. Biol. 27 2007 5147 5160
275. M. Suter, P. Bocock, L. Showalter, M. Hu, C. Shope, R. McKnight, K. Grove, R. Lane, and K. Aagaard-Tillery Epigenomics: maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primates FASEB J. 25 2011 714 726
276. M.E. Symonds, S. Sebert, and H. Budge The obesity epidemic: from the environment to epigenetics - not simply a response to dietary manipulation in a thermoneutral environment Front. Genet. 2 2011 24
277. I.M. Szeto, P.J. Das, A. Aziz, and G.H. Anderson Multivitamin supplementation of Wistar rats during pregnancy accelerates the development of obesity in offspring fed an obesogenic diet Int. J. Obes. 33 2009 364 372
278. T. Szkudelski Resveratrol-induced inhibition of insulin secretion from rat pancreatic islets: evidence for pivotal role of metabolic disturbances Am. J. Physiol. Endocrinol. Metab. 293 2007 E901 E907
279. J. Takaya, A. Iharada, H. Okihana, and K. Kaneko Magnesium deficiency in pregnant rats alters methylation of specific cytosines in the hepatic hydroxysteroid dehydrogenase-2 promoter of the offspring Epigenetics 6 2011 573 578
280. H. Takigawa-Imamura, T. Sekine, M. Murata, K. Takayama, K. Nakazawa, and J. Nakagawa Stimulation of glucose uptake in muscle cells by prolonged treatment with scriptide, a histone deacetylase inhibitor Biosci. Biotechnol. Biochem. 67 2003 1499 1506
281. P.B. Talbert, and S. Henikoff Spreading of silent chromatin: inaction at a distance Nat. Rev. Genet. 7 2011 793 803
282. K.L. Tamashiro, R.R. Sakai, C.A. Shively, I.N. Karatsoreos, and L.P. Reagan Chronic stress, metabolism, and metabolic syndrome Stress 14 2011 468 474
283. H. Taniguchi, A.F. Fernández, F. Setién, S. Ropero, E. Ballestar, A. Villanueva, H. Yamamoto, K. Imai, Y. Shinomura, and M. Esteller Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies Cancer Res. 69 2009 8447 8454
284. K. Tateishi, Y. Okada, E.M. Kallin, and Y. Zhang Role of Jhdm2a in regulating metabolic gene expression and obesity resistance Nature 458 2009 757 761
285. M. Tatemichi, H. Hata, H. Tazawa, and T. Nakadate Lipopolysaccharide induces aberrant hypermethylation of Hic-1 in mouse embryonic fibroblasts lacking p53 gene Anticancer Res. 28 2008 2101 2108
286. T. Tayaramma, B. Ma, M. Rohde, and H. Mayer Chromatin-remodeling factors allow differentiation of bone marrow cells into insulin-producing cells Stem Cells 24 2006 2858 2867
287. H. Thomassin, M. Flavin, M.L. Espinás, and T. Grange Glucocorticoid-induced DNA demethylation and gene memory during development EMBO J. 20 2001 1974 1983
288. E.W. Tobi, B.T. Heijmans, D. Kremer, H. Putter, H.A. Delemarre-van de Waal, M.J. Finken, J.M. Wit, and P.E. Slagboom DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age Epigenetics 6 2011 171 176
289. S. Tonna, A. El-Osta, M.E. Cooper, and C. Tikellis Metabolic memory and diabetic nephropathy: potential role for epigenetic mechanisms Nat. Rev. Nephrol. 6 2010 332 341
290. G. Toperoff, D. Aran, J.D. Kark, M. Rosenberg, T. Dubnikov, B. Nissan, J. Wainstein, Y. Friedlander, E. Levy-Lahad, B. Glaser, and A. Hellman Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood Hum. Mol. Genet. 21 2012 371 383
291. P.J. Turnbaugh, R.E. Ley, M.A. Mahowald, V. Magrini, E.R. Mardis, and J.I. Gordon An obesity-associated gut microbiome with increased capacity for energy harvest Nature 444 2006 1027 1031
292. H. Urakawa, A. Katsuki, Y. Sumida, E.C. Gabazza, S. Murashima, K. Morioka, N. Maruyama, N. Kitagawa, T. Tanaka, Y. Hori, K. Nakatani, Y. Yano, and Y. Adachi Oxidative stress is associated with adiposity and insulin resistance in men J. Clin. Endocrinol. Metab. 88 2003 4673 4676
293. V. Valinluck, and L.C. Sowers Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1 Cancer Res. 67 2007 946 950
294. V. Valinluck, H.H. Tsai, D.K. Rogstad, A. Burdzy, A. Bird, and L.C. Sowers Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2) Nucleic Acids Res. 32 2004 4100 4108
295. M. Valko, C.J. Rhodes, J. Moncol, M. Izakovic, and M. Mazur Free radicals, metals and antioxidants in oxidative stress-induced cancer Chem. Biol. Interact. 160 2006 1 40
296. W. Vanden Berghe, M.N. Ndlovu, R. Hoya-Arias, N. Dijsselbloem, S. Gerlo, and G. Haegeman Keeping up NF-kappaB appearances: epigenetic control of immunity or inflammation-triggered epigenetics Biochem. Pharmacol. 72 2006 1114 1131
297. K.S. vel Szic, M.N. Ndlovu, G. Haegeman, G. Haegeman, and W. Vanden Berghe Nature or nurture: let food be your epigenetic medicine in chronic inflammatory disorders Biochem. Pharmacol. 80 2010 1816 1832
298. L.A. Velloso, E.P. Araujo, and C.T. de Souza Diet-induced inflammation of the hypothalamus in obesity NeuroImmunoModulation 15 2008 189 193
299. L. Venu, I.J. Padmavathi, Y.D. Kishore, N.V. Bhanu, K.R. Rao, P.B. Sainath, M. Ganeshan, and M. Raghunath Long-term effects of maternal magnesium restriction on adiposity and insulin resistance in rat pups Obesity 16 2008 1270 1276
300. H.K. Vincent, and A.G. Taylor Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans Int. J. Obes. 30 2006 400 418
301. M. Volkmar, S. Dedeurwaerder, D.A. Cunha, M.N. Ndlovu, M. Defrance, R. Deplus, E. Calonne, U. Volkmar, M. Igoillo-Esteve, N. Naamane, S. Del Guerra, M. Masini, M. Bugliani, P. Marchetti, M. Cnop, D.L. Eizirik, and F. Fuks DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients EMBO J. 31 2012 1405 1426
302. C.C. Voorhees, D.J. Catellier, J.S. Ashwood, D.A. Cohen, A. Rung, L. Lytle, T.L. Conway, and M. Dowda Neighborhood socioeconomic status and non school physical activity and body mass index in adolescent girls J. Phys. Act. Health 6 2009 731 740
303. Z. Vucetic, J. Kimmel, K. Totoki, E. Hollenbeck, and T.M. Reyes Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes Endocrinology 151 2010 4756 4764
304. I. Wakabayashi, and T. Daimon Age-dependent decline of association between obesity and hyperglycemia in men and women Diabetes Care 35 2012 175 177
305. C.D. Walker Maternal touch and feed as critical regulators of behavioral and stress responses in the offspring Dev. Psychobiol. 52 2010 638 650
306. J. Wang, Z. Wu, D. Li, N. Li, S.V. Dindot, M.C. Satterfield, F.W. Bazer, and G. Wu Nutrition, epigenetics, and metabolic syndrome Antioxid. Redox Signal. 17 2012 282 301
307. X. Wang, H. Zhu, H. Snieder, S. Su, D. Munn, G. Harshfield, B.L. Maria, Y. Dong, F. Treiber, B. Gutin, and H. Shi Obesity related methylation changes in DNA of peripheral blood leukocytes BMC Med. 8 2010 87
308. Z. Wang, T. Yao, M. Pini, Z. Zhou, G. Fantuzzi, and Z. Song Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease Am. J. Physiol. Gastrointest. Liver Physiol. 298 2010 G634 G642
309. R.A. Waterland, M. Travisano, K.G. Tahiliani, M.T. Rached, and S. Mirza Methyl donor supplementation prevents transgenerational amplification of obesity Int. J. Obes. 32 2008 1373 1379
310. I.C. Weaver, N. Cervoni, F.A. Champagne, A.C. D'Alessio, S. Sharma, J.R. Seckl, S. Dymov, M. Szyf, and M.J. Meaney Epigenetic programming by maternal behavior Nat. Neurosci. 7 2004 847 854
311. I.C. Weaver, F.A. Champagne, S.E. Brown, S. Dymov, S. Sharma, M.J. Meaney, and M. Szyf Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life J. Neurosci. 25 2005 11045 11054
312. J. Weems, and A.L. Olson Class II histone deacetylases limit GLUT4 gene expression during adipocyte differentiation J. Biol. Chem. 286 2011 460 468
313. H. Wehbe, R. Henson, F. Meng, J. Mize-Berge, and T. Patel Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression Cancer Res. 66 2006 10517 10524
314. S.L. Werner, D. Barken, and A. Hoffmann Stimulus specificity of gene expression programs determined by temporal control of IKK activity Science 309 2005 1857 1861
315. K.E. Wheatley, L.M. Nogueira, S.N. Perkins, and S.D. Hursting Differential effects of calorie restriction and exercise on the adipose transcriptome in diet-induced obese mice J. Obes. 2011 2011 265417
316. C.L. White, M.N. Purpera, and C.D. Morrison Maternal obesity is necessary for programming effect of high-fat diet on offspring Am. J. Physiol. Regul. Integr. Comp. Physiol. 296 2009 R1464 R1472
317. S. Widiker, S. Karst, A. Wagener, and G.A. Brockmann High-fat diet leads to a decreased methylation of the Mc4r gene in the obese BFMI and the lean B6 mouse lines J. Appl. Genet. 51 2010 193 197
318. M. Widschwendter, S. Apostolidou, E. Raum, D. Rothenbacher, H. Fiegl, U. Menon, C. Stegmaier, I.J. Jacobs, and H. Brenner Epigenotyping in peripheral blood cell DNA and breast cancer risk: a proof of principle study PLoS One 3 2008 e2656
319. I.S. Wood, F.P. de Heredia, B. Wang, and P. Trayhurn Cellular hypoxia and adipose tissue dysfunction in obesity Proc. Nutr. Soc. 68 2009 370 377
320. D.L. Worthley, R.K. Le Leu, V.L. Whitehall, M. Conlon, C. Christophersen, D. Belobrajdic, K.A. Mallitt, Y. Hu, N. Irahara, S. Ogino, B.A. Leggett, and G.P. Young A human, double-blind, placebo-controlled, crossover trial of prebiotic, probiotic, and synbiotic supplementation: effects on luminal, inflammatory, epigenetic, and epithelial biomarkers of colorectal cancer Am. J. Clin. Nutr. 90 2009 578 586
321. C.S. Yajnik, S.S. Deshpande, A.A. Jackson, H. Refsum, S. Rao, D.J. Fisher, D.S. Bhat, S.S. Naik, K.J. Coyaji, C.V. Joglekar, N. Joshi, H.G. Lubree, V.U. Deshpande, S.S. Rege, and C.H. Fall Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study Diabetologia 51 2008 29 38
322. J. Yan, Y. Zhao, S. Suo, Y. Liu, and B. Zhao Green tea catechins ameliorates adipose insulin resistance by improving oxidative stress Free. Radic. Biol. Med. 52 2012 1648 1657
323. J.Y. Yeon, Y.J. Suh, S.W. Kim, H.W. Baik, C.J. Sung, H.S. Kim, and M.K. Sung Evaluation of dietary factors in relation to the biomarkers of oxidative stress and inflammation in breast cancer risk Nutrition 27 2011 912 918
324. J.M. Yun, I. Jialal, and S. Devaraj Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin J. Nutr. Biochem. 22 2011 450 458
325. S.H. Zeisel Epigenetic mechanisms for nutrition determinants of later health outcomes Am. J. Clin. Nutr. 89 2009 1488S 1493S
326. I.N. Zelko, M.W. Stepp, A.L. Vorst, and R.J. Folz Histone acetylation regulates the cell-specific and interferon-gamma-inducible expression of extracellular superoxide dismutase in human pulmonary arteries Am. J. Respir. Cell Mol. Biol. 45 2011 953 961
327. M.B. Zemel The role of dairy foods in weight management J. Am. Coll. Nutr. 24 2005 537S 546S
328. F.F. Zhang, R. Cardarelli, J. Carroll, S. Zhang, K.G. Fulda, K. Gonzalez, J.K. Vishwanatha, A. Morabia, and R.M. Santella Physical activity and global genomic DNA methylation in a cancer-free population Epigenetics 6 2011 293 299
329. F.F. Zhang, A. Morabia, J. Carroll, K. Gonzalez, K. Fulda, M. Kaur, J.K. Vishwanatha, R.M. Santella, and R. Cardarelli Dietary patterns are associated with levels of global genomic DNA methylation in a cancer-free population J. Nutr. 141 2011 1165 1171
330. S. Zhang, L. Rattanatray, S.M. MacLaughlin, J.E. Cropley, C.M. Suter, L. Molloy, D. Kleemann, S.K. Walker, B.S. Muhlhausler, J.L. Morrison, and I.C. McMillen Periconceptional undernutrition in normal and overweight ewes leads to increased adrenal growth and epigenetic changes in adrenal IGF2/H19 gene in offspring FASEB J. 24 2010 2772 2782
331. Y.J. Zhang, H.C. Wu, J. Shen, H. Ahsan, W.Y. Tsai, H.I. Yang, L.Y. Wang, S.Y. Chen, C.J. Chen, and R.M. Santella Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA Clin. Cancer Res. 13 2007 2378 2384
332. J. Zhao, J. Goldberg, and V. Vaccarino Promoter methylation of serotonin transporter gene is associated with obesity measures: a monozygotic twin study Int. J. Obes. 12 2012 12 14 (Epub ahead of print)
333. H. Zheng, S.A. Whitman, W. Wu, G.T. Wondrak, P.K. Wong, D. Fang, and D.D. Zhang Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy Diabetes 60 2011 3055 3066
334. S. Zheng, M. Rollet, and Y.X. Pan Maternal protein restriction during pregnancy induces CCAAT/enhancer-binding protein (C/EBPβ) expression through the regulation of histone modification at its promoter region in female offspring rat skeletal muscle Epigenetics 6 2011 161 170
335. S. Zheng, M. Rollet, and Y.X. Pan Protein restriction during gestation alters histone modifications at the glucose transporter 4 (GLUT4) promoter region and induces GLUT4 expression in skeletal muscle of female rat offspring J. Nutr. Biochem. 63 2011 1 15
336. D. Zhou, and Y.X. Pan Gestational low protein diet selectively induces the amino acid response pathway target genes in the liver of offspring rats through transcription factor binding and histone modifications Biochim. Biophys. Acta 1809 2011 549 556
337. J.G. Zhu, L. Xia, C.B. Ji, C.M. Zhang, G.Z. Zhu, C.M. Shi, L. Chen, D.N. Qin, and X.R. Guo Differential DNA methylation status between human preadipocytes and mature adipocytes Cell. Biochem. Biophys. 63 2012 1 15