Hypoxia induces genomic DNA demethylation through the activation of HIF-1α and transcriptional upregulation of MAT2A in hepatoma cells

Molecular Cancer Therapeutics

Volumn 10, Issue 6, 2011, Pages 1113-1123

  Liu, Quanyan ^a   Liu, Li ^a   Zhao, Yuhong ^b   Zhang, Jin ^a   Wang, Dongfeng ^a   Chen, Jiwei ^a   He, Yueming ^a   Wu, Jianguo ^a   Zhang, Zhonglin ^a   Liu, Zhisu ^a  

^a WUHAN UNIVERSITY   (China)

^b GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; GENOMIC DNA; HYPOXIA INDUCIBLE FACTOR 1; METHIONINE ADENOSYLTRANSFERASE; METHIONINE ADENOSYLTRANSFERASE 2A; PROTEIN P300; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER TISSUE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; FEMALE; GENETIC TRANSCRIPTION; HEPATOMA CELL; HUMAN; HUMAN TISSUE; HYPOXIA; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; TUMOR VOLUME; UPREGULATION;

BINDING SITES; CARCINOMA, HEPATOCELLULAR; CELL HYPOXIA; CELL LINE, TRANSFORMED; CHROMATIN IMMUNOPRECIPITATION; CPG ISLANDS; DNA; DNA METHYLATION; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HISTONE DEACETYLASE 1; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIVER NEOPLASMS; METHIONINE ADENOSYLTRANSFERASE; MUTAGENESIS, SITE-DIRECTED; P300-CBP TRANSCRIPTION FACTORS; PROMOTER REGIONS, GENETIC; S-ADENOSYLHOMOCYSTEINE; S-ADENOSYLMETHIONINE; TUMOR MICROENVIRONMENT; UP-REGULATION;

EID: 79958710992     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-10-1010     Document Type: Article

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