Acetate supplementation increases brain histone acetylation and inhibits histone deacetylase activity and expression

Molecular and Cellular Biochemistry

Volumn 352, Issue 1-2, 2011, Pages 173-180

  Soliman, Mahmoud L ^a   Rosenberger, Thad A ^a  

^a UNIVERSITY OF NORTH DAKOTA   (United States)

Author keywords

Acetate; Acetyl CoA; Acetylation; Histone; Histone acetyltransferase; Histone deacetylase

Indexed keywords

ACETYL COENZYME A; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE H3; HISTONE H4; NITRATE REDUCTASE (NADH); TRIACETIN;

ACETATE SUPPLEMENTATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HISTONE ACETYLATION; MALE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OPTICAL DENSITY; PROTEIN EXPRESSION; PROTEIN ISOLATION; RAT; SINGLE DRUG DOSE; SUPPLEMENTATION; WESTERN BLOTTING;

ACETATES; ACETYLATION; ANIMALS; BLOTTING, WESTERN; BRAIN; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HISTONES; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 79959196642     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-011-0751-3     Document Type: Article

References (53)

1. Namboodiri AM, Peethambaran A, Mathew R, Sambhu PA, Hershfield J, Moffett JR, Madhavarao CN (2006) Canavan disease and the role of N-acetylaspartate in myelin synthesis. Mol Cell Endocrinol 252:216-223
2. Madhavarao CN, Arun P, Anikster Y, Mog SR, Staretz-Chacham O, Moffett JR, Grunberg NE, Gahl WA and Namboodiri AM (2009) Glyceryl triacetate for Canavan disease: a low-dose trial in infants and evaluation of a higher dose for toxicity in the tremor rat model. J Inherit Metab Dis 32:640-650
3. Arun P, Madhavarao CN, Moffett JR, Hamilton K, Grunberg NE, Ariyannur PS, Gahl WA, Anikster Y, Mog S, Hallows WC, Denu JM, Namboodiri AM (2010) Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan disease. J Inherit Metab Dis 33:195-210
4. Arun P, Ariyannur PS, Moffett JR, Xing G, Hamilton K, Grunberg NE, Ives JA, Namboodiri AM (2010) Metabolic acetate therapy for the treatment of traumatic brain injury. J Neurotrauma 27:293-298
5. Reisenauer CJ, Bhatt DP, Mitteness DJ, Slanczka ER, Gienger HM, Watt JA and Rosenberger TA (2011) Acetate supplementation attenuates lipopolysaccharide-induced neuroinflammation. J Neurochem. doi:10.1111/j.1471- 4159.2011.07198.x
6. Ariyannur PS, Moffett JR, Madhavarao CN, Arun P, Vishnu N, Jacobowitz DM, Hallows WC, Denu JM, Namboodiri AM (2010) Nuclear-cytoplasmic localization of acetyl coenzyme a synthetase-1 in the rat brain. J Comp Neurol 518:2952-2977
7. Fujino T, Kondo J, Ishikawa M, Morikawa K, Yamamoto TT (2001) Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate. J Biol Chem 276:11420-11426 (Pubitemid 38089336)
8. Deutsch J, Rapoport SI, Rosenberger TA (2002) Coenzyme A and short-chain acyl-CoA species in control and ischemic rat brain. Neurochem Res 27:1577-1582 (Pubitemid 36020108)
9. Des Rosiers C, David F, Garneau M, Brunengraber H (1991) Nonhomogeneous labeling of liver mitochondrial acetyl-CoA. J Biol Chem 266:1574-1578 (Pubitemid 21908339)
10. McGarry JD, Foster DW (1980) Regulation of hepatic fatty acid oxidation and ketone body production. Annu Rev Biochem 49:395-420
11. Fukao T, Lopaschuk GD, Mitchell GA (2004) Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry. Prostaglandins Leukot Essent Fatty Acids 70:243-251 (Pubitemid 38200951)
12. Tanner KG, Trievel RC, Kuo MH, Howard RM, Berger SL, Allis CD, Marmorstein R, Denu JM (1999) Catalytic mechanism and function of invariant glutamic acid 173 from the histone acetyltransferase GCN5 transcriptional coactivator. J Biol Chem 274:18157-18160
13. Strahl BD, Allis CD (2000) The language of covalent histone modifications. Nature 403:41-45 (Pubitemid 30038513)
14. Gorisch SM, Wachsmuth M, Toth KF, Lichter P, Rippe K (2005) Histone acetylation increases chromatin accessibility. J Cell Sci 118:5825-5834 (Pubitemid 43079275)
15. Wade PA (2001) Transcriptional control at regulatory checkpoints by histone deacetylases: molecular connections between cancer and chromatin. Hum Mol Genet 10:693-698
16. Shi L, Wu J (2009) Epigenetic regulation in mammalian preimplantation embryo development. Reprod Biol Endocrinol 7:59
17. Haumaitre C, Lenoir O, Scharfmann R (2009) Directing cell differentiation with small-molecule histone deacetylase inhibitors: the example of promoting pancreatic endocrine cells. Cell Cycle 8:536-544
18. Peleg S, Sananbenesi F, Zovoilis A, Burkhardt S, Bahari-Javan S, Agis-Balboa RC, Cota P, Wittnam JL, Gogol-Doering A, Opitz L, Salinas-Riester G, Dettenhofer M, Kang H, Farinelli L, Chen W, Fischer A (2010) Altered histone acetylation is associated with age-dependent memory impairment in mice. Science 328:753-756
19. Levenson JM, O'Riordan KJ, Brown KD, Trinh MA, Molfese DL, Sweatt JD (2004) Regulation of histone acetylation during memory formation in the hippocampus. J Biol Chem 279:40545-40559 (Pubitemid 39287646)
20. Dang W, Steffen KK, Perry R, Dorsey JA, Johnson FB, Shilatifard A, Kaeberlein M, Kennedy BK, Berger SL (2009) Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature 459:802-807
21. Sharma SK (2010) Protein acetylation in synaptic plasticity and memory. Neurosci Biobehav Rev 34:1234-1240
22. Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, Gao J, Nieland TJ, Zhou Y, Wang X, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R, Tsai LH (2009) HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459:55-60
23. Vecsey CG, Hawk JD, Lattal KM, Stein JM, Fabian SA, Attner MA, Cabrera SM, McDonough CB, Brindle PK, Abel T, Wood MA (2007) Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. J Neurosci 27:6128-6140 (Pubitemid 46890024)
24. Balasubramaniyan V, Boddeke E, Bakels R, Kust B, Kooistra S, Veneman A, Copray S (2006) Effects of histone deacetylation inhibition on neuronal differentiation of embryonic mouse neural stem cells. Neuroscience 143:939-951 (Pubitemid 44827521)
25. Kim HJ, Rowe M, Ren M, Hong JS, Chen PS, Chuang DM (2007) Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J Pharmacol Exp Ther 321:892-901 (Pubitemid 46762687)
26. Rouaux C, Panteleeva I, Rene F, Gonzalez de Aguilar JL, Echaniz- Laguna A, Dupuis L, Menger Y, Boutillier AL, Loeffler JP (2007) Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse model. J Neurosci 27:5535-5545 (Pubitemid 350021087)
27. Zhang B, West EJ, Van KC, Gurkoff GG, Zhou J, Zhang XM, Kozikowski AP, Lyeth BG (2008) HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in rats. Brain Res 1226:181-191
28. Ryu H, Lee J, Olofsson BA, Mwidau A, Dedeoglu A, Escudero M, Flemington E, Azizkhan-Clifford J, Ferrante RJ, Ratan RR (2003) Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway. Proc Natl Acad Sci USA 100:4281-4286 (Pubitemid 36418194)
29. McCampbell A, Taye AA, Whitty L, Penney E, Steffan JS, Fischbeck KH (2001) Histone deacetylase inhibitors reduce polyglutamine toxicity. Proc Natl Acad Sci USA 98:15179-15184 (Pubitemid 34013989)
30. Steffan JS, Bodai L, Pallos J, Poelman M, McCampbell A, Apostol BL, Kazantsev A, Schmidt E, Zhu YZ, Greenwald M, Kurokawa R, Housman DE, Jackson GR, Marsh JL, Thompson LM (2001) Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature 413:739-743 (Pubitemid 33009952)
31. Kargas G, Rudy T, Spennetta T, Takayama K, Querishi N, Shrago E (1990) Separation and quantitation of long-chain free fatty acids in human serum by high-performance liquid chromatography. J Chromatogr 526:331-340 (Pubitemid 20111729)
32. Kim JS, Shukla SD (2006) Acute in vivo effect of ethanol (binge drinking) on histone H3 modifications in rat tissues. Alcohol Alcohol 41:126-132
33. Shechter D, Dormann HL, Allis CD, Hake SB (2007) Extraction, purification and analysis of histones. Nat Protoc 2:1445-1457 (Pubitemid 46952324)
34. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
35. de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB (2003) Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J 370:737-749 (Pubitemid 36399066)
36. Avalos JL, Bever KM, Wolberger C (2005) Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. Mol Cell 17:855-868 (Pubitemid 40386946)
37. Sanders BD, Zhao K, Slama JT, Marmorstein R (2007) Structural basis for nicotinamide inhibition and base exchange in Sir2 enzymes. Mol Cell 25:463-472 (Pubitemid 46199287)
38. Peterson CL (2002) HDAC's at work: everyone doing their part. Mol Cell 9:921-922
39. Clarke DJ, O'Neill LP, Turner BM (1993) Selective use of H4 acetylation sites in the yeast Saccharomyces cerevisiae. Biochem J 294(Pt 2):557-561 (Pubitemid 23268861)
40. Turner BM, O'Neill LP, Allan IM (1989) Histone H4 acetylation in human cells. Frequency of acetylation at different sites defined by immunolabeling with site-specific antibodies. FEBS Lett 253:141-145
41. Thorne AW, Kmiciek D, Mitchelson K, Sautiere P, Crane-Robinson C (1990) Patterns of histone acetylation. Eur J Biochem 193:701-713 (Pubitemid 20381701)
42. Makowski AM, Dutnall RN, Annunziato AT (2001) Effects of acetylation of histone H4 at lysines 8 and 16 on activity of the Hat1 histone acetyltransferase. J Biol Chem 276:43499-43502
43. Santini V, Gozzini A, Ferrari G (2007) Histone deacetylase inhibitors: molecular and biological activity as a premise to clinical application. Curr Drug Metab 8:383-393
44. Langley B, Gensert JM, Beal MF, Ratan RR (2005) Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents. Curr Drug Targets CNS Neurol Disord 4:41-50 (Pubitemid 41403313)
45. Morrison BE, Majdzadeh N, D'Mello SR (2007) Histone deacetylases: focus on the nervous system. Cell Mol Life Sci 64:2258-2269 (Pubitemid 47347953)
46. Blanchard F, Chipoy C (2005) Histone deacetylase inhibitors: new drugs for the treatment of inflammatory diseases? Drug Discov Today 10:197-204
47. Adcock IM (2007) HDAC inhibitors as anti-inflammatory agents. Br J Pharmacol 150:829-831
48. Li Y, Yuan Z, Liu B, Sailhamer EA, Shults C, Velmahos GC, Demoya M, Alam HB (2008) Prevention of hypoxia-induced neuronal apoptosis through histone deacetylase inhibition. J Trauma 64:863-870 discussion 870-1
49. Shogren-Knaak M, Ishii H, Sun JM, Pazin MJ, Davie JR, Peterson CL (2006) Histone H4-K16 acetylation controls chromatin structure and protein interactions. Science 311:844-847 (Pubitemid 43228847)
50. Braunstein M, Sobel RE, Allis CD, Turner BM, Broach JR (1996) Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern. Mol Cell Biol 16:4349-4356 (Pubitemid 26251236)
51. Li X, Corsa CA, Pan PW, Wu L, Ferguson D, Yu X, Min J, Dou Y (2010) MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1. Mol Cell Biol 30:5335-5347
52. Mathew R, Arun P, Madhavarao CN, Moffett JR, Namboodiri MA (2005) Progress toward acetate supplementation therapy for Canavan disease: glyceryl triacetate administration increases acetate, but not N-acetylaspartate, levels in brain. J Pharmacol Exp Ther 315:297-303 (Pubitemid 41380524)
53. Bourre JM, Paturneau-Jouas MY, Daudu OL, Baumann NA (1977) Lignoceric acid biosynthesis in the developing brain. Activities of mitochondrial acetyl-CoA-dependent synthesis and microsomal malonyl-CoA chain-elongating system in relation to myelination. Comparison between normal mouse and dysmyelinating mutants (quaking and jimpy). Eur J Biochem 72:41-47