메뉴 건너뛰기




Volumn 134, Issue 7, 2008, Pages

Hypoxia-Inducible Factor Augments Experimental Colitis Through an MIF-Dependent Inflammatory Signaling Cascade

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRAN SULFATE; HYPOXIA INDUCIBLE FACTOR; MIGRATION INHIBITION FACTOR; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN;

EID: 44649179392     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.03.009     Document Type: Article
Times cited : (150)

References (53)
  • 1
    • 0027210562 scopus 로고
    • General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
    • Wang G.L., and Semenza G.L. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci U S A 90 (1993) 4304-4308
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 4304-4308
    • Wang, G.L.1    Semenza, G.L.2
  • 2
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang G.L., Jiang B.H., Rue E.A., et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A 92 (1995) 5510-5514
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3
  • 3
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza G.L., and Wang G.L. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12 (1992) 5447-5454
    • (1992) Mol Cell Biol , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 4
    • 0027427588 scopus 로고
    • Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia
    • Wang G.L., and Semenza G.L. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J Biol Chem 268 (1993) 21513-21518
    • (1993) J Biol Chem , vol.268 , pp. 21513-21518
    • Wang, G.L.1    Semenza, G.L.2
  • 5
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
    • Tian H., McKnight S.L., and Russell D.W. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 11 (1997) 72-82
    • (1997) Genes Dev , vol.11 , pp. 72-82
    • Tian, H.1    McKnight, S.L.2    Russell, D.W.3
  • 6
    • 0035969508 scopus 로고    scopus 로고
    • Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
    • Makino Y., Cao R., Svensson K., et al. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 414 (2001) 550-554
    • (2001) Nature , vol.414 , pp. 550-554
    • Makino, Y.1    Cao, R.2    Svensson, K.3
  • 7
    • 0035917808 scopus 로고    scopus 로고
    • Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
    • Jaakkola P., Mole D.R., Tian Y.M., et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292 (2001) 468-472
    • (2001) Science , vol.292 , pp. 468-472
    • Jaakkola, P.1    Mole, D.R.2    Tian, Y.M.3
  • 8
    • 0035917313 scopus 로고    scopus 로고
    • HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
    • Ivan M., Kondo K., Yang H., et al. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292 (2001) 464-468
    • (2001) Science , vol.292 , pp. 464-468
    • Ivan, M.1    Kondo, K.2    Yang, H.3
  • 9
    • 0035852668 scopus 로고    scopus 로고
    • Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor
    • Haase V.H., Glickman J.N., Socolovsky M., et al. Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc Natl Acad Sci U S A 98 (2001) 1583-1588
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 1583-1588
    • Haase, V.H.1    Glickman, J.N.2    Socolovsky, M.3
  • 10
    • 0345491599 scopus 로고    scopus 로고
    • Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
    • Hu C.J., Wang L.Y., Chodosh L.A., et al. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol 23 (2003) 9361-9374
    • (2003) Mol Cell Biol , vol.23 , pp. 9361-9374
    • Hu, C.J.1    Wang, L.Y.2    Chodosh, L.A.3
  • 11
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: role of the HIF system
    • Pugh C.W., and Ratcliffe P.J. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 9 (2003) 677-684
    • (2003) Nat Med , vol.9 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 12
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza G.L. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3 (2003) 721-732
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 13
    • 33845357105 scopus 로고    scopus 로고
    • Role of HIF-1 in iron regulation: potential therapeutic strategy for neurodegenerative disorders
    • Lee D.W., and Andersen J.K. Role of HIF-1 in iron regulation: potential therapeutic strategy for neurodegenerative disorders. Curr Mol Med 6 (2006) 883-893
    • (2006) Curr Mol Med , vol.6 , pp. 883-893
    • Lee, D.W.1    Andersen, J.K.2
  • 14
    • 15444342958 scopus 로고    scopus 로고
    • Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha
    • Iyer N.V., Kotch L.E., Agani F., et al. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev 12 (1998) 149-162
    • (1998) Genes Dev , vol.12 , pp. 149-162
    • Iyer, N.V.1    Kotch, L.E.2    Agani, F.3
  • 15
    • 0032213236 scopus 로고    scopus 로고
    • The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
    • Tian H., Hammer R.E., Matsumoto A.M., et al. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev 12 (1998) 3320-3324
    • (1998) Genes Dev , vol.12 , pp. 3320-3324
    • Tian, H.1    Hammer, R.E.2    Matsumoto, A.M.3
  • 16
    • 0030943461 scopus 로고    scopus 로고
    • Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
    • Maltepe E., Schmidt J.V., Baunoch D., et al. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 386 (1997) 403-407
    • (1997) Nature , vol.386 , pp. 403-407
    • Maltepe, E.1    Schmidt, J.V.2    Baunoch, D.3
  • 17
    • 0030847165 scopus 로고    scopus 로고
    • Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice
    • Gnarra J.R., Ward J.M., Porter F.D., et al. Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice. Proc Natl Acad Sci U S A 94 (1997) 9102-9107
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 9102-9107
    • Gnarra, J.R.1    Ward, J.M.2    Porter, F.D.3
  • 18
    • 9644302527 scopus 로고    scopus 로고
    • Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis
    • Karhausen J., Furuta G.T., Tomaszewski J.E., et al. Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J Clin Invest 114 (2004) 1098-1106
    • (2004) J Clin Invest , vol.114 , pp. 1098-1106
    • Karhausen, J.1    Furuta, G.T.2    Tomaszewski, J.E.3
  • 20
    • 34347262689 scopus 로고    scopus 로고
    • Chemically induced mouse models of intestinal inflammation
    • Wirtz S., Neufert C., Weigmann B., et al. Chemically induced mouse models of intestinal inflammation. Nat Protoc 2 (2007) 541-546
    • (2007) Nat Protoc , vol.2 , pp. 541-546
    • Wirtz, S.1    Neufert, C.2    Weigmann, B.3
  • 21
    • 34247621784 scopus 로고    scopus 로고
    • Molecular pathogenesis of inflammatory bowel disease: genotypes, phenotypes and personalized medicine
    • Goyette P., Labbe C., Trinh T.T., et al. Molecular pathogenesis of inflammatory bowel disease: genotypes, phenotypes and personalized medicine. Ann Med 39 (2007) 177-199
    • (2007) Ann Med , vol.39 , pp. 177-199
    • Goyette, P.1    Labbe, C.2    Trinh, T.T.3
  • 22
    • 33847381116 scopus 로고    scopus 로고
    • The fundamental basis of inflammatory bowel disease
    • Strober W., Fuss I., and Mannon P. The fundamental basis of inflammatory bowel disease. J Clin Invest 117 (2007) 514-521
    • (2007) J Clin Invest , vol.117 , pp. 514-521
    • Strober, W.1    Fuss, I.2    Mannon, P.3
  • 23
    • 24144450331 scopus 로고    scopus 로고
    • Mucosal epithelium in health and disease
    • Ponda P.P., and Mayer L. Mucosal epithelium in health and disease. Curr Mol Med 5 (2005) 549-556
    • (2005) Curr Mol Med , vol.5 , pp. 549-556
    • Ponda, P.P.1    Mayer, L.2
  • 24
    • 4043059169 scopus 로고    scopus 로고
    • Tissue-specific and inducible Cre-mediated recombination in the gut epithelium
    • el Marjou F., Janssen K.P., Chang B.H., et al. Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis 39 (2004) 186-193
    • (2004) Genesis , vol.39 , pp. 186-193
    • el Marjou, F.1    Janssen, K.P.2    Chang, B.H.3
  • 25
    • 33746369144 scopus 로고    scopus 로고
    • Dual regulation of macrophage migration inhibitory factor (MIF) expression in hypoxia by CREB and HIF-1
    • Baugh J.A., Gantier M., Li L., et al. Dual regulation of macrophage migration inhibitory factor (MIF) expression in hypoxia by CREB and HIF-1. Biochem Biophys Res Commun 347 (2006) 895-903
    • (2006) Biochem Biophys Res Commun , vol.347 , pp. 895-903
    • Baugh, J.A.1    Gantier, M.2    Li, L.3
  • 26
    • 0141669198 scopus 로고    scopus 로고
    • Defective brain development in mice lacking the Hif-1alpha gene in neural cells
    • Tomita S., Ueno M., Sakamoto M., et al. Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol Cell Biol 23 (2003) 6739-6749
    • (2003) Mol Cell Biol , vol.23 , pp. 6739-6749
    • Tomita, S.1    Ueno, M.2    Sakamoto, M.3
  • 27
    • 0033777202 scopus 로고    scopus 로고
    • Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha
    • Tomita S., Sinal C.J., Yim S.H., et al. Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha. Mol Endocrinol 14 (2000) 1674-1681
    • (2000) Mol Endocrinol , vol.14 , pp. 1674-1681
    • Tomita, S.1    Sinal, C.J.2    Yim, S.H.3
  • 28
    • 34447117473 scopus 로고    scopus 로고
    • Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut
    • Ito S., Chen C., Satoh J., et al. Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut. J Clin Invest 117 (2007) 1940-1950
    • (2007) J Clin Invest , vol.117 , pp. 1940-1950
    • Ito, S.1    Chen, C.2    Satoh, J.3
  • 29
    • 33847039159 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator-activated receptor-gamma in macrophage suppresses experimentally induced colitis
    • Shah Y.M., Morimura K., and Gonzalez F.J. Expression of peroxisome proliferator-activated receptor-gamma in macrophage suppresses experimentally induced colitis. Am J Physiol Gastrointest Liver Physiol 292 (2007) G657-G666
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292
    • Shah, Y.M.1    Morimura, K.2    Gonzalez, F.J.3
  • 30
    • 0029971584 scopus 로고    scopus 로고
    • Crystal structure of the macrophage migration inhibitory factor from rat liver
    • Suzuki M., Sugimoto H., Nakagawa A., et al. Crystal structure of the macrophage migration inhibitory factor from rat liver. Nat Struct Biol 3 (1996) 259-266
    • (1996) Nat Struct Biol , vol.3 , pp. 259-266
    • Suzuki, M.1    Sugimoto, H.2    Nakagawa, A.3
  • 31
    • 33746123520 scopus 로고    scopus 로고
    • Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia
    • Kaidi A., Qualtrough D., Williams A.C., et al. Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia. Cancer Res 66 (2006) 6683-6691
    • (2006) Cancer Res , vol.66 , pp. 6683-6691
    • Kaidi, A.1    Qualtrough, D.2    Williams, A.C.3
  • 32
    • 2142695733 scopus 로고    scopus 로고
    • Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic
    • Warner T.D., and Mitchell J.A. Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic. FASEB J 18 (2004) 790-804
    • (2004) FASEB J , vol.18 , pp. 790-804
    • Warner, T.D.1    Mitchell, J.A.2
  • 33
    • 17644397560 scopus 로고    scopus 로고
    • Local and systemic inflammation in chronic obstructive pulmonary disease
    • Wouters E.F. Local and systemic inflammation in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2 (2005) 26-33
    • (2005) Proc Am Thorac Soc , vol.2 , pp. 26-33
    • Wouters, E.F.1
  • 34
    • 33847136182 scopus 로고    scopus 로고
    • Thoracic manifestations of inflammatory bowel disease
    • Black H., Mendoza M., and Murin S. Thoracic manifestations of inflammatory bowel disease. Chest 131 (2007) 524-532
    • (2007) Chest , vol.131 , pp. 524-532
    • Black, H.1    Mendoza, M.2    Murin, S.3
  • 35
    • 0031690631 scopus 로고    scopus 로고
    • Hyperbaric oxygen: a novel modality to ameliorate experimental colitis
    • Rachmilewitz D., Karmeli F., Okon E., et al. Hyperbaric oxygen: a novel modality to ameliorate experimental colitis. Gut 43 (1998) 512-518
    • (1998) Gut , vol.43 , pp. 512-518
    • Rachmilewitz, D.1    Karmeli, F.2    Okon, E.3
  • 36
    • 0033104847 scopus 로고    scopus 로고
    • Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha
    • Yu A.Y., Shimoda L.A., Iyer N.V., et al. Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. J Clin Invest 103 (1999) 691-696
    • (1999) J Clin Invest , vol.103 , pp. 691-696
    • Yu, A.Y.1    Shimoda, L.A.2    Iyer, N.V.3
  • 37
    • 0037423948 scopus 로고    scopus 로고
    • HIF-1alpha is essential for myeloid cell-mediated inflammation
    • Cramer T., Yamanishi Y., Clausen B.E., et al. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 112 (2003) 645-657
    • (2003) Cell , vol.112 , pp. 645-657
    • Cramer, T.1    Yamanishi, Y.2    Clausen, B.E.3
  • 38
    • 43549112364 scopus 로고    scopus 로고
    • HIF-1{alpha} regulates epithelial inflammation by cell autonomous NF{kappa}B activation and paracrine stromal remodeling
    • Scortegagna M., Cataisson C., Martin R.J., et al. HIF-1{alpha} regulates epithelial inflammation by cell autonomous NF{kappa}B activation and paracrine stromal remodeling. Blood 111 (2008) 3343-3354
    • (2008) Blood , vol.111 , pp. 3343-3354
    • Scortegagna, M.1    Cataisson, C.2    Martin, R.J.3
  • 39
    • 37349048502 scopus 로고    scopus 로고
    • Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition
    • Robinson A., Keely S., Karhausen J., et al. Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology 134 (2008) 145-155
    • (2008) Gastroenterology , vol.134 , pp. 145-155
    • Robinson, A.1    Keely, S.2    Karhausen, J.3
  • 40
    • 37349118314 scopus 로고    scopus 로고
    • The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis
    • Cummins E.P., Seeballuck F., Keely S.J., et al. The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis. Gastroenterology 134 (2008) 156-165
    • (2008) Gastroenterology , vol.134 , pp. 156-165
    • Cummins, E.P.1    Seeballuck, F.2    Keely, S.J.3
  • 41
    • 85047685683 scopus 로고    scopus 로고
    • Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia
    • Synnestvedt K., Furuta G.T., Comerford K.M., et al. Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. J Clin Invest 110 (2002) 993-1002
    • (2002) J Clin Invest , vol.110 , pp. 993-1002
    • Synnestvedt, K.1    Furuta, G.T.2    Comerford, K.M.3
  • 42
    • 0037096732 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene
    • Comerford K.M., Wallace T.J., Karhausen J., et al. Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res 62 (2002) 3387-3394
    • (2002) Cancer Res , vol.62 , pp. 3387-3394
    • Comerford, K.M.1    Wallace, T.J.2    Karhausen, J.3
  • 43
    • 0035821249 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia
    • Furuta G.T., Turner J.R., Taylor C.T., et al. Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia. J Exp Med 193 (2001) 1027-1034
    • (2001) J Exp Med , vol.193 , pp. 1027-1034
    • Furuta, G.T.1    Turner, J.R.2    Taylor, C.T.3
  • 44
    • 34047156190 scopus 로고    scopus 로고
    • HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
    • Gordan J.D., Bertout J.A., Hu C.J., et al. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell 11 (2007) 335-347
    • (2007) Cancer Cell , vol.11 , pp. 335-347
    • Gordan, J.D.1    Bertout, J.A.2    Hu, C.J.3
  • 45
    • 0032189844 scopus 로고    scopus 로고
    • Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha
    • Wiesener M.S., Turley H., Allen W.E., et al. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. Blood 92 (1998) 2260-2268
    • (1998) Blood , vol.92 , pp. 2260-2268
    • Wiesener, M.S.1    Turley, H.2    Allen, W.E.3
  • 46
    • 2442544693 scopus 로고    scopus 로고
    • Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha
    • Uchida T., Rossignol F., Matthay M.A., et al. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. J Biol Chem 279 (2004) 14871-14878
    • (2004) J Biol Chem , vol.279 , pp. 14871-14878
    • Uchida, T.1    Rossignol, F.2    Matthay, M.A.3
  • 47
    • 0037446250 scopus 로고    scopus 로고
    • HIF-2alpha regulates glyceraldehyde-3-phosphate dehydrogenase expression in endothelial cells
    • Graven K.K., Bellur D., Klahn B.D., et al. HIF-2alpha regulates glyceraldehyde-3-phosphate dehydrogenase expression in endothelial cells. Biochim Biophys Acta 1626 (2003) 10-18
    • (2003) Biochim Biophys Acta , vol.1626 , pp. 10-18
    • Graven, K.K.1    Bellur, D.2    Klahn, B.D.3
  • 48
    • 17944369782 scopus 로고    scopus 로고
    • Development of chronic colitis is dependent on the cytokine MIF
    • de Jong Y.P., Abadia-Molina A.C., Satoskar A.R., et al. Development of chronic colitis is dependent on the cytokine MIF. Nat Immunol 2 (2001) 1061-1066
    • (2001) Nat Immunol , vol.2 , pp. 1061-1066
    • de Jong, Y.P.1    Abadia-Molina, A.C.2    Satoskar, A.R.3
  • 49
    • 0036307628 scopus 로고    scopus 로고
    • Amelioration of dextran sulfate sodium-induced colitis by anti-macrophage migration inhibitory factor antibody in mice
    • Ohkawara T., Nishihira J., Takeda H., et al. Amelioration of dextran sulfate sodium-induced colitis by anti-macrophage migration inhibitory factor antibody in mice. Gastroenterology 123 (2002) 256-270
    • (2002) Gastroenterology , vol.123 , pp. 256-270
    • Ohkawara, T.1    Nishihira, J.2    Takeda, H.3
  • 50
    • 33751164387 scopus 로고    scopus 로고
    • Resistance to experimental colitis depends on cytoprotective heat shock proteins in macrophage migration inhibitory factor null mice
    • Ohkawara T., Nishihira J., Ishiguro Y., et al. Resistance to experimental colitis depends on cytoprotective heat shock proteins in macrophage migration inhibitory factor null mice. Immunol Lett 107 (2006) 148-154
    • (2006) Immunol Lett , vol.107 , pp. 148-154
    • Ohkawara, T.1    Nishihira, J.2    Ishiguro, Y.3
  • 51
    • 20244379867 scopus 로고    scopus 로고
    • Transgenic over-expression of macrophage migration inhibitory factor renders mice markedly more susceptible to experimental colitis
    • Ohkawara T., Miyashita K., Nishihira J., et al. Transgenic over-expression of macrophage migration inhibitory factor renders mice markedly more susceptible to experimental colitis. Clin Exp Immunol 140 (2005) 241-248
    • (2005) Clin Exp Immunol , vol.140 , pp. 241-248
    • Ohkawara, T.1    Miyashita, K.2    Nishihira, J.3
  • 52
    • 27744530222 scopus 로고    scopus 로고
    • ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis
    • Al-Abed Y., Dabideen D., Aljabari B., et al. ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. J Biol Chem 280 (2005) 36541-36544
    • (2005) J Biol Chem , vol.280 , pp. 36541-36544
    • Al-Abed, Y.1    Dabideen, D.2    Aljabari, B.3
  • 53
    • 4043119692 scopus 로고    scopus 로고
    • The HIF pathway as a therapeutic target
    • Hewitson K.S., and Schofield C.J. The HIF pathway as a therapeutic target. Drug Discov Today 9 (2004) 704-711
    • (2004) Drug Discov Today , vol.9 , pp. 704-711
    • Hewitson, K.S.1    Schofield, C.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.