Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology

Nature

Volumn 456, Issue 7224, 2008, Pages 997-1000

  Alenghat, Theresa ^a   Meyers, Katherine ^a   Mullican, Shannon E ^a   Leitner, Kirstin ^a   Adeniji Adele, Adetoun ^a   Avila, Jacqueline ^a   Bućan, Maja ^a   Ahima, Rexford S ^a   Kaestner, Klaus H ^a   Lazar, Mitchell A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE 3; NUCLEAR RECEPTOR COREPRESSOR;

CHROMOSOME; CIRCADIAN RHYTHM; ENZYME ACTIVITY; GENE EXPRESSION; MAMMAL; METABOLISM; PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; EMBRYO; ENERGY BALANCE; ENERGY EXPENDITURE; FEMALE; GENE DISRUPTION; GENE EXPRESSION; IN VIVO STUDY; INSULIN SENSITIVITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; WEIGHT REDUCTION;

AMINO ACID SUBSTITUTION; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BIOLOGICAL CLOCKS; CELLS, CULTURED; CIRCADIAN RHYTHM; DIET; ENERGY METABOLISM; FEMALE; GENE EXPRESSION REGULATION; HISTONE DEACETYLASES; LIVER; MALE; MICE; MICE, INBRED C57BL; NUCLEAR PROTEINS; OBESITY; REPRESSOR PROTEINS;

MAMMALIA; MUS;

EID: 57749195091     PISSN: 00280836     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/nature07541     Document Type: Article

References (34)

1. Ripperger, J. A. & Schibler, U. Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions. Nature Genet. 38, 369-374 (2006).
2. Doi, M., Hirayama, J. & Sassone-Corsi, P. Circadian regulator CLOCK is a histone acetyltransferase. Cell 125, 497-508 (2006).
3. Etchegaray, J. P., Lee, C., Wade, P. A. & Reppert, S. M. Rhythmic histone acetylation underlies transcription in the mammalian circadian clock. Nature 421, 177-182 (2003).
4. Kohsaka, A. et al. High-fat diet disrupts behavioral and molecular circadian rhythms in mice. Cell Metab. 6, 414-421 (2007).
5. Rudic, R. D. et al. BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biol. 2, e377 (2004).
6. Turek, F. W. et al. Obesity and metabolic syndrome in circadian Clock mutant mice. Science 308, 1043-1045 (2005).
7. Liu,C., Li,S.,Liu,T.,Borjigin, J.&Lin, J.D.Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism. Nature 447, 477-481 (2007).
8. Guenther, M. G., Barak, O. & Lazar, M. A. The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3. Mol. Cell. Biol. 21, 6091-6101 (2001).
9. Jepsen, K. et al. Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell 102, 753-763 (2000).
10. Gachon, F., Nagoshi, E., Brown, S. A., Ripperger, J. & Schibler, U. The mammalian circadian timing system: from gene expression to physiology. Chromosoma 113, 103-112 (2004).
11. Lowrey, P. L. & Takahashi, J. S. Mammalian circadian biology: elucidating genome-wide levels of temporal organization. Annu. Rev. Genomics Hum. Genet. 5, 407-441 (2004).
12. Schultz, T. F. & Kay, S. A. Circadian clocks in daily and seasonal control of development. Science 301, 326-328 (2003).
13. Shearman, L. P. et al. Interacting molecular loops in the mammalian circadian clock. Science 288, 1013-1019 (2000).
14. Reppert, S. M. & Weaver, D. R. Molecular analysis of mammalian circadian rhythms. Annu. Rev. Physiol. 63, 647-676 (2001).
15. Desvergne, B., Michalik, L. & Wahli, W. Transcriptional regulation of metabolism. Physiol. Rev. 86, 465-514 (2006).
16. Yang, X. et al. Nuclear receptor expression links the circadian clock to metabolism. Cell 126, 801-810 (2006).
17. Yin, L. et al. Rev-erbaa, a heme sensor that coordinates metabolic and circadian pathways. Science 318, 1786-1789 (2007).
18. Ishizuka, T. & Lazar, M. A. The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor. Mol. Endocrinol. 19, 1443-1451 (2005).
19. Bhaskara, S. et al. Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Mol. Cell 30, 61-72 (2008).
20. Yin, L. & Lazar, M. A. The orphan nuclear receptor Rev-erbα recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene. Mol. Endocrinol. 19, 1452-1459 (2005).
21. Preitner, N. et al. The orphan nuclear receptor REV-ERBα controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110, 251-260 (2002).
22. Liu, A. C. et al. Redundant function of REV-ERBα and β and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms. PLoS Genet. 4, e1000023 (2008).
23. Yu, C. et al. The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor γ transcriptional activity and repress 3T3-L1 adipogenesis. J. Biol. Chem. 280, 13600-13605 (2005).
24. Knutson, S. K. et al. Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. EMBO J. 27, 1017-1028 (2008).
25. Matsuzaka, T. et al. Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. Nature Med. 13, 1193-1202 (2007).
26. Jansen, M. S., Cook, G. A., Song, S. & Park, E. A. Thyroid hormone regulates carnitine palmitoyltransferase Ia gene expression through elements in the promoter and first intron. J. Biol. Chem. 275, 34989-34997 (2000).
27. Leone, T. C. et al. The human medium chain Acyl-CoA dehydrogenase gene promoter consists of a complex arrangement of nuclear receptor response elements and Sp1 binding sites. J. Biol. Chem. 270, 16308-16314 (1995).
28. Martino, T. A. et al. Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294, R1675-R1683 (2008).
29. Fuller, P. M., Lu, J. & Saper, C. B. Differential rescue of light- and food-entrainable circadian rhythms. Science 320, 1074-1077 (2008).
30. Ramsey, K. M., Marcheva, B., Kohsaka, A. & Bass, J. The clockwork of metabolism. Annu. Rev. Nutr. 27, 219-240 (2007).
31. Kapfhamer, D. et al. Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse. Nature Genet. 32, 290-295 (2002).
32. Qi, Y. et al. Loss of resistin improves glucose homeostasis in leptin deficiency. Diabetes 55, 3083-3090 (2006).
33. Balsalobre, A., Damiola, F. & Schibler, U. A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell 93, 929-937 (1998).
34. Ishizuka, T. & Lazar, M. A. The N-CoR/histone deacetylase 3 complex is required for repression by thyroid hormone receptor. Mol. Cell. Biol. 23, 5122-5131 (2003).