A small molecule differentiation inducer increases insulin production by pancreatic β cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 51, 2011, Pages 20713-20718

  Dioum, Elhadji M ^a   Osborne, Jihan K ^a   Goetsch, Sean ^a   Russell, Jamie ^a   Schneider, Jay W ^a   Cobb, Melanie H ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Differentiation; Glucose stimulated insulin secretion; Human islets; p300

Indexed keywords

ANTIDIABETIC AGENT; CELL PROTEIN; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; INSULIN; ISOXAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN P300;

ANTIDIABETIC ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EX VIVO CULTURE; EX VIVO STUDY; GENETIC TRANSCRIPTION; HISTONE ACETYLATION; HUMAN; HUMAN CELL; INSULIN RELEASE; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CELL NUCLEUS; GENE EXPRESSION REGULATION; GLUCOSE; HEK293 CELLS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; ISOXAZOLES; MICE; NEURONS; P300-CBP TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS;

EID: 84855512177     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1118526109     Document Type: Article

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