Hypoxia-inducible factor 1α induces corticosteroid-insensitive inflammation via reduction of histone deacetylase-2 transcription

Journal of Biological Chemistry

Volumn 284, Issue 52, 2009, Pages 36047-36054

  Charron, Catherine E ^a   Chou, Pai Chien ^a,b   Coutts, David J C ^a   Kumar, Vaibhav ^a   To, Masako ^a   Akashi, Kenichi ^a   Pinhu, Liao ^c   Griffiths, Mark ^c   Adcock, Ian M ^a   Barnes, Peter J ^a   Ito, Kazuhiro ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c Unit of Critical Care   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

A549 CELLS; ANTI-INFLAMMATORY AGENTS; CHRONIC INFLAMMATORY DISEASE; DEXAMETHASONES; HISTONE DEACETYLASES; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTORS; HYPOXIC CONDITION; INTERLEUKIN-1; INTERLEUKIN-8; MACROPHAGE CELLS; POINT MUTATIONS; POLYMERASE II; PROMOTER ACTIVITIES; PROTEIN EXPRESSIONS; RESPONSE ELEMENTS;

PATHOLOGY; TRANSCRIPTION; TRANSCRIPTION FACTORS;

DRUG PRODUCTS;

CORTICOSTEROID; DEXAMETHASONE; DNA DIRECTED DNA POLYMERASE ALPHA; HISTONE DEACETYLASE 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; INTERLEUKIN 8; MESSENGER RNA;

ARTICLE; BINDING SITE; CELL STRAIN; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG RESISTANCE; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; HUMAN; HUMAN CELL; HYPOXIA; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM; MACROPHAGE; MUTATIONAL ANALYSIS; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL HYPOXIA; DEXAMETHASONE; DRUG RESISTANCE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOCORTICOIDS; HISTONE DEACETYLASE 2; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-8; MACROPHAGES; POINT MUTATION; RESPIRATORY MUCOSA; RESPONSE ELEMENTS; RNA, MESSENGER; U937 CELLS;

EID: 73649086907     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.025387     Document Type: Article

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